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11. 发明公开

EP3990442A1 RHO KINASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF 有权
公开(公告)号：EP3990442A1
公开(公告)日：2022-05-04
申请号：EP20743910.0
申请日：2020-06-26
申请人： CHDI Foundation, Inc.
发明人： MAILLARD, Michel C. , LEE, Matthew R. , DOMINGUEZ, Celia , BARNES, Michael , HAUGHAN, Alan F. , LADDUWAHETTY, Tammy , LUCKHURST, Christopher A. , STOTT, Andrew J. , TIERNEY, Jason
IPC分类号： C07D401/04 , C07D405/14 , C07D413/14 , C07D487/04 , C07D487/08 , A61P25/28 , A61K31/496

12. 发明授权

EP2968232B1 HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF 有权转让
公开(公告)号：EP2968232B1
公开(公告)日：2018-12-05
申请号：EP14773968.4
申请日：2014-03-10
申请人： CHDI Foundation, Inc.
发明人： DOMINGUEZ, Celia , MUÑOZ-SANJUAN, Ignacio , BEAUMONT, Vahri , BECONI, Maria , BÜRLI, Roland, W. , HAUGHAN, Alan, F. , LUCKHURST, Christopher, A. , WALL, Michael , RAPHY, Gilles , THOMAS, Beth
IPC分类号： C07D239/26 , A61K31/505 , A61P35/00 , A61P25/00
CPC分类号： A61K31/505 , C07D239/26
摘要： Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.

13. 发明公开

EP3186233A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN 有权
标题翻译：成像探针亨廷顿蛋白
公开(公告)号：EP3186233A1
公开(公告)日：2017-07-05
申请号：EP15836321.8
申请日：2015-08-28
申请人： CHDI Foundation, Inc.
发明人： DOMINGUEZ, Celia , WITYAK, John , BARD, Jonathan , KISELYOV, Alex , BROWN, Christopher John , GALAN, Sebastien Rene Gabriel , PRIME, Michael Edward , GILES, Paul Richard , GADOULEAU, Elise Luciennen Paulette , KRÜLLE, Thomas Martin , CLARK-FREW, Daniel , JOHNSON, Peter David , COE, Samuel , HAYES, Sarah
IPC分类号： C07D279/00
CPC分类号： C07D513/04 , A61K51/0455 , A61K51/0459 , A61K51/0463 , C07D263/57 , C07D405/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D471/04 , C07D498/04
摘要： Provided are imaging agents comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and methods of their use.
摘要翻译：提供包含式（I）化合物或其药学上可接受的盐的成像剂及其使用方法。

14. 发明授权

EP2750677B1 KYNURENINE-3-MONOOXYGENASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF 有权转让
标题翻译：犬尿氨酸3单加氧酶抑制剂，其药物组合物及其使用方法
公开(公告)号：EP2750677B1
公开(公告)日：2017-03-22
申请号：EP12828501.2
申请日：2012-08-28
申请人： CHDI Foundation, Inc.
发明人： COURTNEY, Stephen Martin , PRIME, Michael , MITCHELL, William , BROWN, Christopher John , DE AGUIAR PENA, Paula C. , JOHNSON, Peter , DOMINGUEZ, Celia , TOLEDO-SHERMAN, Leticia M. , MUNOZ, Ignacio
IPC分类号： A61K31/44 , C07D403/04 , C07D405/14 , C07D405/04 , C07D409/04 , C07D413/04 , C07H13/10
CPC分类号： C07D239/28 , C07D239/42 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/10 , C07D403/12 , C07D405/04 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/04 , C07D413/04 , C07D417/04 , C07D471/04 , C07D491/048 , C07D491/052 , C07H13/10
摘要： Certain chemical entities are provided herein. Also provided are pharmaceutical compositions comprising at least one chemical entity and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of KMO activity are described, which comprise administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are disclosed. These diseases include neurodegenerative disorders such as Huntington's disease. Also described are methods of treatment include administering at least one chemical entity as a single active agent or administering at least one chemical entity in combination with one or more other therapeutic agents. Also provided are methods for screening compounds capable of inhibiting KMO activity.

15. 发明公开

EP3049077A2 KYNURENINE-3-MONOOXYGENASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF 无效转让
标题翻译：犬尿氨酸3单加氧酶抑制剂，药物组合物及其方法使用
公开(公告)号：EP3049077A2
公开(公告)日：2016-08-03
申请号：EP14847911.6
申请日：2014-09-23
申请人： CHDI Foundation, Inc.
发明人： DOMINGUEZ, Celia , TOLEDO-SHERMAN, Leticia M. , PRIME, Michael , MITCHELL, William , WENT, Naomi
IPC分类号： A61K31/381
CPC分类号： C07D413/12 , C07D209/08 , C07D213/46 , C07D215/18 , C07D217/02 , C07D231/56 , C07D235/08 , C07D237/28 , C07D239/74 , C07D241/42 , C07D261/20 , C07D263/56 , C07D277/24 , C07D277/64 , C07D307/79 , C07D319/18 , C07D333/06 , C07D333/10 , C07D333/28 , C07D407/12
摘要： Certain compounds, or pharmaceutically acceptable salts or prodrugs thereof, are provided herein. Also provided are pharmaceutical compositions comprising at least one compound, or pharmaceutically acceptable salt or prodrug thereof, described herein and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of KMO activity are described, which comprise administering to such patients an amount of at least one compound, or pharmaceutically acceptable salt or prodrug thereof, described herein effective to reduce signs or symptoms of the disease or disorder are disclosed. These diseases include neurodegenerative disorders such as Huntington's disease. Also described are methods of treatment include administering at least one compound, or pharmaceutically acceptable salt or prodrug thereof, described herein as a single active agent or administering at least one compound, or pharmaceutically acceptable salt or prodrug thereof, described herein in combination with one or more other therapeutic agents. Also provided are methods for screening compounds capable of inhibiting KMO activity.
摘要翻译：某些化合物，或其药学上可接受的盐或前药，在被提供。所以提供了药物组合物，包含至少一种化合物，或其药学上可接受的盐或前药，在描述的和一种或多种药学上可接受的载体。治疗某些疾病以及响应于KMO活性的抑制的疾病的患者的方法中，其包括施用来搜索患者中的至少一种化合物，或其药学上可接受的盐或前药的量，描述在有效减少体征或症状疾病或障碍是游离缺失盘。这些疾病包括神经变性疾病：如亨廷顿病。如此描述是治疗方法包括施用至少一种化合物，或其药学上可接受的盐或前药，被描述在作为单一活性剂或施用至少一种化合物，或其药学上可接受的盐或前药，在组合的本文所述的一个或多种其他治疗剂。这样提供了用于能够KMO抑制活性的筛选化合物的方法。

16. 发明公开

EP2968207A1 HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS 无效转让
标题翻译： HISTM-DEACETYLASE-HEMMER UND ZUSAMMENSETZUNGEN
公开(公告)号：EP2968207A1
公开(公告)日：2016-01-20
申请号：EP14775535.9
申请日：2014-03-10
申请人： CHDI Foundation, Inc.
发明人： DOMINGUEZ, Celia , MUÑOZ-SANJUAN, Ignacio , MAILLARD, Michel , LUCKHURST, Christopher, A. , JARVIS, Rebecca, E. , BÜRLI, Roland, W. , ALLEN, Daniel, R. , HAUGHAN, Alan, F. , BRECCIA, Perla , VATER, Huw, D. , STOTT, Andrew, J. , PENROSE, Stephen, D. , WALL, Michael , SAVILLE-STONES, Elizabeth, A. , WISHART, Grant , HUGHES, Samantha, J.
IPC分类号： A61K31/015 , A61K31/02 , A61K31/166
CPC分类号： C07D471/04 , C07C259/08 , C07C2601/02 , C07C2601/10 , C07D213/56 , C07D213/61 , C07D213/64 , C07D231/12 , C07D231/56 , C07D239/26 , C07D241/12 , C07D241/42 , C07D261/20 , C07D275/04 , C07D277/62 , C07D277/64 , C07D333/60
摘要： Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.
摘要翻译：提供了式I的组蛋白脱乙酰酶（HDAC）抑制剂，其组合物及其使用方法。

17. 发明公开

EP2667709A1 HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF 审中-公开
标题翻译：组蛋白去乙酰化酶抑制剂和组合物以及申请流程。
公开(公告)号：EP2667709A1
公开(公告)日：2013-12-04
申请号：EP12738982.3
申请日：2012-01-23
申请人： CHDI Foundation, Inc.
发明人： LUCKHURST, Christopher A. , HAUGHAN, Alan F. , BRECCIA, Perla , STOTT, Andrew J. , BURLI, Roland W. , HUGHES, Samantha J. , MUNOZ-SANJUAN, Ignacio , DOMINGUEZ, Celia , MANGETTE, John E.
IPC分类号： A01N37/08 , A61K31/19
CPC分类号： C07D401/06 , C07C259/08 , C07C311/14 , C07C2601/02 , C07C2601/14 , C07D205/04 , C07D207/10 , C07D209/44 , C07D209/46 , C07D209/82 , C07D211/58 , C07D211/70 , C07D213/56 , C07D213/74 , C07D215/18 , C07D231/12 , C07D233/61 , C07D233/64 , C07D237/08 , C07D239/26 , C07D263/32 , C07D265/36 , C07D267/14 , C07D277/30 , C07D295/155 , C07D317/46 , C07D319/18 , C07D401/04 , C07D409/08 , C07D413/04 , C07D417/08 , C07D471/04 , C07D487/04 , C07D491/10
摘要： Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.
摘要翻译：本发明提供式I化合物，其组合物，以及它们的使用方法的某些组蛋白脱乙酰酶（HDAC）抑制剂。

18. 发明公开

EP4192819A1 HETEROBIARYL COMPOUNDS AND IMAGING AGENTS FOR IMAGING HUNTINGTIN PROTEIN 审中-实审
公开(公告)号：EP4192819A1
公开(公告)日：2023-06-14
申请号：EP21769835.6
申请日：2021-08-05
申请人： CHDI Foundation, Inc.
发明人： LIU, Longbin , DOMINGUEZ, Celia , CHEN, Xuemei , MANGETTE, John, E.
IPC分类号： C07D239/28 , C07D401/06 , C07D401/12 , C07D401/14 , C07D239/34 , C07D239/36 , C07D403/06 , C07D403/12 , C07D471/04 , A61P25/28 , C07B59/00

20. 发明授权

EP3186241B1 PROBES FOR IMAGING HUNTINGTON PROTEIN 有权
公开(公告)号：EP3186241B1
公开(公告)日：2020-10-07
申请号：EP15836970.2
申请日：2015-08-28
申请人： CHDI Foundation, Inc.
发明人： DOMINGUEZ, Celia , WITYAK, John , BARD, Jonathan , BROWN, Christopher, John , KRÜLLE, Thomas, Martin , CLARK-FREW, Daniel , HAYES, Sarah
IPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D487/04 , C07D513/04 , C07D513/14 , A61K51/04

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