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11. 发明公开

EP0825189A1 1,4-BENZODIOXIN DERIVATIVES 失效
标题翻译： 1,4-苯并二衍生物
公开(公告)号：EP0825189A1
公开(公告)日：1998-02-25
申请号：EP96913732.2
申请日：1996-05-13
申请人： NISSHIN FLOUR MILLING CO., LTD.
发明人： TAKAHASHI, Toshihiro Nisshin Fluor Milling Co., , INOMATA, Kohei Nisshin Fluor Milling Co., Ltd. , OSHIDA, Norio Nisshin Fluor Milling Co., Ltd. , KUBOTA, Nobutoshi Nisshin Fluor Milling Co., Ltd. , HAMADA, Tamiko Nisshin Fluor Milling Co., Ltd. , IWATA, Naohito Nisshin Fluor Milling Co., Ltd.
IPC分类号： C07D319/20 , A61K31/335
CPC分类号： C07D405/06 , C07D319/20 , C07D407/12 , C07D413/06
摘要： A 1,4-benzodioxin derivative represented by formula ( )
wherein A is an aryl group or a (C 3 -C 8 )cycloalkyl group, R 1 and R 2 individually are a hydrogen atom, a halogen atom, an alkyl group, a trifluoromethyl group, an alkoxy group, an aryl group, an aryloxy group, or R 1 and R 2 together form a methylenedioxy group, R 3 is a hydrogen atom or an alkyl group, R 4 is a hydrogen atom or CO 2 R 5 , R 5 is a hydrogen atom or an alkyl group, X is a radical of formula ( ) or ( )
wherein n is 1 or 2.
The compounds are useful for a prophylactic or therapeutic agent for diabetes, hyperglycemia and obesity.
摘要翻译：其中A为芳基或（C3-C8）环烷基的式（Ⅰ）所表示的1,4-苯并二恶英衍生物，R1和R2分别为氢原子，卤素原子，烷基，三氟甲基，烷氧基，芳基，芳氧基或R 1和R 2一起形成亚甲二氧基，R 3为氢原子或烷基，R 4为氢原子或CO 2 R 5，R 5为氢原子或烷基，X是式（@）或（@）的基团，其中n为1或2.该化合物可用于糖尿病，高血糖症和肥胖症的预防或治疗剂。

12. 发明公开

EP0815858A1 Pharmaceutical composition for the treatment of leukemia containing 9-cis-retinoic acid-alpha-tocopherol ester 失效
标题翻译：药物化学治疗Zusammensetzung zur Behandlung derLeukämieenthaltend 9-顺式视黄醛-α-生育酚
公开(公告)号：EP0815858A1
公开(公告)日：1998-01-07
申请号：EP97304678.2
申请日：1997-06-27
申请人： NISSHIN FLOUR MILLING CO., LTD.
发明人： Makishima, Makoto , Kanatani, Yasuhiro , Honma, Yoshio , Inomata, Kohei, c/o Nisshin Flour Milling Co. Ltd. , Kishiye, Takao, c/o Nisshin Flour Milling Co. Ltd.
IPC分类号： A61K31/355
CPC分类号： A61K31/355 , A61K31/59 , A61K31/20 , A61K2300/00
摘要： 9-Cis-retinoic acid-α-tocopherol esters, pharmaceutical compositions containing the same and use of the same as a medicine for the treatment of leukemia, in particular, the remission of leukemia are provided and a combined use of a 9-cis-retinoic acid-α-tocopherol ester and either 1α,25-dihydroxyvitamin D 3 or 9-cis-retinoic acid exhibits a synergistic effect in the treatment of leukemia without any side effects caused by 1α,25-dihydroxyvitamin D 3 or 9-cis-retinoic acid.
摘要翻译：提供9-顺式视黄酸-α-生育酚酯，含有该组合物的药物组合物，以及用于治疗白血病药物，特别是白血病缓解用途的药物组合物，并结合使用9-顺式 - 视黄酸-α-生育酚酯和1α，25-二羟基维生素D3或9-顺式 - 视黄酸在白血病的治疗中表现出协同效应，而没有由1α，25-二羟基维生素D3或9-顺式 - 视黄酸引起的任何副作用，视黄酸。

13. 发明授权

EP0499995B1 Piperidine derivatives 失效
标题翻译： Piperidinderivate
公开(公告)号：EP0499995B1
公开(公告)日：1997-01-02
申请号：EP92102559.9
申请日：1992-02-15
申请人： NISSHIN FLOUR MILLING CO., LTD.
发明人： Kikuchi, Haruhiko , Satoh, Hiroaki , Suguro, Toshio , Hagihara, Koichiro, Castle Me Jour , Hayakawa, Toru , Mino, Setsuko
IPC分类号： C07D401/12 , C07D211/22 , A61K31/445 , C07D417/12 , C07D471/04
CPC分类号： C07D401/12 , C07D211/18 , C07D211/22 , C07D417/12 , C07D471/04

14. 发明公开

EP0712941A1 Diamond sinter, high-pressure phase boron nitride sinter, and processes for producing those sinters 失效
标题翻译：金刚石烧结体，高压氮化物相硼烧结体及其制造方法，该烧结体
公开(公告)号：EP0712941A1
公开(公告)日：1996-05-22
申请号：EP94118222.2
申请日：1994-11-18
申请人： AGENCY OF INDUSTRIAL SCIENCE AND TECHNOLOGY , NISSHIN FLOUR MILLING CO., LTD. , READ CO., LTD.
发明人： Kume, Shoichi , Yoshida, Haruo , Yamada, Yukiyoshi , Fuyuki, Tadashi , Akiyama, Satoshi , Hamada, Yoshiaki , Kuroda, Eisuke , Nabeya, Tadakatsu , Sumita, Yukio , Kimura, Kenichi
IPC分类号： C23C14/22
CPC分类号： C04B35/5831 , B01J3/062 , B01J2203/062 , B01J2203/0645 , B01J2203/0655 , B01J2203/066 , B01J2203/0685 , C22C26/00 , C23C16/4417
摘要： A powder of diamond or high-pressure phase boron nitride core particles is charged into a coating space as it is dispersed to a dispersity that is preset in accordance with the average diameter of those core particles and a precursor of a coat forming substance that is either generated via the vapor phase or in a vapor-phase state is allowed to contact and/or impinge against the particles in said powder of core particles so that their surfaces are covered with the coat forming substance, thereby preparing coated diamond or high-pressure phase boron nitride particles, and these particles or mixtures containing them or mixtures of these particles with bonding materials are sintered under appropriate sintering conditions at a predetermined high temperature and pressure. The thusly produced diamond or high-pressure phase boron nitride sinter is composed of coated core particles of high performance that are superhard, uniform, dense and sintered firmly and which have a controlled microstructure. If sintering is done at pressures less than 2000 MPa, the invention offers the advantage of eliminating the constraint of the need to use equipment capable of creating ultrahigh pressures of at least 2000 MPa. The use of ultrahigh pressure HIP apparatus or other types of HIP apparatus offers the added advantage of enabling the production of shaped sinters, thereby presenting significant benefits to manufacture on an industrial scale.
摘要翻译：因为它是分散到分散性并在雅舞蹈预置与芯颗粒的平均直径和外套形成物质的前体所做的是无论是金刚石或高压相氮化硼核粒子的粉末被装入涂层空间通过汽相或在气相状态下产生被允许接触和/或撞击在这样做了他们的表面覆盖有涂层形成物质，从而制备涂覆的金刚石或高压相芯颗粒的所述粉末的颗粒氮化硼颗粒，以及颗粒或论文混合物含有它们的混合物或论文颗粒粘结材料以预定的高的温度和压力的适当的烧结条件下烧结。将这样生产的金刚石或高压相氮化硼烧结由高性能涂覆芯颗粒确实是超硬的，均匀的，致密的和烧结的牢固且具有受控的微结构。如果烧结在2000兆帕的压力少做，本发明提供消除了需要使用能够产生至少2000兆帕的超高压力的设备约束的优势。使用超高压HIP装置或其它类型的HIP装置的提供使生产成形烧结体的，从而呈现显著好处制造上在工业规模的附加优点。

15. 发明公开

EP0665216A1 Urea derivatives and their use as acat inhibitors 失效
标题翻译： Harnstoff Derivate und deren Verwendung als ACAT Inhibitoren。
公开(公告)号：EP0665216A1
公开(公告)日：1995-08-02
申请号：EP94307398.1
申请日：1994-10-10
申请人： NISSHIN FLOUR MILLING CO., LTD.
发明人： Sueda, Noriyoshi, c/o Nisshin Flour Milling Co. , Yamada, Kazuhiko, c/o Nisshin Flour Milling Co. , Yanai, Makoto, c/o Nisshin Flour Milling Co, Ltd. , Miura, Katsutoshi, c/o Nisshin Flour Milling Co., , Horigome, Masato, c/o Nisshin Flour Milling Co. , Oshida, Norio, c/o Nisshin Flour Milling Co., Ltd. , Hiramoto, Shigeru, c/o Nisshin Flour Milling Co. , Katsuyama, Koichi, c/o Nisshin Flour Milling Co. , Nakata, Fumihisa, c/o Nisshin Flour Milling Co. , Kinoshita, Nobuhiro, c/o Nisshin Flour Milling Co, , Tsukada, Yoko, c/o Nisshin Flour Milling Co.
IPC分类号： C07C275/42 , C07C275/40 , C07C275/34 , A61K31/17 , A61K31/395 , C07D295/215 , C07D211/56 , C07D213/40
CPC分类号： C07D295/215 , C07C275/34 , C07C275/40 , C07C275/42 , C07C2601/08 , C07C2603/74
摘要： A compound of formula (I) or a pharmaceutically acceptable salt thereof

(in which R₁ and R₂ each represent hydrogen, halogen or (C₁-C₆)alkoxy; R₃ and R₄ each represent hydrogen, (C₁-C₈)alkyl, cyclo(C₃-C₈)alkyl, aryl(C₁-C₆)alkyl in which the aryl moiety is optionally substituted by one or two halogen, (C₁-C₆)alkyl and/or (C₁-C₆)alkoxy, a diaryl(C₁-C₆)alkyl group, pyridyl(C₁-C₆)alkyl, diazabicyclo(C₇-C₁₀)alkyl optionally substituted by (C₁-C₆)alkyl, adamantyl or piperidyl group optionally substituted by aryl(C₁-C₆)alkyl, or R₃ and R₄, together with the nitrogen atom to which they are attached, form a 5 or 6 membered ring monocyclic, heterocyclic group optionally substituted by (C₁-C₆)alkyl; R₅ and R₇ each represent hydrogen or (C₁-C₆)alkyl; R₆ represents -OR₈ or -N(R₈)₂ wherein R₈ represents hydrogen or (C₁-C₆)alkyl, or -C(O)NHR₃ wherein R₃ is as defined above; R₆ and R₇ together may form -O-CH₂-O- which may be fused with a phenyl ring; X represents nitrogen or methine; A represents

wherein R₉ represents hydrogen, (C₁-C₆)alkyl, (C₁-C₆)alkylcarbonyl, geranyl or -C(O)NHR₃, and m and n independently represent 0, 1 or 2) possess both an ACAT inhibitory activity and an antioxidative activity. Those derivatives are useful in the prophylaxis and treatment of hypercholesterolemia and atherosclerosis.
摘要翻译：式（I）化合物或其药学上可接受的盐（其中R 1和R 2各自代表氢，卤素或（C 1 -C 6）烷氧基; R 3和R 4各自代表氢，（C 1 -C 8）烷基，环（C 1 -C 6）烷基，其中芳基部分任选被一个或两个卤素，（C 1 -C 6）烷基和/或（C 1 -C 6）烷氧基取代的芳基（C 1 -C 6）烷基，（C 1 -C 6）烷基，任选被（C 1 -C 6）烷基取代的二（C 1 -C 6）烷基，任选被（C 1 -C 6）烷基取代的金刚烷基或哌啶基，或者R 3和R 4一起与其连接的氮原子形成任选被（C 1 -C 6）烷基取代的5或6元环单环杂环基; R 5和R 7各自代表氢或（C 1 -C 6）烷基; R 6表示-OR 8或 -N（R 8）2，其中R 8表示氢或（C 1 -C 6）烷基或-C（O）NHR 3，其中R 3如上所定义; R 6和R 7可一起形成-O-CH 2 -O- 苯环; X表示氮或次甲基; A表示其中R 9表示氢，（C 1 -C 6）烷基，（C 1 -C 6）烷基羰基，香叶基或-C（O）NHR 3，m和n独立地表示0,1或2）具有ACAT抑制活性和抗氧化活性。这些衍生物可用于预防和治疗高胆固醇血症和动脉粥样硬化。

16. 发明授权

EP0350801B1 Polyprenols and polyprenyl phosphates for the inhibition of tumour metastasis 失效
标题翻译：使用聚戊烯醇和聚异戊二烯类磷酸盐抑制肿瘤细胞转移。
公开(公告)号：EP0350801B1
公开(公告)日：1995-04-05
申请号：EP89112422.4
申请日：1989-07-07
申请人： NISSHIN FLOUR MILLING CO., LTD.
发明人： Okamoto, Yasushi , Tahara, Yoshiyuki , Mishima, Yoshio
IPC分类号： A61K31/74 , C08L9/00 , A61K31/80
CPC分类号： A61K31/66 , A61K31/045 , Y10S514/937

17. 发明授权

EP0285089B1 4-Thioquinazoline derivatives, processes for their preparation and pharmaceutical compositions 有权
标题翻译： 4- thioquinazoline衍生物，它们的制备方法和药物组合物。
公开(公告)号：EP0285089B1
公开(公告)日：1994-12-07
申请号：EP88105062.9
申请日：1988-03-29
申请人： NISSHIN FLOUR MILLING CO., LTD.
发明人： Takahashi, Toshihiro , Nakamaru, Koichi , Suzuki, Yoshikuni , Horaguchi, Tatsuo
IPC分类号： C07D239/93 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , A61K31/505
CPC分类号： C07D239/93

18. 发明公开

EP0625507A3 Urea derivatives and their use as acat inhibitors 失效
标题翻译：尿素衍生物及其作为acat抑制剂的用途
公开(公告)号：EP0625507A3
公开(公告)日：1994-11-30
申请号：EP94303568.3
申请日：1994-05-19
申请人： NISSHIN FLOUR MILLING CO., LTD.
发明人： Sueda, Noriyoshi, c/o Nisshin Flour Milling Co. , Yamada, Kazuhiko, c/o Nisshin Flour Milling Co. , Yanai, Makoto, c/o Nisshin Flour Milling Co. , Miura, Katsutoshi, c/o Nisshin Flour Milling Co. , Horigome, Masato, c/o Nisshin Flour Milling Co. , Oshida, Norio, c/o Nisshin Flour Milling Co. , Hiramoto, Shigeru, c/o Nisshin Flour Milling Co. , Katsuyama, Koichi, c/o Nisshin Flour Milling Co. , Nakata, Fumihisa, c/o Nisshin Flour Milling Co. , Kinoshita, Nobuhiro, c/o Nisshin Flour Milling Co. , Tsukada, Yoko, c/o Nisshin Flour Milling Co.
IPC分类号： C07C275/32 , A61K31/17 , C07C275/34 , C07D307/52 , C07D295/13 , C07D211/58 , C07D317/58 , C07D295/215 , C07D211/16 , C07D213/40 , C07D295/20 , C07D295/12
CPC分类号： C07D213/40 , A61K9/1623 , A61K9/2018 , A61K9/4866 , C07C275/32 , C07C275/34 , C07C323/44 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2601/20 , C07C2602/10 , C07C2602/22 , C07C2603/74 , C07D207/14 , C07D209/08 , C07D209/16 , C07D211/16 , C07D211/22 , C07D211/42 , C07D211/48 , C07D211/56 , C07D211/58 , C07D211/60 , C07D213/75 , C07D213/82 , C07D215/08 , C07D217/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D265/30 , C07D295/13 , C07D295/135 , C07D295/215 , C07D295/26 , C07D307/52 , C07D317/58 , C07D333/20 , C07D401/06 , C07D401/12 , C07D451/04 , C07D453/02 , C07D471/04 , C07D471/08 , C07D491/10 , Y10S514/824
摘要： Urea derivatives of formula (I)
wherein the valuable groups are as defined in the specification, which possess both an ACAT inhibitory activity and an antioxidative activity. Those derivatives are useful in the prophylaxis and treatment of hypercholesterolemia and atherosclerosis.
摘要翻译：式（I）的尿素衍生物，其中有价基团如说明书中所定义，同时具有ACAT抑制活性和抗氧化活性。这些衍生物可用于预防和治疗高胆固醇血症和动脉粥样硬化。

19. 发明授权

EP0410006B1 EYE DROPS FOR HEALING WOUND OF CORNEAL EPITHELIUM 失效
标题翻译：眼药水愈合伤口AT角膜上皮。
公开(公告)号：EP0410006B1
公开(公告)日：1994-05-04
申请号：EP90902842.5
申请日：1990-02-13
申请人： NISSHIN FLOUR MILLING CO., LTD. , HAYASHI, Masao
发明人： HAYASHI, Masao
IPC分类号： A61K37/02
CPC分类号： A61K38/39 , Y10S514/912 , Y10S514/914 , Y10S514/915 , Y10S530/83
摘要： Vitronectin is quite effective in healing maladies of a corneal epithelium. When it is applied to the wound of the epithelium in the form of eye drops, the wound can be healed quickly and normal epithelial cells as regenerated. Vitronectin is capable of autoclave sterilization.

20. 发明公开

EP0591937A1 Use of isoquinolinone derivatives for treating hyperlipoproteinemia 失效
标题翻译：使用Isoquinolinon衍生物为动脉粥样硬化和高脂蛋白血症的治疗。
公开(公告)号：EP0591937A1
公开(公告)日：1994-04-13
申请号：EP93116125.1
申请日：1993-10-06
申请人： NISSHIN FLOUR MILLING CO., LTD.
发明人： Hasegawa, Motoharu, c/o Toho University , Shirai, Kohji, c/o Toho University , Matsumoto, Kiyohiko, c/o Toho University , Suzuki, Yasuhiko, c/o Toho University , Takahasi, Isao, c/o Toho University , Takarada, Yuuiti, c/o Toho University , Saito, Mitsuyo, c/o Toho University , Yamamoto, Kumiko, c/o Toho University , Takayama, Yositaka, c/o Toho University , Komazawa, Tsutomu, c/o Toho University , Sugai, Toshiji, c/o Nisshin Flour Milling Co. Ltd.
IPC分类号： A61K31/47
CPC分类号： A61K31/47
摘要： The use of isoquinolinone derivatives as an antiarteriosclerosis agent and antihyperlipoproteinemics. The derivatives are of the formula

wherein R₁ is hydrogen or a C₁-C₆ alkyl group and R₂ is a C₁-C₆ alkyl group or the pharmaceutically acceptable salt thereof.
摘要翻译：使用衍生于异喹啉酮antiarteriosclerosis剂和antihyperlipoproteinemics。的衍生物是式 worin R1是氢或C1-C6烷基，R2是C1-C6烷基或其药学上可接受的盐。

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