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111. 发明公开

EP2336297A3 Gynogenetic or androgenetic production of pluripotent cells and cell lines, and use thereof to produce differentiated cells and tissues 审中-公开
标题翻译：雌核发育或雄激素产生的多能细胞和细胞系以及它们用于生产分化细胞和组织的利用
公开(公告)号：EP2336297A3
公开(公告)日：2011-11-16
申请号：EP10183704.5
申请日：2000-10-27
申请人： University of Massachusetts
发明人： Robl, James M , Cibelli, Jose , Burnside, Amy
IPC分类号： C12N5/00 , C12N5/02 , A01K67/00 , C12Q1/02
CPC分类号： G01N33/5073 , A61K35/12 , C12N5/0606 , C12N15/873 , C12N2500/14 , C12N2501/999 , C12N2502/13 , C12N2506/04 , C12N2510/00 , C12N2517/10 , G01N33/5008 , G01N33/502 , G01N2333/475
摘要： Methods for obtaining pluripotent (embryonic stem) cells from parthenogenetic embryos, especially primates, are provided. These cells are useful for producing differentiated cells, tissues and organs, especially human and non-human primate cells, tissues and organs.
摘要翻译：从孤雌胚胎多能获得（胚胎干细胞）的方法，尤其是爱的灵长类动物，提供。这些细胞可用于产生分化的细胞，组织和器官，尤其是爱人类和非人类的灵长类动物的细胞，组织和器官有用。

112. 发明授权

EP1943345B1 A METHOD FOR THE TRANSFER OF EPISOMAL VECTORS INTO ANIMAL CELLS 有权
标题翻译：方法在动物细胞中传输游离载体
公开(公告)号：EP1943345B1
公开(公告)日：2011-04-06
申请号：EP05812957.8
申请日：2005-10-05
申请人： Università Degli Studi Di Milano - Bicocca
发明人： LAVITRANO, Marialuisa , BACCI, Maria, Laura , FORNI, Monica , LIPPS, Hans, Joachim , DONINI, Pierluigi
IPC分类号： C12N15/87 , A01K67/00
CPC分类号： C12N15/8778 , A01K2227/108 , C12N2517/10 , C12N2800/108 , C12N2830/46
摘要： The present invention refers to a method for the transfer of DNA sequences or exogenous genes into animal sperm cells by means of the use of episomal vectors. The invention also relates to the use of “Sperm Mediated Gene Transfer” (SMGT) technology for the creation of genetically modified individuals.

113. 发明公开

EP2283724A2 Low pressure sperm separation system using heterospermic insemination to access sperm function 有权转让
标题翻译：异精子授精als祖哥zur精子补充
公开(公告)号：EP2283724A2
公开(公告)日：2011-02-16
申请号：EP10178407.2
申请日：2003-08-01
申请人： XY, LLC , Colorado State University
发明人： Seidel, George E. , Schenk, John , SUH, Tae, Kwang
IPC分类号： A01K67/027 , C12N5/076
CPC分类号： C12N5/0612 , A01K67/027 , A01K2227/10 , A01K2227/101 , A61D19/00 , C12N5/061 , C12N2517/10 , Y10T442/2115
摘要： A sperm cell process system providing to generate sperm cell insemination samples having controlled sperm cell fertility characteristics of sperm cells.
摘要翻译：精子细胞过程系统提供产生精子细胞授精样品，其具有受精精细胞的精子细胞生殖力特征。

114. 发明公开

EP2199392A2 Genetic modification of somatic cells and uses thereof 审中-公开
标题翻译：体细胞的遗传修饰及其用途
公开(公告)号：EP2199392A2
公开(公告)日：2010-06-23
申请号：EP09015852.8
申请日：2000-03-03
申请人： REVIVICOR, INC.
发明人： Colman, Alan , Schnieke, Angelika, Elisabeth , Kind, Alexander, Jarvis , Ayares, David Lee , Dai, Yifan
IPC分类号： C12N15/10 , C12N15/90 , C12N15/88 , A01K67/027
CPC分类号： A01K67/0275 , A01K2217/05 , A61K48/00 , C12N15/102 , C12N15/907 , C12N2510/00 , C12N2517/10 , C12N2800/60 , C12N2830/00 , C12N2830/42 , C12N2830/85 , C12N2840/203 , H04L41/0213 , H04L41/12 , H04L41/22
摘要： The production of genetically modified animals, in which the genetic modifications are engineered in somatic cells cultured in vitro by gene targeting, is described. Genetically modified cells may then be used as nuclear donors loci in animal chromosomes which are suitable sites for transgene addition to cells.
摘要翻译：描述了基因修饰的动物的生产，其中遗传修饰被工程化在通过基因靶向在体外培养的体细胞中。遗传修饰的细胞然后可以用作动物染色体中的核供体基因座，所述动物染色体是适合于向细胞添加转基因的位点。

115. 发明授权

EP1341901B8 METHOD FOR IN VITRO CULTURE OF OVARIAN FOLLICLES 有权
标题翻译：卵母细胞体外培养方法
公开(公告)号：EP1341901B8
公开(公告)日：2008-12-24
申请号：EP01994564.1
申请日：2001-12-11
申请人： EggCentris NV
发明人： CORTVRINDT, Rita , SMITZ, Johan
IPC分类号： C12N5/06 , C12N5/08 , G01N33/50
CPC分类号： C12N5/0609 , C12N2500/25 , C12N2501/11 , C12N2501/31 , C12N2502/243 , C12N2517/10
摘要： The present invention is related to a method for in vitro culture of mammalian ovarian follicles for bioassay purposes, comprising the following subsequent steps: - providing a suitable container for the in vitro culture, - selecting a follicle from an ovary of a mammal, said follicle comprising at least a theca or pre-theca cell, a granulosa cell and an oocyte, - an optional first cultur e step using an attachment prohibiting first medium free from oil, - a second culture step using an attachment promoting second medium free from oil arranged to, and - the retrieval of the matured follicle.
摘要翻译：本发明涉及用于生物测定目的的哺乳动物卵巢卵泡的体外培养方法，其包括以下后续步骤： - 提供用于体外培养的合适容器， - 从哺乳动物的卵巢中选择卵泡，所述卵泡其包含至少一个茶花或卵囊前细胞，颗粒细胞和卵母细胞， - 任选的使用阻止第一培养基无油的附着的第一培养步骤， - 使用促进第二培养基无附着油的附着的第二培养步骤以及 - 取回成熟的卵泡。

116. 发明公开

EP1931768A1 USE OF A CELLULAR EXTRACT FOR A MITOTIC REMODELING OF CHROMOSOMES 审中-公开
标题翻译：使用细胞提取物有丝分裂染色体ALTER
公开(公告)号：EP1931768A1
公开(公告)日：2008-06-18
申请号：EP06805974.0
申请日：2006-09-29
申请人： Centre National de la Recherche Scientifique
发明人： MECHALI, Marcel , LEMAITRE, Jean-Marc
IPC分类号： C12N5/06 , C12N15/87
CPC分类号： A61K35/65 , A01K67/0271 , C12N5/0609 , C12N5/061 , C12N5/0696 , C12N5/16 , C12N15/873 , C12N2500/80 , C12N2517/10
摘要： The present invention relates to the use of a female germinal cell (egg) extract of pericellular organisms in M-phase of the cell cycle for a mitotic remodeling of chromosomes of donor cells of pericellular organisms, wherein the mitotic remodeling confers to the nucleus of the aforesaid donor cells the ability to adapt themselves to the early embryonic development, in particular to the replication phases, in order to carry out the embryonic development or to obtain stem cells.

117. 发明授权

EP1284285B1 Method for collecting cells in M phase or G1 phase and method for nuclear transplantation using the cells 有权
标题翻译：一种用于在M期或G1和用于与这些细胞的核转移收集细胞的方法
公开(公告)号：EP1284285B1
公开(公告)日：2008-01-02
申请号：EP02255192.3
申请日：2002-07-25
申请人： The Japanese Research Association For Animal Embryo Transfer Technology
发明人： Urakawa, Manami , Aoyagi, Yoshito
IPC分类号： C12N5/06 , A01K67/027
CPC分类号： C12N15/873 , C12N2517/10

118. 发明公开

EP1695059A4 METHOD FOR SEX BIASING SPERMATOZOA 审中-公开
标题翻译：程序对性别因素影响精子
公开(公告)号：EP1695059A4
公开(公告)日：2007-11-14
申请号：EP04800642
申请日：2004-11-02
申请人： VLP WATERTOWN LTD PARTNERSHIP
发明人： COHEN BARB ARIEL , MORRIS MICHAEL F
IPC分类号： A01N1/02 , A01K67/027 , C12N5/00 , C12N5/071 , G01N20060101
CPC分类号： C12N5/0612 , A01K2227/101 , A01K2227/105 , C12N2517/10
摘要： A method is described for treating a specimen of semen containing sperm cells to increase the relative number of sperm cells of a desired sex type in a treated specimen to increase the potential for conceiving an offspring of the desired sex. A specimen of semen is treated after a predetermined time to increase the relative ability of a at least a portion of the semen to conceive an offspring of the desired sex. The treatment preferably comprises contacting the sperm cells with an agent that preferentially effects sperm cells of a selected sex type. In some preferred embodiments, the semen is separated into two components. A first component has a higher number of sperm of the desired sex type than sperm of a non desired sex type and a second component has a higher number of sperm of the non desired sex type relative to sperm of the desired sex type. In one embodiment, the separating step is performed after a predetermined percent of the sperm cells exhibit a punctate pattern, which is capable of determination by labeling the sperm cells with Koo antibody and determining the percent of cells labeled. In another embodiment, the separating step is performed after waiting for a time determined by locating a maximum in the curve obtained by plotting percent female cells determined by FISH against percent Koo positive cells, determining the time at which the maximum percent female cells occurs, and beginning the following step no earlier than about one hour before the time of the maximum percent female cells. In yet another embodiment, the separating step is performed after waiting for a period of time between about 2 hours and about 24 hours after collection of the ejaculate. Preferably, in the separating step, the sperm is contacted with a cell binding agent, permitting the sperm of the non desired sex type to preferentially bind to the cell binding agent, and the cell binding agent with preferentially bound sperm of the non desired sex type is separated from non bound sperm.

119. 发明公开

EP1762624A3 Methods for amplifying genetic material and uses thereof 审中-公开
标题翻译：一种用于扩增基因材料及其应用方法
公开(公告)号：EP1762624A3
公开(公告)日：2007-11-07
申请号：EP06010492.4
申请日：2000-12-21
申请人： THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH
发明人： Melton, David William
IPC分类号： C12Q1/68 , C12N15/00 , C12N15/85 , A01K67/027
CPC分类号： C12N15/85 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/01 , C12N9/1077 , C12N9/6464 , C12N15/00 , C12N15/8509 , C12N15/873 , C12N15/90 , C12N2510/02 , C12N2517/10 , C12N2820/00 , C12Y304/21069
摘要： The present invention concerns a method of making a transgenic non-human animal cell which is totipotent or totipotent for nuclear transfer and which cell comprises amplified copies of a nucleic acid sequence of interest. The method comprising subjecting a cell from a host cell population to a gene amplification protocol to produce a cell which retains its totipotency or totipotency for nuclear transfer and which comprises amplified copies of the nucleic acid sequence of interest. Because the resulting cells retain totipotency, or totipotency for nuclear transfer, they may be used to generate a transgenic non-human animal which expresses amplified copies of a gene of interest. Consequently, high levels of a product of interest may be obtained from the animal.

120. 发明公开

EP1781192A4 METHOD TO DECREASE THE RATE OF POLYSPERMY IN IVF 审中-公开
标题翻译： VERFAHREN ZUR VERRINGERUNG DER RATE VON POLYSPERMIE BEI IVF
公开(公告)号：EP1781192A4
公开(公告)日：2007-10-03
申请号：EP05762608
申请日：2005-06-23
申请人： UNIV MISSOURI
发明人： PRATHER RANDALL S
IPC分类号： A61B17/43 , A61D7/00 , C12N5/02
CPC分类号： C12N15/873 , A01K2227/108 , C12N5/0609 , C12N5/061 , C12N15/8778 , C12N2501/11 , C12N2501/20 , C12N2501/31 , C12N2501/58 , C12N2501/998 , C12N2517/10
摘要： The field of invention generally relates to increasing the efficiency of in vitro fertilization by decreasing the rate of polyspermy. One aspect of the invention provides a method of reducing polyspermy in in vitro fertilization by forming an in vitro fertilization mixture that contains osteopontin, oocytes, and sperm, and allowing fertilization of the oocyte by sperm. Another aspect of the invention provides an aqueous mixture for in vitro fertilization that contains osteopontin, oocytes, and sperm.
摘要翻译：发明领域通常涉及通过降低多精的速率来增加体外受精的效率。本发明的一个方面提供了一种通过形成含有骨桥蛋白，卵母细胞和精子的体外受精混合物，并允许精子受精的卵母细胞在体外受精中减少多精的方法。本发明的另一方面提供了用于体外受精的含有骨桥蛋白，卵母细胞和精子的含水混合物。

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