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11. 发明公开

EP3156113A1 LIQUID PURIFICATION METHOD AND SYSTEM FOR THE IMPLEMENTATION THEREOF 审中-公开
标题翻译： VERFAHREN ZURFLÜSSIGKEITSREINIGUNGUND系统ZURDURCHFÜHRUNGDES VERFAHRENS
公开(公告)号：EP3156113A1
公开(公告)日：2017-04-19
申请号：EP15807541.6
申请日：2015-04-06
申请人： Electrophor, Inc.
发明人： SHMIDT, Joseph Lvovich , TATUEV, Yurij Vladimirovich , ZOTKIN, Evgenij Anatoljevich , VINOGRADOV, Mikhail Grigorjevich
IPC分类号： B01D37/00 , B01D61/00 , B01D63/00 , C02F1/44
CPC分类号： B01D61/022 , B01D37/00 , B01D61/025 , B01D61/06 , B01D61/08 , B01D61/10 , B01D65/02 , B01D2311/12 , B01D2311/20 , B01D2311/25 , B01D2311/2626 , B01D2313/24 , B01D2313/246 , B01D2315/10 , B01D2315/12 , B01D2321/04 , C02F1/44 , C02F1/441 , C02F1/442 , C02F9/00 , C02F2301/046 , Y02A20/131
摘要： This group of inventions (a liquid purification method and a system for the implementation thereof) relates to technologies for the purification and/or desalination of liquids, preferably water for the domestic and/or drinking water supply, involving recycling and pneumatic start-up. The group of inventions is intended for use in domestic and/or industrial settings and in allotments and gardens. The present liquid purification method, carried out with the aid of a liquid purification system, consists of a three-stage liquid filtration cycle, during which all of the drain liquid can be continuously fed back into the purification system until the liquid filtration cycle is complete. During this continuous recycling, a high liquid flow rate is maintained and the feed rate of the liquid can be controlled during the continuous mixing of initial liquid and drain liquid. The common aim of the group of inventions and the technical result achieved in the use of same is the development of a novel energy-efficient method and system for purifying liquids which makes it possible to improve the energy-efficiency of liquid purification while simultaneously increasing the degree of purification and the extent to which the initial liquid is used.
摘要翻译：这一组发明（液体净化方法及其实施系统）涉及用于纯化和/或脱盐液体的技术，优选用于家用和/或饮用水的水，涉及回收和气动启动。这组发明是用于家庭和/或工业场所，分配和花园。借助于液体净化系统进行的本液体净化方法由三级液体过滤循环组成，在此期间，所有的排液可以被连续反馈进入净化系统，直到液体过滤循环完成。在连续回收期间，保持高的液体流速，并且可以在初始液体和排出液体的连续混合期间控制液体的进料速率。发明集团的共同目标以及在使用中实现的技术成果是开发了一种新型的节能方法和液体净化系统，可以提高液体净化的能源效率，同时增加纯化程度以及使用初始液体的程度。

12. 发明授权

EP2393579B1 OPTIMIZATION OF SEPARATION FOR VISCOUS SUSPENSIONS 有权
标题翻译：改善的分离粘性SUSPENSIONS
公开(公告)号：EP2393579B1
公开(公告)日：2017-03-08
申请号：EP10738945.4
申请日：2010-01-21
申请人： Smartflow Technologies, Inc.
发明人： KOPF, Henry, B. , KACMAE, James, A.
IPC分类号： B01D61/58 , B01D65/00
CPC分类号： C07H1/08 , B01D29/56 , B01D61/142 , B01D61/145 , B01D61/147 , B01D61/58 , B01D63/082 , B01D2315/10 , B01D2315/16 , B01D2317/022 , B01D2317/025
摘要： The present invention relates to methods and systems for optimization of dilution of a viscous starting material to isolate and/or concentrate the product of interest from the starting source material such that the process minimizes the volume of diluent and the total volume of the waste stream generated during the process as well as maximizing the yield of desired product. The system employs cross-flow filtration modules with sub-channels that are equidistant to the inlet and outlet of said modules and such modules are characterized by optimal channel height, optimal transmembrane pressure, etc., which are selected in order to achieve the best combination of product quality and production yield.

13. 发明公开

EP3115340A1 LIQUID TREATMENT APPARATUS INCLUDING AT LEAST ONE CROSS-FLOW FILTRATION DEVICE AND METHOD OF OPERATING THE APPARATUS 审中-公开
标题翻译：与至少一个交叉流式过滤装置和方法液体处理设备运行设备
公开(公告)号：EP3115340A1
公开(公告)日：2017-01-11
申请号：EP15176274.7
申请日：2015-07-10
申请人： Brita GmbH
发明人： Weidner, Peter , Floren, Simon
IPC分类号： C02F1/00 , C02F1/44 , B01D65/02 , B01D61/12
CPC分类号： B01D65/02 , B01D61/025 , B01D2315/10 , B01D2315/18 , B01D2321/02 , B01D2321/14 , B01D2321/2083 , B01D2321/40 , C02F1/008 , C02F1/44 , C02F2209/006 , C02F2209/05 , C02F2209/40 , C02F2209/42 , C02F2307/10
摘要： A method of operating a liquid treatment apparatus including at least one cross-flow filtration device (5;5';40,41), each cross-flow filtration device (5;5';40,41) having an inlet (4;4';42,43), an outlet (6;6';46,47) for retentate and an outlet for filtrate (7;7';44,45)includes operating one of the at least one cross-flow filtration devices (5;5';40,41) to obtain filtrate. The filtrate is used to produce product liquid for delivery through an outlet (23;23';58) of the apparatus. At least one of the at least one cross-flow filtration devices (5;5';40,41) is operated in a rinse mode, in which a larger proportion of liquid entering through the inlet (4;4';42,43) passes to the retentate outlet (6;6';46,47) than during a preceding filtrate production mode of operation of that cross-flow filtration device (5;5';40,41), and liquid originating from that retentate outlet (6;6';46,47) is used to produce the product liquid.
摘要翻译：一种操作液体处理装置包括至少一个错流过滤装置的方法（5; 5“; 40,41），每个横流式过滤装置（5; 5”; 40,41），其具有在入口（4; 4“; 42,43）到出口（6; 6”; 46,47），用于截留和抽出口的滤液（7; 7“; 44,45）包括操作所述至少一个交叉流动过滤装置中的一个（5; 5“; 40,41），以得到滤液。该装置的滤液被用于通过向出口以产生用于输送液体产物（58 23; 23”）。至少所述至少一个交叉流动过滤装置中的一个（5; 5“; 40,41）在漂洗模式中操作，其中的液体通过入口进入（4比重较大; 4”; 42,43 ）传递到滞留物出口（6;“; 46,47）比在交叉流过滤设备的操作的preceding-滤液生产模式做（5; 5”; 6 40.41），以及液体源自于做渗余出口（6; 6“; 46,47）用于产生所述产物液。

14. 发明公开

EP3107641A1 ULTRAFILTRATIONSUNIT ZUM KONTINUIERLICHEN PUFFER- BZW. MEDIENAUSTAUSCH AUS EINER PROTEINLÖSUNG. 审中-公开
标题翻译：超声波清洗机ZUM KONTINUIERLICHEN PUFFER- BZW MEDIENAUSTAUSCH AUS EINERPROTEINLÖSUNG。
公开(公告)号：EP3107641A1
公开(公告)日：2016-12-28
申请号：EP15705577.3
申请日：2015-02-13
申请人： Bayer Aktiengesellschaft
发明人： SCHWAN, Peter , LENZ, Lutz-Peter , BAUMARTH, Kerstin , LOBEDANN, Martin
IPC分类号： B01D61/24 , B01D61/28 , B01D61/32 , B01D61/58
CPC分类号： B01D61/145 , B01D61/243 , B01D61/246 , B01D61/28 , B01D61/32 , B01D61/58 , B01D63/02 , B01D2311/04 , B01D2311/08 , B01D2311/165 , B01D2311/25 , B01D2315/10 , B01D2317/02 , B01D2317/04 , C07K1/34 , C07K16/00 , C07K16/065 , C12M47/10
摘要： The invention relates to an ultrafiltration unit for continuously exchanging buffer or media, a method for continuously exchanging buffer or media in the ultrafiltration unit, and a system especially for (semi)continuously producing biopharmaceutical and biological macromolecular products, in particular proteins, e.g. monoclonal antibodies and vaccines comprising the ultrafiltration unit of the invention.
摘要翻译：本发明涉及用于连续缓冲或介质交换的超滤单元，在超滤单元中连续缓冲或介质交换的方法，特别是用于（半）连续生产生物药物和生物大分子产物，特别是如蛋白质，例如单克隆抗体和疫苗，其包含根据本发明的超滤单元。

15. 发明公开

EP3069127A1 A METHOD FOR QUANTITATIVE DETERMINATION OF NITROGEN IN AN AQUEOUS FLUID 有权转让
标题翻译： VERFAHREN ZUR数量BESTIMMUNG VON STICKSTOFF在WÄSSRIGENFLÜSSIGKEITEN
公开(公告)号：EP3069127A1
公开(公告)日：2016-09-21
申请号：EP14862472.9
申请日：2014-11-11
申请人： NanoNord A/S
发明人： JENSEN, Ole Nørgaard , NIELSEN, Niels Christian , SØRENSEN, Morten Kjærulff
IPC分类号： G01N24/08
CPC分类号： G01N24/082 , A01C23/007 , B01D61/025 , B01D61/027 , B01D61/145 , B01D63/08 , B01D63/10 , B01D2311/246 , B01D2315/10 , C02F1/008 , C02F1/441 , C02F1/442 , C02F1/444 , C02F2101/105 , C02F2101/12 , C02F2101/16 , C02F2101/20 , C02F2101/32 , C02F2101/36 , C02F2209/16 , C02F2209/20 , C02F2209/29 , G01N24/08 , G01N24/084 , G01N33/1813 , G01N33/1833 , G01N33/1846 , G01N33/188 , G01N33/24
摘要： The invention concerns a method for quantitative determination of nitrogen present in the form of one or more nitrogen containing compounds and/or ions thereof in an aqueous fluid, the method comprises subjecting at least a part of the aqueous fluid to an NMR reading comprising generating a 14N data comprising a
14 N NMR data spectra and correlating the
14 N NMR data to calibration data. A system suitable for carrying out the method as well as a moveable manure spreader comprising a system is also described.
摘要翻译：本发明涉及一种在含水流体中以一种或多种含氮化合物和/或其离子的形式存在的氮的定量测定方法，该方法包括使至少一部分含水流体进行NMR读数，其包括生成 14N数据具有14N NMR数据谱，并将14N NMR数据与校准数据相关联。还描述了适用于实施该方法的系统以及包括系统的可移动肥料撒布机。

16. 发明公开

EP2883592A4 GAS-SEPARATING MEMBRANE MODULE 有权转让
标题翻译： GASTRENNMEMBRANMODUL
公开(公告)号：EP2883592A4
公开(公告)日：2016-09-21
申请号：EP13827746
申请日：2013-08-08
申请人： UBE INDUSTRIES
发明人： YAMAOKA SHOICHI , SUEHIRO TOMOYUKI , NAKAMURA TOMOHIDE , TANIHARA NOZOMU
IPC分类号： B01D53/22 , B01D63/02
CPC分类号： B01D63/02 , B01D53/22 , B01D63/022 , B01D2313/23 , B01D2315/10 , B01D2319/04 , Y02C10/10
摘要： To provide a gas separation membrane module in which deformation of a tube sheet such as swelling and shrinkage can be prevented in gas separation. Gas separation membrane module (100) includes hollow fiber bundle (115) provided by bundling a plurality of hollow fiber membranes (114), module vessel (110) in which the hollow fiber bundle is placed, and tube sheet (120) fixing the plurality of hollow fiber membranes (114) at an end portion of hollow fiber bundle (115). The cross section of tube sheet (120) includes hollow fiber membrane embedded portion (120A) in which hollow fiber membranes (114) are embedded and a solid portion (120B) in which no hollow fiber membrane is embedded, the solid potion is located outside the hollow fiber membrane embedded portion. At least some of the hollow fiber membranes (114) are wound with reinforcing fiber cloth (125) at least within hollow fiber membrane embedded portion (120A).

17. 发明公开

EP3022282A1 QUERSTROMFILTER FÜR WEIN 有权
标题翻译： CROSS电力滤波器葡萄酒
公开(公告)号：EP3022282A1
公开(公告)日：2016-05-25
申请号：EP14742487.3
申请日：2014-07-17
申请人： Mahle International GmbH
发明人： HERB, Matthias , MUNZ, Sebastian , OECHSLE, Ulrich , SCHOOP, Marco
IPC分类号： C12H1/07 , B01D61/20 , B01D63/04
CPC分类号： C12H1/063 , B01D61/20 , B01D63/046 , B01D2313/105 , B01D2313/125 , B01D2315/10 , B01D2317/04
摘要： The invention relates to a cross-flow filtration system (1) for filtering a suspension, in particular a wine, comprising at least three substantially cylindrical hollow fibre modules (3 – 22) for retaining a retentate of the suspension; a circulation pump (23), fluidically connected to the hollow fibre modules (3 – 22), for generating a mechanical flow of the suspension; a flow distributor (25) for distributing the suspension to the hollow fibre modules (3 – 22); and a flow collector (30) for collecting the suspension from the hollow fibre modules (3 – 22), said flow distributor (25) and flow collector (30) being fluidically connected to the circulation pump (23) and to the hollow fibre modules (3, 4, 5, 6), and being substantially centrally arranged on a longitudinal axis (24) of the cross-flow filtration system (1). A homogenous flow is produced when the hollow fibre modules (3 – 22) are arranged in an axially parallel manner about the longitudinal axis (24).

18. 发明公开

EP3013461A1 MEMBRANE FILTRATION DEVICE HAVING AN IMPROVED DESIGN 审中-公开
标题翻译：具有改进的设计膜过滤装置
公开(公告)号：EP3013461A1
公开(公告)日：2016-05-04
申请号：EP14741214.2
申请日：2014-06-25
申请人： Tetra Laval Holdings & Finance SA
发明人： INNINGS, Fredrik , LINDAU, Jeanette , SKOGLUND, Tomas
IPC分类号： B01D63/08 , B01D65/08
CPC分类号： B01D63/082 , B01D61/147 , B01D65/08 , B01D2313/143 , B01D2313/19 , B01D2315/10 , B01D2321/2016
摘要： A cross-flow filtration device comprises a retentate plate, a permeate plate, and a membrane sandwiched between the retentate plate and the permeate plate. The retentate plate comprises at least one feed channel extending from a distribution manifold, and at least one drain channel extending from a collection manifold, and a feed channel is fluidly connected to a drain channel via through-holes extending from a first side of the retentate plate, from a feed channel, to an opposing second side of the retentate plate, and through-holes extending from the second side of the retentate plate to the first side of the retentate plate, into a drain channel. One or more of the through-holes extending from the feed channel have a chamfered inlet.

19. 发明公开

EP2536399A4 Method for activation and conjugation of biomolecules 有权
标题翻译：方法用于生物分子的激活和共轭
公开(公告)号：EP2536399A4
公开(公告)日：2016-02-24
申请号：EP11745404
申请日：2011-02-21
申请人： BAYER HEALTHCARE LLC
发明人： VOGEL JENS H , TO CHI SHUNG BRIAN , BIANCO CAROLINA LUCIA
IPC分类号： A61K31/00 , A61K38/37 , A61K47/48
CPC分类号： A61K47/48215 , A61K38/37 , A61K47/60 , B01D61/025 , B01D2315/10 , B01D2315/16
摘要： The present invention is directed to a method for producing a biomolecule conjugate where the method is integrated into a single unit operation.

20. 发明公开

EP2914612A1 PURIFICATION OF POLYPEPTIDES USING DUAL STAGE TANGENTIAL-FLOW ULTRAFILTRATION 审中-公开
标题翻译：多肽的了两级TANGENTIALFLUSSULTRAFILTRIERUNG清洁
公开(公告)号：EP2914612A1
公开(公告)日：2015-09-09
申请号：EP13794828.7
申请日：2013-10-28
申请人： F.Hoffmann-La Roche AG
发明人： BECKER, Peter , NEUMANN, Sebastian
IPC分类号： C07K1/34
CPC分类号： C07K1/34 , B01D15/362 , B01D15/363 , B01D61/145 , B01D2315/10 , B01D2317/02 , C07K1/36 , C12M47/10 , C12M47/12
摘要： The present invention is directed to methods for the separation of a molecule of interest from a solution containing the molecule using dual stage tangential-flow ultrafiltration (“TFF”). In particular, the methods of the invention are directed to the processing of crude feed streams such as conditioned cell culture supernatant to dramatically reduce contaminant and/or impurity levels prior to subsequent, i.e., downstream, refining unit operations. The methods of the invention may be used in the processing of a crude feed stream from biological production systems such as fermentation or other cell culture process, and may further eliminate the need for time consuming impurity precipitation (e.g., pH driven) and/or precipitate filtration processes prior to downstream processes that are sensitive to high impurity loads such as chromatographic unit operations. The disclosed dual stage TFF process combines at least two TFF unit operations that may be advantageously conducted at a pH that corresponds to or is about that of the pH of the feed stream, e.g., a cell culture supernatant, typically a pH of 7.5±1.0. The use of the TFF unit operations to supplement, improve or replace traditional processes for purification of proteins of interest for a feed stream may represent significant savings in both direct and indirect processing costs, For example, in addition to indirect savings by eliminating precipitation and precipitate filtration processes, the reduction in impurity loads effected by the dual stage TFF unit operations may result in indirect savings by improving downstream column performance, e.g., chromatographic separation, dynamic binding capacity, operational lifetime and/or a reduction of the required column size. In particular embodiments, the methods of the invention are used in processes for the purification of immunoglobulin molecules, e.g., antibodies, which processes are devoid of affinity purification steps, e.g., protein A affinity chromatography purification.

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