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11. 发明公开

EP0917574A2 BCL-x$g(g), A NOVEL BCL-x ISOFORM, AND USES RELATED THERETO 失效
标题翻译： BCL-γ，一种新的BCL-X亚型和事实基础的应用
公开(公告)号：EP0917574A2
公开(公告)日：1999-05-26
申请号：EP97936180.0
申请日：1997-07-25
申请人： DANA-FARBER CANCER INSTITUTE
发明人： YANG, Xiao-Feng , WEBER, Georg, F. , CANTOR, Harvey
IPC分类号： C07K14 , C12N15 , A61K38
CPC分类号： C07K14/4747 , A01K2217/05 , A61K38/00 , C07K2319/00
摘要： The present invention relates to BCL-xη, a novel isoform of the BCL-x family of proteins which is predominantly expressed in T-lymphocytes and is associated with resistance to apoptosis. Both compositions of matter and methods are described which are useful in the treatment or prevention of immune system disorders.

12. 发明公开

EP0898709A2 $i(IN VITRO) FLUORESCENCE POLARIZATION ASSAY 失效
标题翻译：在维多利亚州 - 极地考察
公开(公告)号：EP0898709A2
公开(公告)日：1999-03-03
申请号：EP97922393.0
申请日：1997-04-18
申请人： ARIAD PHARMACEUTICALS, INC.
发明人： LYNCH, Berkley, A. , MACNEIL, Ian, A. , ZOLLER, Mark, J.
IPC分类号： G01N21 , G01N33
CPC分类号： G01N33/542
摘要： An in vitro assay method permits the identification of a test substance which inhibits the mutual association of a pair of proteins. The method includes the steps of providing a pair of proteins capable of mutual association, one of said proteins bearing a covalently linked fluorophore; preparing a mixture containing the two proteins and at least one test substance; irradiating the mixture with polarized light of a suitable wavelength permitting excitation of the fluorophore as indicated by emission of polarized light; measuring the degree of polarization of the emission, and determining the effect of the presence or concentration of the test substance in decreasing the observed emission polarization of a mixture of the two proteins alone. Inhibitory activity of in the test substance correlates with decreased depolarization values.

13. 发明公开

EP0894132A2 ADAM PROTEINS AND USES THEREOF 失效
标题翻译： ADAM蛋白及其用途
公开(公告)号：EP0894132A2
公开(公告)日：1999-02-03
申请号：EP97917346.0
申请日：1997-04-16
申请人： THE UNIVERSITY OF SHEFFIELD
发明人： CROUCHER, Peter, Ian , MCKIE, Norman , RUSSELL, Robert, Graham, Goodwin
IPC分类号： C07K14 , C12N9 , C12N15 , A61K38 , A61K48
CPC分类号： C12N9/6489 , A61K38/00 , A61K48/00 , C07K14/705
摘要： Described are ADAM 12 proteins, species variants, homologues, allelic forms, mutant forms, derivatives, muteins and equivalents thereof, and various individual domains of ADAM 12 proteins, various domain combinations, inhibitors thereof and various forms of therapy, diagnosis and prophylaxis based thereon. Various therapeutic, diagnostic and prophylatic applications of proteins of the ADAM (reprolysin) family in general, as well as their individual domains, domain combinations, inhibitors and other materials based thereon, are also described.

14. 发明公开

EP0879091A1 SOLIDS SCRAPING ASSEMBLY FOR A CENTRIFUGE 失效
标题翻译：离心机固体废料装配
公开(公告)号：EP0879091A1
公开(公告)日：1998-11-25
申请号：EP96937897.0
申请日：1996-10-24
申请人： Carr Separations Inc.
发明人： CARR, Robert, B.
IPC分类号： B04B3 , B04B11
CPC分类号： B04B11/08 , B04B2011/086 , B04B2011/088
摘要： A scraper assembly (32) for removing the collected solids component (50) of a feed material from an interior wall surface (28) of a centrifugal separator bowl (18) comprises a supporting shaft (34) positioned within the bowl (18) along a vertically disposed longitudinal axis. The supporting shaft (34) is pivotal between a stowed position and an operational position. At least two longitudinally spaced scraper blades (36) are attached to the supporting shaft (34) along the longitudinal axis and are adapted to contact the solids component (50) when the support shaft (34) is in the operational position. An upper scraper blade (36) is angularly offset with respect to the lower scraper blade (36) along the longitudinal axis so that any collected solids component (50) removed by the upper scraper blade (36) may freely drop clear of the lower scraper blade (36).
摘要翻译：用于从离心分离器转筒（18）的内壁表面（28）移除进料的收集固体成分（50）的刮板组件（32）包括沿着转筒（18）定位在转筒（18）内的支撑轴（34）垂直设置的纵向轴线。支撑轴（34）在收起位置和操作位置之间枢转。至少两个纵向间隔的刮刀片（36）沿纵向轴线连接到支承轴（34）上，并且适于在支承轴（34）处于操作位置时与固体部件（50）接触。上部刮刀（36）沿着纵向轴线相对于下部刮刀（36）成角度地偏移，使得由上部刮刀（36）移除的任何收集的固体成分（50）可以自由地从下部刮刀刀片（36）。

15. 发明公开

EP0877620A1 PEPTIDES FOR ALTERING OSTEOBLAST ADHESION 失效
标题翻译：肽变革成骨细胞的黏附
公开(公告)号：EP0877620A1
公开(公告)日：1998-11-18
申请号：EP97904788.0
申请日：1997-01-15
申请人： RENSSELAER POLYTECHNIC INSTITUTE
发明人： DEE, Kay, C. , ANDERSEN, Thomas, T. , BIZIOS, Rena
IPC分类号： A61K38 , A61K31 , A61L27 , A61P19 , C07K5 , C07K7 , C12N5 , A61K35
CPC分类号： C07K7/06 , A61K35/12 , A61K38/00 , A61L27/227 , A61L27/34 , C07K5/1019 , C12N5/0068 , C12N5/0654 , C12N2533/30 , C12N2533/50 , A61F2/28 , C08L89/00
摘要： Peptides containing the amino acid sequence, aa1-aa2-aa3-aa4-(Gly)n, devices for implantation coated with the peptides and methods for altering cell adhesion using the peptides are disclosed. The residues aa1, aa2, and aa4 are independently Lys, Arg, Orn or, when the residue is N-terminal, Acp. The residue aa3 is Ala, Gly, Val, Leu, Ile, Ser, Thr, Cys, Met, Asn, Nle, Nva or Abu. The preferred sequence is KRSR. Peptides containing cell adhesion-related sequences can be incorporated into or coated onto substrates to enhance osteoblast adhesion.

16. 发明公开

EP0866712A1 ANTINEOPLASTIC METHODS AND COMPOSITIONS EMPLOYING OPTICALLY PURE (-)-FOTEMUSTINE 失效
标题翻译：（ - ） - FOTEMUSTINE的抗移植方法和组合物
公开(公告)号：EP0866712A1
公开(公告)日：1998-09-30
申请号：EP96941430.0
申请日：1996-11-19
申请人： SEPRACOR, INC.
发明人： GRAY, Nancy, M.
IPC分类号： A61K31 , A61P35
CPC分类号： A61K31/662
摘要： Methods and compositions are disclosed utilizing optically pure (-)-fotemustine for the treatment of various malignancies, while substantially reducing the concomitant liability of adverse effects associated with the racemic mixture of fotemustine.
摘要翻译：公开了使用光学纯的（ - ） - 福莫司汀用于治疗各种恶性肿瘤的方法和组合物，同时显着降低与福莫司汀的外消旋混合物相关的副作用的伴随可能性。

17. 发明公开

EP0862492A1 A SOLID PHASE SYNTHESIS REACTION VESSEL AND METHOD OF USING THE SAME 失效
标题翻译：反应容器固相合成和使用DESSELBEM方法
公开(公告)号：EP0862492A1
公开(公告)日：1998-09-09
申请号：EP96933035.0
申请日：1996-09-18
申请人： PHARMACOPEIA, INC.
发明人： DILLARD, Lawrence, W. , HENDERSON, Ian , OHLMEYER, Michael, H., J. , READER, John, C.
IPC分类号： B01J8 , B01J19 , C07B61 , C08F2 , C08G85 , C40B60
CPC分类号： B01J19/0046 , B01J2219/00286 , B01J2219/00342 , B01J2219/00346 , B01J2219/00414 , B01J2219/00418 , B01J2219/00423 , B01J2219/00459 , B01J2219/00479 , B01J2219/00484 , B01J2219/00493 , B01J2219/00495 , B01J2219/005 , B01J2219/0059 , B01J2219/00596 , C40B60/14
摘要： A solid phase synthesis reaction vessel (1) includes a vessel (1) with a first inlet (3), a second inlet (5), and an outlet (7). A first stopcock (11) is disposed within the first inlet (3) and a second stopcock (13) is disposed within the outlet (7). Solid phase material is prevented from escaping the reaction vessel (1) via the outlet (7) while allowing fluid to flow through the outlet by a frit (9). In one embodiment, the reaction vessel (1) includes an outer hollow shell (31, 34) surrounding the vessel (1) to allow cooling or heating fluid to flow therein for controlling the temperature in the interior reaction volume (15). The solid phase synthesis reaction vessel (1) provides for the independent opening and closing of each of the inlets (3) and outlet (7) to provide for various ways of draining the vessel (1), varying the conditions within the vessel (1), and/or adding additional materials into the vessel (1).

18. 发明公开

EP0861070A2 USE OF NADPH OXIDASE INHIBITORS FOR THE MANUFACTURE OF A MEDICAMENT FOR PREVENTION OF ATHEROSCLEROSIS 失效
标题翻译： NADPH氧化酶抑制剂的药物生产用于预防动脉硬化
公开(公告)号：EP0861070A2
公开(公告)日：1998-09-02
申请号：EP96940912.0
申请日：1996-11-27
申请人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK
发明人： HOLLAND, James A. , JOHNSON, David K.
IPC分类号： C12N9 , A61K31 , A61K45 , A61P9 , A61P43
CPC分类号： A61K31/235 , Y10S514/824
摘要： A method for the prevention and treatment of atherosclerosis and its related diseases in mammals, in which an NADPH oxidase inhibitor is administered, is provided. The NADPH oxidase inhibitor prevents the production of reactive oxygen species upon exposure of endothetial cells to atherogenic LDL levels, thus resulting in decreased endocytosis and vascular hyperpermeability. Preferred NADPH oxidase inhibitors are of formula (I). Additionally, there is provided a diagnostic method for predicting risk of a human patient to atherosclerotic-related diseases.

19. 发明公开

EP0850304A1 CEREBELLUM-DERIVED GROWTH FACTORS, AND USES RELATED THERETO 失效
标题翻译：生长因子FROM ZERBELLUM及其用途
公开(公告)号：EP0850304A1
公开(公告)日：1998-07-01
申请号：EP96932981.0
申请日：1996-09-09
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , Trustees of Leland S. Stanford University
发明人： CHANG, Han
IPC分类号： C12N15 , C07K14 , C07K16 , C12Q1 , A61K48
CPC分类号： C07K14/4756 , A01K2217/05 , A61K48/00 , C07K2319/00
摘要： The present invention relates to erbB receptor ligands, referred to hereinafter as 'cerebellum-derived growth factors' or 'CDGFs', which proteins have apparently broad involvement in the formation and maintenance of ordered spatial arrangements of differentiated tissues in vertebrates, and can be used to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.

20. 发明公开

EP0837701A1 TERMINALLY STERILIZED OSTEOGENIC DEVICES AND PREPARATION THEREOF 失效
标题翻译： TERMINAL消毒的成骨设备和生产
公开(公告)号：EP0837701A1
公开(公告)日：1998-04-29
申请号：EP96922473.0
申请日：1996-06-07
申请人： STRYKER CORPORATION
发明人： TUCKER, Marjorie, M. , RUEGER, David, C. , SAMPATH, Kuber, T.
IPC分类号： A61L2 , A61L27
CPC分类号： A61L2/007 , A61L2/0011 , A61L2/0035 , A61L27/12 , A61L27/20 , A61L27/227 , A61L27/24 , Y10S530/84 , C08L1/28
摘要： Disclosed are terminally sterilized osteogenic devices for implantation into a mammal. The devices contain a combination of a biologically active osteogenic protein and an insoluble carrier which after being combined are sterilized by exposure to ionizing radiation, for example, by exposure to gamma rays or an electron beam. The terminally sterilized devices of the invention are characterized in that they induce bone formation following implantation into a mammal. Also disclosed is a method for inducing bone formation in a mammal by implanting a terminally sterilized device of the invention into a preselected locus in a mammal. Also disclosed is a method for preparaing the terminally sterilized device of the invention.

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