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131. 发明授权

EP0946306B1 PROCEDE ET INSTALLATION POUR REVETIR UNE SURFACE D'UN SUBSTRAT AVEC UNE COUCHE D'UNE MATIERE FLUIDE 失效
标题翻译： METHOD AND SYSTEM FOR将液体施加材料的层到基材表面
公开(公告)号：EP0946306B1
公开(公告)日：2001-03-07
申请号：EP97947823.7
申请日：1997-12-30
申请人： BIO MERIEUX
发明人： COLIN, Bruno
IPC分类号： B05B15/04 , B05B7/24
CPC分类号： B05B7/2483 , B05B14/30 , Y02P70/36
摘要： Disclosed is a process for covering a surface (1a) of a substrate (1) with a layer (2) of fluid material, said process being characterized by the following: (a) a containing wall (3) forming an enclosure and disposed at a distance and above the surface to be covered (1a), the lower edge (3a) of this wall forming a peripheral void (4) with the surface, said wall being used to define a processing chamber (5) which outlines an area (6) to be treated on said surface to be covered; (b) controlled negative pressure is established within the processing chamber (5), by means of the admission of an incoming gas stream (7) via the peripheral void (4), and of the extraction from the processing chamber of an outgoing gas stream (8), in order to obtain an internal pressure within said chamber which is lower than the external pressure; (c) a controlled fluid flow (10) is introduced into the processing chamber (5) under pressure, said flow comprising the fluid covering material which, together with the incoming gas stream (7), forms a turbulent flow in the peripheral void. Upon contact with the processed surface (1b), the turbulent flow is aspirated into the area (6) to be treated, depositing the fluid material in this area; the fluid flow is then evacuated with the outgoing gas stream (8).

132. 发明公开

EP0975747A1 POLYPEPTIDE CAPABLE DE REAGIR AVEC LES ANTICORPS DE PATIENTS ATTEINTS DE SCLEROSE EN PLAQUES ET UTILISATIONS 失效
标题翻译：多肽抗体复合性硬化患者BIND及其用途
公开(公告)号：EP0975747A1
公开(公告)日：2000-02-02
申请号：EP98922903.4
申请日：1998-04-29
申请人： BIO MERIEUX
发明人： JOLIVET-REYNAUD, Colette , PERRON, Hervé , MANDRAND, Bernard
IPC分类号： C12N15/10 , C07K14/47 , C07K14/15 , C07K7/06 , C07K7/08 , G01N33/564 , G01N33/569
CPC分类号： C07K7/06 , A61K39/00 , C07K5/1013 , C07K5/1021 , C07K7/08 , C07K14/005 , C07K14/4713 , C12N2740/10022 , Y10S435/81 , Y10S435/975
摘要： The invention concerns a polypeptide specifically reacting with the antibodies of patients suffering from multiple sclerosis (SEP) and whereof the peptide sequence comprises at least one sequence selected among SEQ ID No: 1 to SEQ ID No: 19, and their equivalent sequences, and the use of this polypeptide in a reagent and a kit for detecting multiple sclerosis, an immunoreactive composition and in a method for fixing, in a biological sample, antibodies characteristic and/or specific of multiple sclerosis.

133. 发明授权

EP0587873B1 PROCEDE POUR L'OBTENTION DE CELLULES INFECTEES PAR UN VIRUS ASSOCIE A LA SCLEROSE EN PLAQUES 有权
标题翻译：多发性硬化症，病毒制造方法相关感染的细胞来获得
公开(公告)号：EP0587873B1
公开(公告)日：2000-01-19
申请号：EP93908989.2
申请日：1993-04-02
申请人： BIO MERIEUX
发明人： PERRON, Hervé , SEIGNEURIN, Jean-Marie
IPC分类号： C12N7/00 , C12N5/08 , C12N5/10 , C12N15/38 , C12N15/85 , G01N33/569 , C12P21/08 , A61K39/21
CPC分类号： G01N33/56983 , C07K14/005 , C07K16/10 , C12N7/00 , C12N15/85 , C12N2710/16622 , C12N2740/10022 , C12N2740/10051 , G01N2469/20
摘要： Process for in vitro production of a culture or cell line infected by a viral strain associated with multiple sclerosis. According to the process, a sample is taken from a person with multiple sclerosis, the sample is cultivated in a medium promoting the growth of infected cells to obtain a culture of primary infected cells. A sample of the primary cell culture or a sub-culture of the latter is then cultivated in series, i.e. by means of successive cultures, in said culture medium to obtain the culture or cell line infected by a multiple sclerosis associated virus. The invention is characterized in that the culture medium further contains a beta anti-interferon antibody or antibody which is directed against an antigenically close molecule. Said antibody plays an inhibiting role in viral expression, has long-lasting expression and propagates the viral strain in the culture or cell line.

134. 发明公开

EP0946306A1 PROCEDE ET INSTALLATION POUR REVETIR UNE SURFACE D'UN SUBSTRAT AVEC UNE COUCHE D'UNE MATIERE FLUIDE 失效
标题翻译： METHOD AND SYSTEM FOR将液体施加材料的层到基材表面
公开(公告)号：EP0946306A1
公开(公告)日：1999-10-06
申请号：EP97947823.0
申请日：1997-12-30
申请人： BIO MERIEUX
发明人： COLIN, Bruno
IPC分类号： B05B7 , B05B15 , B05D1
CPC分类号： B05B7/2483 , B05B14/30 , Y02P70/36
摘要： Disclosed is a process for covering a surface (1a) of a substrate (1) with a layer (2) of fluid material, said process being characterized by the following: (a) a containing wall (3) forming an enclosure and disposed at a distance and above the surface to be covered (1a), the lower edge (3a) of this wall forming a peripheral void (4) with the surface, said wall being used to define a processing chamber (5) which outlines an area (6) to be treated on said surface to be covered; (b) controlled negative pressure is established within the processing chamber (5), by means of the admission of an incoming gas stream (7) via the peripheral void (4), and of the extraction from the processing chamber of an outgoing gas stream (8), in order to obtain an internal pressure within said chamber which is lower than the external pressure; (c) a controlled fluid flow (10) is introduced into the processing chamber (5) under pressure, said flow comprising the fluid covering material which, together with the incoming gas stream (7), forms a turbulent flow in the peripheral void. Upon contact with the processed surface (1b), the turbulent flow is aspirated into the area (6) to be treated, depositing the fluid material in this area; the fluid flow is then evacuated with the outgoing gas stream (8).

135. 发明公开

EP0928221A1 PROCEDE ET DISPOSITIF DE MISE EN SUSPENSION DE PARTICULES LOURDES D'UN SOLIDE DANS UN LIQUIDE 失效
标题翻译：方法和装置用于流体SUSPENDING重实粒子
公开(公告)号：EP0928221A1
公开(公告)日：1999-07-14
申请号：EP98917278.0
申请日：1998-03-31
申请人： BIO MERIEUX
发明人： COLIN, Bruno
IPC分类号： B01F13
CPC分类号： B01F13/0233
摘要： Disclosed is a process for suspending heavy particles in a predetermined volume (2) of liquid contained inside a container (3), a deposit (4) of said particles settled on the bottom (3a) of the container being bathed in said volume of liquid. The invention is characterized by the establishment of a gas circuit (5) in the container, partially in direct contact with the liquid (2) and forming a loop comprising at least two substantially parallel flows (5a, 5b) separated by a pressure difference (6) situated at the level of the bottom (3a) of the container (3). A gas stream is alternated along said gas circuit (5).

136. 发明公开

EP0880599A1 PROCEDE DE MISE EN EVIDENCE D'UNE ACTIVITE ENZYMATIQUE DE MICROORGANISMES 失效
标题翻译：程序对认证微生物中酶活性的
公开(公告)号：EP0880599A1
公开(公告)日：1998-12-02
申请号：EP97935649.0
申请日：1997-07-29
申请人： BIO MERIEUX
发明人： ORENGA, Sylvain
IPC分类号： C12Q1
CPC分类号： C12Q1/37 , C12Q1/04 , C12Q2337/50
摘要： The method consists in the use of one compound of formula: X-NH-R in which X represents one 5-bromoindole-3-yle group and R represents the acyl radical of one amino acid selected between leucine and alanine, as tracer for demonstrating, by the formation of a coloured product, a peptidase activity in a culture of micro-organisms.

137. 发明公开

EP0843594A1 CARTE D'ANALYSE A USAGE UNIQUE COMPRENANT UN CONDUIT D'ECOULEMENT DE LIQUIDES 失效
标题翻译：与液体管线一次性分析卡
公开(公告)号：EP0843594A1
公开(公告)日：1998-05-27
申请号：EP97928314.0
申请日：1997-06-09
申请人： BIO MERIEUX
发明人： COLIN, Bruno , JARAVEL, Cécile , CLEUZIAT, Philippe
IPC分类号： G01N33 , B01L3 , G01N35
CPC分类号： B01L3/502
摘要： The invention features an analysing device (1) comprising a body (2) in which are arranged or provided: an intake aperture (3) for a starting liquid sample, a liquid flow circuit (5) comprising at least one operating cell (6) for a processed liquid sample, obtained from all or part of the original sample, communicating with the said intake aperture (3), the said flow circuit defining, in at least two dimensions of the card, one determined geometric line, such that any alteration in the card orientation in a three-dimensional reference frame, causes the liquid to flow under gravity only, from one part of the said circuit to another,for instance from one side or another of the operating cell, (6) characterised in that, the flow circuit (5) is continuous, and looped on itself between the said aperture (3) and the said operating cell (6).

138. 发明公开

EP0840648A1 PARTICULES SUPERPARAMAGNETIQUES ET MONODISPERSES 失效
标题翻译： SUPER PARA磁及颗粒单分散
公开(公告)号：EP0840648A1
公开(公告)日：1998-05-13
申请号：EP97925131.0
申请日：1997-05-23
申请人： BIO MERIEUX
发明人： ELAISSARI, Abdelhamid , PICHOT, Christian , MANDRAND, Bernard , SAUZEDDE, Florence
IPC分类号： B03C1 , G01N33 , H01F1
CPC分类号： H01F1/37 , B03C1/01 , G01N33/5375 , G01N33/5434 , G01N2446/10 , G01N2446/40 , G01N2446/84 , G01N2446/86 , H01F1/44 , Y10S436/806 , Y10S436/824 , Y10T428/2982 , Y10T428/2989 , Y10T428/2991 , Y10T428/2998 , Y10T436/24
摘要： The invention discloses superparamagnetic monodispersed particles, their method of preparation and their uses. These particles comprise: a core of a first polymer, an internal layer of a second polymer coating the core, and in which is distributed a magnetic material, and an external layer of a third polymer coating the magnetic layer, and capable of interacting with at least one biological molecule, at least the second polymer being heat sensitive and having a predetermined lower critical solubility temperature (LCST) of 15 to 65 °C.

139. 发明公开

EP0827512A1 ANTICORPS SPECIFIQUE DE $i(STAPHYLOCOCCUS AUREUS) ET UTILISATIONS 失效
标题翻译： FOR-I（金黄色葡萄球菌）特异性抗体和及其用途
公开(公告)号：EP0827512A1
公开(公告)日：1998-03-11
申请号：EP97915542.0
申请日：1997-03-21
申请人： BIO MERIEUX
发明人： MERLIN, Sylviane , BATTAIL, Nicole , FLANDROIS, Jean-Pierre , CARRET, Gérard
IPC分类号： G01N33 , C07K16 , C12N5 , C12N15 , C12P21
CPC分类号： C07K16/1271 , C12N5/16
摘要： A monoclonal or polyclonal antibody specific for an epitope common to Staphylococcus aureus strains of various capsular serotypes, particularly meticillin-resistant strains, said antibody being selected from immunoglobulins G, M and A, and the use thereof in a reagent for detecting Staphylococcus aureus, are disclosed.

140. 发明公开

EP0785433A3 Test sample card 失效
标题翻译：分析仪的测试卡
公开(公告)号：EP0785433A3
公开(公告)日：1997-12-29
申请号：EP96303456
申请日：1996-05-15
申请人： BIO MERIEUX VITEK INC
发明人： O'BEAR RAYMOND E , STAPLES JOHN , TEGELER GARRY R
IPC分类号： G01N33/50 , B01L3/00 , B29C45/00 , C12M1/34 , G01N21/77 , G01N21/78 , G01N35/00 , G01N35/02
CPC分类号： B01L3/5025 , B29C45/0025 , G01N2035/00148

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