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101. 发明公开

EP0807632A4 PYRROLOAZEPINE DERIVATIVES 失效
标题翻译： PYRROLOAZEPIN衍
公开(公告)号：EP0807632A4
公开(公告)日：1998-12-09
申请号：EP96939340
申请日：1996-12-02
申请人： SUNTORY LTD
发明人： MIZUNO AKIRA , SHIBATA MAKOTO , IWAMORI TOMOE , SHIMAMOTO TETSUO , NAKANISHI KYOKO , INOMATA NORIO
IPC分类号： A61P7/00 , A61P9/00 , C07D207/34 , C07D487/04 , C07D495/20 , A61K31/55
CPC分类号： C07D487/04 , C07D207/34
摘要： Disclosed is a pyrroloazepine derivative or a salt thereof. The pyrroloazepine derivative is represented by the following formula (I): wherein the ring P represented by means a pyrrole ring represented by the following structure: in which R1 represents alkyl, cycloalkyl or the like, and R2 represents H or alkyl; the dashed line indicates the presence or absence of a bond; and, when the bond is present, Z2 is not present/and Z1 represents H but, when the bond is absent, Z1 and Z2 are both H; Z1 represents H and Z2 represents a group OR3 in which R3 represents H, alkyl, aralkyl or the like; Z1 and Z2 both represent groups SR4 in which R4 represents alkyl, aralkyl or the like; or Z1 and Z2 are combined together to represent O, a group NOR5 in which R5 represents H, alkyl or the like, or a C2-C3 alkylenedithio; A represents alkylene, alkenylene or alkynylene; and Y represents a group in which W represents CH, C= or N, m stands for 0 or 1, n stands for 1, 2 or 3, G represents O, S, C=O, sulfinyl, sulfonyl, alkylene, alkenylene, acetal or the like; E1 and E2 represent H or lower alkyl group; and D represents an aromatic hydrocarbon or am aromatic heterocyclic ring. The compound (I) has strong serotonin-2 receptor antagonistic action and low toxicity and less side effects, and is useful as a therapeutic for circulatory diseases such as ischemic heart diseases, cerebrovascular disturbances and peripheral circulatory disturbances.
摘要翻译：（1）表示的环P是指由（2）或（3）表示的吡咯环（其中R 1表示烷基，环烷基等，并且R 2表示H）表示的吡咯环，其中R表示吡咯并氮杂环庚烯衍生物或其盐，或烷基）; 虚线表示键的存在或不存在; 当键存在时，则Z 2不存在且Z 1表示H; 当键不存在时，则Z 1和Z 2各自表示H，Z 1表示H，Z 2表示OR 3（其中R 3表示H，烷基，芳烷基等）表示的基团，Z 1和Z 2各自表示SR 4 其中R 4代表烷基，芳烷基等），或Z 1和Z 2结合表示O，NOR 5（其中R 5代表H，烷基等）或C 2-3亚烷基二硫代表的基团; A代表亚烷基，亚烯基或亚炔基; Y代表由（4）表示的基团（其中W代表CH，C =或N; m为0或1; n为1,2或3; G代表O，S，C = O，亚磺酰基，磺酰基，亚烷基，亚烯基，缩醛等; E1和E2各自表示H或低级烷基;并且D表示芳族烃基或杂芳基）。化合物（I）具有有效的血清素-2受体拮抗作用，毒性和副作用减少，是缺血性心脏病，脑血管障碍等循环系统疾病的有用治疗剂; 和外周循环障碍。

102. 发明授权

EP0276541B2 Process for production of arachidonic acid 有权转让
标题翻译：一种用于生产花生四烯酸的过程
公开(公告)号：EP0276541B2
公开(公告)日：1998-08-26
申请号：EP87308690.4
申请日：1987-09-30
申请人： SUNTORY LIMITED
发明人： Shinmen, Yoshifumi , Yamada, Hideaki , Shimizu, Sakayu
IPC分类号： C12P7/64
CPC分类号： C12P7/6427 , C12P7/6472

103. 发明公开

EP0811385A3 Conjugate of a factor specifically recognizing interleukin-2 receptor with ribonuclease 失效
标题翻译：口腔on em em em em em em lease lease lease lease lease lease lease lease lease lease lease lease lease lease lease lease lease
公开(公告)号：EP0811385A3
公开(公告)日：1998-05-13
申请号：EP97109034
申请日：1997-06-04
申请人： SUNTORY LTD
发明人： UEDA MASAKAZU
IPC分类号： C12N15/09 , A61K38/00 , A61K47/48 , A61P35/02 , C07H21/04 , C07K14/52 , C07K14/54 , C07K14/55 , C07K14/705 , C07K14/715 , C07K19/00 , C12N9/22
CPC分类号： C12N9/22 , A61K38/00 , A61K47/642 , C07K14/55 , C07K2319/00
摘要： A drug useful as an anticancer agent which has scarcely any antigenecity or side-effect, can be produced at a practically available yield and is usable in the treatment of immunological diseases too.
A conjugate of a factor specifically recognizing interleukin-2 receptor with a ribonuclease and a medicinal composition containing this conjugate as the active ingredient.
摘要翻译：用作抗癌剂的药物几乎不具有任何抗原性或副作用，可以以实际可获得的产量生产，也可用于治疗免疫疾病。特异性识别白细胞介素-2受体与核糖核酸酶的因子的缀合物和含有该结合物作为活性成分的药物组合物。

104. 发明公开

EP0684210A4 WATER PURIFYING MATERIAL, PROCESS FOR PRODUCING THE SAME, AND WATER PURIFICATION EQUIPMENT. 失效
标题翻译：水清洗材料，水和清洁器件制造方法。
公开(公告)号：EP0684210A4
公开(公告)日：1996-11-06
申请号：EP94931192
申请日：1994-10-31
申请人： SUNTORY LTD , KURARAY CHEMICAL KK , TAKUMA KK
发明人： MATSUMOTO NOBUYA , KUNISAKI SHINICHI , FUJII YOHICHI , TSUSHIMA TETSUYA , FUJIWARA GORO , MASUDA MITSUNOBU
IPC分类号： B01J20/18 , B01J20/20 , B01J20/34 , C01B31/08 , C02F1/28 , C02F1/50
CPC分类号： C02F1/28 , C02F1/283 , C02F1/288 , C02F1/505
摘要： A water purifying material which is used for treating water for domestic and industrial uses and comprises activated carbon and zeolite containing silver combined therewith or a zirconium phosphate compound containing silver supported thereon. The material has an excellent antibacterial activity, a high rate of operation, and an improved function of adsorbing and removing various factors detrimental to the taste of water, such as limy odor due to free chlorine, impurities, malodorous materials and musty odor. The invention material serves to solve the problems of the conventional materials, such as a reduced rate of operation resulting from the necessity for prolonged thermal sterilization for providing aseptic treated water and, particularly in the thermal sterilization using boiler water, the contamination of treated water with boiler chemicals.

105. 发明公开

EP0535241A4 NOVEL LEUCINE AMINOPEPTIDASE 失效
标题翻译：新型白蛋白氨基酸
公开(公告)号：EP0535241A4
公开(公告)日：1994-11-23
申请号：EP92907603
申请日：1992-03-31
申请人： SUNTORY LTD
发明人： TSUJIMOTO MASAFUMI , ADACHI HIDEKI , NAKAZATO HIROSHI
IPC分类号： A61K38/46 , A61P13/02 , A61P15/00 , C12N9/48
CPC分类号： C12N9/48

106. 发明公开

EP0517918A4 MONOCLONAL ANTIBODY AGAINST CARDIAC GLYCOSIDE AND UTILIZATION THEREOF 有权
标题翻译：单克隆抗坏血酸及其利用的单克隆抗体
公开(公告)号：EP0517918A4
公开(公告)日：1994-08-17
申请号：EP91916591
申请日：1991-09-24
申请人： SUNTORY LTD
发明人： TERANO YOSHITAKE , NAKAZATO HIROSHI
IPC分类号： C07K16/44 , C12N5/20 , C12P21/08
CPC分类号： C07K16/44

107. 发明授权

EP0114670B1 Novel cell lines for use in the preparation of hybridoma cells 有权
标题翻译：用于制备杂交细胞的新细胞系
公开(公告)号：EP0114670B1
公开(公告)日：1991-10-02
申请号：EP84100548.1
申请日：1984-01-19
申请人： SUNTORY KABUSHIKI KAISHA, also known as SUNTORY LTD.
发明人： Nakanishi, Toshihiro , Matsui, Masashi , Miura, Kenju Matsunokichodanchi 1-704 , Fukuda, Yoshiaki , Noguchi, Teruhisa
IPC分类号： C12N5/00 , C12N5/20 , C12P21/08
CPC分类号： C12N5/163 , C07K14/52 , C07K14/57 , Y10S435/948

108. 发明授权

EP0162208B1 Novel N-substituted 3,4-dihydropyrimidine derivatives, processes for preparing them and pharmaceutical compositions 有权
标题翻译：新型N-取代的3,4-二羟基嘧啶衍生物，其制备方法和药物组合物
公开(公告)号：EP0162208B1
公开(公告)日：1989-11-23
申请号：EP85102645.0
申请日：1985-03-08
申请人： SUNTORY KABUSHIKI KAISHA, also known as SUNTORY LTD.
发明人： Cho, Hidetsura , Aisaka, Kazuo , Satoh, Fumio , Ishihara, Takafumi
IPC分类号： C07D239/20 , A61K31/505
CPC分类号： C07D239/20

109. 发明公开

EP0276541A3 Process for production of arachidonic acid 有权转让
标题翻译：生产亚硝酸的方法
公开(公告)号：EP0276541A3
公开(公告)日：1989-07-26
申请号：EP87308690.4
申请日：1987-09-30
申请人： SUNTORY LIMITED
发明人： Shinmen, Yoshifumi , Yamada, Hideaki , Shimizu, Sakayu
IPC分类号： C12P7/64
CPC分类号： C12P7/6427 , C12P7/6472
摘要： A process for the production of arachidonic acid comprising culturing a microorganism belonging to the genus Mortierella capable of producing arachidonic acid to produce arachidonic acid or a lipid comprising arachidonic acid, and recovering the arachidonic acid or a lipid comprising arachidonic acid, wherein the culturing is carried out in the presence of a hydrocarbon, fatty acid or a salt thereof, or a fat, or a combination thereof.

110. 发明公开

EP0114670A3 Novel cell lines for use in the preparation of hybridoma cells 有权
标题翻译：用于制备杂交细胞的新细胞系
公开(公告)号：EP0114670A3
公开(公告)日：1987-01-21
申请号：EP84100548
申请日：1984-01-19
申请人： SUNTORY KABUSHIKI KAISHA, also known as SUNTORY LTD.
发明人： Nakanishi, Toshihiro , Matsui, Masashi , Miura, Kenju Matsunokichodanchi 1-704 , Fukuda, Yoshiaki , Noguchi, Teruhisa
IPC分类号： C12N05/00 , C12N15/00 , C12P21/00
CPC分类号： C12N5/163 , C07K14/52 , C07K14/57 , Y10S435/948
摘要： A novel cell line for use as a parent for hybridoma preparation is provided. This cell line is derived from tumor cells, in particular human tumor cells, other than those originating from bone marrow cells. A method for establishing this cell line is also provided. By fusing this cell line with cells producing useful physiologically active substances, such as B cells immunized with an antigen, a hybridoma capable of active growth can be prepared. This hybridoma can be cultivated for the production of useful physiologically active substances.

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