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111. 发明公开

EP2180313A1 METHOD AND APPARATUS FOR DETECTION OF BIOMICROMOLECULE 审中-公开
标题翻译： VERFAHREN UND VORRICHTUNG ZUM NACHWEIS EINESBIOMIKROMOLEKÜLS
公开(公告)号：EP2180313A1
公开(公告)日：2010-04-28
申请号：EP08777807.2
申请日：2008-07-03
申请人： National University Corporation Tokyo University of Agriculture and Technology , Kabushiki Kaisha Kobe Seiko Sho
发明人： IKEBUKURO, Kazunori , KATAYAMA, Ryo , TAKAHASHI, Eiji
IPC分类号： G01N25/16 , G01N21/41 , G01N33/543 , G01N35/08 , G01N37/00
CPC分类号： G01N33/54373 , B01L3/5027 , B01L7/00 , B01L2300/0654 , B01L2300/0861 , B01L2300/0877 , B01L2300/0883 , B01L2300/1827 , G01N21/171 , G01N35/1095 , G01N2035/1034
摘要： An object of the present invention is to detect a small biomolecule in a sample using simple and inexpensive equipment. To achieve this, the small biomolecule in a sample S is detected optically. Specifically, the sample S containing an aptamer capable of interacting with the small biomolecule is irradiated with an excitation light Le and irradiated with a measurement light L2 for measuring the photothermal effect produced in the sample S by the irradiation with the excitation light Le. The photothermal effect induced in the sample S by the excitation light Le is measured from the phase change in the measurement light L2, and the presence or absence of the interaction between the biomolecule and the aptamer is assessed based on the temporal variation in the measurement signal.
摘要翻译：本发明的目的是使用简单且便宜的设备来检测样品中的小生物分子。为了实现这一点，光学检测样品S中的小生物分子。具体地说，将含有能够与小生物分子相互作用的适体的样品S用激发光Le1照射，并用用于通过照射激发光Le测量在样品S中产生的光热效应的测量光L2照射。根据测量光L2的相变测量由激发光Le引起的样品S中的光热效应，并且基于测量信号的时间变化来评估生物分子和适体之间的相互作用的存在或不存在。

112. 发明公开

EP2147973A1 GENE-DISRUPTED STRAIN, RECOMBINANT PLASMID, TRANSFORMANT AND METHOD OF PRODUCING 3-CARBOXYMUCONOLACTONE 审中-公开
标题翻译：具有精确的电路，重组质粒转化及其制造方法3 CARBOXYMUCONOLACTON STEM
公开(公告)号：EP2147973A1
公开(公告)日：2010-01-27
申请号：EP08752842.8
申请日：2008-05-09
申请人： KABUSHIKI KAISHA TOYOTA JIDOSHOKKI , National University Corporation Tokyo University of Agriculture and Technology , Nagaoka University of Technology , FORESTRY AND FOREST PRODUCTS RESEARCH INSTITUTE
发明人： SHIMO, Toshihisa , MASE, Kohei , KATAYAMA, Yoshihiro , MASAI, Eiji , FUKUDA, Masao , SHIGEHARA, Kiyotaka , OHARA, Seiji , NAKAMURA, Masaya , OTSUKA, Yuichiro
IPC分类号： C12N15/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P7/44 , C12P17/04
CPC分类号： C12P7/48 , C12N9/0069 , C12P17/04 , C12Y113/11003
摘要： Industrial-scale fermentative production of 3-carboxy-cis,cis-muconic acid from terephthalic acid.
Also, a protocatechuate 4,5-ring-cleaving enzyme gene-disrupted strain in which the gene coding for (a) the amino acid sequence set forth in SEQ ID NO: 1 or 3, or (b) the amino acid sequence set forth in SEQ ID NO: 1 or 3 which has a deletion, substitution, addition and/or insertion of one or more amino acids and exhibits protocatechuate 4,5-ring cleavage activity, present in the chromosomal DNA of microbial cells, has been disrupted; recombinant plasmids comprising the Tph gene and protocatechuate 3,4-dioxygenase gene; transformants obtained by introducing the recombinant plasmids into the disrupted strain; and a process for production of 3-carboxy-cis,cis-muconic acid and/or 3-carboxymuconolactone characterized by culturing the transformants in the presence of terephthalic acid.
摘要翻译：工业规模发酵生产3-羧基 - 顺，顺 - 粘康来自对苯二甲酸的酸。因此，一个原儿茶酸酯4,5-环 - 切割酶基因被破坏的菌株，其中阐述了（a）所述的氨基酸序列的基因编码在SEQ ID NO：1或3，或（b）的氨基酸序列阐述在SEQ ID NO：1或3，其具有缺失，取代，添加和/或一个或多个氨基酸和展品插入儿茶酸酯4,5-环切割活性，存在于微生物细胞的染色体DNA中，已被破坏; 重组质粒包含了phr基因和原儿茶酸3,4-双加氧酶基因; 通过将重组质粒导入的被破坏的菌株获得的转化体; 和用于生产3-羧基 - 顺，顺 - 黏康酸和/或3-羧基通过在对苯二甲酸存在下培养转化体为特征的方法。

113. 发明公开

EP2114004A1 ULTRASONIC OPERATION DEVICE AND MICROTUBE INSIDE SYSTEM 有权
标题翻译： MIKRORÖHREN-INSIDE系统的超声波 - BETRIEBSEINRICHTUNG
公开(公告)号：EP2114004A1
公开(公告)日：2009-11-04
申请号：EP07828888.3
申请日：2007-09-25
申请人： National University Corporation Tokyo University of Agriculture and Technology
发明人： MASHIMO, Tomoaki , TOYAMA, Shigeki
IPC分类号： H02N2/00 , A61B1/00 , A61B8/12 , A61B17/00 , A61B17/22
CPC分类号： A61B17/2202 , A61B8/12 , A61B8/445 , A61B8/4488 , A61B34/70 , H02N2/16
摘要： An ultrasonic wave handling device for freely revolving and/or sliding (protruding and pulling in) a working member is provided.
An ultrasonic wave handling device (1) includes a stator (11) with a working member hole H and a pillar shaped working member (12) which is inserted in the working member hole H. The outline of the working member hole H forms a square shape. Ultrasonic wave generating elements (13) for revolving and /or sliding the working member (12) are attached to each side of the square stators.
摘要翻译：提供了用于自由地旋转和/或滑动（突出和拉入）工作构件的超声波处理装置。超声波处理装置（1）包括：具有工作构件孔H的定子（11）和插入到工作构件孔H中的柱状作用构件（12）。工作构件孔H的轮廓形成正方形形状。用于使工作构件（12）旋转和/或滑动的超声波发生元件（13）附接到方形定子的每一侧。

114. 发明公开

EP2062966A1 MATERIAL FOR CONTROL OF SOIL-BORNE DISEASE IN PLANT UTILIZING NOVEL FILAMENTOUS FUNGI 审中-公开
标题翻译：材料ZURBEKÄMPFUNGEINER IM BODEN BEFINDLICHEN PFLANZENKRANKHEIT UNTER NUTZUNG NEUARTIGER FADENPILZE
公开(公告)号：EP2062966A1
公开(公告)日：2009-05-27
申请号：EP07807037.2
申请日：2007-09-11
申请人： Idemitsu Kosan Co., Ltd. , National University Corporation Tokyo University of Agriculture and Technology
发明人： KAWABATA, Takahiro , ABE, Hiroshi , NARITA, Yasusaburo
IPC分类号： C12N1/14 , A01N63/00 , A01P3/00 , C12N15/09
CPC分类号： C12R1/645 , A01N63/00
摘要： Disclosed is a novel filamentous fungus SD-F06 strain which can infect a root of a plant and grow symbiotically with the plant and is capable of controlling a soil-borne disease. Also disclosed is a material for controlling a soil-borne disease, which comprises a fungus body or fungal culture of a filamentous fungus SD-F06 strain. Further disclosed is a method for controlling a soil-borne disease in a plant by utilizing the material.
摘要翻译：公开了一种新颖的丝状真菌SD-F06菌株，其可以感染植物的根并且与植物共生生长并且能够控制土壤传播的疾病。还公开了用于控制土传疾病的材料，其包含丝状真菌SD-F06菌株的真菌体或真菌培养物。进一步公开的是通过利用该材料来控制植物中的土传病的方法。

115. 发明公开

EP2003104A2 REAGENT FOR ORGANIC SYNTHESIS AND METHOD OF ORGANIC SYNTHESIS REACTION WITH THE REAGENT 有权转让
标题翻译：试剂用试剂有机合成过程中的有机合成反应
公开(公告)号：EP2003104A2
公开(公告)日：2008-12-17
申请号：EP07714522.5
申请日：2007-02-19
申请人： National University Corporation Tokyo University of Agriculture and Technology , Jitsubo Co. Ltd.
发明人： CHIBA, Kazuhiro , KIM, Shokaku , KONO, Yusuke
IPC分类号： C07B61/00 , C07C41/22 , C07C41/26 , C07C43/225 , C07C43/23 , C07C67/08 , C07C69/734 , C07C217/84 , C07C265/12 , C07C273/18 , C07C275/34 , C07C281/20 , C07D233/60 , C07D487/04 , C07F9/50
CPC分类号： C07C69/96 , C07C67/08 , C07C217/58 , C07C265/12 , C07C275/34 , C07C281/20 , C07D233/60 , C07D487/04 , C07F9/5022 , C07C69/734
摘要： A reagent for organic synthesis with which a chemical reaction can be conducted in a liquid phase and unnecessary compound(s) can be easily separated at low cost from the liquid phase after completion of the reaction. The reagent for organic synthesis reversibly changes from a liquid-phase state to a solid-phase state with changes in solution composition and/or solution temperature, and is for use in organic synthesis reactions. This reagent for organic syntheses facilitates process development. With the reagent, research on and development of, e.g., medicines through, e.g., compound library synthesis, etc. can be accelerated. It can hence contribute to technical innovations in the biochemical industry and chemical industry.
摘要翻译：用于有机合成与化学反应可以在液相和不必要的化合物（S）中进行的试剂可以以低成本在反应完成后容易地分离从液相。用于有机合成的试剂可逆地从液相状态变为固相状态，在溶液组合物和/或溶液温度的变化，并且是用于在有机合成反应中的用途。此试剂的有机合成便于过程开发。与试剂，研究和开发，通过，E. G.，化合物库合成等E. G.药物可以被加速。它可以在生物化学和化学工业因此有助于技术创新。

116. 发明公开

EP1785485A1 ARABINOGALACTAN PROTEIN HAVING ACTIVITY OF IMPROVING TOLERANCE TO HEAT OR MOISTURE STRESS 有权
标题翻译：和作业阿拉伯半乳聚糖蛋白耐受热或水分胁迫的改进
公开(公告)号：EP1785485A1
公开(公告)日：2007-05-16
申请号：EP05767458.2
申请日：2005-08-01
申请人： National University Corporation Tokyo University of Agriculture and Technology
发明人： YAMADA, Akiyo , OZEKI, Yoshihiro , AKATSUKA, Satoko c/o Japan Women's University
IPC分类号： C12N15/09 , A01H5/00 , C07K14/415 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02
CPC分类号： C12N15/8273 , C07K14/415
摘要： It is intended to provide a gene encoding a protein having an activity of improving a tolerance to an environmental stress such as salt, moisture, or heat stress, in particular, a tolerance to water stress; a protein having an activity of improving a tolerance to an environmental stress; a transgenic plant having an enhanced tolerance to an environmental stress, and so on. A halophyte Salicornia europaea, which has a strong activity of improving a tolerance to water stress and can grow even in a dry area with much salt accumulation, was used to search genes participating in the salt tolerance of Salicornia europaea by a functional screening method using an Escherichia coli gene expression system, with the aim of isolating genes (cDNAs) participating in the salt-tolerance mechanism of Salicornia europaea. As a result, it was found out that an arabinogalactan protein consisting of 427 amino acids and having partial homology to a Fasciclin-like arabinogalactan protein of Arabidopsis thaliana has a function of enhancing salt tolerance, water stress tolerance (sorbitol tolerance), and heat tolerance.
摘要翻译：它的目的是提供编码具有对提高一个的环境胁迫耐受的活性的蛋白质的基因：如盐，水分，或热应力，特别是耐受水胁迫; 具有改进的容差对环境胁迫的活性的蛋白质; 具有增强的转基因植物对向环境压力，等等。一个盐生植物海蓬子，其中有提高耐受水分胁迫较强的活性，能与很多盐分积累，其用于通过使用在功能性筛选方法来搜索参与海蓬子的耐盐基因的干燥区域甚至长出大肠杆菌的基因表达系统，具有分离的基因（cDNA的）参加海蓬子的耐盐性机制的目的。其结果是，它什么发现没有到阿拉伯半乳聚糖蛋白质的427个氨基酸由...组成和具有部分同源性的拟南芥的Fasciclin状阿拉伯半乳聚糖蛋白质具有强化耐盐性，水分胁迫耐受性（山梨醇公差）和耐热性的功能，

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