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91. 发明公开

EP1299391A2 INDOLINOSPIROPYRAN COMPOUNDS AND METHODS FOR THEIR MANUFACTURE 有权
标题翻译： INDOLINOSPIROPYRANVERBINDUNGEN及其生产方法
公开(公告)号：EP1299391A2
公开(公告)日：2003-04-09
申请号：EP01944175.7
申请日：2001-05-24
申请人： Johnson & Johnson Vision Care, Inc.
发明人： CARREIRA, Erick, M. , WEILI, Zhao
IPC分类号： C07D491/00
CPC分类号： C07D491/10
摘要： The present invention provides indolinospiropyran compounds and methods for their manufacture, which compounds are useful as photochromic compounds. The compounds of the invention are substituted on the indole ring with succinimide, which substitution permits ring opening of the succinimide and modulation of the bulk and photochromic properties of the compounds. The compounds may be conveniently prepared using the solid phase organic synthesis of the invention.

92. 发明公开

EP1023295A4 FIBRINOGEN RECEPTOR ANTAGONIST PRODRUGS 失效
标题翻译：纤维蛋白原受体拮抗剂药物前体
公开(公告)号：EP1023295A4
公开(公告)日：2001-01-24
申请号：EP98906092
申请日：1998-02-02
申请人： MERCK & CO INC
发明人： EGBERTSON MELISSA S , YOUNG STEVE D , HARTMAN GEORGE D , COOK JACQUELYNN J
IPC分类号： C07D333/40 , A61K31/216 , A61K31/381 , A61K31/404 , A61K31/5517 , A61P7/02 , A61P9/10 , A61P43/00 , C07C311/19 , C07D209/42 , C07D333/38 , C07D487/04 , C07D487/00 , A61K31/55 , C07C69/02 , C07D491/00 , C07D495/00
CPC分类号： C07D487/04 , C07D209/42 , C07D333/38

93. 发明公开

EP1023295A1 FIBRINOGEN RECEPTOR ANTAGONIST PRODRUGS 失效
标题翻译：纤维蛋白原受体拮抗剂药物前体
公开(公告)号：EP1023295A1
公开(公告)日：2000-08-02
申请号：EP98906092.6
申请日：1998-02-02
申请人： MERCK & CO., INC.
发明人： EGBERTSON, Melissa, S. , YOUNG, Steve, D. , HARTMAN, George, D. , COOK, Jacquelynn, J.
IPC分类号： C07D487/00 , C07D491/00 , C07D495/00 , C07C69/02
CPC分类号： C07D487/04 , C07D209/42 , C07D333/38
摘要： Fibrinogen receptor antagonist prodrugs having the structure, for example, of formula (I), and more particularly, of formula (II).

94. 发明公开

EP0638584A4 5-O-DESOSAMINYLERYTHRONOLIDE A DERIVATIVE. 失效
标题翻译： 5-0-去甲氨基胆碱酯衍生物。
公开(公告)号：EP0638584A4
公开(公告)日：1994-12-23
申请号：EP93909403
申请日：1993-04-21
申请人： TAISHO PHARMA CO LTD
发明人： ASAKA TOSHIFUMI TAISHO PHARMAC , KASHIMURA MASATO TAISHO PHARMA , MISAWA YOKO TAISHO PHARMACEUTI , MORIMOTO SHIGEO TAISHO PHARMAC , HATAYAMA KATSUO TAISHO PHARMAC
IPC分类号： A61K31/395 , C07D491/00 , C07H17/00 , C07H17/08
CPC分类号： C07H17/08 , C07H17/00
摘要： A novel macrolide antibiotic having a potent antibacterial activity, 11-amino-3,11-dideoxy-3-oxo-5-O-desosaminyl-6-O-methylerythronolide A 11-N, 12-O-cyclic carbamate represented by formula (I), and a pharmaceutically acceptable acid addition salt thereof.

95. 发明授权

EP0340169B1 Chromogene Laktonverbindungen von Benzopyrano-2H-pyrazolen 失效
标题翻译：色素Laktonverbindungen von Benzopyrano-2H-pyrazolen。
公开(公告)号：EP0340169B1
公开(公告)日：1994-11-30
申请号：EP89810293.4
申请日：1989-04-18
申请人： CIBA-GEIGY AG
发明人： Fletcher, Ian John, Dr.
IPC分类号： C07D491/20 , B41M5/124 , C07D491/00 , B41M5/00 , B41M5/30
CPC分类号： C07D491/14 , B41M5/145 , B41M5/1455 , B41M5/327 , B41M5/3275

96. 发明授权

EP0322248B1 Compounds effective against cerebral insufficiency 失效
标题翻译：化合物对谷物无效有效
公开(公告)号：EP0322248B1
公开(公告)日：1993-08-04
申请号：EP88312263.2
申请日：1988-12-22
申请人： SUNTORY LIMITED
发明人： Tatsuoka, Toshio , Sumoto, Kunihiro , Suzuki, Kenji , Satoh, Fumio , Miyano, Seiji
IPC分类号： C07C59/90 , C07C69/608 , C07D491/00 , C07D513/00
CPC分类号： C07C59/90 , C07C59/86 , C07D311/58 , C07D311/66

97. 发明公开

EP0472526A4 5-AMINOCARBONYL-5H-DIBENZO A,D)CYCLOHEPTEN-5,10-IMINES FOR TREATMENT OF EPILEPSY AND COCAINE ADDICTION 失效
标题翻译： 5-氨基羰基-5H-二苯并咪唑A，D）环磷酰胺-5,10-IMINES用于治疗癫痫和加拿大
公开(公告)号：EP0472526A4
公开(公告)日：1992-05-20
申请号：EP90905307
申请日：1990-03-23
申请人： US HEALTH
发明人： MONN, JAMES, A. , THURKAUF, ANDREW , YAMAGUCHI, SHUNICHI , ROGAWSKI, MICHAEL, A. , RICE, KENNETH, C. , MATTSON, MARIENA, V. , JACOBSON, ARTHUR, E.
IPC分类号： C07D451/00 , A61K31/395 , A61K31/435 , A61K31/46 , A61K31/55 , A61P25/08 , A61P25/30 , C07D451/02 , C07D471/18 , C07D471/20 , A61K31/44 , A61K31/495 , C07D221/22 , C07D223/04 , C07D241/36 , C07D401/00 , C07D487/00 , C07D491/00
CPC分类号： C07D451/00

98. 发明公开

EP0340169A3 Chromogene Laktonverbindungen von Benzopyrano-2H-pyrazolen 失效
标题翻译：苯并吡喃-2H-吡唑的染料化合物化合物
公开(公告)号：EP0340169A3
公开(公告)日：1991-05-29
申请号：EP89810293.4
申请日：1989-04-18
申请人： CIBA-GEIGY AG
发明人： Fletcher, Ian John, Dr.
IPC分类号： C07D491/20 , B41M5/124 , C07D491/00 , B41M5/00 , B41M5/30
CPC分类号： C07D491/14 , B41M5/145 , B41M5/1455 , B41M5/327 , B41M5/3275
摘要： Chromogene Laktonverbindungen von Benzopyrano-2H-pyrazolen der Formel
worin
Ar einen unsubstituierten oder durch Halogen, Nitro, Cyano, Niederalkyl, Niederalkoxy, Niederalkylthio, Niederalkoxycarbonyl, Trifluormethyl, Phenoxy, Phenylthio oder -NX₃X₄ substituierten Arylrest,
R₁ Wasserstoff, Halogen, Niederalkyl oder Niederalkoxy,
R₂ Niederalkyl, Phenyl oder durch Halogen, Niederalkyl oder Niederalkoxy substituiertes Phenyl, und
X₁, X₂, .X₃ und X₄, unabhängig voneinander, je Wasserstoff, unsubstituiertes oder durch Halogen, Hydroxy, Cyano, Tetrahydrofuryl oder Niederalkoxy substituiertes Alkyl, Acyl, Cycloalkyl oder unsubstituiertes oder durch Halogen, Cyano, Nitro, Trifluormethyl, Niederalkyl, Niederalkoxy oder Niederalkoxycarbonyl substituiertes Aralkyl oder Aryl oder die Substituentenpaare (X₁ und X₂) und (X₃ und X₄) je zusammen mit dem gemeinsamen Stickstoffatom einen fünf- oder sechsgliedrigen, vorzugsweise gesättigten, heterocyclischen Rest bedeuten und worin
der Ring A unsubstituiert oder durch Halogen, Nitro, Niederalkyl, Niederalkoxy, Niederalkylthio, Niederalkoxycarbonyl, Amino, Mononiederalkylamino oder Diniederalkylamino substituiert ist. Diese neuen Laktonverbindungen eignen sich insbesondere als Farbbildner in druckempfindlichen oder wärmeempfindlichen Aufzeichnungsmaterialien und ergeben intensive gelbe, orange oder rote Färbungen.

99. 发明公开

EP0369733A3 Fluorescent indicator dyes for alkali metal cations, their preparation and use 有权转让
标题翻译：碱性金属染色剂的荧光指示剂及其制备和使用
公开(公告)号：EP0369733A3
公开(公告)日：1991-03-27
申请号：EP89311760.6
申请日：1989-11-14
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： Tsien, Roger Yonchien , Minta, Akwasi, (Nmn)
IPC分类号： C07D273/00 , C07D413/04 , C07D413/14 , C07D491/00 , C07D519/00 , G01N33/84
CPC分类号： C07D273/00 , C07D413/04 , C07D413/14 , C07D491/04 , G01N33/582 , G01N33/84
摘要： The invention discloses fluorescent chelator compounds that are especially useful to monitor and measure cytosolic concentrations of alkali metal cations such as Na⁺, K⁺, and Li⁺. The new compounds are comprised of: (1) crown ethers (that may or may not have substituent groups attached to the core carbons, but will always contain at least one core nitrogen) that are linked via the core nitrogen(s) to at least one (2) fluorophore that contains an additional heteroaromatic liganding center. In the currently preferred dye, SBFI , the core compound is crown ether 1,7-diaza-4,10,13-trioxacyclopentadecane and the heteroaromatic fluorophores are benzofurans that are linked to isophthalate groups. Selectivities for Na⁺ over K⁺ of about 20 are observed, resulting in effective dissociation constants for Na⁺ of about 20 mM against a background of 120 mM K⁺. Increasing [Na⁺] increases the ratio of excitation efficiency at 330-345 nm to that at 370-390 nm with emission collected at 450-550 nm, so that ratio fluorometry and imaging work at the same wavelengths as used with the well-known Ca²⁺ indicator fura-2. If the macrocyclic ring is increased in size to a 1,10-diaza-4,7,13,16-tetraoxacyclooctadecane, the chelators become selective for K⁺ over Na⁺. If the ring is decreased in size, for example to a 1,7-diaza-4,10-dioxacyclododecane, the chelators become selective for Li⁺ over Na⁺.

100. 发明公开

EP0113782A4 BICYCLIC NITROGEN HETEROCYCLIC ETHERS AND THIOETHERS, AND THEIR PHARMACEUTICAL USES. 失效
标题翻译：包含二环杂环醚和氮硫醚及其作为药物。
公开(公告)号：EP0113782A4
公开(公告)日：1986-03-18
申请号：EP83902711
申请日：1983-07-21
申请人： RORER INTERNAT OVERSEAS INC
发明人： CAMPBELL HENRY FLUD , KUHLA DONALD ERNEST , STUDT WILLIAM LYON , DODSON STUART ALAN
IPC分类号： C07D217/02 , C07D217/04 , C07D217/10 , C07D217/14 , C07D217/22 , C07D217/24 , C07D217/26 , C07D401/00 , C07D401/12 , C07D401/14 , C07D405/14 , C07D417/00 , C07D417/12 , C07D491/00 , C07D491/04 , C07D495/00 , C07D495/04 , A61K31/47 , A61K31/505 , C07D217/16
CPC分类号： C07D401/12 , C07D217/02 , C07D217/04 , C07D217/10 , C07D217/14 , C07D217/22 , C07D217/24 , C07D217/26 , C07D401/14 , C07D405/14 , C07D417/12 , C07D491/04 , C07D495/04

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