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11. 发明公开

EP2414372A1 CHEMICAL SYNTHESIS OF PHOSPHATIDYLINOSITOL MANNOSIDE GLYCANS FROM MYCOBACTERIUM TUBERCULOSIS 有权
标题翻译：磷脂酰肌醇甘露糖苷的化学合成聚糖OFF结核杆菌
公开(公告)号：EP2414372A1
公开(公告)日：2012-02-08
申请号：EP09751802.1
申请日：2009-11-03
申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
发明人： SEEBERGER, Peter H. , BOONYARATTANAKALIN, Siwarutt , LEPENIES Bernd
IPC分类号： C07H11/04 , C08B37/00 , A61K31/7024 , A61P43/00
CPC分类号： C07H11/04
摘要： The efficient synthesis of phosphatidylinositol mono- to hexa-mannoside (PIM
1 to PIM
6 ) is reported. The invention relates to these phosphatidylinositol mono- to hexa-mannosides carrying a linker and a reactive functional group, e.g. the sulfhydryl group, a protein, a fluorescent probe, or a solid phase. The invention further relates to vaccines comprising the PIMs linked to a carrier protein or an antigen

12. 发明授权

EP2019147B1 NOVEL K04-0144 SUBSTANCES AND PROCESS FOR PRODUCTION THEREOF 有权
标题翻译：新K04-0144物质和方法及其生产
公开(公告)号：EP2019147B1
公开(公告)日：2011-05-04
申请号：EP06732665.2
申请日：2006-05-16
申请人： THE KITASATO INSTITUTE
发明人： TOMODA, Hiroshi , KIM, Yong-pil , HANAKI, Hideaki , MATSUMOTO, Atsuko , TAKAHASHI, Yoko , OMURA, Satoshi
IPC分类号： C12P19/26 , C07H11/04 , A61K31/7024 , A61P31/04
CPC分类号： C07H11/04 , C07C323/59 , C12P13/02 , C12P19/26 , C12P19/44 , C12R1/465
摘要： K04-0144 substances A, B and C which can be produced by culturing a microorganism exemplified by Streptomyces sp. strain K04-0144 (which is capable of producing K04-0144 substances) in a culture medium and then collecting the substances from the culture medium. The substances have a potent antibacterial activity against gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) and are therefore useful as therapeutic agents for MRSA infection and infectious diseases caused by multidrug-resistant bacteria including β-lactam antibiotic-resistant bacteria. A novel K04-0144 substance D which is also collected from the culture medium can enhance the effect of a β-lactam antibiotic (which has been used as an antibacterial agent) by using it in combination with the β-lactam antibiotic, and is therefore useful as a therapeutic agent for methicillin-resistant Staphylococcus aureus (MRSA) infection and infectious diseases caused by multidrug-resistant bacteria including β-lactam antibiotic-resistant bacteria.

13. 发明公开

EP2223931A1 Novel nucleic acid base pair 审中-公开
标题翻译：新的核酸碱基对
公开(公告)号：EP2223931A1
公开(公告)日：2010-09-01
申请号：EP10003750.6
申请日：2000-07-14
申请人： Japan Science and Technology Agency
发明人： Hirao, Ichiro , Ishikawa, Masahide , Fujihara, Tsuyoshi , Yokoyama, Shigeyuki
IPC分类号： C07H21/02 , C07H21/04 , C12N15/00 , C12N1/21 , C12N5/10 , G01N33/50 , G01N33/15 , C07H21/00 , C12N15/11
CPC分类号： C07H11/04 , C07H19/207 , C07H21/00 , C12N15/11 , C12P21/02
摘要： A codon comprising one or more artificial bases so as to form a selective base pair with the use of steric hindrance and/or electrostatic repulsion, and stacking action at the base moiety of a nucleic acid; a nucleic acid comprising the codon; process for producing nucleic acid and protein using the nucleic acid.
摘要翻译：密码子，其包含一个或多个人造碱基以便利用空间位阻和/或静电排斥形成选择性碱基对，并且在核酸的碱基部分处具有堆叠作用; 包含密码子的核酸; 使用该核酸产生核酸和蛋白质的方法。

14. 发明公开

EP2221311A1 Novel nucleic acid base pair 有权
标题翻译： NeuartigesNukleinsäurebasispaar
公开(公告)号：EP2221311A1
公开(公告)日：2010-08-25
申请号：EP10003749.8
申请日：2000-07-14
申请人： Japan Science and Technology Agency
发明人： Hirao, Ichiro , Ishikawa, Masahide , Fujihara, Tsuyoshi , Yokoyama, Shigeyuki
IPC分类号： C07H21/02 , C07H21/04 , C12N15/00 , C12N1/21 , C12N5/10 , G01N33/50 , G01N33/15 , C07H21/00 , C12N15/11
CPC分类号： C07H11/04 , C07H19/207 , C07H21/00 , C12N15/11 , C12P21/02
摘要： A method for forming a selective base pair by introducing a dialkylamino group at the base moiety of a nucleic acid so as to create steric hindrance between bases; a method for designing a nucleic acid which can form a selective base pair, which method comprises utilising steric hindrance in the nucleic acid base part of the nucleic acid; optionally wherein the steric hindrance hinders the formation of a base pair with a natural nucleic acid base part, and a nucleic acid designed by such a method.
摘要翻译：通过在核酸的碱基部分引入二烷基氨基以在碱基之间产生空间位阻来形成选择性碱基对的方法; 用于设计可以形成选择性碱基对的核酸的方法，所述方法包括在核酸的核酸碱基部分中利用空间位阻; 任选地其中空间位阻阻碍与天然核酸碱基部分形成碱基对，以及通过这种方法设计的核酸。

15. 发明公开

EP2199280A1 Novel K04-0144 substances and process for production thereof 有权
标题翻译： K04-0144新物质，以及它们的制备方法
公开(公告)号：EP2199280A1
公开(公告)日：2010-06-23
申请号：EP09016105.0
申请日：2006-05-16
申请人： The Kitasato Institute
发明人： Tomoda, Hirishi , Kim, Yong-pil , Hanaki, Hideaki , Matsumoto, Atsuko , Takahashi, Yoko , Omura, Satoshi
IPC分类号： C07C323/59 , C12P19/26 , A61K31/195 , A61P31/04
CPC分类号： C07H11/04 , C07C323/59 , C12P13/02 , C12P19/26 , C12P19/44 , C12R1/465
摘要： A K04-0144 substance, which is
- K04-144D substance of the following formula [IV]:

and a process for producing the K04-0144 substance.
摘要翻译：甲K04-0144物质，所有这一切都为 - K04-144D物质下式[IV]中：及其制造K04-0144物质的方法。

16. 发明公开

EP1870468A3 LPS with reduced toxicity from genetically modified gram negative bacteria 审中-公开
标题翻译：与来自遗传修饰的革兰氏阴性细菌降低的毒性LPS
公开(公告)号：EP1870468A3
公开(公告)日：2010-01-13
申请号：EP07112938.1
申请日：1998-11-03
申请人： DE STAAT DER NEDERLANDEN, VERTEGENWOORDIGD DOOR DE MINISTER VAN WELZIJN, VOLKSGEZONDHEID EN CULTUUR
发明人： van der Ley, Peter Andre , Hamstra, Hendrik Jan , Steeghs, Liana Juliana Josephine Margriet
IPC分类号： C12N15/54 , A61K31/715 , A61K39/095 , C07H13/02 , C12P19/26
CPC分类号： C07H13/06 , A61K31/715 , A61K31/739 , A61K39/095 , A61K39/39 , A61K2039/55572 , C07H11/04 , C12P19/26
摘要： The subject invention lies in the field of vaccines. Specifically new compounds that can be used as adjuvants are provided. Recombinant LPS having a reduced number of secondary acyl chains per molecule of LPS vis a vis the corresponding non modified LPS molecule, said secondary acyl chains being bound to primary acyl chains, said primary acyl chains being bound to the glucosamine of said recombinant LPS molecule, said recombinant LPS being homogenous in acylation pattern is an example of such a compound. Also recombinant LPS having a phosphate group attached to the glucosamine at the non-reducing end of the LPS molecule and a phosphate group attached to the glucosamine at the reducing end of the molecule per recombinant LPS molecule provides a further example.

17. 发明公开

EP1676853A4 ALPHA-1-PHOSPHORYLATED-2-DEOXY-2-FLUOROARABINOSIDE AND PROCESS FOR PRODUCING 2 -DEOXY-2 -FLUORO-BETA-D-ARABINONUCLEOSID E 审中-公开
标题翻译： ALPHA-1磷酸化的-2-脱氧-2- FLUORARABINOSID及其制造方法的2-脱氧-2-氟-β-D-ARABINONUKLEOSID
公开(公告)号：EP1676853A4
公开(公告)日：2009-12-23
申请号：EP04792854
申请日：2004-10-22
申请人： YAMASA CORP
发明人： YAMADA KOHEI , MATSUMOTO NORITAKE , HAYAKAWA HIROYUKI
IPC分类号： C07H1/02 , C07H11/04 , C12P19/40
CPC分类号： C12P19/40 , C07H1/02 , C07H11/04

18. 发明授权

EP1709056B1 PHOSPHORAMIDATE DERIVATIVES 有权
标题翻译：磷酰胺衍生物
公开(公告)号：EP1709056B1
公开(公告)日：2009-06-17
申请号：EP05701927.5
申请日：2005-01-18
申请人： University College Cardiff Consultants Limited
发明人： MCGUIGAN, Christopher , CARANGIO, Antonella , CATERSON, Bruce , HUGHES, Clare, Elizabeth , CURTIS, Clare Louise
IPC分类号： C07H11/04 , A61K31/7024 , A61P29/00
CPC分类号： C07H11/04 , Y02P20/55
摘要： The present invention provides a phosphoramidate compound comprising the structure (I) Formula (I)wherein: X comprises a monosaccharide group comprising the structure (II) or (III),8Formula (II) , (III) B and B are independently selected from the group consisting of -O-, -CH2- and a bond, preferably -O-; R is selected from the group consisting of -H, protecting groups and monovalent hydrocarbon radicals; R and R are independently selected from the group consisting of -H and monovalent hydrocarbon radicals, or R2 and R3 together form an alkylene or heteroalkylene chain so as to provide, together with the C atom to which they are attached, a cyclic system; R is selected from the group consisting of -H and monovalent hydrocarbon radicals; R -R are independently selected from the group consisting of -H, -OH, N3, halogen, -SH,-OR , -SR , -NHR , -NR 2 and group Formula (1) wherein B" is selected from the group consisting of -O-, -CH2- and a bond, preferably -O-; R -R are independently selected and are as defined above, wherein R and R are independently selected from the group consisting of -H, monovalent hydrocarbon radicals, protecting groups and -C(O)R , and wherein R is selected from the group consisting of -H, monovalent hydrocarbon radicals, protecting groups and -C(O)R , wherein R is selected from the group consisting of -H and monovalent hydrocarbon radicals; or a pharmaceutically acceptable derivative or metabolite of a compound of formula (I). The present invention also provides processes for the production of (I) and uses thereof.
摘要翻译：本发明提供了包含结构（I）式（I）的氨基磷酸酯化合物，其中：X包含包含结构（II）或（III）的单糖基团，式（II），（III）B和B独立地选自由-O - ， - CH 2 - 和键组成的基团，优选-O-; R 1选自-H，保护基和单价烃基; R 2和R 3独立地选自-H和一价烃基，或者R 2和R 3一起形成亚烷基或亚杂烷基链，从而与它们所连接的C原子一起提供，一个循环系统; R 4选自-H和一价烃基; R 5 -R 12独立地选自-H，-OH，N 3，卤素，-SH，-OR 13，-SR 13'，-NHR 14， - NR 14 2和式（1）的基团，其中B“选自-O - ， - CH 2 - 和键，优选-O-; R 1 -R 4独立地选自如上所定义，其中R 13和R 13'独立地选自-H，一价烃基，保护基和-C（O）R 15，并且其中R 14和R 14独立地选自-H，选自-H，一价烃基，保护基和-C（O）R 15，其中R 15选自-H和一价烃基;或药学上可接受的基团（I）化合物的衍生物或代谢物，本发明还提供了用于生产（I）的方法及其用途。

19. 发明公开

EP2019147A1 NOVEL K04-0144 SUBSTANCES AND PROCESS FOR PRODUCTION THEREOF 有权
标题翻译： NOVEL K04-0144物质及其生产方法
公开(公告)号：EP2019147A1
公开(公告)日：2009-01-28
申请号：EP06732665.2
申请日：2006-05-16
申请人： THE KITASATO INSTITUTE
发明人： TOMODA, Hiroshi , KIM, Yong-pil , HANAKI, Hideaki , MATSUMOTO, Atsuko , TAKAHASHI, Yoko , OMURA, Satoshi
IPC分类号： C12P19/26 , C07H11/04 , A61K31/7024 , A61P31/04
CPC分类号： C07H11/04 , C07C323/59 , C12P13/02 , C12P19/26 , C12P19/44 , C12R1/465
摘要： Amicroorganism represented by a strain K04-0144 belonging to Streptomyces sp. having ability to produce K04-0144 substance is cultured in the medium, and the isolated K04-0144A substance, K04-0144B substance and K04-0144C substance therefrom have strong antibacterial activities against Gram-positive bacteria including methicillin-resistant Streptococcus aureus (MRSA), consequently these are useful as the therapeutic agents for infectious disease caused by MRSA as well as infectious diseases caused by multidrug including β-lactam antibiotics resistant bacteria. Further, similarly, since the novel K04-0144D substance isolated from the cultured liquid has the action for enhancing the effect of β-lactam antibiotics, which are utilized as the antibacterial agents, in combination with them, it is useful as the therapeutic agent for infectious diseases caused by methicillin-resistant Staphylococcus aureus (MRSA) and multidrug including β-lactam antibiotics resistant bacteria.
摘要翻译：由属于链霉菌属的菌株K04-0144代表的微生物。在培养基中培养具有产生K04-0144物质的能力，并且分离出的K04-0144A物质，K04-0144B物质和K04-0144C物质对包括耐甲氧西林金黄色葡萄球菌（MRSA）在内的革兰氏阳性菌具有强的抗菌活性，因此它们可用作由MRSA引起的感染性疾病的治疗剂以及由包括β-内酰胺抗生素抗性细菌在内的多种药物引起的感染性疾病。此外，类似地，由于从培养液中分离出的新型K04-0144D物质具有提高作为抗菌剂使用的β-内酰胺抗生素的效果的作用，因此与它们组合使用时，可用作由耐甲氧西林金黄色葡萄球菌（MRSA）引起的传染病和包括β-内酰胺抗生素耐药细菌在内的多种药物。

20. 发明公开

EP1995323A1 Method for preparing C-6 phosphorylated D-aldohexoses and C-6 phosphorylated D-aldohexose derivatives 审中-公开
标题翻译： Verfahren zur Herstellung von C-6-phosphorylierten D-Aldohexosen und C-6-phosphorylierten D-Aldohexosederivaten
公开(公告)号：EP1995323A1
公开(公告)日：2008-11-26
申请号：EP07108889.2
申请日：2007-05-24
申请人： Libragen
发明人： Auriol, Daniel , Nalin, Renaud , Lefevre, Fabrice , Ginolhac, Aurélien , de Guembecker, Daphné , Zago, Caroline
IPC分类号： C12P17/00 , C12P19/02 , C12P19/26 , C12P19/28 , C07D309/10 , C07D309/14 , C07D335/02 , C07H1/02 , C07H5/10 , C07H11/04 , C07H15/04 , C07H15/12 , C07D211/40 , C07D211/54 , C07D211/56 , C07D309/08
CPC分类号： C12P19/02 , C07D211/46 , C07D211/54 , C07D309/10 , C07D309/14 , C07D335/02 , C07H11/04 , C07H15/04 , C12P17/00 , C12P19/26 , C12P19/28
摘要： The present invention concerns a method for preparing C-6 phosphorylated D-aldohexoses and C-6 phosphorylated D-aldohexose derivatives, and uses thereof. The method comprises incubating polyphosphate as sole source of phosphate donor and a polyphosphate-glucose phosphotransferase (polyphosphate: D-glucose 6-phosphotransferase, EC 2.7.1.63) in an aqueous solution with a D-aldohexose or a D-aldohexose derivative.
摘要翻译：本发明涉及一种制备C-6磷酸化D-己内酯和C-6磷酸化D-己糖衍生物的方法及其应用。该方法包括将多磷酸盐作为磷酸供体的唯一来源和在D-二氢己糖或D-己糖糖衍生物的水溶液中的多磷酸 - 葡萄糖磷酸转移酶（多磷酸：D-葡萄糖-6-磷酸转移酶，EC 2.7.1.63）。

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