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11. 发明公开

EP3084473A1 DOSIMETERS INCLUDING LENSLESS IMAGING SYSTEMS 有权
标题翻译：有很多镜头成像系统剂量计
公开(公告)号：EP3084473A1
公开(公告)日：2016-10-26
申请号：EP14870804.3
申请日：2014-12-16
申请人： Alentic Microscience Inc.
发明人： FINE, Alan Marc
IPC分类号： G01T1/02 , G02B21/00 , G06M11/00
CPC分类号： G02B21/0008 , C12M41/36 , G01B9/02041 , G01N15/1429 , G01N15/1434 , G01N15/1463 , G01N15/1475 , G01N33/80 , G01N2011/008 , G01N2015/0069 , G01N2015/1006 , G01N2015/1486 , G01N2015/149 , G01T1/02 , G02B21/00 , G02B21/0004 , G02B21/361 , G02B21/365 , G03H2001/005 , G03H2001/045 , G06K9/00127 , G06K9/00147 , G06T7/0012 , G06T2207/10056 , G06T2207/30242 , Y10S435/808
摘要： Among other things, a method comprises imaging a sample displaced between a sensor surface and a surface of a microscopy sample chamber to produce an image of at least a part of the sample. The image is produced using lensless optical microscopy, and the sample contains at least blood from a subject. The method also comprises automatically differentiating cells of different types in the image, generating a count of one or more cell types based on the automatic differentiation, and deriving a radiation dose the subject has absorbed based on the count.

12. 发明公开

EP3066526A1 SYSTEM AND METHOD FOR PHASE RETRIEVAL IN LENSLESS IMAGING 审中-公开
标题翻译：艾琳·林森森ABBILDUNG相位检测系统
公开(公告)号：EP3066526A1
公开(公告)日：2016-09-14
申请号：EP14811989.4
申请日：2014-11-04
申请人： Yeda Research and Development Co., Ltd.
发明人： DUDOVICH, Nirit , RAZ, Oren , NADLER, Boaz , ORON, Dan
IPC分类号： G03H1/08 , G01N23/20 , G01J9/02 , G03H1/12 , G03H1/04
CPC分类号： G01N23/2055 , G01N23/20 , G02B21/0056 , G02B21/367 , G03H1/0443 , G03H1/0866 , G03H1/12 , G03H5/00 , G03H2001/0447 , G03H2001/045 , G03H2001/0454 , G03H2222/42 , G06T7/30
摘要： A method and system for use in reconstruction and retrieval of phase information associated with a two-dimensional diffractive response are presented. The method comprising: providing (75) input data indicative of one or more diffractive patterns corresponding to diffractive responses from one or more objects (50). Dividing (130) said input data into a plurality of one-dimensional slices and determining (140) one-dimensional phase data for at least some of said one-dimensional slices. Tailoring (150) the reconstructed phase data of said one-dimensional slices to form a two-dimensional phase solution. The two-dimensional phase solution is defined by phase shifts of said reconstructed one-dimensional phase data of said one-dimensional slices. The two-dimensional phase solution thus enables obtaining two-dimensional reconstructed phase data suitable for reconstruction of image data (250).
摘要翻译：提出了一种用于重建和检索与二维衍射响应相关的相位信息的方法和系统。该方法包括：提供（75）指示与来自一个或多个对象（50）的衍射响应相对应的一个或多个衍射图案的输入数据。将所述输入数据划分成多个一维切片并且确定（140）所述一维切片中的至少一些的一维相位数据。裁剪（150）所述一维切片的重建相位数据以形成二维相位解。所述二维相位解是由所述一维切片的所述重建的一维相位数据的相移定义的。因此，二维相位解决方案能够获得适于重建图像数据的二维重建相位数据（250）。

13. 发明授权

EP1676121B1 METHOD FOR HOLOGRAPHIC REFRACTOMETRY 有权
标题翻译：方法用于全息折射
公开(公告)号：EP1676121B1
公开(公告)日：2011-01-05
申请号：EP04775524.4
申请日：2004-10-07
申请人： Phase Holographic Imaging PHI AB
发明人： GUSTAFSSON, Mats , SEBESTA, Mikael , EGELBERG, Peter , LENART, Thomas , PETTERSSON, Sven-Göran , BENGTSSON, Bengt
IPC分类号： G01N21/41 , G01M11/02 , G03H1/00
CPC分类号： G03H1/0005 , G03H2001/0033 , G03H2001/0038 , G03H2001/045 , G03H2210/12
摘要： A method and device for determining refractive index of an object compared to a refractive index of a surrounding medium. The object is exposed to a laser object beam and the scattered light interferes with a laser reference beam to obtain a hologram. The hologram is analyzed for phase information, and based thereon, it is determined if the refractive index of the object is higher or lower than the refractive index of the surrounding medium.

14. 发明公开

EP3186616A4 COHERENT DIFFRACTIVE IMAGING WITH ARBITRARY ANGLE OF INCIDENCE 有权
公开(公告)号：EP3186616A4
公开(公告)日：2018-02-28
申请号：EP15836361
申请日：2015-08-28
申请人： UNIV COLORADO REGENTS
发明人： ZHANG BOSHENG , SEABERG MATTHEW D , ADAMS DANIEL E , KAPTEYN HENRY C , MURNANE MARGARET M
IPC分类号： G01N21/25 , G01N23/20 , G02B21/00 , G02B27/02 , G06T5/00 , G06T5/50 , G06T7/00
CPC分类号： G03H1/0443 , G01N21/4788 , G01N23/20 , G01N23/2055 , G01N2021/95676 , G01N2223/33 , G01N2223/345 , G01N2223/611 , G01N2223/6116 , G01T1/00 , G02B21/0016 , G02B27/4205 , G03F1/84 , G03F7/70625 , G03H1/0465 , G03H1/16 , G03H2001/005 , G03H2001/0445 , G03H2001/045 , G03H2001/0456 , G21K7/00 , G21K2207/005
摘要： Apparatus and methods for coherent diffractive imaging with arbitrary angle of illumination incidence utilize a method of fast remapping of a detected diffraction intensity pattern from a detector pixel array (initial grid) to a uniform spatial frequency grid (final grid) chosen to allow for FFT on the remapped pattern. This is accomplished by remapping the initial grid to an intermediate grid chosen to result in a final grid that is linear in spatial frequency. The initial grid is remapped (generally by interpolation) to the intermediate grid that is calculated to correspond to the final grid. In general, the initial grid (x,y) is uniform in space, the intermediate grid ({tilde over (x)},{tilde over (y)}) is non-uniform in spatial frequency, and the final grid ({tilde over (f)}x,{tilde over (f)}y) is uniform in spatial frequency.

15. 发明公开

EP3268816A1 DISPLAY SYSTEM 有权转让
公开(公告)号：EP3268816A1
公开(公告)日：2018-01-17
申请号：EP17709776.3
申请日：2017-03-03
申请人： Daqri Holographics Limited
发明人： CHRISTMAS, Jamieson
IPC分类号： G03H1/04 , G03H1/02 , G03H1/22
CPC分类号： G03H1/30 , G02B27/0103 , G02B2027/0112 , G03H1/02 , G03H1/0443 , G03H1/2205 , G03H1/2294 , G03H2001/0224 , G03H2001/045 , G03H2001/2218 , G03H2001/2271 , G03H2001/303 , G03H2222/13 , G03H2225/52 , G03H2225/61 , H04N9/3105
摘要： A display system comprising a first plurality of pixels, a second plurality of pixels, a first Fourier transform lens and a second Fourier transform lens. The first plurality of pixels is arranged to display first holographic data corresponding to a first holographic reconstruction and receive light of a first wavelength. The a second plurality of pixels is arranged to display second holographic data corresponding to a second holographic reconstruction and receive light of a second wavelength. The first Fourier transform lens is arranged to receive spatially modulated light having a first wavelength from the first plurality of pixels and perform an optical Fourier transform of the received light to form the first holographic reconstruction at a replay plane, wherein the first holographic reconstruction is formed of light at the first wavelength. The second Fourier transform lens is arranged to receive spatially modulated light having a second wavelength from the second plurality of pixels and perform an optical Fourier transform of the received light to form the second holographic reconstruction at the replay plane, wherein the second holographic reconstruction is formed of light at the second wavelength. The optical path length from the first Fourier transform lens to the replay plane is not equal to the optical path length from the second Fourier transform lens to the replay plane.

16. 发明公开

EP2565702A4 OBSERVATION DEVICE 有权
公开(公告)号：EP2565702A4
公开(公告)日：2017-12-13
申请号：EP11775162
申请日：2011-05-02
申请人： HAMAMATSU PHOTONICS KK
发明人： IWAI HIDENAO , FUJIMOTO MASATOSHI
IPC分类号： G02B27/52 , G01J9/02 , G01N21/45 , G03H1/04 , G03H1/08
CPC分类号： G01B9/02045 , G01N21/41 , G02B21/14 , G02B27/52 , G03H1/0443 , G03H1/0866 , G03H2001/0447 , G03H2001/045 , G03H2001/0463 , G03H2210/62
摘要： Provided is an observation device which can obtain a phase image of a moving object rapidly with high sensitivity even when using a photodetector having a slow read-out speed per pixel. The observation device 1 comprises a light source 10, a first modulator 20, a second modulator 30, a lens 40, a beam splitter 41, a photodetector 46, and an arithmetic unit 50. The lens 40 receives scattered light generated by a moving object 2 and forms a Fourier transform image of the object 2. The photodetector 46 outputs data representing a sum in a v direction of data temporally changing at a frequency corresponding to a Doppler shift frequency of the light having reached each position on a light-receiving surface through the lens 40 at each position in a u direction at each time. The arithmetic unit 50 obtains an image of the object 2 according to the output of the photodetector 46.

17. 发明公开

EP3084473A4 DOSIMETERS INCLUDING LENSLESS IMAGING SYSTEMS 有权
标题翻译： DOSIMETER MIT LINSENLOSEN ABBILDUNGSSYSTEMEN
公开(公告)号：EP3084473A4
公开(公告)日：2017-08-23
申请号：EP14870804
申请日：2014-12-16
申请人： ALENTIC MICROSCIENCE INC
发明人： FINE ALAN MARC
IPC分类号： G01T1/02 , G02B21/00 , G06M11/00
CPC分类号： G02B21/0008 , C12M41/36 , G01B9/02041 , G01N15/1429 , G01N15/1434 , G01N15/1463 , G01N15/1475 , G01N33/80 , G01N2011/008 , G01N2015/0069 , G01N2015/1006 , G01N2015/1486 , G01N2015/149 , G01T1/02 , G02B21/00 , G02B21/0004 , G02B21/361 , G02B21/365 , G03H2001/005 , G03H2001/045 , G06K9/00127 , G06K9/00147 , G06T7/0012 , G06T2207/10056 , G06T2207/30242 , Y10S435/808
摘要： Among other things, a method comprises imaging a sample displaced between a sensor surface and a surface of a microscopy sample chamber to produce an image of at least a part of the sample. The image is produced using lensless optical microscopy, and the sample contains at least blood from a subject. The method also comprises automatically differentiating cells of different types in the image, generating a count of one or more cell types based on the automatic differentiation, and deriving a radiation dose the subject has absorbed based on the count.
摘要翻译：尤其是，一种方法包括对位于传感器表面和显微镜样品室表面之间的样品进行成像以产生至少一部分样品的图像。使用无透镜光学显微镜产生图像，并且样品至少包含来自受试者的血液。该方法还包括自动区分图像中不同类型的细胞，基于自动区分生成一种或多种细胞类型的计数，并基于该计数导出受试者吸收的辐射剂量。

18. 发明公开

EP3065001A1 HOLOGRAPHIC MICROSCOPE AND DATA PROCESSING METHOD FOR HIGH-RESOLUTION HOLOGRAM IMAGE 失效
标题翻译： HOLOGRAFISCHES MIKROSKOP UND DATENVERARBEITUNGSVERFAHRENFÜRHOCHAUFLÖSENDESHOLOGRAMMBILD
公开(公告)号：EP3065001A1
公开(公告)日：2016-09-07
申请号：EP14857928.7
申请日：2014-10-28
申请人： University of Hyogo
发明人： SATO, Kunihiro
IPC分类号： G03H1/00 , G02B21/00
CPC分类号： G03H1/0443 , G02B21/00 , G02B21/365 , G03H2001/005 , G03H2001/0445 , G03H2001/0447 , G03H2001/045 , G03H2001/0452 , G03H2001/046 , G03H2001/0463 , G03H2001/0469 , G03H2001/0471 , G03H2222/42 , G03H2222/44 , G03H2222/52 , G03H2240/56
摘要： The present invention can realize both a transmission type and a reflection type, and provides a holographic microscope which can exceed the resolution of the conventional optical microscope, a hologram data acquisition method for a high-resolution image, and a high-resolution hologram image reconstruction method. In-line spherical wave reference light (L) is recorded in a hologram (I LR ) using spherical wave reference light (R), and an object light (O j ) and an illumination light (Q j ) are recorded in a hologram (I j OQR ) using a spherical wave reference light (R) by illuminating the object with an illumination light (Q j , j=1, .., N) which is changed its incident direction. From those holograms, a hologram (J j OQL ), from which the component of the reference light (R) is removed, is generated, and from the hologram, a light wave (h j ) is generated. A light wave (c j ) of the illumination light (Q j ) is separated from the light wave (h j ), and using its phase component (ξ j =c j /|c j |), a phase adjustment reconstruction light wave is derived and added up as (H P =∑h j /ξ j ), and an object image (S P =|H P | 2 ) is reconstructed.
摘要翻译：本发明可以实现透射型和反射型，并且提供可以超过常规光学显微镜的分辨率的全息显微镜，用于高分辨率图像的全息图数据获取方法和高分辨率全息图像重构方法。使用球面波参考光（R）将线内球面参考光（L）记录在全息图（I LR）中，并且将目标光（O j）和照明光（Q j）记录在全息图 I j OQR），其通过用改变其入射方向的照明光（Q j，j = 1，...，N）照射物体来使用球面波参考光（R）。从这些全息图中，生成参考光（R）的分量被去除的全息图（J j OQL），并且从全息图产生光波（h j）。照明光（Q j）的光波（cj）与光波（hj）分离，并且使用其相位分量（¾j = cj / | cj |），导出并添加相位调整重建光波（HP ='hj /¾j），并且重建对象图像（SP = | HP | 2）。

19. 发明公开

EP2915009A1 SYSTÈME D'IMAGERIE HOLOGRAPHIQUE AUTO-RÉFÉRENCE 有权
标题翻译：具有自动覆盖全息图象系统
公开(公告)号：EP2915009A1
公开(公告)日：2015-09-09
申请号：EP13783557.5
申请日：2013-10-28
申请人： Centre National de la Recherche Scientifique , Université du Maine
发明人： PICART, Pascal , MALEK, Mokrane
IPC分类号： G03H1/04 , G03H1/00 , G03H1/28 , G03H1/26
CPC分类号： G03H1/0443 , G03H1/0011 , G03H1/265 , G03H1/28 , G03H2001/005 , G03H2001/0447 , G03H2001/045 , G03H2001/0458 , G03H2001/266 , G03H2225/12 , G03H2225/32 , G03H2227/03
摘要： The invention relates to a system for recording a digital hologram of an object (10) which comprises: - a coherent source (1) intended to illuminate the object and thus to produce a wave diffracted by the object, - a digital sensor (12) intended to record the digital hologram of the object, it furthermore comprises a phase spatial modulation assembly (9, 15, 16, 17, 18) able to produce in the plane of the sensor several replicas of the wave diffracted by the object, which are shifted mutually but overlap partially, these replicas forming on the sensor (12) a so-called auto-referenced digital hologram (12') of the object.

20. 发明公开

EP1852890A1 ELECTRON MICROSCOPE AND COMPOSITE IRRADIATION LENS 审中-公开
标题翻译： ELEKTRONENMIKROSKOP UND ZUSAMMUSTRETZTE BESTRAHLUNGSLINSE
公开(公告)号：EP1852890A1
公开(公告)日：2007-11-07
申请号：EP06714025.1
申请日：2006-02-17
申请人： National University Corporation Kyoto Institute of Technology
发明人： ENDOH, Hisamitsu c/oNational University Corporation Kyoto , ACHIHARA, Masato c/o National University Corporation Kyoto , TSUNO, Katsushige , OIKAWA, Tetsuo
IPC分类号： H01J37/295 , H01J37/141
CPC分类号： H01J37/26 , G03H1/0866 , G03H5/00 , G03H2001/045 , H01J37/141 , H01J37/295 , H01J2237/1415 , H01J2237/1514 , H01J2237/153 , H01J2237/228 , H01J2237/2614
摘要： An object of the present invention is to provide an electron microscope that employs a hologram of a diffraction pattern to reconstruct a microscopic image involving no imaging aberration due to image forming lenses, as well as a combined illumination lens used for such an electron microscope. The electron microscope according to the present invention has an electron source (11), a condenser lens (12), a biprism (13) to split an electron beam supplied from the condenser lens (12) into coherent first and second electron beams (L1, L2) that are parallel to each other, a combined illumination lens (15) to make the first electron beam (L1) into a parallel wave and the second electron beam (L2) into a converging wave that converges at a predetermined distance, a sample stage (16) to hold a sample illuminated with the first electron beam (L1), a detector (17) to detect a hologram of a diffraction pattern formed by interference of the first electron beam (L1) with the second electron beam (L2), a computing unit (18) to conduct a predetermined Fourier transform on the hologram supplied from the detector (17) and reconstruct a microscopic image of the sample, and a display (19) to display the reconstructed microscopic image.
摘要翻译：本发明的目的在于提供一种电子显微镜，其使用衍射图案的全息图来重构由于图像形成透镜而不涉及像差的微观图像，以及用于这种电子显微镜的组合式照明透镜。根据本发明的电子显微镜具有电子源（11），聚光透镜（12），将从聚光透镜（12）提供的电子束分成相干的第一和第二电子束（L1）的双棱镜（13），L2），使第一电子束（L1）成并联波的组合照明透镜（15）和第二电子束（L2）成为以规定距离收敛的会聚波，用于保持用第一电子束（L1）照射的样本的检测器（16），检测器（17），用于检测由第一电子束（L1）与第二电子束（L2）的干涉形成的衍射图案的全息图），计算单元（18），用于对从检测器（17）提供的全息图进行预定的傅立叶变换，并重建样本的显微镜图像，以及显示重建的显微图像（19）。

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