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    • 19. 发明公开
    • SPINAL FUSION METHODS AND DEVICES
    • VERFAHREN UND VORRICHTUNGENFÜRDIE SPINALFUSION
    • EP1335686A4
    • 2005-06-01
    • EP01988544
    • 2001-10-24
    • SDGI HOLDINGS INC
    • MCKAY WILLIAM F
    • A61B17/56A61B17/58A61F2/00A61F2/02A61F2/28A61F2/44A61F2/46A61L27/00A61L27/12A61L27/18A61L27/22A61L27/24A61L27/54A61L27/58
    • A61B17/58A61B2017/564A61F2/442A61F2/4455A61F2002/2817A61F2002/30062A61F2002/30092A61F2002/4635A61F2210/0004A61F2210/0014A61F2310/00293A61F2310/00353A61F2310/00365A61L2430/38
    • Methods, devices and compositions for fusing adjacent vertebrae, and otherwise localizing bone growth, are provided. In one form of the invention, a method for fusing adjacent vertebrae includes preparing a disc space for receipt of an intervertebral disc implant in an intervertebral disc space between adjacent vertebrae, inserting the implant into the intervertebral disc space and providing an osteoinductive composition that includes an osteoinductive factor in a pharmaceutically acceptable carrier. The carrier is advantageously substantially impermeable to efflux of the osteoinductive factor and is released as the carrier is resorbed or biodegraded. Preferred carriers include a hardened, resorbable carrier, such as a calcium phosphate cement that retains at least about 50 % of the osteoinductive factors greater than about 2 days. Preferred osteoinductive factors are growth factors and include bone morphogenetic proteins and LIM mineralization proteins. In alternative forms of the invention, the method may be performed without utilization of a load-bearing spinal implant by disposing the osteoinductive composition in the disc space. The method is advantageously performed on lumbar vertebrae by a posterior approach. Intervertebral fusion devices and methods for their preparation are also provided.
    • 提供了用于融合相邻椎骨的方法,装置和组合物,以及另外定位骨生长。 在本发明的一种形式中,用于融合相邻椎骨的方法包括:准备用于在相邻椎骨之间的椎间盘间隙中接收椎间盘植入物的椎间盘空间,将植入物插入椎间盘空间中并提供骨诱导性组合物,其包括 可药用载体中的骨诱导因子。 载体有利地基本上不渗透造骨诱导因子,并且当载体吸收或生物降解时被释放。 优选的载体包括硬化,可再吸收的载体,例如保留至少约50%的骨诱导因子大于约2天的磷酸钙骨水泥。 优选的骨诱导因子是生长因子,包括骨形态发生蛋白和LIM矿化蛋白。 在本发明的替代形式中,可以通过将骨诱导性组合物置于椎间盘空间中而不利用承载脊柱植入物进行该方法。 该方法有利于通过后路进行在腰椎上。 还提供了椎间融合装置及其制备方法。