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11. 发明公开

EP3091067A4 CELL TRAY AND DEVICE, METHOD AND SYSTEM FOR PRODUCING CELL STRUCTURE 有权
标题翻译： ZELLENTRÄGERUND VORRICHTUNG，VERFAHREN UND SYSTEM ZUR HERSTELLUNG EINER ZELLSTRUKTUR
公开(公告)号：EP3091067A4
公开(公告)日：2017-02-08
申请号：EP15845301
申请日：2015-09-25
申请人： CYFUSE BIOMEDICAL K K
发明人： KUCHIISHI KOJI , TAMURA TADASHI
IPC分类号： C12M1/00 , C12N5/07 , C12N11/02
CPC分类号： C12N5/0062 , C12M21/08 , C12M23/12 , C12M25/00 , C12M33/04 , C12M33/06 , C12M41/46 , C12N5/00 , C12N11/00
摘要： Provided are: a cell tray provided with a concave part for supporting a cell aggregate and a hole formed on the bottom of the concave part; and a device for producing a cell structure, said device being provided with the cell tray and a puncture part passing through the cell tray and the cell aggregate, characterized in that the puncture part passes through the cell aggregate supported by the concave part until the tip thereof intrudes into the hole. Also provided is a system for producing a cell structure, said system comprising: a determination part that examines the characteristics of cell aggregates; a fractionation part that classifies the cell aggregates depending on the results of the examination by the determination part; a discharge part that disposes the cell aggregates in a cell tray depending on the results of the classification by the fractionation part; a puncture part that pass through a plurality of cell aggregates disposed in the cell tray; and a holding part that aligns and holds a plurality of puncture parts passing through a plurality of cell aggregates.
摘要翻译：提供有：设置有用于支撑细胞骨架的凹部的细胞托盘和形成在凹部的底部上的孔; 以及用于制造电池结构的装置，所述装置设置有电池托盘和穿过电池托盘和电池组件的穿孔部件，其特征在于，穿刺部件穿过由凹部支撑的电池组件，直到尖端其侵入孔中。还提供了一种用于生产细胞结构的系统，所述系统包括：确定部分，其检查细胞聚集体的特性; 分解部，其根据测定部的检查结果对细胞聚集进行分类; 排出部，其根据分级部的分类结果将细胞聚集体配置在细胞托盘中; 刺穿部，其穿过设置在所述细胞托盘中的多个细胞聚集体; 以及保持部，其对准并保持穿过多个细胞聚集体的多个穿刺部。

12. 发明公开

EP2781590A1 DEVICE FOR MANUFACTURING SUPPORTING BODY FOR CELL STRUCTURE MANUFACTURE 审中-公开
标题翻译： VORRICHTUNG ZUR HERSTELLUNG EINESSTÜTZKÖRPERSZUR HERSTELLUNG EINER ZELLKULTUR
公开(公告)号：EP2781590A1
公开(公告)日：2014-09-24
申请号：EP12848980.4
申请日：2012-11-16
申请人： Saga University , Cyfuse Biomedical K. K.
发明人： NAKAYAMA Koichi
IPC分类号： C12M3/00 , C12N5/071 , C12N11/00
CPC分类号： C12N5/0062 , C12M21/08 , C12M25/00 , C12M25/14 , C12M33/04 , Y10T29/49826 , Y10T29/53961
摘要： A device for manufacturing a support for fixing cells of the present invention is capable of easily manufacturing a support that has needle-like bodies arranged on a base. The manufacturing device 2 is provided with a base 10, a holder 4, an insertion guide 6 and an alignment mechanism. The base 10 is retained by a holder 4. The base 10 is provided with a plurality of openings 15, into which needle-like bodies 20 are inserted and fixed. An insertion guide 6 is provided next to the holder 4 and includes slots 12 for placing a plurality of needle-like bodies 20 generally parallel to each other. The insertion guide 6 is provided with a plurality of slots 12 for placing the needle-like bodies 20 at corresponding positions to the openings 15, so that the alignment mechanism moves the insertion guide 6 such that the feed openings 12a are positioned adjacent to the openings 15. After positioning the feed openings 12a adjacent to the openings 15, the needle-like bodies 20 are introduced into the openings 15, whereby the needle-like bodies 20 are implanted into the base 10 to form a support.
摘要翻译：用于制造本发明的固定单元的支撑体的装置能够容易地制造布置在基部上的具有针状物体的支撑体。制造装置2设置有基部10，保持器4，插入引导件6和对准机构。基座10由保持器4保持。基座10设置有多个开口15，针状体20插入并固定到开口15中。插入引导件6设置在保持器4的旁边，并且包括用于放置大体上彼此平行的多个针状体20的槽12。插入引导件6设置有多个狭缝12，用于将针状物体20放置在与开口15相对应的位置，使得对准机构移动插入引导件6，使得进给开口12a邻近开口在将进给开口12a定位在与开口15相邻的位置之后，将针状体20引入到开口15中，由此将针状体20注入到基部10中以形成支撑体。

13. 发明公开

EP2671539A1 TRANSPLANT GUIDING PART AND TRANSPLANT TOOL 有权转让
标题翻译： TRANSPLANTATFÜHRUNGSTEILUND TRANSPLANTATWERKZEUG
公开(公告)号：EP2671539A1
公开(公告)日：2013-12-11
申请号：EP12741664.2
申请日：2012-02-03
申请人： Cyfuse Biomedical K. K.
发明人： NAKAYAMA Koichi
IPC分类号： A61F2/02 , A61L31/00
CPC分类号： C12M33/00 , A61B2017/00004 , A61B2017/00907 , A61B2017/00969 , C12M23/06 , C12M25/02 , C12M33/04
摘要： The present invention provides a transplantation guide which is formed into a bottomed cylinder having a base material that allows communication of a culture fluid, wherein:
a cell mass supplied from the open end side is placed on the base material, and
the guide is used as a mold for forming a three-dimensional cell construct by culturing the cell mass placed on the base material by immersing the base material side in an excessive amount of a culture fluid.
摘要翻译：本发明提供一种移植引导件，其形成为具有允许培养流体连通的基材的有底圆筒，其中：从开口端供给的细胞块放置在基材上，将引导件用作通过将基材侧浸渍在过量的培养液中来培养放置在基材上的细胞块来形成三维细胞构建体的模具。

14. 发明公开

EP3514225A1 CELL STRUCTURE PRODUCTION DEVICE 有权
公开(公告)号：EP3514225A1
公开(公告)日：2019-07-24
申请号：EP17911399.8
申请日：2017-10-30
申请人： Cyfuse Biomedical K. K.
发明人： KISHII Yasuto , TOKUNAGA Norihiko
IPC分类号： C12M3/00
摘要： The cell structure producing apparatus including needles, a sticking unit configured to detachably hold an end portion of each of the needles, descend the each of the needles with respect to a cell tray in which cell aggregates are held, stick and penetrate each of the cell aggregates with the tip end, and ascend the needle after sticking, at least one time or more, a base unit, and a control unit configured to move the sticking unit so that for the each of the needles, each of the needles sticking the cell aggregates is positioned at a predetermined position over the base unit, descend each of the needles by a predetermined amount to stick the tip end into the base unit at the predetermined position on the base unit, and control the sticking unit.

15. 发明公开

EP3222997A4 QUALITY EVALUATION METHOD AND QUALITY EVALUATION DEVICE 审中-公开
公开(公告)号：EP3222997A4
公开(公告)日：2017-11-29
申请号：EP15860167
申请日：2015-11-18
申请人： SUMITOMO ELECTRIC INDUSTRIES , CYFUSE BIOMEDICAL K K , KYOTO STEM CELL INNOVATION INC
发明人： SUGANUMA HIROSHI , OKUNO TAKUYA , MOTOMURA ASAKO , AKIEDA SHIZUKA , TSUJI MANAMI , OKINA YUNA , SUGIYAMA YOKO , AIBA KAZUHIRO , LIU LI
IPC分类号： G01N21/359 , G01N21/47
CPC分类号： G01N21/255 , G01J3/42 , G01N17/004 , G01N21/01 , G01N21/359 , G01N21/4738 , G01N2021/0106 , G01N2201/10 , G01N2201/129 , G06F17/30247 , G06K9/00147 , G06K9/0055 , G06N99/005 , G06T2207/30024
摘要： A quality evaluation method includes an acquisition step of acquiring spectral data related to transmitted light or diffusely reflected light from a cell mass by irradiating the cell mass with measurement light including near-infrared light, and an evaluation step of evaluating quality of the cell mass, based on the spectral data of the cell mass acquired in the acquisition step.

16. 发明公开

EP2781590A4 DEVICE FOR MANUFACTURING SUPPORTING BODY FOR CELL STRUCTURE MANUFACTURE 审中-公开
标题翻译：器具，用于产生支撑体，用于生产细胞培养
公开(公告)号：EP2781590A4
公开(公告)日：2015-07-15
申请号：EP12848980
申请日：2012-11-16
申请人： UNIV SAGA , CYFUSE BIOMEDICAL K K
发明人： NAKAYAMA KOICHI
IPC分类号： C12M3/00 , A61L27/00 , C12N5/071 , C12N11/00
CPC分类号： C12N5/0062 , C12M21/08 , C12M25/00 , C12M25/14 , C12M33/04 , Y10T29/49826 , Y10T29/53961

17. 发明公开

EP2725091A4 CELL STRUCTURE PRODUCTION DEVICE 有权转让
标题翻译：器具，用于产生胞状结构
公开(公告)号：EP2725091A4
公开(公告)日：2015-04-01
申请号：EP12802594
申请日：2012-06-19
申请人： NAT UNIVERSITY INCOPORATION SAGA UNIVERSITY , CYFUSE BIOMEDICAL K K , SHIBUYA KOGYO CO LTD
发明人： NAKAYAMA KOICHI , YONEDA KENJI , SAKAMOTO MASAHIRO , KOSHIDA ICHIRO , SHOMURA MASAHARU , FUKAMURA ISAO
IPC分类号： C12M3/00 , C12M1/12 , C12M1/32
CPC分类号： C12M33/04 , C12M21/08 , C12M23/12 , C12M25/00 , C12M25/14 , C12M25/16

18. 发明公开

EP2725091A1 CELL STRUCTURE PRODUCTION DEVICE 有权转让
标题翻译： VORRICHTUNG ZUR HERSTELLUNG EINER ZELLSTRUKTUR
公开(公告)号：EP2725091A1
公开(公告)日：2014-04-30
申请号：EP12802594.7
申请日：2012-06-19
申请人： National University Incoporation Saga University , Cyfuse Biomedical K. K. , SHIBUYA KOGYO CO., LTD
发明人： NAKAYAMA, Koichi , YONEDA, Kenji , SAKAMOTO, Masahiro , KOSHIDA, Ichiro , SHOMURA, Masaharu , FUKAMURA, Isao
IPC分类号： C12M1/00 , A61L27/00 , C12N11/02
CPC分类号： C12M33/04 , C12M21/08 , C12M23/12 , C12M25/00 , C12M25/14 , C12M25/16
摘要： A device 2 for producing a three-dimensional structural body comprising an accommodating plate 3 in which an accommodating recess portion 3a for accommodating a cell mass 1 is formed, a support body 4 provided with a plurality of needle-shaped bodies 6 penetrating the cell mass, a suction nozzle 19 for adsorbing/holding the cell mass, and moving means 20 for moving the suction nozzle.
The suction nozzle is provided with a tubular adsorbing portion 19a for adsorbing/holding one cell mass, and a diameter of the adsorbing portion is formed smaller than an outer diameter of the cell mass and larger than an outer peripheral diameter of a needle-shaped body 6a of the support body 4.
When the cell mass is adsorbed/held by the adsorbing portion of the suction nozzle, the moving means moves the suction nozzle to above the needle-shaped body and further moves the suction nozzle in an axial direction of the needle-shaped body, the needle-shaped body is stuck into the cell mass, and the needle-shaped body penetrating the cell mass is inserted into the adsorbing portion.
The three-dimensional structural cell can be produced automatically.
摘要翻译：一种用于制造三维结构体的装置2，包括：容纳板3，其中形成有用于容纳电池块1的容纳凹部3a;支撑体4，其设置有穿过电池块的多个针状体6 ，用于吸附/保持电池块的吸嘴19和用于移动吸嘴的移动装置20。吸嘴设置有用于吸附/保持一个电池组的管状吸附部分19a，并且吸附部分的直径形成为小于电池组件的外径并且大于针状体的外周径当细胞块被吸嘴的吸附部分吸附/保持时，移动装置将吸嘴移动到针状体上方，并使吸嘴沿轴向方向移动针状体，将针状体粘贴到细胞块中，将穿透细胞块的针状体插入吸附部。三维结构单元可以自动生成。

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