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21. 发明公开

EP3285790A1 ZUSAMMENSETZUNG FÜR DIE BEHANDLUNG DES HALS-/RACHENRAUMS 有权
公开(公告)号：EP3285790A1
公开(公告)日：2018-02-28
申请号：EP16738074
申请日：2016-06-08
申请人： MARIA CLEMENTINE MARTIN KLOSTERFRAU VERTRIEBSGESELLSCHAFT MBH
发明人： GALÁN SOÚSA JOSE , VESTWEBER ANNA MARIA
IPC分类号： A61K36/898 , A61K9/00 , A61K31/08 , A61K31/155 , A61K31/728 , A61K31/731 , A61K36/04 , A61K36/09 , A61K36/185 , A61K36/48 , A61K36/68 , A61K36/73 , A61K45/06 , A61P11/04 , A61P11/14
CPC分类号： A61K36/73 , A61K9/006 , A61K9/12 , A61K31/08 , A61K31/155 , A61K31/728 , A61K31/731 , A61K36/04 , A61K36/09 , A61K36/185 , A61K36/48 , A61K36/68 , A61K36/898 , A61K45/06 , A61K47/10 , A61K47/12 , A61K2300/00
摘要： The invention relates to a composition, in particular a pharmaceutical preparation, preferably in the form of a liquid dose, which is suitable for the prophylactic or therapeutic treatment of, in particular, inflammatory diseases of the oral cavity and of the throat/pharynx, wherein the composition contains, in combination and in effective, in particular pharmaceutically effective, amounts, (a) at least one mucilaginous drug, in particular marshmallow (Althaea officinalis L.), (b) at least one local anesthetic, in particular polidocanol, and (c) at least one surface disinfectant, in particular polyhexanide.

22. 发明公开

EP3129075A4 BONE REPAIR COMPOSITIONS 审中-实审
公开(公告)号：EP3129075A4
公开(公告)日：2017-12-06
申请号：EP15777375
申请日：2015-04-09
申请人： BONUS THERAPEUTICS LTD
发明人： MERETZKI SHAI
IPC分类号： A61L27/38 , A61K31/728 , A61K35/12 , A61K35/28 , C12M1/00
CPC分类号： A61L27/3891 , A61K31/728 , A61K35/28 , A61K35/44 , A61L27/12 , A61L27/20 , A61L27/3604 , A61L27/3608 , A61L27/3808 , A61L27/3834 , A61L27/3847 , A61L27/46 , A61L27/58 , A61L2400/06 , A61L2430/02 , A61K2300/00 , C08L5/08
摘要： A composition including, (a) a mineral particle, (b) endothelial cells and mesenchymal cells, and (3) hyaluronic acid, is provided. Moreover, a kit which includes: a syringe, a mineral particle covered with endothelial cells and mesenchymal cells organized in 2 or more cell layers attached to the mineral particle, and hyaluronic acid, is also provided. Last, a method for filling a gap in a bone of a subject in need thereof, including contacting the gap with a composition of: (a) a mineral particle, (b) endothelial cells and mesenchymal cells, and (3) hyaluronic acid is provided.

23. 发明授权

EP2252290B1 PHARMACEUTICAL COMPOSITION FOR USE IN THE TREATMENT AND/OR THE PREVENTION OF OSTEOARTICULAR DISEASES 有权转让
标题翻译：用于治疗和/或预防骨关节疾病的药物组合物
公开(公告)号：EP2252290B1
公开(公告)日：2017-11-29
申请号：EP09710250.3
申请日：2009-02-13
申请人： Bone Therapeutics S.A.
发明人： BASTIANELLI, Enrico , ATTALI, Pierre , VERVAET, Chris
IPC分类号： A61K31/4164 , A61K31/4174 , A61K31/4178 , A61K31/4168 , A61K31/728 , A61K9/00 , A61P19/02
CPC分类号： A61K31/728 , A61K9/0019 , A61K31/4164 , A61K31/4168 , A61K31/4174 , A61K31/4178 , A61K31/56 , A61K31/573 , A61K31/726 , A61K35/12 , A61K35/28 , A61K35/545 , A61K45/06 , A61K47/36 , A61M5/283 , Y02A50/401 , A61K2300/00
摘要： An intra-articular pharmaceutical composition is used for the treatment and/or the prevention of acute or chronic osteoarticular diseases and acute or chronic osteoarticular symptoms especially osteoarthritis. The composition includes a possibly adequate pharmaceutical carrier or diluent, a glycosaminoglycan, a compound activating the alpha 2 adrenergic receptor, an anti-inflammatory agent and stem cells.

24. 发明公开

EP3142705A4 POLYMER-FLAVONOID CONJUGATE AND USES THEREOF 有权
公开(公告)号：EP3142705A4
公开(公告)日：2017-11-22
申请号：EP15792453
申请日：2015-05-15
申请人： AGENCY SCIENCE TECH & RES
发明人： KURISAWA MOTOICHI , LEE FAN
IPC分类号： A61K47/50 , A61K31/353 , A61K31/728 , A61K47/36 , A61P19/02 , A61P19/04 , C08L5/08
CPC分类号： A61K47/4823 , A61K9/0024 , A61K31/353 , A61K31/728 , A61K47/61 , C08B37/0072 , C08L5/08
摘要： There is provided a polymer-flavonoid conjugate, or a pharmaceutically acceptable salt thereof, uses thereof, and methods of making thereof. The disclosed polymer-flavonoid conjugates may be useful in the therapeutic and/or prophylactic treatment of a joint condition in a subject.

25. 发明授权

EP2727581B1 COMPOSITION INJECTABLE ASSOCIANT UN AGENT DE COMBLEMENT ET UN MILIEU DE CROISSANCE DES FIBROBLASTES 有权
标题翻译：包含填充剂和成纤维细胞生长培养基的可注射组合物
公开(公告)号：EP2727581B1
公开(公告)日：2017-11-15
申请号：EP13198504.6
申请日：2010-07-06
申请人： Thorel, Jean-Noël
发明人： Thorel, Jean-Noël , Gatto, Hugues
IPC分类号： A61K8/67 , A61K8/73 , A61Q19/08 , A61K31/728 , A61L27/50 , A61K9/00 , A61P17/00 , A61K45/06 , A61L27/52
CPC分类号： A61K8/735 , A61K8/675 , A61K9/0019 , A61K31/728 , A61K33/00 , A61K45/06 , A61K2800/91 , A61L27/20 , A61L27/52 , A61L2400/06 , A61Q19/08 , A61K2300/00 , C08L5/08

26. 发明公开

EP3241852A1 HYALURONIC ACID-BASED AMPHIPHILIC POLYMER, PREPARATION METHOD AND APPLICATION THEREOF 有权转让
标题翻译：透明质酸基两性聚合物及其制备方法和应用
公开(公告)号：EP3241852A1
公开(公告)日：2017-11-08
申请号：EP16734888.7
申请日：2016-01-04
申请人： BrightGene Bio-Medical Technology Co., Ltd.
发明人： ZHONG, Zhiyuan , ZHONG, Yinan , MENG, Fenghua , YUAN, Jiandong , HUANG, Yangqing , CHI, Jianwen
IPC分类号： C08B37/08 , A61K47/36 , A61P35/00 , A61K9/51
CPC分类号： A61K9/5161 , A61K9/51 , A61K31/704 , A61K31/728 , A61K31/795 , A61K47/183 , A61K47/20 , A61K47/36 , C08B37/0072
摘要： Disclosed are a hyaluronic acid-based amphiphilic polymer, preparation method and application thereof. A main chain of the amphiphilic polymer is a hydrophilic hyaluronic acid and can be employed in active targeting, and a side chain thereof is a hydrophobic group represented by Formula (1). The amphiphilic polymer can carry a small molecule anticancer drug. Polymer nanoparticles are obtained via chemical crosslinking, such that the nanoparticles are not readily dissociated outside a cell or in blood, thus ensuring the stability of a drug encapsulated by the nanoparticles. Upon arriving at a tumor tissue, the hyaluronic acid on a surface of the nanoparticle can immediately combine with a CD44 receptor on a surface of a tumor cell, and effectively enter the tumor cell via endocytosis mediated by the receptor, and then quickly de-crosslink to be dissociated. The drug is quickly released, obtaining an enrichment ratio at a tumor site markedly higher than that of the prior art, resulting in a highly effective treatment, and addressing deficiencies such as drug leakage, low carrying efficiency, low occurrence of endocytosis and slow release in a cell.
摘要翻译：公开了一种基于透明质酸的两亲聚合物及其制备方法和应用。两亲性聚合物的主链是亲水性透明质酸，可以用于主动靶向，其侧链是由式（1）表示的疏水性基团。两亲聚合物可以携带小分子抗癌药物。通过化学交联获得聚合物纳米颗粒，使得纳米颗粒不容易在细胞外或血液中解离，从而确保纳米颗粒包封的药物的稳定性。当到达肿瘤组织时，纳米颗粒表面上的透明质酸可以立即与肿瘤细胞表面上的CD44受体结合，并且通过受体介导的内吞作用有效地进入肿瘤细胞，然后快速地解交联被分离。药物迅速释放，获得比现有技术显着更高的肿瘤部位的富集比率，得到高度有效的治疗，并且解决了诸如药物泄漏，携带效率低，内吞作用发生率低以及缓慢释放一个小区。

27. 发明公开

EP3238718A1 ORAL COMBINATION FOR THE PREVENTION AND TREATMENT OF BLADDER, PELVIC AND UROGENITAL APPARATUS PATHOLOGIES 审中-公开
标题翻译：口服组合预防和治疗膀胱，盆腔和尿道装置病理
公开(公告)号：EP3238718A1
公开(公告)日：2017-11-01
申请号：EP17172190.5
申请日：2014-01-20
申请人： ALTERGON S.A.
发明人： GIORI, Andrea Maria , LUCHERINI, Enzo
IPC分类号： A61K31/12 , A61K31/352 , A61K31/728 , A61K31/737 , A61P13/00 , A61P15/00
CPC分类号： A61K31/12 , A23L33/10 , A23V2002/00 , A61K9/0053 , A61K9/4825 , A61K31/352 , A61K31/728 , A61K31/737 , A61K2300/00
摘要： The invention describes a pharmaceutical association of active ingredients comprising: curcumin, quercetin, chondroitin sulfate and hyaluronic acid, used for the prevention or treatment of bladder, pelvic and urogenital apparatus pathologies.
摘要翻译：本发明描述了一种活性成分的药物组合物，其包含：姜黄素，槲皮素，硫酸软骨素和透明质酸，用于预防或治疗膀胱，骨盆和泌尿生殖器病理。

28. 发明授权

EP2540284B1 Compositions and methods for stabilized polysaccharide formulations 有权转让
标题翻译：用于稳定多糖制剂的组合物和方法
公开(公告)号：EP2540284B1
公开(公告)日：2017-09-06
申请号：EP12174614.3
申请日：2012-07-02
申请人： DePuy Mitek, Inc.
发明人： Su, Dongling , Hwang, Julia , Story, Brooks J.
IPC分类号： A61K9/19 , A61K31/728 , A61K31/726 , A61K47/22 , A61K47/26 , A61P19/02
CPC分类号： A61K47/26 , A61K9/0019 , A61K9/19 , A61K31/726 , A61K31/728 , A61K31/737 , A61K47/02 , A61K47/10 , A61K2300/00

29. 发明公开

EP3071188A4 MICELLE-BASED DELIVERY OF DERMAL THERAPEUTIC MATERIALS 审中-公开
标题翻译： AUF MICELLEN BASIERENDE VERABREICHUNG VON DERMALEN THERAPEUTIKA
公开(公告)号：EP3071188A4
公开(公告)日：2017-08-23
申请号：EP14861222
申请日：2014-11-18
申请人： POLYREMEDY INC
发明人： RICHARD DAVID A
IPC分类号： A61K9/06 , A61K9/08
CPC分类号： A61K31/728 , A61K8/0212 , A61K8/34 , A61K8/86 , A61K9/0014 , A61K9/08 , A61K9/1075 , A61K31/192 , A61K31/355 , A61K31/375 , A61K31/455 , A61K31/702 , A61K47/10 , A61K47/14 , A61K47/18 , A61K47/22 , A61Q19/00 , A61Q19/008 , A61Q19/08

30. 发明公开

EP3081232A4 HYALURONIC ACID GEL COMPOSITION HAVING SUSTAINED RELEASE PROPERTY 审中-公开
标题翻译： HYALURONSÄUREGELZUSAMMENSETZUNGMITVERZÖGERTERFREISETZUNG
公开(公告)号：EP3081232A4
公开(公告)日：2017-06-14
申请号：EP14869008
申请日：2014-12-05
申请人： NEW MEDIC CO LTD
发明人： WOO HEE DONG , HUR JUNG MU
IPC分类号： A61K47/38 , A61K9/06 , A61K47/30 , A61K47/40
CPC分类号： A61K31/728 , A61K8/042 , A61K8/365 , A61K8/42 , A61K8/63 , A61K8/735 , A61K9/0014 , A61K9/06 , A61K31/167 , A61K47/36 , A61K47/554 , A61K47/6903 , A61K2800/91 , A61Q19/00 , A61Q19/08

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