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91. 发明公开

EP2197419A2 MEDICAL DEVICES AND METHODS INCLUDING POLYMERS HAVING BIOLOGICALLY ACTIVE AGENTS THEREIN 有权转让
标题翻译：医疗器械和使用聚合物具有生物活性物质的方法
公开(公告)号：EP2197419A2
公开(公告)日：2010-06-23
申请号：EP09732647.4
申请日：2009-04-17
申请人： Medtronic, Inc
发明人： MCDONALD, Phillip, Edward
IPC分类号： A61K9/00 , A61K9/16 , A61K31/4162
CPC分类号： A61L31/16 , A61K9/0024 , A61K9/1688 , A61K31/4162 , A61K47/34 , A61L27/18 , A61L27/54 , A61L27/58 , A61L31/06 , A61L2300/204 , A61L2300/602 , A61L2300/604 , A61L2300/622 , A61L2300/63 , C08L67/04
摘要： The implant design is a drug loaded polymer device, such as a rod, designed to control the release of a biologically active agent, such as clonidine or its derivatives, such as clonidine HCl for a prolonged period of time, such as 2 months, 3 months, 4 months, and even 4.5 months. The polymer is preferably a biodegradable polymer, such as poly(lactide-co-glycolide) or polylactic acid/polylactide. The challenge in using the HCl salt forms of drugs such as clonidine, is controlling the release of the highly water soluble drug for up to 4.5 months. It has been found that by controlling the particle size distribution of the drug powder, the drug distribution within the polymer matrix is more uniform and can be controlled. Therefore, the large aggregates, which cause rapid drug release can be eliminated.

92. 发明公开

EP2061850A1 SUBSTRATE CONTAINING A DEODORIZING INK 有权
标题翻译：基板与除臭INK
公开(公告)号：EP2061850A1
公开(公告)日：2009-05-27
申请号：EP08700218.4
申请日：2008-01-08
申请人： KIMBERLY-CLARK WORLDWIDE, INC.
发明人： QUINCY, III, Roger, B.
IPC分类号： C09D11/00 , D06M23/08 , D06M23/12 , A61L9/014 , A61L15/46 , A61F13/15
CPC分类号： D06M23/12 , A61F13/8405 , A61F2013/842 , A61L9/014 , A61L15/18 , A61L15/46 , A61L2300/108 , A61L2300/622 , C09D11/30 , C09D11/38 , D06M23/08 , Y10T442/653
摘要： A substrate that contains a deodorizing ink is provided. The composition contains carbonaceous particles (e.g., activated carbon) for adsorbing one or more malodorous compounds to reduce odor. Because carbonaceous particles typically have a dark black color that is sometimes aesthetically displeasing to the user, the deodorizing ink of the present invention also contains voided synthetic particles that mask, at least to some extent, the darker carbonaceous particles. More specifically, the voids of the particles contain air, which can scatter or diffract light to create an opaque effect that may hide the black color of the carbonaceous particles. In this manner, the color presented to the user may be more aesthetically pleasing.

93. 发明公开

EP1216132A4 A METHOD OF MAKING BIODEGRADABLE POLYMERIC IMPLANTS 审中-公开
标题翻译：用于生产可生物降解植入
公开(公告)号：EP1216132A4
公开(公告)日：2009-04-29
申请号：EP00957793
申请日：2000-08-23
申请人： ABSORBABLE POLYMER TECHNOLOGIE
发明人： ENGLISH JAMES P
IPC分类号： A61L31/06 , A61L31/12 , A61L31/16 , B29C45/00
CPC分类号： A61L31/16 , A61L31/06 , A61L31/12 , A61L31/125 , A61L31/126 , A61L31/129 , A61L31/148 , A61L2300/604 , A61L2300/622 , C08L67/00 , C08L67/04 , C08L69/00 , C08L71/02 , C08L73/02 , C08L77/12 , Y10S623/901
摘要： A method of making a biodegradable polymeric implant comprising the steps of aseptically mixing at least one monomer with at least one catalyst to form a polymerization mixture, injecting the polymerization mixture into a sterile mold, and polymerizing and/or cross-linking the polymerization mixture in the sterile mold to form a sterilized biodegradable polymeric implant. Additives may be included in the polymerization mixture as needed.

94. 发明公开

EP1774928A3 Expandable medical device for delivery of beneficial agent 审中-公开
标题翻译：用于递送有益剂的可扩张医疗装置
公开(公告)号：EP1774928A3
公开(公告)日：2008-07-09
申请号：EP07001395.8
申请日：2002-06-05
申请人： Conor Medsystems, Inc.
发明人： Shanley, John F. , Eigler, Neal L. , Edelmann, Elazer R.
IPC分类号： A61F2/90
CPC分类号： A61L31/10 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2002/91558 , A61F2210/0004 , A61F2210/0076 , A61F2250/003 , A61F2250/0031 , A61F2250/0068 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2300/42 , A61L2300/602 , A61L2300/622
摘要： An expandable medical device comprises: a plurality of substantially cylindrical tissue supporting bodies (12) which are each expandable from a cylinder having a first diameter to a cylinder having a second diameter; a plurality of flexible bridging members (14) connecting the substantially cylindrical tissue supporting bodies (12) to form an expandable device; and a plurality of openings formed in the flexible bridging members (14), the openings containing a beneficial agent for delivery to tissue.

95. 发明公开

EP1772122A3 Expandable medical device for delivery of beneficial agent 有权
标题翻译：用于递送有益药剂的可扩展医疗装置
公开(公告)号：EP1772122A3
公开(公告)日：2008-07-09
申请号：EP07001394.1
申请日：2002-06-05
申请人： Conor Medsystems, Inc.
发明人： Shanley, John F. , Eigler, Neal L. , Park, Kinam , Edelmann, Elazar R.
IPC分类号： A61F2/90
CPC分类号： A61L31/10 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2002/91558 , A61F2210/0004 , A61F2210/0076 , A61F2250/003 , A61F2250/0031 , A61F2250/0068 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2300/42 , A61L2300/602 , A61L2300/622
摘要： An expandable medical device comprises: a plurality of substantially cylindrical tissue supporting bodies (12) which are each expandable from a cylinder having a first diameter to a cylinder having a second diameter; a plurality of flexible bridging members (14) connecting the substantially cylindrical tissue supporting bodies (12) to form an expandable device; and a plurality of openings formed in the flexible bridging members (14), the openings containing a beneficial agent for delivery to tissue.
摘要翻译：一种可扩张的医疗装置，包括：多个基本上圆柱形的组织支承体（12），每个基本上圆柱形的组织支承体（12）均可从具有第一直径的圆柱体扩张到具有第二直径的圆柱体; 多个柔性桥接构件（14），其连接所述大致圆柱形的组织支撑体（12）以形成可扩张装置; 以及在柔性桥接构件（14）中形成的多个开口，开口含有用于递送到组织的有益剂。

96. 发明授权

EP0706376B2 ANTI-ANGIOGENIC COMPOSITIONS AND METHODS OF USE 失效
标题翻译：抗血管生成资源，并使用方法
公开(公告)号：EP0706376B2
公开(公告)日：2007-08-08
申请号：EP94920360.8
申请日：1994-07-19
申请人： Angiotech Pharmaceuticals, Inc. , THE UNIVERSITY OF BRITISH COLUMBIA
发明人： BURT, Helen, M. , HUNTER, William, L. , MACHAN, Lindsay, S. , ARSENAULT, A., Larry , JACKSON, John, K.
IPC分类号： A61K9/16 , A61K9/70 , A61L31/00 , A61K31/20 , A61K31/335 , A61K38/57
CPC分类号： A61K9/14 , A61K9/0019 , A61K9/0048 , A61K9/0051 , A61K9/1635 , A61K9/1641 , A61K9/1647 , A61K9/1658 , A61K9/5031 , A61K9/5146 , A61K9/5153 , A61K9/7007 , A61K31/122 , A61K31/136 , A61K31/165 , A61K31/185 , A61K31/203 , A61K31/335 , A61K31/337 , A61K31/426 , A61K31/427 , A61K31/4745 , A61K31/519 , A61K31/525 , A61K31/555 , A61K31/565 , A61K31/57 , A61K31/702 , A61K33/00 , A61K33/06 , A61K33/24 , A61K33/30 , A61K38/57 , A61K45/06 , A61L31/10 , A61L31/145 , A61L31/16 , A61L2300/416 , A61L2300/606 , A61L2300/622 , A61L2430/36 , B82Y5/00 , C07C233/64 , C07K14/811 , C08L23/0853 , C08L29/04 , C08L67/04 , C08L2203/02 , C08L2312/00 , Y10S977/773 , Y10S977/915 , C08L23/08 , A61K2300/00 , C08L2666/18 , C08L2666/06 , C08L2666/04
摘要： The present invention provides compositions comprising an anti-angiogenic factor, and a polymeric carrier. Representative examples of anti-angiogenic factors include Anti-Invasive Factor, Retinoic acids and derivatives thereof, and taxol. Also provided are methods for embolizing blood vessels, and eliminating biliary, urethral, esophageal, and tracheal/bronchial obstructions.

98. 发明公开

EP1796644A2 DRUG DELIVERY FROM EMBOLIC AGENTS 有权转让
标题翻译：药物CHARGE从栓塞基金
公开(公告)号：EP1796644A2
公开(公告)日：2007-06-20
申请号：EP05777645.2
申请日：2005-09-06
申请人： Biocompatibles UK Limited
发明人： LEWIS, Andrew, Lennard, Biocompatibles UK Limited , STRATFORD, Peter, William, Biocompatibles UK Ltd. , GONZALEZ-FAJARDO, Maria V., Biocompatibles UKLtd. , TANG, Yiqing, Biocompatibles UK Limited
IPC分类号： A61K9/16 , A61K31/4745 , A61P35/04
CPC分类号： A61K31/4745 , A61K9/1635 , A61L24/0015 , A61L24/06 , A61L2300/416 , A61L2300/434 , A61L2300/622 , A61L2430/36 , C08L29/04
摘要： An embolic composition comprises microspheres formed of water-insoluble water-swellable anionic polymer having swollen diameter more than 100µm, and a cationic camptothecin compound, preferably irinotecan. The microspheres are preferably formed of crosslinked polyvinylalcohol, preferably of ethylenically unsaturated polyvinylalcohol macromer, crosslinked with anionic ethylenically unsaturated anionic comonomer. The compositions are used to treat hypervascular tumours for instance colorectal metastases of the liver.

99. 发明授权

EP1420719B9 Expandable medical device for delivery of beneficial agent 有权
标题翻译：用于递送有益药剂的可扩展医疗装置
公开(公告)号：EP1420719B9
公开(公告)日：2007-05-09
申请号：EP02737363.8
申请日：2002-06-05
申请人： Conor Medsystems, Inc.
发明人： SHANLEY, John, F. , EIGLER, Neal, L. , PARK, Kinam , EDELMAN, Elazer, R.
IPC分类号： A61F2/06
CPC分类号： A61L31/10 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2002/91558 , A61F2210/0004 , A61F2210/0076 , A61F2250/003 , A61F2250/0031 , A61F2250/0068 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2300/42 , A61L2300/602 , A61L2300/622
摘要： Expandable medical device comprising: elongated struts (18) joined together to form a cylindrical device (12) which is expandable from a cylinder having a first diameter to a cylinder with a second diameter, struts having width and thickness in a radial direction, at least one opening (16) in at least one of the struts, and at least one beneficial agent provided in the at least one opening in layers, is new. Expandable medical device comprises: (a) elongated struts(18) , elongated struts joined together to form a cylindrical device (12) which is expandable from a cylinder having a first diameter to a cylinder with a second diameter; (b) struts each having strut width in a circumferential direction and a strut thickness in a radial direction; (c) at least one opening (16) in at least one of the struts; and (d) at least one beneficial agent provided in the at least one opening in layers Independent claims are also included for the following: (1) an expandable medical device for treating cardiac arrhythmias, comprising: an expandable cylindrical device having struts with openings containing a chemically ablative, the openings being configured to deliver the ablative to tissue surrounding the device without permanently trapping any agent in the openings; and (2) a method of forming an expandable medical device by providing the device with struts joined together to form a device which is expandable from a cylinder with a first diameter to a cylinder with a second diameter; forming at least one opening in at least one of the struts, and delivering at least one beneficial agent into the at least one opening in layers.
摘要翻译：可扩张的医疗装置具有多个连接在一起的细长支柱以形成基本上圆柱形的装置，该装置可从具有第一直径的圆柱体扩张成具有第二直径的圆柱体。多个支柱中的至少一个包括至少一个开口，该至少一个开口至少部分地延伸穿过所述支柱的厚度。将有益药剂以层的形式装载到撑杆内的开口中以实现药剂的期望的暂时释放动力学。或者，有益药剂以被配置为实现期望的药剂递送特征的形状负载。可以实现多种输送配置文件，包括零阶，脉动，增加，减少，正弦和其他输送配置文件。

100. 发明公开

EP1772122A2 Expandable medical device for delivery of beneficial agent 有权
标题翻译：扩展器medizinische Vorrichtung zumZuführeneines Heilmittels
公开(公告)号：EP1772122A2
公开(公告)日：2007-04-11
申请号：EP07001394.1
申请日：2002-06-05
申请人： Conor Medsystems, Inc.
发明人： Shanley, John F. , Eigler, Neal L. , Park, Kinam , Edelmann, Elazar R.
IPC分类号： A61F2/90 , A61F2/06
CPC分类号： A61L31/10 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2002/91558 , A61F2210/0004 , A61F2210/0076 , A61F2250/003 , A61F2250/0031 , A61F2250/0068 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2300/42 , A61L2300/602 , A61L2300/622
摘要： An expandable medical device comprises: a plurality of substantially cylindrical tissue supporting bodies (12) which are each expandable from a cylinder having a first diameter to a cylinder having a second diameter; a plurality of flexible bridging members (14) connecting the substantially cylindrical tissue supporting bodies (12) to form an expandable device; and a plurality of openings formed in the flexible bridging members (14), the openings containing a beneficial agent for delivery to tissue.
摘要翻译：一种可扩张的医疗装置包括：多个基本上圆柱形的组织支撑体（12），它们均可从具有第一直径的圆柱体扩展到具有第二直径的圆筒; 多个柔性桥接构件（14），其连接所述基本上圆柱形的组织支撑体（12）以形成可扩张装置; 以及形成在所述柔性桥接构件（14）中的多个开口，所述开口包含用于递送至组织的有益剂。

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