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31. 发明授权

EP1988953B1 DELIVERY DEVICE 有权转让
标题翻译：交付设备
公开(公告)号：EP1988953B1
公开(公告)日：2017-07-19
申请号：EP07705192.8
申请日：2007-02-14
申请人： Optinose AS
发明人： DJUPESLAND, Per, Gisle , BODEN, Keith, McMurray
IPC分类号： A61M11/08 , A61M15/00 , A61M15/08 , A61M16/00
CPC分类号： A61M11/08 , A61M15/0065 , A61M15/0091 , A61M15/0095 , A61M15/0098 , A61M15/08 , A61M2016/0021 , A61M2016/0042 , A61M2202/04 , A61M2202/064 , A61M2205/276 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M2205/75

32. 发明授权

EP1407795B1 Nasal delivery devices 有权
标题翻译：鼻腔给药的装置
公开(公告)号：EP1407795B1
公开(公告)日：2016-06-29
申请号：EP04000919.3
申请日：2002-06-12
申请人： Optinose AS
发明人： Djupesland, Per Gisle, Dr.
IPC分类号： A61M15/08
CPC分类号： A61M15/0098 , A61M15/0021 , A61M15/0091 , A61M15/08 , A61M2202/064 , A61M2210/0618 , A61M2210/0625

33. 发明公开

EP2653183A1 Nasal delivery devices 有权转让
标题翻译： Vorrichtungen zur nasalen Freisetzung
公开(公告)号：EP2653183A1
公开(公告)日：2013-10-23
申请号：EP13177297.2
申请日：2008-10-03
申请人： Optinose AS
发明人： Djupesland, Per Gisle , Sheldarake, Colin David
IPC分类号： A61M15/08
CPC分类号： A61M15/08 , A61M11/006 , A61M11/007 , A61M11/02 , A61M11/08 , A61M15/0003 , A61M15/0015 , A61M15/002 , A61M15/0021 , A61M15/009 , A61M15/0095 , A61M15/0098 , A61M2202/0468 , A61M2202/064 , A61M2205/8281
摘要： A nasal delivery device for delivering substance to a nasal airway of a subject, comprising: a mouthpiece (919) through which the subject in use exhales to cause closure of the oropharyngeal velum of the subject; a nosepiece (917) for fitting to a nostril of a subject, the nosepiece including a nozzle (949) through which substance is in use delivered to the nasal airway; a manually-actuatable substance supply unit (920) for delivering substance through the nozzle of the nosepiece, wherein the substance supply unit comprises a body part (955) which is movable from a first, rest position to a second, actuated position on manual actuation of the substance supply unit; and a body member (921) which receives the substance supply unit, wherein the body member includes an inlet (925) which is in fluid communication with the mouthpiece and an outlet (927) which is in fluid communication with the nosepiece; wherein the inlet of the body member is opened when the body part of the substance supply unit is moved to the actuated position, thereby providing for an air flow through the nosepiece simultaneously with manual actuation of the substance supply unit.
摘要翻译：一种用于将物质输送到受试者的鼻气道的鼻输送装置，包括：口部（919），所述受试者在使用中呼气以引起所述受试者的口咽膜闭合; 用于装配到受试者的鼻孔的鼻梁（917），所述鼻梁包括通过物质被使用的喷嘴（949）传送到鼻气道; 用于通过所述喷嘴的喷嘴输送物质的手动致动物质供应单元（920），其中所述物质供应单元包括主体部分（955），所述主体部分（955）可在手动致动时从第一静止位置移动到第二致动位置的物质供应单位; 以及容纳所述物质供给单元的本体构件（921），其中，所述主体构件包括与所述接口管流体连通的入口（925）和与所述喷嘴流体连通的出口（927）其中当所述物质供应单元的主体部分移动到致动位置时，主体构件的入口打开，从而在物质供应单元的手动致动的同时提供通过喷嘴的气流。

34. 发明公开

EP2462972A3 Nasal delivery devices 有权转让
标题翻译： Nasale Abgabevorrichtungen
公开(公告)号：EP2462972A3
公开(公告)日：2013-08-28
申请号：EP12001499.8
申请日：2005-09-15
申请人： Optinose AS
发明人： Djupesland, Per, Gisle, Dr. , Hafner, Roderick, Peter, Dr. , Sheldrake, Colin, David, Dr.
IPC分类号： A61M15/00 , A61M15/08
CPC分类号： A61M15/002 , A61M15/0021 , A61M15/0028 , A61M15/0035 , A61M15/0041 , A61M15/0045 , A61M15/0086 , A61M15/0091 , A61M15/0098 , A61M15/08 , A61M16/1055 , A61M16/1065 , A61M16/1075 , A61M2202/064
摘要： A nasal delivery device for delivering substance to a nasal cavity of a subject, the delivery device comprising: a container-receiving unit (16) comprising a container chamber (23) for receiving a substance-containing container (C) which contains substance to be delivered to the nasal cavity of the subject, the container chamber (23) including an inlet (24) and an outlet (25); a nosepiece unit (17) including a nosepiece (47) for fitting to a nasal cavity of the subject and being in fluid communication with the outlet (25) of the container chamber (23); and a mouthpiece unit (19) including a mouthpiece (77) in fluid communication with the inlet (24) of the container chamber (23) and through which the subject in use exhales, such as to entrain substance from the container (C) and deliver the same through the nosepiece (47), and an air chamber (78) which fluidly connects the mouthpiece (77) to the inlet (24) of the container chamber (23), wherein the air chamber (78) incorporates a temperature regulator (79) for cooling an air flow as exhaled therethrough.
摘要翻译：一种用于将物质输送到被检体的鼻腔的鼻输送装置，所述输送装置包括：主体构件（101; 201）; 载体（109; 209），其由本体构件（101; 201）支撑并承载多个含物质容器（C; B）; 包括用于装配到所述对象的鼻腔的鼻梁（147; 247）的鼻梁单元（119; 219）一个接口单元（121; 221），包括一个接口（167; 249），所述受试者在使用中呼气; 以及致动机构，其在每个操作中操作以打开多个所述含物质容器（C; B），并且包括阀单元（169; 251），用于将所述接口件（167; 249）流体连接到相继的一个开放的含物质的容器（C; B）在连续的呼气循环中。

35. 发明授权

EP2197525B1 NASAL DELIVERY DEVICES 有权转让
标题翻译： VORRICHTUNGEN ZUR NASALEN FREISETZUNG
公开(公告)号：EP2197525B1
公开(公告)日：2013-07-24
申请号：EP08836154.8
申请日：2008-10-03
申请人： Optinose AS
发明人： DJUPESLAND, Per Gisle , SHELDRAKE, Colin David
IPC分类号： A61M15/08
CPC分类号： A61M15/08 , A61M11/006 , A61M11/007 , A61M11/02 , A61M11/08 , A61M15/0003 , A61M15/0015 , A61M15/002 , A61M15/0021 , A61M15/009 , A61M15/0095 , A61M15/0098 , A61M2202/0468 , A61M2202/064 , A61M2205/8281
摘要： A nasal delivery device for delivering substance to a nasal airway of a subject, comprising: a mouthpiece (919) through which the subject in use exhales to cause closure of the oropharyngeal velum of the subject; a nosepiece (917) for fitting to a nostril of a subject, the nosepiece including a nozzle (949) through which substance is in use delivered to the nasal airway; a manually-actuatable substance supply unit (920) for delivering substance through the nozzle of the nosepiece, wherein the substance supply unit comprises a body part (955) which is movable from a first, rest position to a second, actuated position on manual actuation of the substance supply unit; and a body member (921) which receives the substance supply unit, wherein the body member includes an inlet (925) which is in fluid communication with the mouthpiece and an outlet (927) which is in fluid communication with the nosepiece; wherein the inlet of the body member is opened when the body part of the substance supply unit is moved to the actuated position, thereby providing for an air flow through the nosepiece simultaneously with manual actuation of the substance supply unit.
摘要翻译：一种用于将物质输送到受试者的鼻气道的鼻输送装置，包括：口部（919），所述受试者在使用中呼气以引起所述受试者的口咽膜闭合; 用于装配到受试者的鼻孔的鼻梁（917），所述鼻梁包括通过物质被使用的喷嘴（949）传送到鼻气道; 用于通过所述喷嘴的喷嘴输送物质的手动致动物质供应单元（920），其中所述物质供应单元包括主体部分（955），所述主体部分（955）可在手动致动时从第一静止位置移动到第二致动位置的物质供应单位; 以及容纳所述物质供给单元的本体构件（921），其中，所述主体构件包括与所述接口管流体连通的入口（925）和与所述喷嘴流体连通的出口（927）其中当所述物质供应单元的主体部分移动到致动位置时，主体构件的入口打开，从而在物质供应单元的手动致动的同时提供通过喷嘴的气流。

36. 发明公开

EP2462973A2 Nasal delivery devices 有权转让
公开(公告)号：EP2462973A2
公开(公告)日：2012-06-13
申请号：EP12001503.7
申请日：2005-09-15
申请人： Optinose AS
发明人： Djupesland, Per, Gisle, Dr. , Hafner, Roderick, Peter, Dr. , Sheldrake, Colin, David, Dr.
IPC分类号： A61M15/00 , A61M15/08
CPC分类号： A61M15/002 , A61M15/0021 , A61M15/0028 , A61M15/0035 , A61M15/0041 , A61M15/0045 , A61M15/0086 , A61M15/0091 , A61M15/0098 , A61M15/08 , A61M16/1055 , A61M16/1065 , A61M16/1075 , A61M2202/064
摘要： A nasal delivery device for delivering substance to a nasal cavity of a subject, the delivery device comprising: a body member (101; 201); a carrier (109; 209) which is supported by the body member (101; 201) and carries a plurality of substance-containing containers (C; B); a nosepiece unit (119; 219) including a nosepiece (147; 247) for fitting to a nasal cavity of the subject; a mouthpiece unit (121; 221) including a mouthpiece (167; 249) through which the subject in use exhales; and an actuating mechanism which is operative, in each operation, to open a plurality of the substance-containing containers (C; B), and including a valve unit (169; 251) for fluidly connecting the mouthpiece (167; 249) to a respective one of the opened substance-containing containers (C; B) in successive exhalation cycles.

37. 发明公开

EP2460554A2 Nasal delivery device 有权转让
标题翻译：鼻腔输送装置
公开(公告)号：EP2460554A2
公开(公告)日：2012-06-06
申请号：EP12001127.5
申请日：2007-11-28
申请人： Optinose AS
发明人： Djupesland, Per, Gisle, Dr. , Sheldrake, Colin, David, Dr. , Smith, Simon , Striebig, Rachel , Pidgeon, Andy , St. Quintin, Tom
IPC分类号： A61M15/00 , A61M15/08
CPC分类号： A61M15/08 , A61M15/0018 , A61M15/0021 , A61M15/0026 , A61M15/0028 , A61M15/0035 , A61M15/0041 , A61M15/0043 , A61M15/0081 , A61M15/0098 , A61M16/1045 , A61M2202/064 , A61M2205/0222 , A61M2210/0618 , A61M2210/0625
摘要： A nasal delivery device for delivering particulate substance to the nasal airway of a subject, the delivery device comprising: a mouthpiece unit (209) which includes a mouthpiece (247) through which the subject in use exhales; a nosepiece unit (205) which includes a nosepiece (241) for fitting to a nostril of the subject; a substance-supply unit (211) which is configured to receive a container (C) containing particulate substance, the container (C) comprising a main body part (215) and first and second bearing support parts (217, 217) at the respective ends of the body part (215), and operable to provide a metered amount of substance in fluid communication with the mouthpiece and nosepiece units (209, 205), such that an exhalation air flow delivered through the substance-supply unit (211) entrains the substance; and a housing (203) which supports the mouthpiece unit (209), the nosepiece unit (205) and the substance-supply unit (211); wherein the substance-supply unit (211) includes a container-receiving member (251) which is movably disposed to the housing (203) between an open position for enabling loading of a container (C) thereinto and a closed position in which the container (C) is contained within the housing (203), and the container-receiving member (251) includes a cavity (253) which defines an air flow channel between the mouthpiece and nosepiece units (209, 205), such that an air flow is delivered therethrough on exhalation by the subject through the mouthpiece (247), and a support section for supporting the container (C) in the cavity (253) which includes first and second container supports (255, 255) for rotatably supporting the respective support parts (217, 217) of the container (C).
摘要翻译： 1。一种用于将粒状物质递送到受试者的鼻气道的鼻递送装置，所述递送装置包括：吸嘴单元（209），其包括吸嘴（247），使用中的受试者通过该吸嘴呼出; 鼻子单元（205），其包括用于配合到对象的鼻孔的鼻部（241）（215）和第一轴承支撑部分（217）以及第二轴承支撑部分（217）的容器（C）的物质供应单元（211），所述容器（C）（215）的端部，并且可操作以提供与喷嘴和喷嘴单元（209,205）流体连通的计量数量的物质，使得通过物质供应单元（211）输送的呼气气流携带物质; （209），喷嘴单元（205）和物质供应单元（211）的壳体（203）;以及支撑喷嘴单元其中所述物质供应单元包括容器接收构件，所述容器接收构件可移动地设置在所述壳体处于打开位置和关闭位置之间，所述打开位置用于使容器（C）能够装载到所述打开位置，（C）容纳在所述壳体（203）内，并且所述容器接收构件（251）包括空腔（253），所述空腔限定了所述吸口和所述喷嘴单元（209,205）之间的空气流动通道，使得空气流（247）和用于将容器（C）支撑在空腔（253）中的支撑部分，所述支撑部分包括用于可旋转地支撑相应支撑件（255,255）的第一和第二容器支撑件（255,255）容器（C）的部件（217,217）。

38. 发明授权

EP2139548B1 NASAL DELIVERY DEVICES 有权转让
标题翻译： NASALE电源器件
公开(公告)号：EP2139548B1
公开(公告)日：2012-03-21
申请号：EP07848414.4
申请日：2007-11-28
申请人： Optinose AS
发明人： DJUPESLAND, Per Gisle , SHELDRAKE, Colin, David
IPC分类号： A61M15/00
CPC分类号： A61M15/08 , A61M15/0018 , A61M15/0021 , A61M15/0026 , A61M15/0028 , A61M15/0035 , A61M15/0041 , A61M15/0043 , A61M15/0081 , A61M15/0098 , A61M16/1045 , A61M2202/064 , A61M2205/0222 , A61M2210/0618 , A61M2210/0625
摘要： A nasal delivery device for and method of delivering particulate substance to the nasal airway of a subject, the delivery device comprising : a body assembly (3) including a mouthpiece unit (9) which includes a mouthpiece through which the subject in use exhales, and a substance-supply unit which is fluidly connected to the mouthpiece unit and actuatable to provide particulate substance for delivery to the nasal airway of the subject; wherein the body assembly is configured to receive a replaceable nosepiece unit (5) which includes a nosepiece and contains a container containing particulate substance.

39. 发明授权

EP1626762B1 DELIVERY DEVICE AND METHOD 失效转让
标题翻译：电源装置和使用方法
公开(公告)号：EP1626762B1
公开(公告)日：2012-03-07
申请号：EP04734063.3
申请日：2004-05-20
申请人： Optinose AS
发明人： DJUPESLAND, Per, Gisle, Dr.
IPC分类号： A61M15/00
CPC分类号： A61M15/0098 , A61M15/0021 , A61M15/009 , A61M15/0091 , A61M15/08 , A61M16/0434 , A61M16/0493 , A61M16/0495 , A61M2016/0021 , A61M2016/0027 , A61M2202/064 , A61M2202/30 , A61M2210/065
摘要： A delivery device for and method of delivering substance, in particular a vaccine, to a mucosal surface within the oral cavity of a subject, the device comprising: a mouthpiece unit to be gripped in the mouth of a subject, wherein the mouthpiece unit is configured such that, on exhalation or attempted exhalation by the subject, a pressure is developed in the oral cavity which is such as to close the oropharyngeal velum of the subject; and an oral outlet unit including at least one outlet from which substance is in use delivered to a mucosal surface within the oral cavity of the subject.

40. 发明公开

EP2332603A3 Nasal delivery device 有权
公开(公告)号：EP2332603A3
公开(公告)日：2011-10-19
申请号：EP10011952.8
申请日：2000-03-03
申请人： Optinose AS
发明人： Djupesland, Per Gisle
IPC分类号： A61M15/00 , A61M15/08 , A61M11/02 , A61M16/00 , A61M11/06
CPC分类号： A61M3/0233 , A61M3/0279 , A61M15/0018 , A61M15/002 , A61M15/0021 , A61M15/0028 , A61M15/0045 , A61M15/0065 , A61M15/009 , A61M15/0091 , A61M15/0098 , A61M15/08 , A61M16/0866 , A61M16/1055 , A61M16/1065 , A61M2202/0468 , A61M2202/064 , A61M2205/43 , A61M2205/59 , A61M2206/10 , A61M2206/14 , A61M2210/0618 , A61M2210/0625
摘要： A nasal delivery device for delivering a substance to the nasal airway of a subject, comprising: a closure unit for causing closure of the oropharyngeal velum of the subject; and a delivery unit for delivering a gas flow and substance to one of the nostrils of the subject, wherein the delivery unit includes an outlet through which the gas flow and substance is in use delivered to the one nostril; characterized in that : the delivery unit is configured to deliver the gas flow at a driving pressure to flow around the posterior margin of the nasal septum and out of the other nostril of the subject; and the delivery unit comprises a nosepiece which includes the outlet and a sealing member for providing a fluid tight seal between the outlet and the one nostril.

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