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21. 发明公开

EP3202428A1 A DEVICE FOR REPAIR SURGERY OF RUPTURED TENDONS, COMPRISING A THERAPEUTIC AGENT FOR STIMULATING REGROWTH 审中-公开
标题翻译：一种用于修复破裂的肌腱手术的装置，包括用于刺激复发的治疗剂
公开(公告)号：EP3202428A1
公开(公告)日：2017-08-09
申请号：EP16178874.0
申请日：2016-07-11
申请人： Universität Zürich
发明人： The designation of the inventor has not yet been filed
IPC分类号： A61L27/18 , A61L27/54
CPC分类号： A61L27/18 , A61L27/54 , A61L2430/10 , C08L67/04 , A61L2300/414
摘要： A device for repair surgery of cylindrical organs, particularly of ruptured tendons, is configured as a tubular sheath (T) made of a mesh of elastic fibers formed by electrospinning a biocompatible and biodegradable polymer. The tubular sheath has a Young elasticity modulus of about 0.1 to about 4 MPa and a strain at break of about 50 to about 1'000 %, and it has a first wall surface and a second wall surface substantially parallel thereto, with said first wall surface being comparatively smooth (W S ) and said second wall surface being comparatively rough (W R ). According to the invention, the elastic fibers comprise first fibers consist of polymer in neat form and second fibers consist of polymer with an admixture of a therapeutic agent for stimulating regrowth processes of a predetermined cylindrical organ. The tubular sheath comprises a first tubular region adjacent to the first wall and a second tubular region adjacent to the second wall, said first tubular region being formed of said first fibers and said second tubular region being formed of said second fibers.
摘要翻译：用于圆柱形器官，特别是破裂腱的修复手术的装置被配置为由弹性纤维网制成的管状护套（T），所述弹性纤维网通过静电纺丝生物相容且可生物降解的聚合物而形成。所述管状护套具有约0.1至约4MPa的杨氏弹性模量和约50至约1'000％的断裂应变，并且其具有第一壁表面和基本平行于其的第二壁表面，所述第一壁表面比较光滑（WS）并且所述第二壁表面比较粗糙（WR）。根据本发明，弹性纤维包括由纯净聚合物形成的第一纤维和由聚合物构成的第二纤维以及用于刺激预定圆柱形器官再生长过程的治疗剂混合物。管状护套包括与第一壁相邻的第一管状区域和与第二壁相邻的第二管状区域，所述第一管状区域由所述第一纤维形成，所述第二管状区域由所述第二纤维形成。

22. 发明授权

EP2813232B1 Process of Production of Allogenic Growth Factor Extract 有权
标题翻译：同种异体生长因子提取物的生产过程
公开(公告)号：EP2813232B1
公开(公告)日：2017-08-09
申请号：EP13171495.8
申请日：2013-06-11
申请人： DOT GmbH
发明人： Neumann, Hans-Georg , Neumann, Barbara.
IPC分类号： A61K35/16 , A61K35/19 , A61L27/54 , A61K45/06 , A61P17/02
CPC分类号： A61K35/19 , A61K35/16 , A61L27/54 , A61L2300/414 , A61L2430/02 , A61L2430/38

23. 发明公开

EP3185922A1 COLLAGEN-BASED THERAPEUTIC DELIVERY SYSTEMS 审中-公开
标题翻译：基于胶原蛋白的治疗性递送系统
公开(公告)号：EP3185922A1
公开(公告)日：2017-07-05
申请号：EP15835953.9
申请日：2015-08-27
申请人： Purdue Research Foundation Office of Technology Commercialization
发明人： VOYTIK-HARBIN, Sherry
IPC分类号： A61L31/04
CPC分类号： A61L27/24 , A61K9/0024 , A61K9/19 , A61K38/18 , A61K47/42 , A61L27/54 , A61L2300/414 , A61L2300/604 , A61L2400/06
摘要： A collagen-based therapeutic delivery device includes an insoluble synthetic collagen-fibril matrix comprising a polymerization product of soluble oligomeric collagen or a polymerization product of a mixture of soluble oligomeric collagen with one or more type of non-oligomeric soluble collagen molecules, such as, for example, soluble telocollagen and/or soluble atelocollagen, and an active agent dispersed throughout the collagen-fibril matrix or within a portion of the collagen-fibril matrix. A pre-matrix composition includes an aqueous solution including soluble collagen-fibril building blocks and an active agent in the aqueous solution. The soluble collagen-fibril building blocks include soluble oligomeric collagen or a mixture of soluble oligomeric collagen with non-oligomeric soluble collagen molecules. The building blocks are operable to self-assemble into a macromolecular synthetic collagen-fibril matrix in the absence of an exogenous cross-linking agent. Methods of making and using the pre-matrix composition and the device are also provided.
摘要翻译：基于胶原的治疗递送装置包括不溶性合成胶原 - 原纤维基质，其包含可溶低聚胶原的聚合产物或可溶低聚胶原与一种或多种非寡聚可溶性胶原分子的混合物的聚合产物，例如，可溶性端粒胶原和/或可溶性整链端胶原，以及分散在整个胶原 - 原纤维基质中或部分胶原 - 原纤维基质内的活性剂。预基质组合物包括含有可溶性胶原 - 原纤结构单元和水溶液中的活性剂的水溶液。可溶性胶原 - 原纤结构单元包括可溶性低聚胶原或可溶低聚胶原与非寡聚可溶性胶原分子的混合物。在不存在外源交联剂的情况下，构建块可操作以自组装成大分子合成胶原 - 原纤维基质。还提供了制造和使用预制基质组合物和装置的方法。

24. 发明公开

EP3185917A1 NOVEL COLLAGEN MICROCARRIERS 审中-公开
标题翻译：新型胶原微载体
公开(公告)号：EP3185917A1
公开(公告)日：2017-07-05
申请号：EP14780902.4
申请日：2014-08-04
申请人： Euroresearch S.r.l. , Swiss Paraplegic Research
发明人： SCALESCIANI, Juan Francisco , BERTOLO, Alessandro , STOYANOV, Jivko
IPC分类号： A61L27/24 , A61L27/54 , A61L27/58 , A61K9/00 , C12N5/00
CPC分类号： A61L27/24 , A61K9/0024 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2300/428 , A61L2430/02 , C12N5/0075
摘要： The present invention relates to novel injectable microcamers, made of collagen or cross-linked collagen, especially equine collagen, said microcamers having the form of agglomerates of filamentous collagen elements and having specific size. The invention also relates to a process for the preparation of said Microcamers, cell cultures comprising said microcamers and the use thereof for implanting cells in a mammal body.
摘要翻译：本发明涉及由胶原蛋白或交联胶原蛋白（尤其是马胶原蛋白）制成的新型可注射微型胶泡，所述微型胶原蛋白具有丝状胶原蛋白成分附聚物的形式并具有特定的尺寸。本发明还涉及制备所述微型调聚物的方法，包含所述微型调聚物的细胞培养物及其用于将细胞植入哺乳动物体内的用途。

25. 发明公开

EP3183224A1 POROUS AND NON-POROUS BODIES 审中-公开
标题翻译：多孔和非多孔的身体
公开(公告)号：EP3183224A1
公开(公告)日：2017-06-28
申请号：EP15762666.4
申请日：2015-08-24
申请人： The University Of Nottingham
发明人： AHMED, Ifty
IPC分类号： C03C11/00 , C03C12/00 , C03B19/10 , C04B35/447 , C04B38/00 , A61K9/16 , A61L27/10 , A61L27/12
CPC分类号： C03B19/1085 , A61K9/167 , A61K45/06 , A61L27/10 , A61L27/12 , A61L27/3834 , A61L27/54 , A61L27/56 , A61L2300/404 , A61L2300/414 , A61L2430/02 , C01B25/32 , C03B19/102 , C03B19/1075 , C03C11/002 , C03C11/007 , C03C12/00 , C04B35/447 , C04B35/622 , C04B38/009 , C04B2111/00836 , C04B2235/528 , C04B2235/5409 , C04B2235/5427 , C04B2235/5436 , C04B2235/5472 , C04B2235/77 , C04B2235/95 , Y02P40/57 , C04B14/366 , C04B38/02
摘要： A method of manufacture of a powder comprising, or consisting essentially of, microspheres, the method comprising: providing a feed powder; and applying at least one spheroidisation flame to the powder. The powder may be suitable for use in medical and/or non-medical applications.
摘要翻译：一种制造包含微球体或基本上由微球体构成的粉末的方法，所述方法包括：提供进料粉末; 并将至少一个球化火焰施加到粉末上。该粉末可适用于医疗和/或非医疗应用。

26. 发明公开

EP3181157A1 COMPOSITIONS AND METHODS FOR ARTHRODETIC PROCEDURES 失效
标题翻译： ZUSAMMENSETZUNGEN UND VERFAHRENFÜRBEHANDLUNGEN VON ARTHRODESE
公开(公告)号：EP3181157A1
公开(公告)日：2017-06-21
申请号：EP16196737
申请日：2007-11-05
申请人： BIOMIMETIC THERAPEUTICS LLC
发明人： HART CHARLES E , LYNCH SAMUEL E
IPC分类号： A61L27/22 , A61F2/28 , A61F2/30 , A61L24/00 , A61L27/54
CPC分类号： A61L24/0015 , A61F2002/2817 , A61F2002/30622 , A61F2310/00293 , A61L27/227 , A61L27/54 , A61L2300/414 , A61L2430/02
摘要： The present invention provides compositions and methods for facilitating fusion of bones in a joint. The present invention provides compositions and methods for promoting fusion of bones in arthrodetic procedures. In one embodiment, a method of performing an arthrodetic procedure comprises providing a composition comprising PDGF disposed in a biocompatible matrix and applying the composition to a site of desired bone fusion in a joint.
摘要翻译：本发明提供了便于骨头在关节中融合的组合物和方法。本发明提供了促进关节融合术中骨融合的组合物和方法。在一个实施方案中，进行关节融合术的方法包括提供包含置于生物相容性基质中的PDGF的组合物，并将该组合物应用于关节中期望的骨融合部位。

27. 发明公开

EP3181144A1 MEDICINAL COMPOSITION FOR TREATING AND/OR PREVENTING ESOPHAGEAL STENOSIS 审中-公开
标题翻译：药物组合物用于治疗和/或预防食管狭窄
公开(公告)号：EP3181144A1
公开(公告)日：2017-06-21
申请号：EP15831534.1
申请日：2015-08-06
申请人： Kagoshima University
发明人： IDO Akio , TSUBOUCHI Hirohito , KOMAKI Yuga
IPC分类号： A61K38/00 , A61P1/04
CPC分类号： A61P1/04 , A61K38/1833 , A61L31/16 , A61L2300/252 , A61L2300/414
摘要： According to this invention, the following are provided: a pharmaceutical composition for treating and/or preventing esophageal stenosis, comprising an HGF protein as an active ingredient (wherein the HGF protein may be a polypeptide that is any one of the following: (a) a polypeptide comprising the amino acid sequence shown in SEQ ID NO: 2; (b) a polypeptide comprising an amino acid sequence shown in SEQ ID NO: 2 in which one to several amino acids are deleted, substituted, or added; or (c) a polypeptide comprising an amino acid sequence having at least 90% identity with the amino acid sequence shown in SEQ ID NO: 2; and a stent comprising the pharmaceutical composition.
摘要翻译：。根据本发明，以下提供了：药物组合物用于治疗和/或预防食管狭窄，HGF蛋白的包含作为活性成分的（worin所述HGF蛋白可以是多肽所做的是以下的任何一个：（a）一个多肽，其包含在SEQ ID NO：2所示的氨基酸序列：2;（b）如SEQ ID NO：1所示，其包括氨基酸序列的多肽：其中2中的一个至数个氨基酸被缺失，取代，或添加，或（c ）一个多肽，其包含于氨基酸与SEQ ID NO：2所示的氨基酸序列至少90％同一性序列：2;以及支架，其包括药物组合物。

28. 发明公开

EP3166653A2 ZWITTERIONIC HYDROGELS FOR DELIVERY OF BIOMOLECULES 审中-公开
标题翻译：用于递送生物分子的ZWTTERTERIC水凝胶
公开(公告)号：EP3166653A2
公开(公告)日：2017-05-17
申请号：EP15818612.2
申请日：2015-07-06
申请人： University of Massachusetts Medical School
发明人： SONG, Jie , LIU, Pingsheng
IPC分类号： A61L27/44 , A61C13/00 , A61L27/58
CPC分类号： A61L27/58 , A61K38/18 , A61K38/1875 , A61K38/30 , A61L27/14 , A61L27/18 , A61L27/50 , A61L27/52 , A61L27/54 , A61L2300/414 , A61L2430/02
摘要： The invention provides a novel approach in which zwitterionic networks are used to sequester and deliver ionic biomolecules, such as proteins, without compromising their native conformation and bioactivity. Zwitterionic networks are designed to effectively retain and deliver ionic or polar biomolecules for guided tissue regeneration. The invention represents a conceptual advance and enables a novel strategy for the utilization of zwitterionic motifs as therapeutics delivery vehicles and tissue engineering scaffolds.
摘要翻译：本发明提供了一种新的方法，其中使用两性离子网络螯合和递送离子生物分子如蛋白质，而不损害它们的天然构象和生物活性。两性离子网络设计用于有效地保留和递送离子或极性生物分子以引导组织再生。本发明代表了概念上的进步，并且实现了利用两性离子图案作为治疗递送载体和组织工程支架的新策略。

29. 发明授权

EP2598437B1 INTRINSICALLY MAGNETIC HYDROXYAPATITE 有权转让
标题翻译：固有磁性的羟基磷灰石
公开(公告)号：EP2598437B1
公开(公告)日：2017-04-05
申请号：EP11752344.9
申请日：2011-07-28
申请人： Consiglio Nazionale Delle Ricerche , Fin-Ceramica Faenza S.p.A.
发明人： TAMPIERI, Anna , LANDI, Elena , SANDRI, Monica , PRESSATO, Daniele , RIVAS REY, José , BANOBRE LOPEZ, Manuel , MARCACCI, Maurilio
IPC分类号： C01B25/32 , C01B25/45 , A61L27/12 , A61L27/54 , A61K47/02 , A61K49/00 , A61K49/08
CPC分类号： A61K47/02 , A61K49/0002 , A61K49/08 , A61L27/12 , A61L27/54 , A61L2300/414 , A61L2300/64 , A61L2400/12 , A61L2430/02 , A61L2430/06 , C01B25/32 , C01B25/322 , C01B25/45 , C01P2004/62 , C01P2006/62 , C01P2006/64

30. 发明授权

EP2398520B1 MEDICAL DEVICE WITH INFLAMMATORY RESPONSE-REDUCING COATING 失效
标题翻译：有涂层以防反应而减少医疗器械
公开(公告)号：EP2398520B1
公开(公告)日：2017-04-05
申请号：EP10712970.2
申请日：2010-02-22
申请人： Sofradim Production
发明人： LADET, Sébastien , GRAVAGNA, Philippe
IPC分类号： A61L27/50 , A61L31/14 , A61L27/34 , A61L31/10
CPC分类号： A61L31/10 , A61L17/005 , A61L17/145 , A61L31/16 , A61L2300/252 , A61L2300/256 , A61L2300/406 , A61L2300/41 , A61L2300/414 , A61L2300/43 , A61L2300/606 , A61L2400/18 , A61L2420/02

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