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91. 发明公开

EP1756150A2 GROUP 1 MITE POLYPEPTIDE VARIANTS 审中-公开
标题翻译：变应原1-MILBENPOLYPEPTIDS
公开(公告)号：EP1756150A2
公开(公告)日：2007-02-28
申请号：EP05731876.8
申请日：2005-04-21
申请人： Novozymes A/S
发明人： BATORI, Vincent , ROGGEN, Erwin, Ludo , ERNST, Steffen , LYNGSTRAND, Stina, Thulesen
IPC分类号： C07K14/435 , C12N15/12 , A61K39/35
CPC分类号： C07K14/43531 , A61K39/00 , A61K2039/57
摘要： This invention concerns variants of a group 1 mite polypeptide, wherein the mature polypeptide of the variants comprise one or more mutations in the positions or corresponding to positions consisting of P11, I14, D15, L16, M19-P24, Q28, F37, S38, T43, A46-A49, Q53-L57, V63, A66-H69, H72, D74-R77, I80, Y82, Q84, H85, S92, I113, S114, P121, V124, K126, R128-A130, A132-S136, A139, L147, A149-H152, T157, Q160, N163, H170, A171, S178, V183, D184, R189, D193, F204, A206, N207, P217, L222 of SEQ ID NO: 1 or alternatively 11, 14, 15, 16, 19-24, 28, 37, 38, 43, 46-49, 53-57, 63, 66-69, 72, 74-77, 80, 82, 84, 85, 92, 113, 114, 121, 124, 126, 128-130, 132-136, 139, 147, 149-152, 157, 160, 163, 170, 178, 183, 189, 193, 204, 206, 207, 217, 222 of the mature Der p 1 polypeptide.
摘要翻译：本发明涉及组1螨多肽的变体，其中变体的成熟多肽包含位置或对应于由P11，I14，D15，L16，M19-P24，Q28，F37，S38， T43，A46-A49，Q53-L57，V63，A66-H69，H72，D74-R77，I80，Y82，Q84，H85，S92，I113，S114，P121，V124，K126，R128-A130，A132-S136， SEQ ID NO：1的A139，L147，A149-H152，T157，Q160，N163，H170，A171，S178，V183，D184，R189，D193，F204，A206，N207，P217，L222或者11,14,15 ，16,19-24,28,37,38,43,46-49,53-57,63,66-69,72,74-77,80,82,84,85,92,113,114,121 ，124,126,128-130,132-136,139,147,149-152,157,160,163,170,178,183,189,193,204,206,207,217,222的成熟Der p 1多肽。

92. 发明公开

EP1743941A1 NOVEL MITE ALLERGEN 有权
标题翻译：关于微生物
公开(公告)号：EP1743941A1
公开(公告)日：2007-01-17
申请号：EP05730025.3
申请日：2005-04-07
申请人： Nippon Zenyaku Kogyo Co., Ltd.
发明人： TSUKUI, Toshihiro, Nippon Zenyaku Kogyo Ltd. , TSUJIMOTO, Hajime , IWABUCHI, Shigehiro, Nippon Zenyaku Kogyo Ltd.
IPC分类号： C12N15/12 , A61K39/35 , A61K49/00 , A61P11/02 , A61P11/06 , A61P17/04 , A61P27/14 , A61P37/08 , C07K14/435 , C07K16/18 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02 , G01N33/53 , C12P21/08
CPC分类号： C07K14/43531 , A61K39/00 , A61K39/35 , G01N33/56905 , G01N33/6854
摘要： A safe and efficient recombinant mite allergen is provided as a therapeutic agent or a diagnostic agent for mite allergic diseases, which contains no anaphylaxis-inducing impurities. The following recombinant protein (a) or (b) is provided:
(a) a protein comprising the amino acid sequence represented by SEQ ID NO: 2 or 35; or
(b) a protein comprising an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO: 2 or 35 by deletion, substitution, or addition of one or several amino acids and having mite allergen activity.
摘要翻译：提供安全有效的重组螨变应原作为治疗剂或螨变态反应性疾病的诊断剂，其不含过敏反应杂质。提供以下重组蛋白（a）或（b）：（a）包含SEQ ID NO：2或35所示的氨基酸序列的蛋白质; 或（b）通过缺失，取代或添加一个或几个氨基酸并具有螨变应原活性的蛋白质，其包含衍生自SEQ ID NO：2或35所示氨基酸序列的氨基酸序列。

93. 发明授权

EP1479773B1 MITE GALECTIN 有权
标题翻译：半乳糖凝集素FROM MITES
公开(公告)号：EP1479773B1
公开(公告)日：2006-08-30
申请号：EP03707178.4
申请日：2003-02-28
申请人： Meiji Seika Kaisha, Ltd. , Fujisaki, Kozo
发明人： FUJISAKI, Kozo, Obihiro Univ.of Agri&Vetenary Med. , NAGASAWA, Hideyuki, Obihiro Univ.Agri& Vet.Med. , IGARASHI, Ikuo, Obihiro Univ.Agri& Vet.Med. , SUZUKI, Hiroshi, Obihiro Univ.Agri & Vet. Med. , SUGIMOTO, Chichiro, Obihiro Univ.Agri & Vet. Med. , GEN, Gakunan, Obihiro Univ.Agri & Vet. Med. , KADOTA, Kimie Obihiro Uni.of Agri&Vetenary Med. , INOUE, Noboru, Obihiro Uni.of Agri.&Vetenary Med. , YOKOYAMA, Naoaki, Obihiro Univ. Agri.& Vet.Med. , TSUJI, Naotoshi
IPC分类号： C12N15/12 , C07K16/18
CPC分类号： C07K14/43531 , A61K39/00 , C07K14/4726 , C07K16/18
摘要： It is intended to disclose a novel galectin; a polynucleotide encoding the same; a vector and a transformant containing the polynucleotide; an antibody against the above galectin; and a method of screening a substance modifying the activity of the above galectin. Use of the galectin, polynucleotide or vector as described above makes it possible to exterminate mites or to treat or prevent mite-mediated infections (for example, rickettsiosis, filariasis, Q fever, African recurrent fever or viral encephalitis).

94. 发明授权

EP0694067B1 T CELL EPITOPES OF THE MAJOR ALLERGENS FROM DERMATOPHAGOIDES (HOUSE DUST MITE) 失效
标题翻译： T-ZELL EPITOPE DER HAUPTALLERGENE VON DERMATOPHAGOIDES（HAUSSTAUBMILBE）
公开(公告)号：EP0694067B1
公开(公告)日：2006-02-08
申请号：EP93910592.0
申请日：1993-04-14
申请人： IMMULOGIC PHARMACEUTICAL CORPORATION
发明人： GARMAN, Richard D. , KUO, Mei-chang , GREENSTEIN, Julia L. , ROGERS, Bruce L. , Franzén, Henry,M.
IPC分类号： C12N15/12 , A61K39/35 , C12N15/62 , G01N33/53 , C07K14/435
CPC分类号： C07K14/43531 , A61K38/00 , C07K2319/00
摘要： The present invention provides isolated peptides and/or modified peptides of the major protein allergens of the genus Dermatophagoides. Peptides within the scope of the invention comprise at least one T cell epitope, or preferably at least two T cell epitopes of a protein allergen selected from the allergens Der p I, Der p II, Der f I, or Der f II. The invention also pertains to peptides which have been further modified having similar or enhanced therapeutic properties as the corresponding, naturally-occurring allergen or portion thereof, but having reduced side effects. The invention further provides nucleic acid sequences coding for peptides of the invention. Methods of treatment or of diagnosis of sensitivity to house dust mites in an individual and therapeutic composition comprising one or more peptides of the invention are also provided.
摘要翻译：本发明提供了皮肤癣菌属的主要蛋白质过敏原的分离的肽和/或修饰的肽。本发明范围内的肽包含至少一种T细胞表位，或优选至少两种选自变应原Der p I，Der p II，Der f I或Der f II的蛋白质变应原的T细胞表位。本发明还涉及已被进一步修饰的肽，其具有与相应的天然存在的变应原或其部分相似或增强的治疗性质，但具有减少的副作用。本发明还提供了编码本发明的肽的核酸序列。还提供了治疗或诊断个体中对尘螨的敏感性的方法和包含本发明的一种或多种肽的治疗组合物。

95. 发明公开

EP1311541A4 IMMUNOGENIC PROTEINS DERIVED FROM DOMESTIC MITE ALLERGEN, BLOMIA TROPICALIS (Bt5) 审中-公开
标题翻译：从房子过敏螨热带无爪螨衍生的免疫原性蛋白BT5
公开(公告)号：EP1311541A4
公开(公告)日：2005-08-03
申请号：EP00969092
申请日：2000-10-10
申请人： CHUA KAW YAN , CHEONG NGE , LEE BEE WAH
发明人： CHUA KAW YAN , CHEONG NGE , LEE BEE WAH , LIEW LIP NYIN
IPC分类号： A61K38/00 , A61K39/00 , A61P37/08 , C07K14/435 , C12N15/12 , A61K39/35 , A61K48/00 , C07H21/04 , C07K16/18
CPC分类号： C07K14/43531 , A61K38/00 , A61K39/00

96. 发明公开

EP1479773A1 MITE GALECTIN 有权
标题翻译：美国加利福尼亚大学
公开(公告)号：EP1479773A1
公开(公告)日：2004-11-24
申请号：EP03707178.4
申请日：2003-02-28
申请人： Meiji Seika Kaisha, Ltd. , Fujisaki, Kozo
发明人： FUJISAKI,K. Obihiro Univ.of Agri.&Vetenary Med. , NAGASAWA,H. Obihiro Univ.of Agri.&Vetenary Med. , IGARASHI,Ikuo Obihiro Univ.of Agri.&Vetenary Med. , SUZUKI,Hiroshi Obihiro Univ.of Agri.&Vetenary Med. , SUGIMOTO,C. Obihiro Univ.of Agri.&Vetenary Med. , GEN,G. Obihiro University of Agri&Vetenary Med. , KADOTA, Kimie Obihiro Uni.of Agri&Vetenary Med. , INOUE, Noboru Obihiro Uni.of Agri.&Vetenary Med. , YOKOYAMA,Naoaki Obihiro Uni.of Agri.&Vetenary Med. , TSUJI, Naotoshi
IPC分类号： C12N15/12
CPC分类号： C07K14/43531 , A61K39/00 , C07K14/4726 , C07K16/18
摘要： A novel galectin, a polynucleotide encoding the same, a vector and a transformant comprising the polynucleotide, an antibody against the galectin, and a screening method for screening a substance capable of modifying the galectin, are disclosed. According to the galectin, polynucleotide, or vector, it is possible, for example, to exterminate ticks, or to treat or prevent tick-borne infections such as rickettsiosis, filariasis, Q fever, African recurrent fever, or viral encephalitis.
摘要翻译：公开了一种新型半乳凝素，编码该多聚核苷酸的多核苷酸，载体和包含该多核苷酸的转化体，抗半乳凝素的抗体，以及筛选能够修饰半乳凝素的物质的筛选方法。根据半乳凝素，多核苷酸或载体，例如可以灭绝蜱，或治疗或预防蜱传播感染如立克次氏体病，丝虫病，Q发热，非洲复发性发热或病毒性脑炎。

97. 发明公开

EP1269837A3 Allergen-containing milk for allergy treatment 审中-公开
标题翻译：含有过敏原牛奶过敏治疗
公开(公告)号：EP1269837A3
公开(公告)日：2003-09-24
申请号：EP02252702.2
申请日：2002-04-17
申请人： TaiMont Biotech, Inc.
发明人： Ching-Hsaing, Hsu , Cheng, Winston T.K. , Chen, Chuan-Mu Dr. Dept. of Zoology,Life. Sc. Col.
IPC分类号： A01K67/027 , C07K14/435 , A61K39/35 , A23C9/20
CPC分类号： C07K14/43531 , A01K67/0275 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/101 , A01K2227/102 , A01K2227/103 , A01K2227/105 , A01K2267/01 , A01K2267/0368 , A61K35/20 , A61K39/35 , C12N15/8509
摘要： A milk composition that includes a heterologous non-milk allergen can be administered to a subject to suppress allergen-specific IgE production in the subject

98. 发明公开

EP1269837A2 Allergen-containing milk for allergy treatment 审中-公开
标题翻译：含过敏原的牛奶用于过敏治疗
公开(公告)号：EP1269837A2
公开(公告)日：2003-01-02
申请号：EP02252702.2
申请日：2002-04-17
申请人： TaiMont Biotech, Inc.
发明人： Ching-Hsaing, Hsu , Cheng, Winston T.K. , Chen, Chuan-Mu Dr. Dept. of Zoology,Life. Sc. Col.
IPC分类号： A01K67/027 , C07K14/435 , A61K39/35 , A23C9/20
CPC分类号： C07K14/43531 , A01K67/0275 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/101 , A01K2227/102 , A01K2227/103 , A01K2227/105 , A01K2267/01 , A01K2267/0368 , A61K35/20 , A61K39/35 , C12N15/8509
摘要： A milk composition that includes a heterologous non-milk allergen can be administered to a subject to suppress allergen-specific IgE production in the subject
摘要翻译：包含异源非乳变应原的乳组合物可以施用于受试者以抑制受试者中过敏原特异性IgE产生

99. 发明公开

EP1105505A2 COMPOUND AND METHOD FOR THE PREVENTION AND/OR THE TREATMENT OF ALLERGY 有权
标题翻译：连接和方法控制和/或过敏治疗
公开(公告)号：EP1105505A2
公开(公告)日：2001-06-13
申请号：EP99936190.0
申请日：1999-07-20
申请人： UCB-BIOPRODUCTS, S.A.
发明人： SAINT-REMY, Jean-Marie , JACQUEMIN, Marc
IPC分类号： C12N15/62 , C07K14/435 , C07K14/38 , C07K14/31 , C07K14/47 , A61K39/35 , A23J3/04 , A61K7/06
CPC分类号： C07K14/43531 , A61K38/00 , A61K2039/51 , C07K14/31 , C07K14/38 , C07K14/4717 , C07K2319/00 , Y10S977/915
摘要： The present invention is related to a compound for the prevention and/or the treatment of allergy consisting of: at least one allergen antigenic determinant which is recognised by a B cell or an antibody secreted by a B cell of a non-atopic individual to said allergen, and at least one antigenic determinant of an antigen different from said allergen which triggers T cell activation.

100. 发明公开

EP1018550A3 Allergenic protein and peptides from house dust mite and uses thereof 失效
标题翻译：从屋尘螨蛋白和肽及其用途过敏原
公开(公告)号：EP1018550A3
公开(公告)日：2000-10-11
申请号：EP00102413.2
申请日：1994-03-11
申请人： INSTITUTE FOR CHILD HEALTH RESEARCH
发明人： Chua, Kaw-Yan, c/o Graduate Inst, of Immunology , Thomas, Wayne Robert
IPC分类号： C12N15/12 , G01N33/68 , C07K14/435 , A61K39/35
CPC分类号： C07K14/43531 , A61K38/00 , C07K14/7051 , C07K2319/00 , G01N33/56966 , G01N33/6893 , G01N2800/24 , Y10S530/868
摘要： Isolated nucleic acids encoding allergens of the species Dermatophagoides pteronyssinus and Dermatophagoides farinae , Der p VII and Der f VII, respectively, are disclosed. A cDNA encoding a peptide having a Der p VII activity and a predicted molecular weight of about 22, 177 daltons is described. A cDNA encoding a peptide having Der f VII activity is also described. The nucleic acids of the invention can be used as probes to detect the presence of Der p VII or Der f VII nucleic acid in a sample or for the recombinant production of peptides having a Der p VII or Der f VII activity. Peptides having a Der p VII or Der f VII activity can be used in compositions suitable for pharmaceutical administration or methods of diagnosing sensitivity to house dust mite allergens.

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