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11. 发明公开

EP4301406A1 VACCINES FOR THE TREATMENT AND PREVENTION OF ZOONOTIC INFECTIONS 审中-实审
公开(公告)号：EP4301406A1
公开(公告)日：2024-01-10
申请号：EP22763831.9
申请日：2022-02-28
申请人： Longhorn Vaccines and Diagnostics, LLC
发明人： DAUM, Luke T. , FISCHER, Gerald W.
IPC分类号： A61K39/145 , A61K39/02 , A61P31/16 , C07K14/11

12. 发明授权

EP3086805B1 USE OF GLYCYL-GLYCINE ENDOPEPTIDASE FOR TREATING MYCOBACTERIA INFECTIONS 有权
公开(公告)号：EP3086805B1
公开(公告)日：2018-10-03
申请号：EP14874375.0
申请日：2014-12-29
申请人： Longhorn Vaccines and Diagnostics, LLC
发明人： FISCHER, Gerald W. , SCHUMAN, Richard F.
IPC分类号： A61P31/00 , A61P31/06 , A61K38/48 , A61K45/06 , A61L29/16 , A61L31/16 , A61K9/00 , C12N9/64
CPC分类号： A61K38/4886 , A61K9/0073 , A61K9/16 , A61K9/50 , A61K45/06 , A61L29/16 , A61L31/16 , A61L2300/254 , A61L2300/404 , A61L2300/45 , A61P31/00 , A61P31/06 , C12N9/6489 , C12Y304/24075 , Y02A50/473
摘要： The present invention is directed to compositions and methods for preventing and/or treating diseases and disorders of patients caused by non-Staphylococcal microorganisms. In particular, compositions and methods contain lysostaphin, altered forms of lysostaphin as compared to wild-type, and synergistic combinations of lysostaphin plus additional conventional treatments such as other enzyme, antibiotic and/or antibody treatment. The invention is also directed to detecting and identifying altered forms of lysostaphin that possess increased efficacy against infections as compared to wild-type lysostaphin, and forms that generate a minimal or no immune response in a patient. The invention is also directed to method of manufacturing lysostaphin and altered forms of lysostaphin, and compositions that direct the lysostaphin to the site of the infection such as aerosolized nanoparticles.

13. 发明公开

EP3063301A1 NEXT GENERATION GENOMIC SEQUENCING METHODS 审中-公开
标题翻译： GENOMISCHE SEQUENZIERUNGSVERFAHREN DERNÄCHSTENGENERATION
公开(公告)号：EP3063301A1
公开(公告)日：2016-09-07
申请号：EP14856946.0
申请日：2014-10-29
申请人： Longhorn Vaccines and Diagnostics, LLC
发明人： DAUM, Luke T. , FISCHER, Gerald W.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/701 , C12Q1/6869 , C12Q1/689 , C12Q1/6893 , Y02A50/52 , Y02A50/58 , C12Q2527/119 , C12Q2535/122 , C12Q2537/165
摘要： Disclosed is an enhanced method for rapid and cost-effective analysis of sequences of a microorganism by semi-conductor sequencing, preferably ion-torrent sequencing. This method provides for full length analysis and of multiple areas (e.g. genes) of multiple genomes. These methods identify genetic mutations of a particular gene that are responsible for conferring resistance or sensitivity to an antibiotic or other chemical compound. Multiple different species, strains and/or serotypes of a particular organism are rapidly and efficiently screened and mutations identified along with the complete genome of an organism. By selecting primers pairs of similar size and GC content that produce amplicons with sequences spanning the entire genome, a single PCR reaction analyzed by ion torrent methodology can determine the sequence of a complete genome. Methods are useful to sequences the genomes of viral agents, such as influenza virus, and bacterial agents, such as tuberculosis bacteria.
摘要翻译：公开了通过半导体测序（优选离子束测序）快速和成本有效地分析微生物序列的增强方法。该方法提供了全长分析和多个基因组的多个区域（例如基因）。这些方法鉴定了负责赋予抗生素或其他化合物抗性或敏感性的特定基因的遗传突变。快速有效地筛选特定生物体的多种不同物种，菌株和/或血清型，并与生物体的完整基因组一起鉴定突变。通过选择产生具有跨越整个基因组的序列的扩增子的相似大小和GC含量的引物对，通过离子束法分析的单个PCR反应可以确定完整基因组的序列。方法可用于对病毒试剂的基因组进行排序，例如流感病毒和细菌试剂如结核菌。

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