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31. 发明公开

EP2146959A1 VANILLOID-REZEPTOR LIGANDEN UND IHRE VERWENDUNG ZUR HERSTELLUNG VON ARZNEIMITTELN 有权
标题翻译：辣椒素受体配体和它们在药品生产
公开(公告)号：EP2146959A1
公开(公告)日：2010-01-27
申请号：EP08735181.3
申请日：2008-04-11
申请人： Grünenthal GmbH
发明人： FRANK, Robert , BAHRENBERG, Gregor , CHRISTOPH, Thomas , SCHIENE, Klaus , DE VRY, Jean , SAUNDERS, Derek, John , LEE, Jeewoo
IPC分类号： C07D211/14 , C07D213/70 , C07D401/04 , C07C311/08 , A61K31/444 , A61K31/18 , A61P29/00
CPC分类号： C07D211/08 , C07C311/08 , C07C323/41 , C07C2601/14 , C07D211/14 , C07D213/70 , C07D401/04
摘要： The present invention relates to novel vanilloid receptor ligands, methods for the production thereof, pharmaceuticals containing these compounds, and the use of these compounds for the production of pharmaceuticals.
摘要翻译：化合物对应于式I：其中充当香草素受体配体，药物组合物S含受试化合物，用于制备化合物的方法，以及使用测试化合物来治疗疼痛和各种其他条件。

32. 发明授权

EP1891004B1 PENTAFLUORSULFANYL-SUBSTITUIERTE VERBINDUNG UND DEREN VERWENDUNG ZUR HERSTELLUNG VON ARZNEIMITTELN 有权
标题翻译： Pentafluorosulfanylbenzoic取代物及它们在药品生产
公开(公告)号：EP1891004B1
公开(公告)日：2009-12-02
申请号：EP06753678.9
申请日：2006-05-17
申请人： Grünenthal GmbH
发明人： FRANK, Robert , SUNDERMANN, Bernd , SCHICK, Hans
IPC分类号： C07C381/00 , A61K31/17
CPC分类号： C07C381/00

33. 发明公开

EP2116357A1 Verfahren zur Herstellung einer Polsterauflage, Vorformling-Werkzeug und derart hergestellte Polsterauflagen 有权转让
标题翻译： Verfahren zur Herstellung einer Polsterauflage
公开(公告)号：EP2116357A1
公开(公告)日：2009-11-11
申请号：EP09006296.9
申请日：2009-05-08
申请人： Johnson Controls GmbH , Alba tooling & engineering GmbH
发明人： Janz, Michael , Weingärtner, Andreas , Klusmeier, Werner , Naue, Anton , Pogorevc, Branko
IPC分类号： B29C70/30 , B29B11/16 , B60N2/70
CPC分类号： B29C70/305 , B29B11/16 , B29L2031/58 , B60N2/7017
摘要： Es wird ein Verfahren zur Herstellung eines Polsterelements, insbesondere ein Sitzpolsterelement zur Verwendung in einem Kraftfahrzeug, ein Polsterelement und ein Füllkragen (2) zur Herstellung des Polsterelements vorgeschlagen, wobei ein Vorläufermaterial in einem Formwerkzeug geformt wird, wobei das Vorläufermaterial an die zu erreichende Endform des Polsterelements angepasst wird, bevor das Formwerkzeug vollständig geschlossen wird.
摘要翻译：该方法包括在成形工具中形成前体材料。在成形工具完全关闭之前，前体材料适应缓冲元件的最终形状。在将前体材料引入成形工具之前，将前体材料部分地填充到填充套环（2）中。

34. 发明授权

EP1758860B1 GESÄTTIGTE UND UNGESÄTTIGTE 3-PYRIDYL-BENZOCYCLOALKYLMETHYL-AMINE ZUR BEHANDLUNG VON SCHMERZEN, DEPRESSIONEN UND ANGSTZUSTÄNDEN 有权
标题翻译：饱和，非饱和3吡啶benzocycloalkylmethyl胺为疼痛，抑郁和焦虑的治疗
公开(公告)号：EP1758860B1
公开(公告)日：2009-09-02
申请号：EP05766092.0
申请日：2005-06-20
申请人： Grünenthal GmbH
发明人： SUNDERMANN, Bernd , HENNIES, Hagen-Heinrich , SCHIENE, Klaus , BLOMS-FUNKE, Petra , ENGLBERGER, Werner , FRORMANN, Sven , SAUNDERS, Derek
IPC分类号： C07D213/38 , C07D417/06 , C07D413/06 , A61K31/435 , A61P25/00
CPC分类号： C07D417/06 , C07D213/38 , C07D413/06
摘要： The invention relates to the saturated and unsaturated 3-pyridyl-benzocycloalkylmethyl-amines of general formula (I), to methods for producing drugs containing said compounds, to the use of saturated and unsaturated 3-pyridyl-benzocycloalkylmethyl-amines in the production of drugs and to methods for treating pains, depressions and/or anxiety states.

35. 发明公开

EP2083922A1 VR1-REZEPTOR-LIGANDEN UND µ-OPIOID-REZEPTOR-LIGANDEN ZUR BEHANDLUNG VON SCHMERZ 审中-公开
标题翻译： VR1受体配体和μ阿片样物质受体配体治疗疼痛的
公开(公告)号：EP2083922A1
公开(公告)日：2009-08-05
申请号：EP07819162.4
申请日：2007-10-19
申请人： Grünenthal GmbH
发明人： KÖGEL, Babette-Yvonne , CHRISTOPH, Thomas , BAHRENBERG, Gregor, Dr. , FRANK, Robert , SCHRÖDER, Wolfgang , DE VRY, Jean , PAQUES, Eric-Paul , SAUNDERS, Derek John , SCHIENE, Klaus , SUNDERMANN, Bernd, Dr. , LEE, Jeewoo , RYU, Hyung-Chul
IPC分类号： A61P29/00 , A61K31/4468 , A61K31/451 , A61K31/4545
CPC分类号： A61K45/06 , A61K31/357 , A61K31/4468 , A61K31/451 , A61K31/4545 , A61K31/485 , A61K2300/00
摘要： The invention relates to a pharmaceutical composition comprising: i) at least one compound which has affinity for the µ opioid receptor, and at least one compound which has affinity for the VR1 receptor, or ii) at least one compound of the general formulae (I), (II), (III), (IV) or (V) which has affinity for the µ opioid receptor and for the VR1 receptor, and to the use of the pharmaceutical compositions (i) and (ii) for the manufacture of a medicament for the treatment of pain.

36. 发明授权

EP1730144B1 SUBSTITUIERTE 1,4,8-TRIAZASPIRO¬4.5 DECAN-2-ON-VERBINDUNGEN 有权
标题翻译：取代-1,4,8-TRIAZASPIRO¬4.5癸烷-2-酮化合物
公开(公告)号：EP1730144B1
公开(公告)日：2009-06-10
申请号：EP05716300.8
申请日：2005-03-22
申请人： Grünenthal GmbH
发明人： SUNDERMANN, Corinna , SUNDERMANN, Bernd , OBERBÖRSCH, Stefan , ENGLBERGER, Werner , HENNIES, Hagen-Heinrich
IPC分类号： C07D471/04 , A61K31/437 , A61P25/24
CPC分类号： C07D471/10
摘要： The invention relates to substituted 1,4,8,-triazaspiro[4.5]decan-2-one compounds, to methods for producing said compounds, to medicaments containing said compounds and to the use of the latter for producing medicaments.

37. 发明公开

EP1893589A1 SUBSTITUIERTE N-BENZO [D] ISOXAZOL-3-YL-AMIN-DERIVATIVE ALS INHIBITOREN VON MGLUR5, SEROTONIN- (5-HT) UND NORADRENALIN REZEPTOREN UND DEREN VERWENDUNG ZUR HERSTELLUNG VON ARZNEIMITTELN 有权
标题翻译：取代的N-苯并[d]异恶唑-3-基 - 胺衍生物作为mGluR5的，血清素（5-HT）的抑制剂和去甲肾上腺素受体和它们用于制备药物的
公开(公告)号：EP1893589A1
公开(公告)日：2008-03-05
申请号：EP06761974.2
申请日：2006-06-06
申请人： Grünenthal GmbH
发明人： MERLA, Beatrix , GERLACH, Matthias , SUNDERMANN, Corinna , JAGUSCH, Utz-Peter , HENNIES, Hagen-Heinrich , OBERBÖRSCH, Stefan , HAURAND, Michael , JOSTOCK, Ruth , REICH, Melanie
IPC分类号： C07D261/20 , C07D413/12 , A61K31/423 , A61P29/00
CPC分类号： C07D413/12 , C07D261/20 , C07D417/12
摘要： The invention relates to substituted N-benzo[d]isoxazol-3-yl-amine derivatives of formula (I) wherein R1,R2,R3,R4 and R5 are defined as in patent claim 1. The invention also relates to the use of said compounds for producing medicaments.

38. 发明公开

EP1886673A2 Solid dosage form of enteric solid dispersion and method for producing the same 有权
标题翻译： Feste Arzneiform einerdarmlöslichenDispersion und Verfahren zur Herstellung derselben
公开(公告)号：EP1886673A2
公开(公告)日：2008-02-13
申请号：EP07015396.0
申请日：2007-08-06
申请人： Shin-Etsu Chemical Co., Ltd.
发明人： Kusaki, Fumie , Hoshino, Takafumi , Maruyama, Naosuke , Nishiyama, Yuichi , Fukui, Ikuo , Umezawa, Hiroshi
IPC分类号： A61K9/20 , A61K47/38 , A61K31/44
CPC分类号： A61K9/1652 , A61K9/1623 , A61K9/2018 , A61K9/2054 , A61K9/2059 , A61K31/44
摘要： Provided are a solid dosage form comprising an enteric solid dispersion that allows a drug in the preparation to be rapidly dissolved without compromising the solubility of the solid dispersion, and a method for producing the same. More specifically, provided is a solid dosage form comprising an enteric solid dispersion comprising a poorly soluble drug, an enteric polymer and a disintegrant, wherein the disintegrant is low-substituted hydroxypropylcellulose having an average particle size of 10 to 100 µm and a specific surface area measured by BET method of at least 1.0 m 2 /g. Moreover, provided is a method for producing a solid dosage form comprising an enteric solid dispersion, the method comprising steps of: spraying an enteric polymer solution in which a poorly soluble drug has been dispersed or dissolved, on a powder of low-substituted hydroxypropylcellulose having an average particle size of 10 to 100 µ m and a specific surface area measured by BET method of at least 1.0 m 2 /g and serving as a disintegrant; and granulating the resultant; and drying.
摘要翻译：本发明提供了一种固体剂型，其包含肠溶固体分散体，其允许制剂中的药物快速溶解而不损害固体分散体的溶解性，及其制备方法。更具体地，提供了包含包含难溶性药物，肠溶性聚合物和崩解剂的肠溶性固体分散体的固体剂型，其中所述崩解剂是平均粒径为10〜100μm的低取代羟丙基纤维素，比表面积通过BET法测量为至少1.0m 2 / g。此外，提供了一种生产包含肠溶固体分散体的固体剂型的方法，所述方法包括以下步骤：将难溶性药物已经分散或溶解的肠溶性聚合物溶液喷雾到具有平均粒径为10〜100μm，BET法测定的比表面积为1.0m 2 / g以上，作为崩解剂; 并造成结果; 并干燥。

39. 发明公开

EP1863504A1 CONTROL OF SUCKING LICE 有权转让
标题翻译：控制吸虱
公开(公告)号：EP1863504A1
公开(公告)日：2007-12-12
申请号：EP06704959.3
申请日：2006-03-07
申请人： Microbial Products Pty Ltd
发明人： PINNOCK, Dudley, Edwin , COOPER, David, John
IPC分类号： A61K35/74 , A61P33/14
CPC分类号： A61K35/742
摘要： The invention describes the use of a microbial preparation of one or more bacteria, for example of the genus Bacillus in the manufacture of a formulation as a medicament for the treatment and prevention of infestation of sucking lice from the order Phthiraptera, Anoplura, Rhynchophthirina and/or Pediculidae. The medicament can be applied to plumage, pelage or hair to control sucking lice.

40. 发明公开

EP1741383A3 Method and apparatus for measuring operating visual acuity 审中-公开
标题翻译：用于活性视力的测量方法和装置
公开(公告)号：EP1741383A3
公开(公告)日：2007-11-28
申请号：EP06014122.3
申请日：2006-07-07
申请人： Kaido, Minako , Qualitas Inc.
发明人： Kaido, Minako , Tsubota, Kazuo
IPC分类号： A61B3/028 , A61B3/032
CPC分类号： A61B3/028 , A61B3/032
摘要： The present invention provides a method and apparatus for measuring operating vision. An optotype mark is displayed (step 103). A subject's response to the optotype mark is accepted via an input device (step 104). A determination is made as to whether or not the response is correct (step 105). When the current response of the subject is correct and the previous response or one of the previous response and the last-but-one response is incorrect, an optotype mark corresponding to the same visual acuity is presented (step 112). When the previous response is correct or both the previous response and the last-but-one response are correct, an optotype mark corresponding to a visual acuity one level higher is presented (step 110). When the current response is incorrect, an optotype mark corresponding to a visual acuity one level lower is presented (step 111).

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