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21. 发明公开

EP1283727A2 COMPOSITIONS AND METHODS FOR INDUCING ACTIVATION OF DENDRITIC CELLS 审中-公开
标题翻译：组合物和方法诱导的树突状细胞激活
公开(公告)号：EP1283727A2
公开(公告)日：2003-02-19
申请号：EP01941463.0
申请日：2001-04-30
申请人： SUPRATEK PHARMA, INC.
发明人： KABANOV, Alexander V. , LEMIEUX, Pierre , GUERIN, Nadia , ALAKHOV, Valery , VINOGRADOV, Serguie
IPC分类号： A61K48/00 , A61K47/32
CPC分类号： C12N15/1132 , A61K38/00 , A61K39/39 , A61K45/06 , A61K47/34 , A61K47/60 , A61K47/6901 , A61K48/00 , A61K2039/53 , A61K2039/55555 , A61K2039/57 , C12N15/1133 , C12N15/1138 , C12N2310/351 , Y02A50/412
摘要： Compositions induce the activation of dendritic cells comprising a polynucleotide, such as viruses, RNA, DNA, plasmid DNA, or derivatives thereof and at least one block copolymer of alkylethers. The present invention further relates to compositions for inducing the activation of dendritic cells wherein the block copolymers are PLURONIC F127 and L61. More particularly, the compositions comprise block copolymers PLURONIC F127/PLURONIC L61. The invention also relates to methods of inducing the activation of dendritic cells in animals comprising administering the compositions of the invention. Additionally, the present invention relates to methods of increasing the immune response of animals comprising administering the compositions of the present invention.

22. 发明公开

EP0975654A1 COMPOSITION AND METHOD FOR TREATMENT OF CMV INFECTIONS 失效
标题翻译：备和方法CMV感染的治疗
公开(公告)号：EP0975654A1
公开(公告)日：2000-02-02
申请号：EP98918034.4
申请日：1998-04-07
申请人： ISIS PHARMACEUTICALS, INC.
发明人： DRAPER, Kenneth, G. , KISNER, Daniel, L. , ANDERSON, Kevin, P. , CHAPMAN, Sharon
IPC分类号： C07H21/04 , C12Q1/68 , A61K48/00
CPC分类号： C12N15/1133 , A61K31/70 , A61K31/711 , A61K38/00 , C07H21/00 , C07K14/005 , C12N9/1252 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/334 , C12N2310/346 , C12N2310/3521 , C12N2310/3525 , C12N2710/16122 , C12Q1/705 , A61K2300/00 , C12N2310/3527
摘要： This invention concerns compositions and methods for the treatment of CMV infections. Antisense oligonucleotides are provided which are effective antiviral agents. In preferred embodiments, the oligonucleotides contain at least one 2'-methoxyethoxy modification and may be chimeric oligonucleotides.

23. 发明授权

EP0649467B1 SELF-STABILIZED OLIGONUCLEOTIDES AS THERAPEUTIC AGENTS 失效
标题翻译：自稳定的寡核苷酸作为治疗
公开(公告)号：EP0649467B1
公开(公告)日：1998-09-16
申请号：EP93918146.7
申请日：1993-07-02
申请人： HYBRIDON, Inc.
发明人： AGRAWAL, Sudhir , TANG, Jin-Yan
IPC分类号： C12N15/11 , C07H21/00 , A61K31/70
CPC分类号： C12N15/113 , A61K38/00 , C07H21/00 , C12N15/1131 , C12N15/1132 , C12N15/1133 , C12N15/1135 , C12N2310/111 , C12N2310/315 , C12N2310/321 , C12N2310/3511 , C12N2310/3521 , C12N2310/53 , Y02A50/387 , Y02A50/409 , Y02A50/411
摘要： The invention provides improved antisense oligonucleotides that are resistant to nucleolytic degradation. Such oligonuclotides are called self-stabilized oligonucleotides and comprise two regions: a target hybridizing region having a nucleotide sequence complementary to a nucleic acid sequence that is from a virus, a pathogenic organism, or a cellular gene; and a self-complementary region having an oligonucleotide sequence complementary to a nucleic acid sequence that is within the self-stabilized oligonucleotide.

24. 发明授权

EP0544713B1 OLIGONUCLEOTIDES FOR MODULATING THE EFFECTS OF CYTOMEGALOVIRUS INFECTIONS 失效
标题翻译：寡核苷酸调制巨细胞病毒影响的
公开(公告)号：EP0544713B1
公开(公告)日：1997-07-02
申请号：EP91914366.9
申请日：1991-08-14
申请人： ISIS PHARMACEUTICALS, INC.
发明人： ANDERSON, Kevin, P. , DRAPER, Kenneth, G. 445 Richmond Park West
IPC分类号： C12N15/11 , A61K31/70 , C07H21/04
CPC分类号： A61K31/711 , A61K38/00 , C07K14/005 , C12N9/1252 , C12N15/1133 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3521 , C12N2710/16122 , C12Q1/705
摘要： Compositions and methods for modulating the effects of cytomegalovirus (CMV) infections are disclosed, comprising contacting CMV mRNA with an oligonucleotide or oligonucleotide analog which can bind with at least portions of the CMV RNA. In accordance with the preferred embodiments, oligonucleotides or oligonucleotide analogs are designed to bind with portions of the CMV mRNAs which code for the IE1, IE2 or DNA polymerase proteins. In accordance with a preferred embodiment, methods of treatment of human cytomegalovirus are disclosed.

25. 发明公开

EP0758242A1 COMPOSITION AND METHOD FOR TREATMENT OF CMV INFECTION 失效
标题翻译：治疗CMV感染的组合物和方法
公开(公告)号：EP0758242A1
公开(公告)日：1997-02-19
申请号：EP95916482.0
申请日：1995-04-24
申请人： ISIS PHARMACEUTICALS, INC.
发明人： DRAPER, Kenneth G. , CHAPMAN, Sharon K. , KISNER, Daniel L.
IPC分类号： C07H21 , A61K31 , A61P27 , C12N15 , A61K38
CPC分类号： A61K31/711 , A61K31/70 , A61K38/00 , C12N15/1133 , C12N2310/315 , C12N2310/321 , C12N2310/322 , A61K2300/00 , C12N2310/3527 , C12N2310/3521
摘要： This invention concerns compositions and methods for the treatment of CMV infections. A composition including an antisense oligonucleotide targeted to the IE2 gene of CMV and a pharmaceutically acceptable carrier were used to stop progression in CMV retinitis.
摘要翻译：本发明涉及用于治疗CMV感染的组合物和方法。使用包含靶向CMV的IE2基因的反义寡核苷酸和药学上可接受的载体的组合物来终止CMV视网膜炎的进展。

26. 发明公开

EP0672193A4 OLIGONUCLEOTIDES HAVING A CONSERVED G 4? CORE SEQUENCE. 失效
标题翻译： OLIGONUKLEOTIDE MIT EINER KONSERVIERTEN G4-KERNSEQUENZ。
公开(公告)号：EP0672193A4
公开(公告)日：1995-11-22
申请号：EP93922788
申请日：1993-09-29
申请人： ISIS PHARMACEUTICALS INC
发明人： HANECAK RONNIE C , ANDERSON KEVIN P , BENNETT C FRANK , CHIANG MING-YI , BROWN-DRIVER VICKIE L , ECKER DAVID J , VICKERS TIMOTHY A , WYATT JACQUELINE R , IMBACH JEAN LOUIS IMPASSE DES
IPC分类号： C12N15/09 , A01N63/00 , A61K31/70 , A61K38/00 , A61P31/12 , A61P31/16 , A61P35/00 , C07H21/00 , C07H21/04 , C12N15/113 , C12N15/115 , C12N15/117 , C12P19/34 , C12Q1/68 , C12Q1/70 , A01N43/04 , C07H15/12 , C07H17/00
CPC分类号： A61K31/70 , A61K38/00 , C07H21/00 , C12N15/1133 , C12N15/1137 , C12N15/115 , C12N15/117 , C12N2310/151 , C12N2310/18 , C12N2310/315 , C12N2310/321 , C12N2310/341 , C12N2310/346 , C12Q1/701 , C12Y207/07049 , C12Y301/01004 , C12N2310/3521
摘要： Modified oligonucleotides having a conserved G4 sequence and a sufficient number of flanking nucleotides to significantly inhibit the activity of a virus such as HSV-1 or phospholipase A2 or to modulate the telomere length of a chromosome are provided. G4 quartet oligonucleotide structures are also provided. Methods of prophylaxis, diagnostics and therapeutics for viral-associated diseases and diseases associated with elevated levels of phospholipase A2 are also provided. Methods of modulating telomere length of a chromosome are also provided; modulation of telomere length is believed to play a role in the aging process of a cell and in control of malignant cell growth.
摘要翻译：提供了具有保守的G4序列和足够数量的侧翼核苷酸以显着抑制诸如HSV-1或磷脂酶A2的病毒的活性或调节染色体的端粒长度的经修饰的寡核苷酸。还提供G4四重子寡核苷酸结构。还提供了用于病毒相关疾病和与磷脂酶A2水平升高相关的疾病的预防，诊断和治疗的方法。还提供了调节染色体端粒长度的方法; 据信端粒长度的调节在细胞的老化过程和恶性细胞生长的控制中起作用。

27. 发明公开

EP0680969A2 Modifizierte Oligonukleotide, deren Herstellung sowie deren Verwendung 失效
标题翻译： Modifizierte Oligonukleotide，deren Herstellung sowie deren Verwendung。
公开(公告)号：EP0680969A2
公开(公告)日：1995-11-08
申请号：EP95106230.6
申请日：1995-04-26
申请人： HOECHST AKTIENGESELLSCHAFT
发明人： Seela, Frank, Prof. Dr. , Lampe, Sigrid, Dr.
IPC分类号： C07H21/00 , A61K31/70 , C12Q1/68 , C07H19/056
CPC分类号： C07H19/16 , C07H19/056 , C07H19/20 , C07H21/00 , C12N15/1132 , C12N15/1133 , C12N15/1135 , C12N15/1137 , C12N15/1138 , C12N2310/333 , C12N2310/336 , C12Q1/68 , C12Y207/11022 , Y02P20/55
摘要： Die Erfindung betrifft neue modifizierte Oligonukleotide, die mindestens eine 8-Azapurinbase aufweisen und stabilere Hybdridisierungskomplexe mit Nukleinsäuren bilden;
Verfahren zu deren Herstellung sowie deren Verwendung als Inhibitoren der Genexpression, als Sonden zum Nachweis von Nukleinsäuren, als Hilfsmittel in der Molekularbiologie und als Arzneimittel oder Diagnostikum.
摘要翻译：式（I）的寡核苷酸及其盐是新的。式中R1 = H，1-18C烷基，2-18C烯基或炔基，2-18C烷基羰基，3-19C烯基或炔基羰基，6-14C芳基（1-8C）烷基，标准保护gp 。（= W）（Z）（Z'）（IIa）; R2 = R1，但不是保护gp。和（IIa）被-P（= W）（Z）（X）（IIb）代替; R2 = H，OH，1-18C烷氧基，1-6C烯氧基（特别是烯丙氧基），卤素，N 3或NH 2; a = O或CH2; n = 3-99; W = O，S或Se; V = O，S或NH; Y = O，S，NH或CH 2; Y'= O，S，NH，（CH 2）m或V（CH 2）m; m = 1-18; X = OH或SH; U = OH，SH，SeH，1-18C烷基或烷氧基，6-20C芳基，（6-14C）芳基 - （1-8C）烷基，NHR3，NR3R4或（OCH2CH2）pO（CH2）qCH2R5（Ⅲ） R3 = 1-18C烷基，6-20C芳基，（6-14C）芳基 - （1-8C）烷基或（CH2）c-（NH（CH2）c）d-NR6R6; c = 2-6; d = 0-6; 每个R6 = H或1-6C烷基（选自被1-4C烷氧基取代）; R4 = 1-18C烷基，6-20C芳基或（6-10C）芳基 - （1-8C）烷基，或与R3完成5-至6-元杂环，其可含有另外的O，S或N原子; p = 1-100; q = 0-22; R5 = H或功能gp。（例如OH，NH 2，1-18C烷基氨基，COOH，CONH 2，COO（1-4C）烷基或卤素）; Z和Z 1各自为OH，SH，SeH，1-22C烷氧基，O（CH 2）b NR 6 R 7，1-18C烷基，6-20C芳基，（6-14C）芳基 - （1-8C）烷基或烷氧基，1-18C烷硫基，NHR3，NR3R4，gp。（III）或gp。其促进细胞内摄取，用作DNA探针的标记，或当（I）与其靶标杂交时，引起结合该靶标的交联/切割; b = 1-6; R7 = 1-6C烷基; 或R6和R7一起完成3-至6-元环; 芳基（其包括杂芳基）是选择性的。 substd。由1-3的COOH，NH 2，NO 2，1-4 C烷基氨基，1-6 C烷氧基，OH，卤素或CN; 支架表示R2和磷酰基可以在2'或3'位置; 每个核苷酸具有D或L构型，每个B是α或β位; 每个B =核苷酸化学中的天然或非天然碱基标准，或其前药形式，但至少一个必须是8-氮杂嘌呤碱基。

28. 发明公开

EP0656942A1 COMPOSITIONS AND METHODS FOR INHIBITING GROWTH OR REPLICATION OF VIRUSES 失效
标题翻译：组合物和抑制生长或病毒复制的方法。
公开(公告)号：EP0656942A1
公开(公告)日：1995-06-14
申请号：EP91918745.0
申请日：1991-09-18
申请人： UNIVERSITY OF MARYLAND , THE JOHNS HOPKINS UNIVERSITY
发明人： AURELIAN, Laure , TS'O, Paul, O., P.
IPC分类号： A61K48 , A61P31 , C12N15 , C12Q1
CPC分类号： A61K31/70 , C12N15/1133 , C12N2310/3125 , C12N2310/321 , C12Q1/701 , C12Q1/703 , C12Q1/705
摘要： The invention relates to compositions and methods for inhibiting the growth or replication of microbes, viruses or self-replicating nucleic acids. Antisense oligonucleotides that bind to strategic sites in the microbe, virus of self-replicating nucleic acid genome find particular utility in preventing proliferation and pathogenesis; and in detecting microbe, virus or self-replicating nucleic acid. Therapeutic compositions comprising at least two oligonucleotides and methods using the compositions are effective in inhibiting the growth or replication of homologous and heterologous microbes, viruses or self-replicating nucleic acids.

29. 发明公开

EP0649467A1 SELF-STABILIZED OLIGONUCLEOTIDES AS THERAPEUTIC AGENTS 失效
标题翻译：自稳定的寡核苷酸作为治疗。
公开(公告)号：EP0649467A1
公开(公告)日：1995-04-26
申请号：EP93918146.0
申请日：1993-07-02
申请人： HYBRIDON, Inc.
发明人： AGRAWAL, Sudhir , TANG, Jin-Yan
IPC分类号： C12N15 , A61K31 , A61K48 , A61P31 , C07H21 , A61K38
CPC分类号： C12N15/113 , A61K38/00 , C07H21/00 , C12N15/1131 , C12N15/1132 , C12N15/1133 , C12N15/1135 , C12N2310/111 , C12N2310/315 , C12N2310/321 , C12N2310/3511 , C12N2310/3521 , C12N2310/53 , Y02A50/387 , Y02A50/409 , Y02A50/411
摘要： The invention provides improved antisense oligonucleotides that are resistant to nucleolytic degradation. Such oligonuclotides are called self-stabilized oligonucleotides and comprise two regions: a target hybridizing region having a nucleotide sequence complementary to a nucleic acid sequence that is from a virus, a pathogenic organism, or a cellular gene; and a self-complementary region having an oligonucleotide sequence complementary to a nucleic acid sequence that is within the self-stabilized oligonucleotide.

30. 发明公开

EP0544713A4 OLIGONUCLEOTIDES FOR MODULATING THE EFFECTS OF CYTOMEGALOVIRUS INFECTIONS 失效
标题翻译：用于调节细胞因子感染的影响的寡核苷酸
公开(公告)号：EP0544713A4
公开(公告)日：1994-05-18
申请号：EP91914366
申请日：1991-08-14
申请人： ISIS PHARMACEUTICALS INC
发明人： ANDERSON KEVIN P , DRAPER KENNETH G RICHMOND PARK
IPC分类号： A61K31/70 , A01N43/04 , A61K38/00 , A61K48/00 , A61P31/12 , C07H20060101 , C07H15/12 , C07H17/00 , C07H21/00 , C07K14/045 , C12N9/12 , C12N15/00 , C12N15/09 , C12N15/113 , C12P19/34 , C12Q1/68 , C12Q1/70 , C12N15/11
CPC分类号： A61K31/711 , A61K38/00 , C07K14/005 , C12N9/1252 , C12N15/1133 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3521 , C12N2710/16122 , C12Q1/705

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