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101. 发明公开

EP2836513A1 MODULATED LYSINE VARIANT SPECIES COMPOSITIONS AND METHODS FOR PRODUCING AND USING THE SAME 审中-公开
标题翻译：方法调制C-末端赖氨酸衍生物的分布的
公开(公告)号：EP2836513A1
公开(公告)日：2015-02-18
申请号：EP13785752.0
申请日：2013-10-18
申请人： AbbVie Inc.
发明人： SUBRAMANIAN, Kartik , PEREZ THIELE, Mayda , ZENG, Xiaobei , WONG, Chee, Furng , KAYMAKCALAN, Zehra , JING, Ying , CHUMSAE, Christopher
IPC分类号： C07K16/00 , C07K16/28 , C12N5/00
CPC分类号： C07K16/241 , C07K16/00 , C07K16/2803 , C07K2317/14 , C07K2317/21 , C07K2317/40 , C07K2317/526 , C12N5/0018 , C12N2500/22 , C12N2500/32 , C12N2511/00 , C12P21/00
摘要： The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the distribution or amount of lysine variants expressed by host cells, as well as to compositions and processes for controlling the amount of lysine variants present in purified preparations.

102. 发明公开

EP2834230A1 CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS V 审中-公开
标题翻译：甲酰胺化合物和它们作为钙蛋白酶抑制剂V选用
公开(公告)号：EP2834230A1
公开(公告)日：2015-02-11
申请号：EP13709139.3
申请日：2013-03-14
申请人： AbbVie Deutschland GmbH & Co KG , AbbVie Inc.
发明人： KLING, Andreas , JANTOS, Katja , MACK, Helmut , MÖLLER, Achim , HORNBERGER, Wilfried , BACKFISCH, Gisela , LAO, Yanbin , NIJSEN, Marjoleen
IPC分类号： C07D401/14 , C07D405/14 , C07D401/04 , C07D471/04 , C07D487/04 , A61K31/4439 , A61P25/00 , A61P31/00 , A61P33/00 , A61P35/00
CPC分类号： C07D401/14 , C07D401/04 , C07D405/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D491/048 , C07D491/107
摘要： The present invention relates to novel carboxamide compounds and their use for the manufacture of a medicament. The carboxamide compounds are inhibitors of calpain (calcium dependant cysteine proteases). The invention therefore also relates to the use of these carboxamide compounds for treating a disorder associated with an elevated calpain activity. The carboxamide compounds are compounds of the general formula (I) in which R1, R2 and n have the meanings mentioned in the claims and the description, Y is a radical of the formulae (Y1) or (Y2) where # indicates the point of attachment of Y to the pyridine ring, R3, R4, R5, Ry and m have the meanings mentioned in the claims and the description, A is (CH2)p with p being 1, 2, 3 or 4, where one or two hydrogen atoms may be replaced by a radical R6, where A is attached to the 3- or 4-position of the pyrazole radical and R6 has the meaning mentioned in the claims and the description; A1 is (CH2)q with q being 0, 1, 2 or 3, where one or two hydrogen atoms may be replaced by halogen or C1-C4-alkyl; and A2 is (CH2)r with r being 0, 1, 2 or 3, where one or two hydrogen atoms may be replaced by halogen or C1-C4-alkyl, provided that that r+q is 2, 3, 4, 5 or 6; their tautomers, the hydrates thereof, the pharmaceutically suitable salts of the carbox-amide compounds (I), the prodrugs of (I) and the pharmaceutically suitable salts of the prodrugs, tautomers or hydrates of (I).

103. 发明公开

EP2830651A1 HUMAN ANTIBODIES THAT BIND HUMAN TNF-ALPHA AND METHODS OF PREPARING THE SAME 审中-公开
标题翻译：人类TNF-ALPHA BINDENDE人类抗体在VERFAHREN ZUR HERSTELLUNG DAVON
公开(公告)号：EP2830651A1
公开(公告)日：2015-02-04
申请号：EP13877986.3
申请日：2013-11-12
申请人： AbbVie Inc.
发明人： CHUMSAE, Chris, M.
IPC分类号： A61K39/00 , C07K16/24 , C07K1/18 , C12N5/10 , G01N33/68
CPC分类号： C07K16/241 , B01D15/362 , C07K1/18 , C07K2317/21 , C07K2317/40 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N30/96
摘要： Methylglyoxal (MGO)-modified recombinant TNF-alpha antibodies (e.g., Adalimumab) are identified. MGO modification decreases binding between Adalimumab and TNF-alpha. Methods are disclosed for reducing the presence of MGO-modified antibodies in the production of Adalimumab TNF-alpha antibodies.
摘要翻译：鉴定出甲基乙二醛（MGO）修饰的重组TNF-α抗体（如阿达木单抗）。 MGO修饰降低阿达木单抗与TNF-α之间的结合。公开了用于在产生阿达木单抗TNF-α抗体中减少MGO修饰的抗体的存在的方法。

104. 发明授权

EP2350127B1 ISOLATION AND PURIFICATION OF ANTIBODIES USING PROTEIN A AFFINITY CHROMATOGRAPHY 无效
标题翻译：澳门特别行政区隔离抗原蛋白抗原蛋白A-AFFINITÄTSCHROMATOGRAPHIE
公开(公告)号：EP2350127B1
公开(公告)日：2015-01-28
申请号：EP09744006.9
申请日：2009-10-20
申请人： AbbVie Inc.
发明人： HICKMAN, Robert, K. , HUANG, Qing , WEED, Cheryl, L. , ENNIS, Scott, T. , PERILLI-PALMER, Barbara , WAN, Min
IPC分类号： C07K16/00 , C07K16/24
CPC分类号： C07K16/241 , C07K1/165 , C07K1/18 , C07K1/20 , C07K1/22 , C07K1/36 , C07K16/00 , C07K16/244 , C07K2317/14 , C07K2317/21 , C07K2317/22 , C07K2317/24 , Y10S436/824

105. 发明公开

EP2772269A3 IL-17 binding proteins 审中-公开
标题翻译： IL-17结合蛋白
公开(公告)号：EP2772269A3
公开(公告)日：2015-01-14
申请号：EP14162807.3
申请日：2010-03-05
申请人： Abbvie Inc.
发明人： Hsieh, Chung-Ming , Hugunin, Margaret , Murtaza, Anwar , McRae, Bradford L. , Kutskova, Yuliya , Memmott, John E. , Perez, Jennifer M. , Zhong, Suju , Tarcsa, Edit , Clabbers, Anca , Wallace, Craig , Bryant, Shaughn H. , Leddy, Mary R.
IPC分类号： A61K39/395
CPC分类号： C07K16/468 , A61K39/3955 , A61K2039/505 , A61K2039/507 , A61K2300/00 , C07K16/241 , C07K16/244 , C07K2317/21 , C07K2317/31 , C07K2317/50 , C07K2317/565 , C07K2317/64 , C07K2317/76 , C07K2317/92 , Y02A50/386 , Y02A50/41 , Y02A50/412 , Y02A50/466
摘要： Proteins that bind IL- 17 and/or IL- 17F are described along with their use in composition and methods for treating, preventing, and diagnosing IL- 17 related diseases and for detecting IL-17 in cells, tissues, samples, and compositions.

106. 发明公开

EP2820640A1 AUTOMATIC INJECTION TRAINING DEVICE 有权
标题翻译：自动注射训练装置
公开(公告)号：EP2820640A1
公开(公告)日：2015-01-07
申请号：EP13710707.4
申请日：2013-03-01
申请人： AbbVie Inc.
发明人： LAURUSONIS, Linas, P. , ANDERSON, Philip, D. , WIDMAN, Matthew, M. , MCLEROY, Timothy, D.
IPC分类号： G09B23/28
CPC分类号： G09B23/285 , G06F19/00
摘要： Exemplary embodiments of the present disclosure provide reusable training automatic injection training devices, and components thereof, to simulate and/or mimic an operation of an actual automatic injection device. Exemplary embodiments of the training device can provide audible instructions, which can be in different languages, output from circuitry associated with the training device. Exemplary embodiment of the training device can be a self-contained and portable device that mimics a shape, size, and function of an actual automatic injection device without including a needle or any drug on board. Exemplary embodiments can be implemented to train a user on an operation and/or usage of an actual automatic injection device using embodiments of the automatic injection training devices so that a user can practice an autoinjection without injecting a therapeutic agent, such as a liquid drug, into a recipient.
摘要翻译：本公开的示例性实施例提供可重复使用的训练自动注射训练装置及其部件以模拟和/或模仿实际自动注射装置的操作。训练设备的示例性实施例可以提供可以用不同语言从与训练设备相关联的电路输出的可听指令。训练装置的示例性实施例可以是模拟实际自动注射装置的形状，尺寸和功能而不包括针或任何药物在船上的独立且便携式装置。示例性实施例可以被实现为使用自动注射训练装置的实施例来训练用户对实际自动注射装置的操作和/或使用，使得用户可以在不注射诸如液体药物的治疗剂的情况下实践自动注射，成为收件人。

107. 发明公开

EP2810654A1 Prostaglandin E2 binding proteins and uses thereof 审中-公开
标题翻译：前列腺素E2结合蛋白和Verrendung
公开(公告)号：EP2810654A1
公开(公告)日：2014-12-10
申请号：EP14176206.2
申请日：2009-07-08
申请人： AbbVie Inc.
发明人： Gu, Jijie , Hutchins, Charles, W. , Zhu, Rong-Rong , Shen, Jianwei , Harris, Maria, C. , Belanger, Eileen , Murtaza, Anwar , Tarcsa, Edit , Stine, William, B. , Hsieh, Chung-ming
IPC分类号： A61K39/395 , C07K16/26
CPC分类号： C07K16/18 , A61K31/405 , A61K31/573 , A61K39/39533 , A61K2039/505 , C07K16/26 , C07K2317/21 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/76 , Y02A50/386 , Y02A50/401 , Y02A50/41 , Y02A50/412 , Y02A50/478 , Y02A50/481
摘要： The present invention encompasses prostaglandin E 2 (PGE 2 ) binding proteins. The invention relates to antibodies that are wild-type, chimeric, CDR grafted and humanized. Preferred antibodies have high affinity for prostaglandin E 2 and neutralize prostaglandin E 2 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody, or an antigen-binding portion thereof. Methods of making and methods of using the antibodies of the invention are also provided. The antibodies, or antigen-binding portions, of the invention are useful for detecting prostaglandin E 2 and for inhibiting prostaglandin E 2 activity, e.g., in a human subject suffering from a disorder in which prostaglandin E 2 activity is detrimental.
摘要翻译：本发明包括前列腺素E 2（PGE 2）结合蛋白。本发明涉及野生型，嵌合型，CDR移植和人源化的抗体。优选的抗体对前列腺素E 2具有高亲和力，并在体外和体内中和前列腺素E 2活性。本发明的抗体可以是全长抗体或其抗原结合部分。还提供了制备方法和使用本发明抗体的方法。本发明的抗体或抗原结合部分可用于检测前列腺素E 2和用于抑制前列腺素E 2活性，例如在患有前列腺素E 2活性有害的病症的人类受试者中。

108. 发明公开

EP2797955A2 DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AGAINST IL-13 AND/OR IL-17 审中-公开
标题翻译： IMMUNGLOBULINE MIT ZWEIFACHER VARIABLERDOMÄNEGEGEN IL-13 UND / ODER IL-17
公开(公告)号：EP2797955A2
公开(公告)日：2014-11-05
申请号：EP12816217.9
申请日：2012-12-28
申请人： AbbVie Inc.
发明人： HSIEH, Chung-Ming , GHAYUR, Tariq , GOODREAU, Carrie, L.
IPC分类号： C07K16/24 , C07K16/46 , C12N15/13 , A61K39/395
CPC分类号： C07K16/468 , A61K39/3955 , A61K45/06 , C07K16/244 , C07K2317/14 , C07K2317/24 , C07K2317/31 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/64 , C07K2317/76 , C07K2317/92 , G01N33/6854 , G01N33/6869 , G01N2333/54 , G01N2333/5437
摘要： Engineered multivalent and multispecific binding proteins that bind IL-13 and/or IL-17 are provided, along with methods of making and uses in the prevention, diagnosis, and/or treatment of disease.
摘要翻译：提供结合IL-13和/或IL-17的工程化多价和多特异性结合蛋白，以及制备和用于预防，诊断和/或治疗疾病的方法。

109. 发明公开

EP2714035A4 ANTI-VIRAL COMPOUNDS 审中-公开
公开(公告)号：EP2714035A4
公开(公告)日：2014-11-05
申请号：EP12790211
申请日：2012-05-25
申请人： ABBVIE INC
发明人： KRUEGER ALLAN C , KATI WARREN M , MARING CLARENCE J , WAGNER ROLF , HUTCHINS CHARLES W
IPC分类号： A61K31/407 , A61K31/4162 , A61P31/00 , A61P31/12
CPC分类号： C07D487/04 , A61K31/407 , A61K31/4162

110. 发明授权

EP2516393B1 CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS 有权
标题翻译：甲酰胺化合物及其作为钙蛋白酶抑制剂
公开(公告)号：EP2516393B1
公开(公告)日：2014-10-29
申请号：EP10795007.3
申请日：2010-12-21
申请人： AbbVie Deutschland GmbH & Co KG , AbbVie Inc.
发明人： KLING, Andreas , JANTOS, Katja , MACK, Helmut , MÖLLER, Achim , HORNBERGER, Wilfried , BACKFISCH, Gisela , LAO, Yanbin , NIJSEN, Marjoleen
IPC分类号： C07D207/28 , C07D401/04 , C07D401/14 , A61K31/4015 , A61K31/4439 , A61P25/28 , A61P27/08 , A61P35/00 , A61P13/12 , A61P31/00 , A61P31/18 , A61P25/00 , A61P9/00 , A61P21/00
CPC分类号： C07D401/04 , C07D207/28 , C07D401/14 , C07D409/14 , C07D417/14

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