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21. 发明授权

EP0155103B1 Cephalosporin derivatives 有权
公开(公告)号：EP0155103B1
公开(公告)日：1989-10-25
申请号：EP85301203.7
申请日：1985-02-22
申请人： KUREHA KAGAKU KOGYO KABUSHIKI KAISHA
发明人： Muto, Shigeaki , Yoshikumi, Chikao , Furusho, Takao , Motokawa, Isamu , Onishi, Yoko , Kanno, Akihiko , Fujii, Takayoshi , Ando, Takao
IPC分类号： C07D501/36 , A61K31/545
CPC分类号： C07D501/36

22. 发明授权

EP0113243B1 Cephalosporin derivatives 有权
标题翻译： CEPHALOSPORIN衍生物
公开(公告)号：EP0113243B1
公开(公告)日：1989-03-22
申请号：EP83307930.4
申请日：1983-12-23
申请人： KUREHA KAGAKU KOGYO KABUSHIKI KAISHA
发明人： Muto, Shigeaki , Ando, Takao , Fujii, Takayoshi , Kanno, Akihiko , Onishi, Yoko , Motokawa, Isamu , Furusho, Takao , Yoshikumi, Chikao
IPC分类号： C07D501/36 , A61K31/545
CPC分类号： C07D501/36

23. 发明授权

EP0113245B1 Cephalosporin derivatives 有权
公开(公告)号：EP0113245B1
公开(公告)日：1989-03-15
申请号：EP83307940.3
申请日：1983-12-23
申请人： KUREHA KAGAKU KOGYO KABUSHIKI KAISHA
发明人： Muto, Shigeaki , Niimura, Kouichi , Ando, Takao , Fujii, Masahiko , Fujii, Takayoshi , Kanno,Akihiko , Furusho, Takao , Yoshikumi, Chikao
IPC分类号： C07D501/20 , A61K31/545
CPC分类号： C07D501/20

24. 发明公开

EP0155103A2 Cephalosporin derivatives 有权
标题翻译： Cephalosporinverbindungen。
公开(公告)号：EP0155103A2
公开(公告)日：1985-09-18
申请号：EP85301203.7
申请日：1985-02-22
申请人： KUREHA KAGAKU KOGYO KABUSHIKI KAISHA
发明人： Muto, Shigeaki , Yoshikumi, Chikao , Furusho, Takao , Motokawa, Isamu , Onishi, Yoko , Kanno, Akihiko , Fujii, Takayoshi , Ando, Takao
IPC分类号： C07D501/36 , A61K31/545
CPC分类号： C07D501/36
摘要： Cephalosporin derivatives represented by formula (I):
wherein R 1 represents a halogenoalkyl group of 1 to 4 carbon atoms, and salts and esters thereof are antibacterial agents.
摘要翻译：由式（I）表示的头孢菌素衍生物：... 其中R 1表示1至4个碳原子的卤代烷基，其盐和酯是抗菌剂。

25. 发明公开

EP0113242A2 Cephalosporin derivatives 有权
标题翻译： Cephalosporinderivate。
公开(公告)号：EP0113242A2
公开(公告)日：1984-07-11
申请号：EP83307929.6
申请日：1983-12-23
申请人： KUREHA KAGAKU KOGYO KABUSHIKI KAISHA
发明人： Muto, Shigeaki , Niimura, Kouichi , Ando, Takao , Fujii, Masahiko , Fujii, Takayoshi , Kanno, Akihiko , Furusho, Takao , Yoshikumi, Chikao
IPC分类号： C07D501/57 , A61K31/545
CPC分类号： C07D501/57
摘要： Derivatives of a substituted cephalosporanic acid, represented by the formula (I):
wherein p is 0, 1 or 2 and R' represents a hydrogen atom, a hydroxyl group, a carbamoyl group, an alkyl group having 1 to 4 carbon atoms or-(CONH) m (CH 2 ) n -COOH wherein m is 0 or 1; n is 0, 1 or 2 and the carboxyl group amy have been converted to a salt or ester thereof, are useful as antibiotics.
摘要翻译：由式（I）表示的取代头孢烷酸的衍生物：... 其中p为0,1或2，R 1表示氢原子，羟基，氨基甲酰基，具有 1至4个碳原子或 - （CONH）m（CH 2）n -COOH，其中m为0或1; n为0,1或2，羧基酰胺已转化为其盐或酯，可用作抗生素。

26. 发明公开

EP0058093A1 Glycoprotein having anti-tumour and lectin-like activity 有权
标题翻译： Glykoprotein mit Antitumor-AktivitätundlektinähnlicherAktivität。
公开(公告)号：EP0058093A1
公开(公告)日：1982-08-18
申请号：EP82300661.4
申请日：1982-02-10
申请人： KUREHA KAGAKU KOGYO KABUSHIKI KAISHA
发明人： Yoshikumi, Chikao , Fujii, Takayoshi , Furusho, Takao , Matsunaga, Kenichi , Ohara, Minoru , Kobayashi, Akira
IPC分类号： C12P21/00 , A61K37/02
CPC分类号： C07K14/375 , A61K38/00
摘要： A glycoprotein suitable for use in treating tumours has a molecular weight of 5,000 to 300,000 as determined by the ultracentrifugation method; the ratio of the weight of its protein moiety, determined by Lowry-Folin's method, to the weight of its saccharide moiety, determined by the phenol - sulfuric acid method, being from 50:50 to 80:20; the amino acid at its N-end being tyrosine, leucine or alanine; the amino acid sequence at its C-end being leucine-phenylalanine-valine; its elementary composition being 35.2 to 49.3% of C, 4.8 to 8.0% of H, 4.3 to 12.3% of N, a trace amount to 2.5% of S, a trace amount to 1.2% of P and the balance being 0; its isoelectric point being from pH 2.5to 5.0; and having a nucleic acid component. The glycoprotein can be obtained from basidiomycetous fungus of genus Coriolus and can be formulated into a pharmaceutical composition with convention carriers or diluents.
摘要翻译：适用于治疗肿瘤的糖蛋白通过超速离心法测定的分子量为5,000〜300,000; 通过Lowry-Folin法测定的蛋白质部分的重量比与通过苯酚 - 硫酸法测定的其糖部分的重量比为50:50至80:20; 其N末端的氨基酸为酪氨酸，亮氨酸或丙氨酸; 其C-末端的氨基酸序列为亮氨基苯丙氨酸 - 缬氨酸; 其元素组成为C的35.2〜49.3％，H为4.8〜8.0％，N为4.3〜12.3％，痕量为S的2.5％，P为1.2％，余量为0; 其等电点为2.5〜5.0; 并具有核酸成分。糖蛋白可以从Coriolus属的肠系膜真菌中获得，并且可以配制成具有常规载体或稀释剂的药物组合物。

27. 发明公开

EP0041792A1 Platinum compounds having antitumor or antimicrobial activity, and pharmaceutical preparations containing them 有权
标题翻译：铂化合物具有抗肿瘤或Antimikrobial活性和含有它们的药物组合物。
公开(公告)号：EP0041792A1
公开(公告)日：1981-12-16
申请号：EP81302288.6
申请日：1981-05-22
申请人： KUREHA KAGAKU KOGYO KABUSHIKI KAISHA
发明人： Yoshikumi, Chikao , Fujii, Takayoshi , Saito, Kenichi , Fujii, Masahiko , Niimura, Koichi
IPC分类号： C07C101/26 , A61K33/24
CPC分类号： C07F15/0093
摘要： The present invention relates to a platinum compound having the formula
wherein R represents hydrogen atom, an alkali metal atom or a lower alkyl group. The platinum compound is effective as an antitumor and antimicrobial drug.

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