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21. 发明授权

EP0683683B1 APPARATUS FOR LIQUID VENTILATION AND CONTROL PROCESS THEREOF 失效
标题翻译： VORRICHTUNG ZUR FLUISIGKEITSVENTILATION UND REGELUNVERVERHHENDAFÜR
公开(公告)号：EP0683683B1
公开(公告)日：2000-01-12
申请号：EP93923821.8
申请日：1993-10-08
申请人： Temple University of the Commonwealth System of Higher Education
发明人： SHAFFER, Thomas, H. , WOLFSON, Marla, R.
IPC分类号： A61M16/00
CPC分类号： A61M16/0054 , A61M16/024 , A61M2016/1025 , A61M2202/0476 , Y10S128/913
摘要： A process is provided for controlling a ventilation procedure wherein a liquid ventilation system passes breathing liquid through at least a portion of a patient's pulmonary pathways. In this process, desired ranges for certain process parameters associated with the liquid ventilation system are established. These desired ranges are input into a central processing unit (50). Initial settings for the liquid ventilation system are then made such that the actual conditions which will initially occur during the liquid ventilation procedure fall within their respective desired ranges. Thereafter, the procedure is commenced. During the procedure, conditions are continually monitored by sensors (16, 21, 27). The CPU (50) compares the sensor readings with the desired ranges, and acts to correct any discrepancy. The CPU can trigger alarms (514).
摘要翻译：提供了一种用于控制通气程序的过程，其中液体通气系统使呼吸液体通过患者肺通路的至少一部分。在该过程中，建立了与液体通气系统相关联的某些工艺参数的期望范围。这些期望的范围被输入到中央处理单元中。然后进行液体通气系统的初始设置，使得在液体通气过程中最初发生的实际状况落入其各自的期望范围内。此后，液体通气程序开始。在液体通气过程中，通过适当的传感器连续监测与建立的范围有关的条件。所监视的信息也被输入到中央处理单元。中央处理单元被设计为将实际发生的监视条件与它们各自的期望范围进行比较，并且确定是否存在差异。如果存在差异，则中央处理单元产生用于校正差异的信号。这些信号可被设计成触发报警，指示操作者进行适当的调整和/或激活伺服控制的阀门网络。

22. 发明公开

EP0910423A1 LIQUID VENTILATION METHOD AND APPARATUS 失效
标题翻译： VERFAHREN UND VORRICHTUNG ZURFLÜSSIGENBEATMUNG
公开(公告)号：EP0910423A1
公开(公告)日：1999-04-28
申请号：EP97914885.0
申请日：1997-03-07
申请人： Life Resuscitation Technologies, Inc.
发明人： FEDEROWICZ, Michael, G. , KLATZ, Ronald, M.
IPC分类号： A61M16 , A61M3
CPC分类号： A61M16/0054 , A61M3/0258 , A61M3/0283 , A61M16/042 , A61M16/1065 , A61M2202/0476 , Y10S128/913
摘要： This invention is a method and apparatus for liquid ventilation to increase the efficacy of cardiopulmonary resuscitation (CPR). The method includes replacing gas in the lungs with an oxygen and carbon dioxide carrying liquid to eliminate the decreased pumping efficiency of the heart seen during conventional or active compression/decompression (ACD) closed chest CPR without a mechanical respirator. An advantage is provided by supplying a continuous flow of liquid (or gaseous) ventilation medium throughout the entire chest compression/re-expansion cycle, accelerating both gas exchange and cooling or warming of the patient or animal subject. In the apparatus (100), breathing liquid returns from a patient via tube (101) and is supplied via tube (190), tubes (101, 190) being connected to an endotracheal tube (200). The apparatus includes a reservoir (110), an oxygenator (120), and a heater (130).
摘要翻译：一种利用液体通气来增加心肺复苏（CPR）功效的方法和装置。该方法包括用携带氧气和二氧化碳的液体替换肺中的气体，以消除在常规或主动压缩减压（ACD）闭合胸腔CPR期间看到的心脏泵送效率降低。 ACD-CPR中的另一个优点是无机械呼吸器进行液体通气的能力。通过在整个胸部压缩/再膨胀循环中提供液体（或气体）通气介质的连续流动来提供进一步的优点，显着加速患者或动物受试者的气体交换和冷却或变暖。

23. 发明授权

EP0583358B1 PARTIAL LIQUID BREATHING OF FLUOROCARBONS 失效
标题翻译：部分液体通气装置的氢氟烃
公开(公告)号：EP0583358B1
公开(公告)日：1998-12-02
申请号：EP92911346.2
申请日：1992-05-01
申请人： ALLIANCE PHARMACEUTICAL CORPORATION
发明人： FAITHFULL, Nicholas, Simon , WEERS, Jeffry, Greg
IPC分类号： A61K31/02 , A61K31/08
CPC分类号： A61K31/135 , A61K31/02 , A61K31/025 , A61K31/035 , A61K31/08 , A61K31/13 , A61K31/685 , A61K45/06 , A61M2202/0476 , Y10S128/913 , A61K2300/00
摘要： The present invention includes the use of an oxygen-carrying breathable fluorocarbon liquid in the preparation of a medicament for delivering oxygen to a patient when administered as an aerosol to a patient breathing a breathing gas. It also includes a fluorocarbon liquid having a particulate pharmaceutical agent dispersed therein for use in partial liquid breathing.

24. 发明公开

EP0873149A1 METHODS AND APPARATUS FOR CLOSED-CIRCUIT VENTILATION THERAPY 失效
标题翻译： VERFAHREN UND VORRICHTUNG MIT GESCHLOSSENEM KREISLAUFFÜRBEATMUNGSTHERAPIE
公开(公告)号：EP0873149A1
公开(公告)日：1998-10-28
申请号：EP96942817.0
申请日：1996-11-27
申请人： ALLIANCE PHARMACEUTICAL CORP.
发明人： FAITHFUL, Nicholas, S. , SCHUTT, Ernest, G.
IPC分类号： A61M16
CPC分类号： A61M16/0054 , A61M16/0009 , A61M16/0081 , A61M16/1055 , A61M16/1065 , A61M16/22 , A61M2016/102 , A61M2016/1025 , A61M2202/0476 , Y10S128/913
摘要： Methods and apparatus are provided which allow for closed-circuit ventilation for the treatment or diagnosis of disorders. The closed-circuit ventilation apparatus of the present invention (200, 300, 400, 500, 600) provide a closed-circuit respirator that isolates the gas flow path from the ventilator apparatus. This allows the prolonged administration of expensive materials such as fluorochemicals without excessive loss due to evaporation. As such the provided methods and apparatus are particularly applicable to liquid ventilation including partial liquid ventilation and total liquid ventilation.
摘要翻译：提供了允许闭路通气用于疾病的治疗或诊断的方法和装置。本发明的闭路通风装置提供一种隔离呼吸机装置的气体流路的闭路呼吸器。这允许长时间地管理诸如含氟化合物的昂贵材料，而不会由于蒸发造成过多的损失。所提供的方法，一种装置特别适用于包括局部液体通气和总液体通气在内的液体通气。

25. 发明公开

EP0808636A1 Method for partial liquid ventilation using fluorocarbons 失效
标题翻译： Verfahren zur teilweisenflüssigenBeatmung mit Fluorkohlwasserstoffen
公开(公告)号：EP0808636A1
公开(公告)日：1997-11-26
申请号：EP97113333.5
申请日：1992-10-22
申请人： ALLIANCE PHARMACEUTICAL CORPORATION
发明人： Schutt, Ernest G.
IPC分类号： A61M16/08 , A61M1/00 , A61M3/02
CPC分类号： A61K9/0026 , A61M16/0051 , A61M16/0054 , A61M16/021 , A61M16/0463 , A61M16/0486 , A61M16/107 , A61M2202/0476 , Y10S128/913
摘要： A method for treating liquid removed from the lungs of a patient undergoing liquid ventilation and for isolating fluorocarbon vapor from breathing gas exhaled by a patient undergoing partial liquid ventilation, wherein the liquid comprises a fluorocarbon liquid and the breathing gas contains fluorocarbon vapor. The method comprises the step of separating said fluorocarbon liquid from pulmonary debris and aqueous material or from the exhaled breathing gas.
摘要翻译：一种用于处理从进行液体通气的患者的肺部排出的液体并将氟碳蒸气与经受部分液体通气的患者呼出的呼吸气体分离的方法，其中所述液体包括碳氟化合物液体，呼吸气体含有碳氟化合物蒸汽。该方法包括从肺碎片和水性物质或呼出呼吸气体中分离出氟碳液体的步骤。

26. 发明公开

EP0789558A1 USE OF LIQUID FLUOROCARBONS TO FACILITATE PULMONARY DRUG DELIVERY 失效
标题翻译：液体氟碳化合物的使用，以促进药物输送至肺部
公开(公告)号：EP0789558A1
公开(公告)日：1997-08-20
申请号：EP95939052.0
申请日：1995-11-02
申请人： ALLIANCE PHARMACEUTICAL CORPORATION
发明人： ROSENBERG, Gwen, H.
IPC分类号： A61K9 , A61K47 , A61M15
CPC分类号： A61K9/007 , A61K9/0075 , A61K9/0082 , A61M2202/0476 , Y10S128/913
摘要： A kit which includes a perfluorocarbon liquid and a microparticulate medicament dispersed in a gas is used in the treatment of a pulmonary condition in a mammal. The kit is used in a multiple step method for delivering the medicament to the lungs. In this method, a biocompatible perfluorocarbon liquid is introduced into the lungs and a microparticulate medicament is introduced into the lungs where it is dispersed into the pulmonary spaces which are filled or coated with the perfluorocarbon liquid.

27. 发明公开

EP0683683A1 PROCESS CONTROL FOR LIQUID VENTILATION 失效
标题翻译： VERFAHRENSREGELUNG BEIFLÜSSIGKEITSVENTILATION。
公开(公告)号：EP0683683A1
公开(公告)日：1995-11-29
申请号：EP93923821.0
申请日：1993-10-08
申请人： Temple University of the Commonwealth System of Higher Education
发明人： SHAFFER, Thomas, H. , WOLFSON, Marla, R.
IPC分类号： A61M16
CPC分类号： A61M16/0054 , A61M16/024 , A61M2016/1025 , A61M2202/0476 , Y10S128/913
摘要： A process is provided for controlling a ventilation procedure wherein a liquid ventilation system passes breathing liquid through at least a portion of a patient's pulmonary pathways. In this process, desired ranges for certain process parameters associated with the liquid ventilation system are established. These desired ranges are input into a central processing unit (50). Initial settings for the liquid ventilation system are then made such that the actual conditions which will initially occur during the liquid ventilation procedure fall within their respective desired ranges. Thereafter, the procedure is commenced. During the procedure, conditions are continually monitored by sensors (16, 21, 27). The CPU (50) compares the sensor readings with the desired ranges, and acts to correct any discrepancy. The CPU can trigger alarms (514).
摘要翻译：提供了一种用于控制通气程序的过程，其中液体通气系统使呼吸液体通过患者肺通路的至少一部分。在该过程中，建立了与液体通气系统相关联的某些工艺参数的期望范围。这些期望的范围被输入到中央处理单元中。然后进行液体通气系统的初始设置，使得在液体通气过程中最初发生的实际状况落入其各自的期望范围内。此后，液体通气程序开始。在液体通气过程中，通过适当的传感器连续监测与建立的范围有关的条件。所监视的信息也被输入到中央处理单元。中央处理单元被设计为将实际发生的监视条件与它们各自的期望范围进行比较，并且确定是否存在差异。如果存在差异，则中央处理单元产生用于校正差异的信号。这些信号可被设计成触发报警，指示操作者进行适当的调整和/或激活伺服控制的阀门网络。

28. 发明公开

EP0583358A1 PARTIAL LIQUID BREATHING OF FLUOROCARBONS 失效
标题翻译：部分液体呼吸装置碳氟化合物。
公开(公告)号：EP0583358A1
公开(公告)日：1994-02-23
申请号：EP92911346.0
申请日：1992-05-01
申请人： ALLIANCE PHARMACEUTICAL CORPORATION
发明人： FAITHFULL, Nicholas, Simon , WEERS, Jeffry, Greg
IPC分类号： A61K9 , A61K31 , A61K45 , A61P11 , A61P31 , A61P43 , C07D207 , C07D217 , C07D307
CPC分类号： A61K31/135 , A61K31/02 , A61K31/025 , A61K31/035 , A61K31/08 , A61K31/13 , A61K31/685 , A61K45/06 , A61M2202/0476 , Y10S128/913 , A61K2300/00
摘要： The present invention includes the use of an oxygen-carrying breathable fluorocarbon liquid in the preparation of a medicament for delivering oxygen to a patient when administered as an aerosol to a patient breathing a breathing gas. It also includes a fluorocarbon liquid having a particulate pharmaceutical agent dispersed therein for use in partial liquid breathing.

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