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21. 发明授权

EP3250580B1 SUGAR-DIPEPTIDE CONJUGATES AS FLAVOR MOLECULES 有权转让
公开(公告)号：EP3250580B1
公开(公告)日：2018-10-24
申请号：EP16702371.2
申请日：2016-01-26
申请人： Nestec S.A.
发明人： SMARRITO-MENOZZI, Candice Marie , VITON, Florian , HOFMANN, Thomas , KRANZ, Maximilian
IPC分类号： C07H7/02 , C07K9/00 , A23L2/56
CPC分类号： C07K5/06026 , A23L23/10 , A23L27/2052 , A23L27/21 , A23L27/215 , A23L27/88 , A23V2002/00 , C07H7/02
摘要： The present invention relates to compounds and compositions for use in enhancing flavor and umami taste of food products. Particularly, the present invention relates to compounds of the general formula (I) and compositions comprising them.

22. 发明公开

EP3250579A1 SUGAR-DIPEPTIDE CONJUGATES AS FLAVOR MOLECULES 有权转让
公开(公告)号：EP3250579A1
公开(公告)日：2017-12-06
申请号：EP16701514.8
申请日：2016-01-26
申请人： Nestec S.A.
发明人： SMARRITO-MENOZZI, Candice Marie , VITON, Florian , HOFMANN, Thomas , KRANZ, Maximilian
IPC分类号： C07H7/02 , C07K9/00
CPC分类号： C07H15/26 , A23L23/00 , A23L27/23
摘要： The present invention relates to compounds and compositions for use in enhancing flavor and umami taste of food products. Particularly, the present invention relates to compounds of the general formula I) and compositions comprising them.

23. 发明公开

EP3204155A1 OXIDATION OF URONIC ACIDS TO ALDARIC ACIDS 有权转让
标题翻译：将铀酸氧化成靛红酸
公开(公告)号：EP3204155A1
公开(公告)日：2017-08-16
申请号：EP15817590.1
申请日：2015-10-06
申请人： Stichting Wageningen Research
发明人： VAN ES, Daniël Stephan , PAZHAVELIKKAKATH PURUSHOTHAMAN, Rajeesh Kumar , FRISSEN, Augustinus Emmanuel , VAN HAVEREN, Jacobus , VAN DER KLIS, Frits
IPC分类号： B01J23/52 , B01J23/66 , C07H1/00 , C07H7/02 , C07H7/033 , C07C51/235
CPC分类号： C07C51/235 , B01J23/52 , B01J23/66 , B01J37/0211 , B01J37/024 , B01J37/18 , C07C51/313 , C07C59/285 , C07H7/033
摘要： Disclosed is the oxidation of uronic acids, such as galacturonic acid, to the corresponding aldaric acids, such as galactaric acid, under neutral or acidic conditions. Use is made of a supported gold catalyst. The oxidation occurs in good selectivity and yield, under unexpectedly mild conditions. A source of galacturonic acids is pectins, such as from sugar beet pulp.
摘要翻译：公开了在中性或酸性条件下将糖醛酸如半乳糖醛酸氧化为相应的醛糖酸，例如半乳糖二酸。使用支持的金催化剂。在出乎意料的温和条件下，氧化以良好的选择性和产率发生。半乳糖醛酸的来源是果胶，例如来自甜菜浆。

24. 发明授权

EP2797945B1 2-((2S,3S,4R,5R)-5-((S)-3-AMINO-2-HYDROXYPROP-1-YL)-4-METHOXY-3-(PHENYLSULFONYLMETHYL)TETRAHYDROFURAN-2-YL)ACETALDEHYDE DERIVATIVES AND PROCESS FOR THEIR PREPARATION 失效
标题翻译：（（2S，3S，4R，5R）-5 - （（S）-3-氨基-2-羟基丙-1-基）-4-甲氧基-3-（苯磺酰基甲基）四氢呋喃-2-基）乙醛衍生物和他们的准备过程
公开(公告)号：EP2797945B1
公开(公告)日：2016-03-16
申请号：EP12863099.3
申请日：2012-12-24
申请人： Alphora Research Inc.
发明人： SOUZA, Fabio E.S. , RUDOLPH, Alena , PAN, Ming , GORIN, Boris , ALBERICO, Dino
IPC分类号： C07H9/02 , C07D307/20 , C07D413/06 , C07D493/04 , C07D493/22 , C07H7/02 , C07D405/06
CPC分类号： C07D307/20 , A61K31/366 , C07D405/06 , C07D413/06 , C07D493/04 , C07D493/22 , C07H7/02 , C07H9/02

25. 发明公开

EP2797945A4 2-((2S,3S,4R,5R)-5-((S)-3-AMINO-2-HYDROXYPROP-1-YL)-4-METHOXY-3-(PHENYLSULFONYLMETHYL)TETRAHYDROFURAN-2-YL)ACETALDEHYDE DERIVATIVES AND PROCESS FOR THEIR PREPARATION 失效
标题翻译： 2 - （（2S，3S，4R，5R）-5 - （（S）-3-氨基-2-羟基丙-1-基）-4-甲氧基-3-（PHENYLSULFONYLMETHYL-）四氢呋喃-2-基）乙醛衍生物及其制备方法
公开(公告)号：EP2797945A4
公开(公告)日：2015-06-03
申请号：EP12863099
申请日：2012-12-24
申请人： ALPHORA RES INC
发明人： SOUZA FABIO E S , RUDOLPH ALENA , PAN MING , GORIN BORIS , ALBERICO DINO
IPC分类号： C07H9/02 , C07D307/20 , C07D405/06 , C07D413/06 , C07D493/04 , C07D493/22 , C07H7/02
CPC分类号： C07D307/20 , A61K31/366 , C07D405/06 , C07D413/06 , C07D493/04 , C07D493/22 , C07H7/02 , C07H9/02

26. 发明授权

EP2373670B1 NOUVEAUX COMPOSÉS C-XYLOSIDES AMINES ET UTILISATION EN COSMÉTIQUE 有权
标题翻译：新的氨基酸取代的C糖苷及其化妆品中
公开(公告)号：EP2373670B1
公开(公告)日：2014-04-16
申请号：EP09801479.8
申请日：2009-12-02
申请人： L'Oréal
发明人： DALKO, Maria , CAVEZZA, Alexandre
IPC分类号： C07H7/02 , A61K8/60 , A61Q19/08 , A61P17/00 , C07D309/10 , C07D405/12 , C07D233/56 , C07D209/10 , A61K31/351 , A61K31/4178 , A61K31/404 , A61K8/49
CPC分类号： A61Q19/08 , A61K8/60

27. 发明公开

EP2168972A3 Preparation and use of carbohydrate-based ring structures with antimicrobial and cytostatic activity 审中-公开
标题翻译：生产和使用具有抗微生物和细胞毒活性碳水化合物基的环结构的
公开(公告)号：EP2168972A3
公开(公告)日：2010-06-02
申请号：EP09160439.7
申请日：2002-10-15
申请人： Kemin Pharma Europe
发明人： Sas, Benedikt , Van Der Eycken, Johan , Van Hemel, Johan , Blom, Petra , Vandenkerckhove, Jan , Ruttens, Bart
IPC分类号： C07H9/02 , C07H9/06 , A61K31/7052 , A61K31/7048 , A61P31/04 , A61P31/12 , A61P35/00 , C07H15/207 , C07H5/10 , C07H7/02 , C07H7/04 , C07H9/04 , C07H15/203 , A61K31/351 , A61K31/357 , C07D309/16 , C07D319/08
CPC分类号： C07H15/10 , C07D309/10 , C07D493/04 , C07H7/02 , C07H7/04 , C07H9/04 , C07H15/203
摘要： A compound of the formula : wherein

R 1 is -H, -SPh, -Ph, -allyl or -benzyl;
R 2 is -H, -Et, -allyl, -Me or -benzyl;
R 3 is -H, -Et, -Me, -allyl or -benzyl; and
R 4 and R 5 are both -OH or R 4 and R 5 together form a ring and are -OCH(Ph)O- ;

or a pharmaceutically active derivative thereof.
Pharmaceutical compositions comprising the above compounds and their use in therapy are also provided.

28. 发明公开

EP1934388A1 METHOD OF DRUG DESIGN 有权转让
标题翻译： VERFAHREN ZUR ENTWICKLUNG VON ARZNEISTOFFEN
公开(公告)号：EP1934388A1
公开(公告)日：2008-06-25
申请号：EP06790302.1
申请日：2006-10-03
申请人： Alchemia Ltd
发明人： TOMETZKI, Gerald, B. , MEUTERMANS, Wim , ZEUGG, Johannes
IPC分类号： C40B30/04 , C07H7/02 , C40B20/06 , A61K31/7052 , C07H15/00 , C40B40/12 , A61P5/02 , C07H15/04 , C40B50/08 , C07B61/00 , C07H15/12 , C40B50/14 , C07D309/10 , C07H15/18 , G01N33/53 , C07D309/14 , C07H15/26 , C07H7/00 , C07K14/655
CPC分类号： G01N33/68 , C07H3/02 , C07H15/18 , G01N33/566 , G01N2333/726 , G01N2500/04
摘要： The invention provides a method of identifying biologically active compounds comprising: (a) designing a first library of compounds of formula (1) to scan molecular diversity wherein each compound of the library has at least two pharmacophoric groups R1 to R5 as defined below and wherein compound of the library has same number of pharmacophoric groups; (b) assaying the first library of compounds in one or more biological assay(s); and (c) designing a second library wherein each compound of the second library contains one or more additional pharmacophoric group with respect to the first library; such that the/each component of the first and second library is a compound of formula (1).
摘要翻译：本发明提供了鉴定生物活性化合物的方法，包括：（a）设计式（1）化合物的第一文库以扫描分子多样性，其中文库的每种化合物具有如下定义的至少两个药用基团R 1至R 5，并且其中文库的化合物具有相同数量的药效团; （b）在一个或多个生物测定中测定化合物的第一文库; 和（c）设计第二文库，其中第二文库的每个化合物相对于第一文库含有一个或多个另外的药物亲和基团; 使得第一和第二文库的每个组分是式（1）的化合物。

29. 发明公开

EP1487812A1 ANOMERIC DERIVATIVES OF MONOSACCHARIDES 审中-公开
标题翻译：单糖异头
公开(公告)号：EP1487812A1
公开(公告)日：2004-12-22
申请号：EP03745223.2
申请日：2003-03-28
申请人： Alchemia Limited
发明人： MEUTERMANS, Wim , WEST, Michael, Leo , THANH LE, Giang , ADAMSON, George , SCHAFER, Karl , ABBENANTE, Giovani
IPC分类号： C07D307/20 , C07D307/22 , C07D307/24 , C07D309/08 , C07D309/10 , C07D309/14 , C07H5/04 , C07H7/02 , C07H7/04
CPC分类号： C07D405/12 , C07D309/14 , C07F7/1856 , C07H15/12
摘要： A compound of formula (I), wherein, n is 0 or 1; R6 and R7 are h ydrogen, or together form a carbonyl oxygen; R1 is selected from the group consisting of hydrogen; -N(Z)Y and -C(Z)Y wherein; When R1 is -N(Z)Y, then: Y is selected from hydrogen, or the following, where G denotes the point of connection to the nitrogen atom in N(Y)Z (i-v); Z is selected from hydrogen or X1; Q is selected from hydrogen or W; The groups W are independently selected from the group consisting of alkyl, alkenyl, alkynyl, heteroalkyl, aryl, heteroaryl, arylalkyl and heteroarylalkyl of 1 to 20 atoms , The groups X1 are independently selected from the group consisting of alkyl, alkenyl, alkynyl, heteroalkyl, acyl, arylacyl, heteroarylacyl, aryl, heteroaryl, arylalkyl and heteroarylalkyl of 1 to 20 atoms , When R1 is -C(Z)Y, then: Y is selected from the group consisting of two hydrogen atoms, a double bonded oxygen (=O) to form a carbonyl, and a triple bonded nitrogen to form a nitrile, Z is absent, or is selected from hydrogen or U, Wherein U is selected from the group consisting of alkyl, alkenyl, alkynyl, heteroalkyl, aminoalkyl, aminoaryl, aryloxy, alkoxy, heteroaryloxy, aminoaryl, aminoheteroaryl, thioalkyl, thioaryl or thioheteroaryl, acyl, arylacyl, heteroarylacyl, aryl, heteroaryl, arylalkyl and heteroarylalkyl of 1 to 20 atoms, . When R1 is H, at least two of the groups R2, R3, R4 and R5 are selected from the group consisting of -OX2 or -N(T)Y, and the others are independently selected from hydrogen, -OH, -OX2, -N(T)Y, wherein Y is as defined above, T is selected from hydrogen or X2; and X2 is independently selected from alkyl, alkenyl, alkynyl, heteroalkyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl of 1 to 20 atoms, When R1 is N(Z)Y or C(Z)Y, at least one of the groups R2, R3, R4 and R5 are selected from the group consisting of -OX2 or -N(T)Y, and the others are independently selected from hydrogen, -OH, -OX2, -N(T)Y, wherein Y is as defined above, T is selected from hydrogen or X2; and X2 is independently selected from alkyl, alkenyl, alkynyl, heteroalkyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl of 1 to 20 atoms.

30. 发明授权

EP1105395B1 PHOTOCYCLIZED RAPAMYCINS 有权
标题翻译： FOTOCYCLISIERTE RAPAMYCINE
公开(公告)号：EP1105395B1
公开(公告)日：2002-06-19
申请号：EP99941166.3
申请日：1999-08-16
申请人： Wyeth
发明人： ZHU, Tianmin , LEE, Hyuk-Koo
IPC分类号： C07D498/22 , A61K31/4353 , C07D498/18 , C07H7/02
CPC分类号： C07D498/18 , C07D498/22
摘要： A compound of structure (I) or (II) or a 31- and/or 42- ester or ether thereof, which is useful as an immunosuppressive, antiinflammatory, antifungal, antiproliferative, and antitumor agent.

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