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11. 发明公开

EP3011062A4 PHAGE-BASED BACTERIAL DETECTION ASSAY 审中-公开
标题翻译： BAKTERIENDETEKTIONSTEST AUF BASIS VON PHAGEN
公开(公告)号：EP3011062A4
公开(公告)日：2017-06-14
申请号：EP14813675
申请日：2014-06-19
申请人： SAMPLE6 TECH INC
发明人： KOERIS MICHAEL SANDOR , THOMASON JULIE , CAPPILLINO MICHAEL , SHIVERS ROBERT PATRICK , BROWNELL DANIEL ROBERT , BOWERS JAYSON L , LU TIMOTHY KUAN TA , KRZYMANSKA-OLEJNIK EDYTA
IPC分类号： C12Q1/70
CPC分类号： C12Q1/66 , C12N7/00 , C12Q1/10 , G01N33/82 , G01N2333/245 , G01N2333/255
摘要： Methods of detecting target bacteria are provided. In some embodiments the methods comprise exposing the sample to a phage capable of infecting a set of target bacteria and comprising a heterologous nucleic acid sequence encoding a marker. In some embodiments the target bacteria comprise Listeria. In some embodiments the target bacteria are all Listeria. Recombinant Listeria phage comprising a heterologous nucleic acid sequence encoding a marker are also provided as are useful combinations of such phage and articles of manufacture comprising such phage, among other things.
摘要翻译：提供了检测靶细菌的方法。在一些实施方案中，所述方法包括将样品暴露于能够感染一组靶细菌并且包含编码标记的异源核酸序列的噬菌体。在一些实施方案中，靶细菌包含李斯特菌。在一些实施方案中，目标细菌全部是李斯特氏菌。还提供了包含编码标记物的异源核酸序列的重组利斯特氏菌噬菌体，以及此类噬菌体和包含此类噬菌体的制品等的有用组合。

12. 发明公开

EP3094623A4 6,7-TRANS CEPHALOSPORIN-BASED PROBES FOR DETECTING BACTERIA EXPRESSING A METALLO- -LACTAMASE 审中-公开
标题翻译： 6,7-TRANS-CEPHALOSPORIN-BASIERTE SONDEN ZUR DETEKON VON BAKTERIEN ZUR Expression EINER METALLO-BETA-LACTAMASE
公开(公告)号：EP3094623A4
公开(公告)日：2017-05-31
申请号：EP15737920
申请日：2015-01-15
申请人： UNIV LELAND STANFORD JUNIOR
发明人： RAO JIANGHONG , SHI HAIBIN
IPC分类号： C07D501/14 , A61K31/545
CPC分类号： C07D501/00 , C12Q1/34 , C12Q1/66 , G01N2333/986

13. 发明公开

EP3146066A1 COMPOSITIONS AND METHODS FOR STABILIZING LUMINOGENIC SUBSTRATES 有权
标题翻译： ZUSAMMENSETZUNGEN UND VERFAHREN ZUR STABILISIERUNG VON LUMINOGENEN SUBSTRATEN
公开(公告)号：EP3146066A1
公开(公告)日：2017-03-29
申请号：EP15730321.5
申请日：2015-05-26
申请人： Promega Corporation
发明人： KIRKLAND, Thomas , WOOD, Keith, V. , HALL, Mary , SCHWINN, Marie
IPC分类号： C12Q1/66 , C07D253/06
CPC分类号： C09K11/06 , A61K31/4985 , A61K31/53 , C07D253/075 , C07D487/04 , C09K2211/1007 , C09K2211/1044 , C12Q1/66
摘要： Disclosed herein are compositions and methods for stabilizing a luminogenic substrate such as coelenterazine or a functional analog thereof. The functional analog may be furimazine. The composition may include the luminogenic substrate, a thionucleoside, and an organic solvent, in which the thionucleoside is present in an amount effective to stabilize the luminogenic composition against decomposition. The method provided herein stabilizes the luminogenic substrate against decomposition by contacting the luminogenic substrate with an effective amount of the thionucleoside in the presence of the organic solvent. Also provided herein is a kit containing the composition.
摘要翻译：本文公开了用于稳定发光底物如脑里脑炎或其功能类似物的组合物和方法。功能类似物可以是呋嘧嗪。组合物可以包括发光底物，硫核苷和有机溶剂，其中硫代核苷以有效稳定发光组合物以防分解的量存在。本文提供的方法通过在有机溶剂存在下使发光底物与有效量的硫代核苷接触来稳定发光底物以防分解。本文还提供了含有该组合物的试剂盒。

14. 发明授权

EP2652142B1 Chemiluminescence-based haemostasis assay 有权转让
标题翻译：化学药物
公开(公告)号：EP2652142B1
公开(公告)日：2017-03-01
申请号：EP11805664.7
申请日：2011-12-14
申请人： Stichting Katholieke Universiteit , Chiralix B.V.
发明人： VAN HEERDE, Waander Laurens , BLAAUW, Richard Hendrik
IPC分类号： C12Q1/56 , C12Q1/66
CPC分类号： C12Q1/37 , C12Q1/56 , C12Q1/66 , G01N2333/745
摘要： The present invention relates to a method for in vitro determining generation of a haemostasis factor such as thrombin and/or plasmin in a test sample using a chemiluminescent substrate specific for said blood clotting factor. Upon cleavage of the substrate, a luminescent signal is generated with the aid of a luciferase. The invention also relates to a kit for in vitro determining generation of a haemostasis factor in a test sample, and to novel chemiluminescent substrates for the determination of thrombin and plasmin.
摘要翻译：本发明涉及使用特异于所述血液凝固因子的化学发光底物体外测定测试样品中凝血酶和/或纤溶酶的血凝素生成因子的方法。在底物裂解后，借助于荧光素酶，通过氨基磺布素生成发光信号。本发明还涉及用于体外测定测试样品中止血因子的产生的试剂盒以及用于测定凝血酶和纤溶酶的新型化学发光底物。

15. 发明授权

EP2870257B1 APPARATUS AND METHODS FOR DETECTING ATP IN A LIQUID SAMPLE 有权
标题翻译： VORRICHTUNG UND VERFAHREN ZUM NACHWEIS VON ATP IN EINERFLÜSSIGENPROBE
公开(公告)号：EP2870257B1
公开(公告)日：2017-02-22
申请号：EP13710925.2
申请日：2013-02-25
申请人： 3M Innovative Properties Company
发明人： DRISCOLL, Mark B. , EVANS, Rachel E. , RAMSAY, Catherine M. , PERCY, Neil
IPC分类号： C12Q1/00 , C12Q1/66
CPC分类号： C12Q1/008 , C12Q1/66

16. 发明公开

EP3121263A1 MICROBE MEASUREMENT SYSTEM AND MICROBE MEASUREMENT METHOD 审中-公开
标题翻译： MIKROBENMESSSYSTEM在MIKROBENMESSVERFAHREN
公开(公告)号：EP3121263A1
公开(公告)日：2017-01-25
申请号：EP15764190.3
申请日：2015-03-13
申请人： Hitachi Plant Services Co., Ltd.
发明人： MIYASHITA Noe , TANAKA Makoto
IPC分类号： C12M1/34 , C12Q1/06 , G01N21/76 , G01N21/77 , G01N33/50
CPC分类号： C12Q1/04 , C12Q1/008 , C12Q1/06 , C12Q1/66
摘要： The present invention makes a microorganism measuring system set control reference values with higher accuracy than ever. Based on results of repeated CFU countings and results of repeated ATP measurements, a microorganism measuring system (1) of the present invention obtains a probability density function of ATP measured values in a normal condition; determines an alert reference value at which a desired probability of false positives is equal to or less than a probability, and an action reference value at which a desired probability of false negatives is equal to or less than a probability; and thereby controls the ATP measured values. For this reason, the microorganism measuring system (1) can set the control reference values with higher accuracy than ever, without being influenced by an error in the conversion of ATP contents into CFU counts. Accordingly, the microorganism measuring system (1) can achieve the microbiological control with desired control accuracy.
摘要翻译：本发明使得微生物测量系统以比以往更高的精度设定控制参考值。基于重复CFU计数的结果和重复ATP测量的结果，本发明的微生物测量系统（1）在正常条件下获得ATP测量值的概率密度函数; 确定误报的期望概率等于或小于概率的警报参考值，以及假阴性的期望概率等于或小于概率的动作参考值; 从而控制ATP测量值。因此，微生物测量系统（1）可以以比以往更高的精度设置控制参考值，而不受ATP内容转换为CFU计数的误差的影响。因此，微生物测量系统（1）可以以期望的控制精度实现微生物控制。

17. 发明授权

EP2918273B1 METHODS AND CELLS FOR IDENTIFYING RIG-I PATHWAY REGULATORS 有权
标题翻译：方法和细胞用于识别RIG-I-PATH调节器
公开(公告)号：EP2918273B1
公开(公告)日：2016-12-21
申请号：EP15158732.6
申请日：2012-02-23
申请人： Kineta, Inc.
发明人： Iadonato, Shawn , Bedard, Kristin
IPC分类号： A61K31/5415 , A61K31/538 , A61K48/00 , A61P31/16 , A61P31/12 , A61K31/353 , C12Q1/18 , C12N7/00 , C12Q1/66
CPC分类号： C12Q1/66 , A61K31/353 , A61K31/5415 , C12N7/00 , C12N2760/16111 , C12N2770/24111 , C12N2770/24211 , C12Q1/18 , Y02A50/463
摘要： Disclosed herein are methods for identifying compounds for the treatment of viral infection, including RNA viral infection and uses of the compounds as pharmaceutical compositions. The identified compounds modulate the RIG-I pathway in vertebrate cells.

18. 发明公开

EP2997355A4 DEGRADABLE CATIONIC SURFACTANTS AND USE THEREOF IN ENHANCING CHEMILUMINESCENCE 有权
标题翻译：可生物降解的阳离子表面活性剂及其用途加强化学发光
公开(公告)号：EP2997355A4
公开(公告)日：2016-12-14
申请号：EP14798016
申请日：2014-05-13
申请人： SIEMENS HEALTHCARE DIAGNOSTICS INC
发明人： NATRAJAN ANAND , WEN DAVID
IPC分类号： G01N21/76
CPC分类号： G01N21/76 , C12Q1/66 , G01N33/582
摘要： The present invention relates to methods of enhancing chemiluminescence from a chemiluminescent label comprising contacting a chemiluminescent label with an acid in the presence of a degradable cationic surfactant and hydrogen peroxide followed by the addition of a base. Related kits containing such degradable cationic surfactant are also provided. The degradable cationic surfactant can compress light emission time of the chemiluminescent label to an extent that is comparable to or shorter than conventional surfactants. The degradable cationic surfactant can also increase chemiluminescence of the chemiluminescent label, providing increased light emission output that is comparable to conventional surfactants.

19. 发明公开

EP3094623A1 6,7-TRANS CEPHALOSPORIN-BASED PROBES FOR DETECTING BACTERIA EXPRESSING A METALLO- -LACTAMASE 审中-公开
标题翻译： 6,7-反式 - 头孢菌素-BASED传感器，用于细菌的用于表达的金属-β-内酰胺酶检测
公开(公告)号：EP3094623A1
公开(公告)日：2016-11-23
申请号：EP15737920.7
申请日：2015-01-15
申请人： The Board of Trustees of the Leland Stanford Junior University
发明人： RAO, Jianghong , SHI, Haibin
IPC分类号： C07D221/00 , C07D501/14 , C07D498/00
CPC分类号： C07D501/00 , C12Q1/34 , C12Q1/66 , G01N2333/986
摘要： The present invention discloses a probe useful for the selective detection of metallo-beta-lactamases, in particular carbapenemases, thereby distinguishing those species of bacteria that are carbapenem-resistant from bacterial strains that are sensitive. Cephalospori based probes that have the 6,7 R,R configuration are susceptible to cleavage by beta-lactamases but cannot distinguish between cleavage by metallo-beta-lactamases and other beta-lactamases. By modifying a side group of the cephalosporin, selectivity can be introduced allowing the probes to distinguish between various types of metallo-beta-lactamases,

20. 发明授权

EP2388254B1 Bioluminescent protease assay 有权
标题翻译： Biolumineszentes蛋白酶测定
公开(公告)号：EP2388254B1
公开(公告)日：2016-08-10
申请号：EP10075526.3
申请日：2003-01-31
申请人： Promega Corporation
发明人： O'Brian, Martha , Wood, Keith , Klaubert, Dieter , Daily, Bill
IPC分类号： C07D277/66 , C12Q1/66 , C12Q1/37
CPC分类号： C07D277/66 , C12Q1/37 , C12Q1/66

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