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11. 发明公开

EP2792405A4 FIXED BED REACTOR OF LIQUID-ENHANCED IMMERSION TYPE 有权
标题翻译：与液体浸泡加固固定床反应器
公开(公告)号：EP2792405A4
公开(公告)日：2015-12-30
申请号：EP12857101
申请日：2012-05-25
申请人： UNIV NANJING
发明人： ZHOU ZHENG , ZHANG ZHIBING , YANG GAODONG , DAI YUE , WU PINGKENG , LIU XIAOJUAN
IPC分类号： B01J8/02
CPC分类号： B01J8/067 , B01J8/008 , B01J8/0214 , B01J8/0278 , B01J8/228 , B01J19/02 , B01J2208/00176 , B01J2208/00283 , B01J2208/00884 , B01J2208/00902 , B01J2208/065 , B01J2219/0286
摘要： An immersion fixed bed reactor intensified by liquid flow contains a cylindrical tank R-1 internally installed an annular cylindrical catalyst bed (ACCB) T-1 packed with solid catalysts. The inner and outer walls of the T-1 are composed of two layers of stainless steel sheets with holes. The outer layer of stainless steel perforated with holes. The inner layer of catalyst contacting stainless steel is covered with stainless steel waved mesh in circumferential direction. The bottom of T-1 is sealed with a steel plate by welding or a blind plate and the top of T-1 is fixed to R-1 with a flange. The solid catalysts are packed in the ACCB. The cylindrical tank R-1 is equipped with a reaction mass inlet duct 1 at the top and mass outlet duct 2 at the bottom and the duct 2 is connected with a liquid circulating pump P-1, a liquid outlet duct valve V-1, a flow meter L-1, a heat exchanger E-1 and a normal tube inlet M-linserting into the central column space of T-1 at axial position through the top of R-1, and enables the liquid is pumped by P-1 into the central column space of T-1 and radically pass through the catalyst bed of T-1 into the space between R-1 and T-1, thus one cycle of reaction operation is accomplished. With the continuous work of the pump P-1 the liquid in R-1 will be repeatedly circulated and the reaction is simulanously carried out again and again. if it is gas-liquid-solid reaction system, the above-stated normal tube inlet M-1 will be substituted by a jet inlet M-2 which has a vacuum inlet tube allowing the surrounding gas or mass vapor sucked and mixed with the liquid into the central column space of T-2, then radially flows together with liquid reactants through the catalyst bed of T-1 into the annular space between R-2and T-2. The vacuum inlet tube of M-2 is connected to the outlet tube of R-2 and the gas reactant is added through the gas inlet and a gas distributor.

12. 发明公开

EP2799418A4 PREPARATION METHOD OF LYCOPENE INTERMEDIATE 3-METHYL-4,4-DIALKOXY-1-BUTALDEHYDE 有权
标题翻译：用于生产番茄红素中间体的3-甲基-4,4-二烷氧基-1- BUTALDEHYD
公开(公告)号：EP2799418A4
公开(公告)日：2015-05-27
申请号：EP12862813
申请日：2012-12-10
申请人： UNIV NANJING , ZHEJIANG MED XINCHANG PHARM
发明人： LV CHUNLEI , PI SHIQING , CHEN JIANHUI , LU DINGQIANG , OUYANG PINGKAI
IPC分类号： C07C45/00 , C07C45/51 , C07C47/198
CPC分类号： C07C45/30 , C07C41/22 , C07C45/00 , C07C45/516 , C07C47/198

13. 发明公开

EP2615100A4 FRUCTOSYLATED PUERARIN, AND PREPARATION METHOD THEREFOR AND USE THEREOF 有权
标题翻译： Fructosylated葛根，工艺用于生产和使用
公开(公告)号：EP2615100A4
公开(公告)日：2013-12-11
申请号：EP11831919
申请日：2011-09-23
申请人： UNIV NANJING
发明人： HE BINGFANG , WU XUEMING , CHU JIANLIN , WU BIN , ZHANG SEN , OUYANG PINGKAI
IPC分类号： C07H17/07 , A61K31/7048 , A61P9/00 , A61P35/00 , C12P19/60
CPC分类号： C07H15/26 , A61K31/353 , A61K31/7048 , C12N1/20 , C12P17/162 , C12P19/58 , C12P19/605

14. 发明公开

EP2657245A4 FRUCTOSYLATED MANGIFERIN AND PREPARATION METHOD THEREFOR AND USE THEREOF 有权
标题翻译： Fructosylated芒果，工艺用于生产和使用
公开(公告)号：EP2657245A4
公开(公告)日：2013-10-30
申请号：EP12807633
申请日：2012-03-08
申请人： UNIV NANJING
发明人： HE BINGFANG , WU XUEMING , CHU JIANLIN , WU BIN , ZHANG SEN , OUYANG PINGKAI
IPC分类号： C07H15/26 , A61K31/7048 , A61P35/00 , A61P35/02 , C12P19/58
CPC分类号： C07H15/26 , C12P17/06 , C12P19/00 , C12P19/14

15. 发明公开

EP2210904A4 FUSION PROTEIN COMPRISING TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND AND INTEGRIN LIGAND AND USE THEREOF 有权
标题翻译：与凋亡的TUMORNEKROSEFAKTORBEDINGTE诱导配体与整合素配和使用融合蛋白
公开(公告)号：EP2210904A4
公开(公告)日：2011-02-09
申请号：EP08851459
申请日：2008-10-08
申请人： UNIV NANJING
发明人： HUA ZICHUN , CAO LIN
IPC分类号： C07K19/00 , A61K38/16 , A61P35/00 , C12N15/62 , C12P21/02
CPC分类号： C07K14/4747 , A61K38/00 , C07K14/7151
摘要： Provided is a fusion protein comprising a tumor necrosis factor related apoptosis inducing ligand (TRAIL), integrin ligands of ±V²3 and ±V²5 and a linking peptide. Also provided are the expression method and simple separation and purification process for the production of the fusion protein which is soluble and has high content of the polymer, and use of the fusion protein for the manufacturing of a medicament for the treatment of tumor. The fusion protein has good tumor tissue targeting property, significantly enhanced anti-tumor effect, which can also reduce the dose of the needed protein for the target treatment effect, improve the bioavailability, reduce the treatment cost, decrease and overcome the potential toxic and side effects of the tumor necrosis factor-related apoptosis inducing ligand.

16. 发明公开

EP2774914A4 N-BENZYLANILINE DERIVATIVE AND USES THEREOF 有权转让
标题翻译： N-苯并苯胺衍生物及其用途
公开(公告)号：EP2774914A4
公开(公告)日：2015-07-01
申请号：EP12846586
申请日：2012-10-24
申请人： UNIV NANJING MEDICAL
发明人： ZHU DONGYA , LI FEI , LUO CHUNXIA
IPC分类号： A61K31/196 , A61K31/245 , A61P9/10 , A61P25/00 , A61P25/28 , A61P29/00 , C07C229/54 , C07C229/60 , C07C233/54
CPC分类号： C07C229/60 , A61K31/196 , A61K31/245 , C07C229/54 , C07C233/54 , C07C2603/64
摘要： Disclosed are an N-benzylaniline derivative and uses thereof. The derivative is a compound represented by formula I or a pharmaceutically acceptable salt thereof. The compound has an action of protecting against cerebral ischemia/reperfusion injury and an analgesic action for chronic pathologic pains, and may be used to prepare drugs for cerebral apoplexy, neuropathic pain, and inflammatory pain. Moreover, because of the unique mechanism of action of the compound, the compound can be used to prepare drugs for epilepsy, affective disorder, and neurodegenerative diseases.
摘要翻译：公开了N-苄基苯胺衍生物及其用途。该衍生物是由式I表示的化合物或其药学上可接受的盐。该化合物具有防止脑缺血/再灌注损伤和慢性病理性疼痛的镇痛作用，可用于制备脑中风，神经性疼痛和炎性疼痛的药物。此外，由于化合物的独特作用机理，该化合物可用于制备癫痫，情感障碍和神经退行性疾病的药物。

17. 发明公开

EP2745924A4 INTEGRATED SYSTEM TECHNIQUE FOR COUPLING FIXED BED AND JET FLUIDIZED BED TO SEPARATOR UNIT 有权
标题翻译：集成系统及方法硬床的交联和流化床分离器
公开(公告)号：EP2745924A4
公开(公告)日：2015-06-17
申请号：EP12807318
申请日：2012-05-25
申请人： UNIV NANJING
发明人： ZHOU ZHENG , ZHANG ZHIBING , YANG GAODONG , GONG XIONGHUI , WU PINGKENG
IPC分类号： B01J8/00
CPC分类号： B01D3/009 , B01J8/005 , B01J8/02 , B01J8/08 , B01J8/20 , B01J19/18 , B01J2208/00557 , B01J2219/00006 , B01J2219/0004 , C07C29/04 , C07C29/48 , C07C67/08 , C07C67/297 , C07C2101/16 , C07C2601/16 , Y02P20/582 , C07C33/025 , C07C33/14 , C07C69/14
摘要： This invention relates to a process of integrated system formed by coupling of fixed bed, jetting floating bed, and separating unit, aimed to provide a new process and equipment of higher efficiency, which integrates multi-type reactors and separation. In this invention, reaction materials will undergo preliminary reaction in fixed bed reactor and intensified reaction in jetting floating bed reactor, and then separation in the subsequent separation system. Unreacted materials will be returned to the raw material intermediate storage tank for mixing with fresh materials, as raw materials for continued reaction. During this process, materials first pass the fixed bed reactor once to achieve certain conversion rate, and then enter the jetting floating bed reactor for intensified reaction. When the product reaches required concentration, the materials will enter subsequent separation equipment for separation. During the whole process, fixed bed reactor, jetting floating bed reactor, and subsequent separation system are coupled, so that the flow path is more integrated, reaction time is greatly shortened, and process energy consumption is further lowered.
摘要翻译：本发明涉及通过固定床的耦合，喷射浮床，和分离单元上综合系统，目的在于提供高效率，它集成了多类型的反应器和分离的新工艺和设备的处理。在本发明中，反应材料将发生固定床反应器预反应并加剧了在随后的分离系统的喷射浮床反应器中，然后分离反应，未反应的材料将被返回到原料中间储罐与新鲜材料混合，作为用于持续反应的原料。在此过程中，材料先通过固定床反应器一旦达到一定的转化率，然后进入喷射浮床反应器，用于增强反应。当产物达到所需的浓度，该材料将进入随后的分离设备进行分离。在整个过程中，固定床反应器，喷射浮床反应器中，和随后的分离系统被耦合，所以没有流动路径是集成度更高，反应时间大大缩短，而且过程的能量消耗进一步降低。

18. 发明公开

EP2585812A4 MULTI-MODE INTERFEROMETER TECHNIQUE 审中-公开
标题翻译：多式联运干涉法
公开(公告)号：EP2585812A4
公开(公告)日：2014-06-11
申请号：EP10853449
申请日：2010-06-25
申请人： UNIV NANJING
发明人： LU YANQING , ZHANG SHUYI , ZHONG QI , XU FEI , LIN XIAOWEN , HU WEI
IPC分类号： G01N21/45 , G02B6/255 , G02F1/225
CPC分类号： G02B6/29344 , G01J2009/004 , G01N21/45 , G02B6/02295 , G02B6/14 , G02B6/2551 , G02B6/262
摘要： Technologies are generally described for techniques useful in an interferometer system. In some examples, a system may include a first waveguide effective to propagate a first wave in a first mode. In some examples, the system may include a second waveguide effective to, in response to the first wave, propagate second and third waves in second and third modes, respectively. In some examples, the second waveguide may be effective to reflect the second and third waves off a reflection surface to produce first, second, third and fourth reflected waves. In some examples, the second waveguide may be effective to propagate the first and third reflected waves in the second mode and propagate the second and fourth reflected waves in the third mode.

19. 发明公开

EP2420827A4 A METHOD OF PRUSSIAN BLUE DRESS ELECTRODE 有权
标题翻译：普鲁士ELECTRODES处理工艺
公开(公告)号：EP2420827A4
公开(公告)日：2014-05-07
申请号：EP09843214
申请日：2009-04-16
申请人： UNIV NANJING
发明人： JIN WANQIN , CHU ZHENYU , LIU YU , XU NANPING
IPC分类号： G01N27/30
CPC分类号： G01N27/30

20. 发明公开

EP2606887A4 DIINDOLYLMETHANE, PRECURSOR AND DERIVATIVES THEREOF IN PREPARATION OF MEDICAMENTS FOR TREATING LIVER DISEASES 有权
标题翻译： DIINDOLYLMETHAN和PRE及其衍生物的药品生产治疗肝病的治疗
公开(公告)号：EP2606887A4
公开(公告)日：2014-04-30
申请号：EP10856099
申请日：2010-12-28
申请人： UNIV NANJING
发明人： ZHANG JUNFENG , DONG LEI , HUANG ZHEN , ZHANG ZHENGPING
IPC分类号： A61K31/404 , A61P1/16
CPC分类号： A61K31/404
摘要： This invention relates to biopharmaceutical technology, specifically to the application of 3,3'-Diindolylmethane, indole-3-carbinol, and derivatives thereof in the preparation of drugs for treating such hepatic diseases as viral hepatitis, alcoholic hepatitis, drug-induced hepatitis, fatty liver, hepatic fibrosis and hepatic cirrhosis. The said indole-3-carbinol, diindolylmethane and derivatives thereof can effectively protect the human body from the damage resulting from ROS by inhibiting ROS-induced activation of hepatic stellate cells and correlated expression of collagen, which consequently ameliorates degree of hepatic fibrosis. Therefore they can be used in treatment of diseases related to hepatic fibrosis. As is verified in the animal models of hepatic fibrosis, the said indole-3-carbinol, diindolylmethane and derivatives thereof present excellent therapeutic effect and positive application prospect.

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