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11. 发明公开

EP1005354A4 PEPTIDE MIMETICS OF THE CYTOKINE RECEPTOR GAMMA CHAIN 失效
标题翻译：细胞因子γ链的模拟肽
公开(公告)号：EP1005354A4
公开(公告)日：2002-05-15
申请号：EP98906204
申请日：1998-02-06
申请人： UNIV JEFFERSON
发明人： TOWNSEND ROBERT MARTIN , KORNGOLD ROBERT
IPC分类号： C12N15/09 , A61K38/00 , A61P35/00 , A61P35/02 , A61P37/06 , A61P37/08 , A61P43/00 , C07K14/47 , C07K14/715 , A61K38/08 , A61K38/12
CPC分类号： C07K14/7155 , A61K38/00

12. 发明公开

EP1098968A4 NITRILASE HOMOLOGS 审中-公开
标题翻译： HOMOLOGE VON NITRILASE
公开(公告)号：EP1098968A4
公开(公告)日：2002-01-02
申请号：EP99934148
申请日：1999-07-20
申请人： UNIV JEFFERSON
发明人： CROCE CARLO M
IPC分类号： A61K38/00 , A61K48/00 , C12N9/78 , C12N15/11 , A61K39/395 , C12N15/12 , C12N15/52
CPC分类号： C12N9/78 , A61K38/00 , A61K48/00

13. 发明公开

EP0801526A4 GENE TRANSDUCTION SYSTEM 失效
标题翻译： GENTRANSDUKTIONSSYSTEM
公开(公告)号：EP0801526A4
公开(公告)日：1999-12-01
申请号：EP95944444
申请日：1995-12-29
申请人： UNIV JEFFERSON
发明人： STRAYER DAVID S
IPC分类号： C12N15/86 , A01N43/04 , A61K31/715 , C12N15/00 , C12N15/09 , C12P21/00
CPC分类号： C12N15/86 , C12N2710/22043

14. 发明公开

EP0840567A4 IMPLANTABLE SENSOR AND SYSTEM FOR MEASUREMENT AND CONTROL OF BLOOD CONSTITUENT LEVELS 失效
标题翻译： IMPLANTIERBARER SENSOR UND ANORDNUNG ZUR MESSUNG ANDD REGELUNG DES GEHALTES VON BLUTBESTANDTEILEN
公开(公告)号：EP0840567A4
公开(公告)日：1998-09-30
申请号：EP96923706
申请日：1996-07-08
申请人： UNIV JEFFERSON , CROTHALL KATHERINE D
发明人： JOSEPH JEFFREY I , SUN XIAOGUANG , CROTHALL KATHERINE D
IPC分类号： A61B5/145 , A61B5/00 , A61B5/029 , A61B5/1459 , A61B5/1495 , A61M5/142 , A61M5/172
CPC分类号： A61M5/14276 , A61B5/0031 , A61B5/029 , A61B5/14532 , A61B5/1459 , A61B5/412 , A61B5/6876 , A61B5/6884 , A61M5/1723 , A61M2205/3507
摘要： An implantable device for sensing in vivo the level of at least one blood constituent in mammalian vascular tissue has at least one source of radiation from infrared through visible light, arranged to direct the radiation at the tissue where it is affected by interaction with the tissue, and a plurality of detectors. Each detector has associated with it a filter transparent to a discrete narrow band of radiation, and each detector provides an output signal representative of detected radiation in that narrow band. The detectors are located with respect to the tissue to receive radiation affected by the tissue. The invention also encompasses a device for measuring and controlling the level of a blood constituent, such as glucose, in a mammal, and includes an implantable infrared source and sensor module for directing infrared radiation through vascular tissue and for sensing the infrared radiation after it has passed through the tissue and generating an output signal representative of the sensed infrared radiation. The device includes a processor module responsive to the output signal from the infrared source and sensor module which performs spectral analysis of the output signal and derives from that analysis a control signal representative of the level of the blood constituent. The device further includes an insulin pump for dispensing doses of insulin in response to the control signal for blood glucose regulation.
摘要翻译：本发明是能够测量，控制，监测和报告血液成分水平的可植入传感器和系统。所述植入式传感器（14）用于体内感测哺乳动物血管组织（20,24）中的至少一种血液成分的水平，所述至少一种血液成分具有至少一个来自红外至可见光的辐射源，被布置成将辐射引导至其处的组织受到与组织相互作用的影响，以及至少一个检测器。本发明还包括用于测量和控制诸如葡萄糖或氧气的血液成分的水平的装置，并且包括用于生成表示所感测的红外辐射的输出信号的可植入的红外源和传感器模块。该系统包括响应输出信号的处理器模块，该输出信号执行输出信号的频谱分析并产生控制信号。该系统还包括用于响应控制信号分配（16）药物剂量或控制器官功能的其他装置。

15. 发明公开

EP0744980A4 DETRUSOR MYOPLASTY AND NEURO-MUSCULAR ELECTRICAL STIMULATION 失效
标题翻译：逼尿肌肌肉和神经肌肉电刺激的MYOPLASTISCHE操作
公开(公告)号：EP0744980A4
公开(公告)日：1998-02-25
申请号：EP95905858
申请日：1994-12-06
申请人： UNIV JEFFERSON
发明人： CHANCELLOR MICHAEL B
IPC分类号： A61N1/36
CPC分类号： A61N1/36007 , A61N1/36042
摘要： An implantable micturition inducer is disclosed. The device comprises an implantable actuatable signal generator (15) that comprises one or more switches (17) and a power source, and at least one electrical lead (16) having one end connected to the signal generator and the other end adapted to be connected to muscle (14) transected to form a muscle bag around an individual's bladder. Actuation of the switch or switches results in the delivery of a series of stimulus pulses from the signal generator to the muscle bag which are sufficient to cause the muscle bag to contract and thereby induce micturition on demand. Methods for inducing micturition in patients with areflexic bladders of an otherwise diminished capacity to intentionally micturate are disclosed.

16. 发明公开

EP0674705A4 ANTISENSE OLIGONUCLEOTIDES TO INHIBIT EXPRESSION OF MUTATED AND WILD TYPE GENES FOR COLLAGEN. 失效
标题翻译：反义寡核苷酸表达抑制突变基因和胶原蛋白的野生型基因。
公开(公告)号：EP0674705A4
公开(公告)日：1997-11-26
申请号：EP94901327
申请日：1993-11-09
申请人： UNIV JEFFERSON
发明人： PROCKOP DARWIN , COLIGE ALAIN , BASERGA RENATO , NUGENT PAUL
IPC分类号： C12N15/09 , A61K31/70 , A61K31/7088 , A61K48/00 , A61P1/16 , A61P11/00 , A61P17/00 , C07H21/04 , C12N15/113 , C12N5/16 , C12N5/22 , C12N15/11 , C12P19/34
CPC分类号： A61K31/70 , C12N15/113 , C12N2310/315

17. 发明公开

EP0733059A4 COMPOUNDS AND METHODS FOR SITE-DIRECTED MUTATIONS IN EUKARYOTIC CELLS 失效
标题翻译：连接和方法在真核细胞LOCAL特定突变
公开(公告)号：EP0733059A4
公开(公告)日：1997-05-21
申请号：EP95905337
申请日：1994-12-09
申请人： UNIV JEFFERSON
发明人： KMIEC ERIC B
IPC分类号： A01K67/027 , C07H21/00 , C07H21/02 , C07H21/04 , C07K14/82 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/80 , C12N15/90 , C12N15/00
CPC分类号： A01K67/0275 , A01K2217/05 , C07H21/00 , C07K14/82 , C12N15/80 , C12N15/907

18. 发明公开

EP0281621A4 GLUCOSE FREE MEDIA FOR STORING BLOOD PLATELETS. 有权
标题翻译：没有葡萄糖的媒体上存储的血小板。
公开(公告)号：EP0281621A4
公开(公告)日：1990-01-11
申请号：EP87906352
申请日：1987-09-08
申请人： UNIV JEFFERSON
发明人： MURPHY SCOTT
IPC分类号： A01N1/02 , A61K35/14
CPC分类号： A01N1/0226 , A01N1/02 , A61K35/19
摘要： Novel methods and storage media for storing platelets in a viable condition for at least five days are disclosed. The disclosed methods comprise the steps of providing a platelet rich suspension of platelets and blood plasma; extracting supernatant plasma from that suspension to leave between about 1 to 15 mls of plasma per unit of blood platelets with those platelets to produce a concentrated platelet button; adding 40 to 70 ml/unit of a glucose free aqueous solution to said concentrated platelet button; agitating the resultant solution to resuspend the platelets to provide a synthetic suspension of those platelets; and storing that synthetic suspension in an oxygen permeable container at about 22 DEG C., until needed for use. Two preferred glucose free aqueous platelet storage media are disclosed which generally comprise sodium citrate, sodium chloride, potassium chloride, and either sodium phosphate or calcium chloride, but not both. The subject media also optionally comprise magnesium sulfate. Results comparable to storing blood platelets in plasma are disclosed using media which free plasma for other uses and which may reduce the risk of disease transmission from platelet infusion.

19. 发明公开

EP0206025A2 Coating for prosthetic devices. 失效
标题翻译：涂层假牙。
公开(公告)号：EP0206025A2
公开(公告)日：1986-12-30
申请号：EP86107600
申请日：1986-06-04
申请人： UNIV JEFFERSON
发明人： WILLIAMS STUART KONRADD , JARRELL BRUCE EVANS
IPC分类号： A61L27/00 , A61L27/34 , A61L27/38 , A61L27/50
CPC分类号： A61L27/3843 , A61L27/34 , A61L27/507 , A61L27/38 , C08L89/06 , A61L27/36 , A61F2/06
摘要： A novel implantable prosthesis for implantation in human patients is disclosed which comprises a synthetic substrate and a Type IV/V collagen surface layer seeded with a confluent monolayer of autologous endothelial cells. In the preferred embodiment, a base layer of interstitial collagen is adhered to the substrate. The Type IV/V collagen surface layer is provided in a laminate comprising an intermediate layer of interstitial collagen which is covalently bound to the aforementioned base layer. A cross linking agent, such as glutaraldehyde, is utilized to covalently bind the interstitial collagen base layer to the substrate, and the collagen intermediate layer to the base layer. The cross linking agent is subsequently deactivated with a soluble peptide, such as lysine. Autologous endothelial cells, such as microvascular endothelial cells derived from adipose tissue, are then seeded at high densities on the pretreated graft material. Those cells adhere in suitable percentages within times compatible with most vascular surgical procedures, and, even more importantly, flatten on that surface to assume the appearance of a natural, cobblestone morphology. The subject surface is resistant to shear stress, and yields good results when tested as a vena cava implant in dog.

20. 发明公开

EP3105327A4 COMPOSITIONS AND METHODS OF USING MICRORNA INHIBITORS 审中-公开
公开(公告)号：EP3105327A4
公开(公告)日：2017-10-18
申请号：EP15748702
申请日：2015-02-12
申请人： UNIV JEFFERSON
发明人： WICKSTROM ERIC , JIN YUAN-YUAN
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , C12N2310/113 , C12N2310/3181 , C12N2310/3231 , C12N2310/341

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