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    • 27. 发明公开
    • PROCESS FOR PRODUCING D-(CHIRO)-INOSITOL
    • 生产D-(CHIRO) - 肌醇的方法
    • EP0712827A1
    • 1996-05-22
    • EP94923085.8
    • 1994-08-08
    • HOKKO CHEMICAL INDUSTRY CO. LTD.ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI
    • SATO, KiyoshiYOSHIDA, MakotoKANBE, KenjiHIRAZAWA, KiyoshiTAKEUCHI, Tomio
    • C07C35/16C07C29/10
    • C07C35/16C07B2200/07C07C29/10C07C2601/14
    • A process for producing D- chiro -inositol which comprises either mixing an aqueous solution of kasugamycin or a salt thereof with a strongly acidic ion-exchange resin (of H⁺ type) in a reactor or bringing the aqueous solution into contact with the resin in a column packed therewith, heating the aqueous solution and the resin under normal or applied pressure to effect hydrolysis of kasugamycin to thereby prepare an acidic reaction solution containing D- chiro -inositol, separating the acidic reaction solution from the resin, and recovering D- chiro -inositol from the solution. In this stage, it is possible to obtain efficiently high-purity D- chiro -inositol by passing the acidic reaction solution first through a column packed with a strongly acidic ion-exchange resin (of H⁺ type) and then through another column packed with a strongly basic ion-exchange resin (of OH⁻ type) to prepare a neutral eluate containing D- chiro -inositol, and concentrating the eluate to effect deposition of D- chiro -inositol crystals.
    • 生产D-手性肌醇的方法,该方法包括在反应器中混合春日
      霉素或其盐的水溶液与强酸性离子交换树脂(H +型)或使水溶液与树脂接触 填充柱,在常压或加压下加热水溶液和树脂以实现春日霉素的水解,由此制备含有D-手性肌醇的酸性反应溶液,将酸性反应溶液与树脂分离,并回收D-手性 从溶液中提取肌醇。 在此阶段,通过使酸性反应溶液首先通过填充有强酸性离子交换树脂(H +型)的柱,然后通过填充有另一个柱的另一个柱,可以有效地获得高纯度D-手性肌醇 强碱性离子交换树脂(OH - 型)制备含D-手性肌醇的中性洗脱液,并浓缩洗脱液以实现D-手性肌醇晶体的沉积。