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91. 发明公开

EP0538486A1 SEWING MACHINE NEEDLE AND METHOD OF MANUFACTURING SAME 失效
标题翻译： Nähmaschinenadelund Herstellungsverfahren。
公开(公告)号：EP0538486A1
公开(公告)日：1993-04-28
申请号：EP92909648.5
申请日：1992-05-11
申请人： ORGAN NEEDLE CO., LTD.
发明人： TAKEI, Yoshitsugu , KOJIMA, Tsutomu
IPC分类号： D05B85/02 , B21G1/04
CPC分类号： A61K31/155 , A61K31/7004 , B21G1/04 , D05B85/02 , A61K31/085 , A61K2300/00
摘要： A sewing machine needle is manufactured by die-pressing the whole needle trunk portion without causing burrs on the needle trunk. A needle material (10) has its needle trunk (14, 16) drawn into two stages, and further, a thin portion (22) previously formed to form a scraped-out portion above a needle hole. By die-pressing, the opposite side portions of a needle groove (28) are extended to a predetermined angle, and the scraped-out portion (40) of a desirable shape and a needle hole portion (33) are formed. The needle thus obtained has sufficiently high rigidity as a whole and a space between the needle trunk and a sewing thread is large, so that sewing work can be stably carried out and operations at high speed can be performed.
摘要翻译：缝纫机针是通过对整个针干部分进行压模而不引起针头上的毛刺来制造的。针状材料（10）具有被拉伸成两个阶段的针头躯干（14,16），此外，预先形成有在针孔上方形成刮出部分的薄部（22）。通过冲压，针槽（28）的相对侧部分延伸到预定角度，形成期望形状的刮出部分（40）和针孔部分（33）。由此得到的针整体的刚性足够高，针筒和缝纫线之间的空间大，能够稳定地进行缝纫作业，能够进行高速的操作。

92. 发明公开

EP0482071A4 NEW ANTIVIRAL AGENTS 失效
标题翻译：新抗病毒剂
公开(公告)号：EP0482071A4
公开(公告)日：1993-03-17
申请号：EP90911124
申请日：1990-07-12
申请人： BIODOR U.S. HOLDING , HENDLER, SHELDON SAUL
发明人： HENDLER, SHELDON, SAUL , SANCHEZ, ROBERT, A. , TARA
IPC分类号： A01N31/08 , A01N31/16 , A01N35/02 , A01N39/00 , A01N41/12 , A01N43/16 , A01N61/00 , A61K31/05 , A61K31/065 , A61K31/085 , A61K31/095 , A61K31/10 , A61P31/12
CPC分类号： A01N61/00 , A01N31/08 , A01N31/16 , A01N35/02 , A01N39/00 , A01N41/12 , A01N43/16 , A61K31/05 , A61K31/085 , A61K31/10

93. 发明公开

EP0516082A2 Gingerol and gingerdiol derivatives as hypocholesterolemic and antiatherosclerotic agents 失效
标题翻译： Ingwerol- undIngwerdiolabkömmlingealshypocholesterolämischeund antiatherosklerotische Mittel。
公开(公告)号：EP0516082A2
公开(公告)日：1992-12-02
申请号：EP92108947.0
申请日：1992-05-27
申请人： MERRELL DOW PHARMACEUTICALS INC.
发明人： Mao, Simon J.T. , King, Chi-Hsin R.
IPC分类号： C07C49/245 , C07C49/255 , C07C43/23 , C07C39/11 , A61K31/085 , A61K31/12
CPC分类号： C07C49/255 , A61K31/05 , A61K31/085 , A61K31/12 , C07C39/11 , C07C43/23 , C07C45/62 , C07C45/673 , C07C45/71 , C07C45/72 , C07C49/245
摘要： The present invention relates to the use of a compound of the formula

wherein R₁ is hydrogen or C₁-C₄ alkyl,
R₂ is a C₁-C₁₂ alkyl,
Y is O or OH, and
Z is a bond when Y is O, or is hydrogen when Y is OH
for the preparation of a pharmaceutical composition useful in lowering plasma cholesterol, inhibiting the progression of atherosclerosis and inhibiting the peroxidation of LDL lipid.
摘要翻译：本发明涉及式（CHEM）化合物的用途，其中R 1为氢或C 1 -C 4烷基，R 2为C 1 -C 12烷基，Y为O或OH，Z为Y时的键，或者当Y为OH时为氢，用于制备可用于降低血浆胆固醇，抑制动脉粥样硬化进展和抑制LDL脂质过氧化的药物组合物。

94. 发明公开

EP0455475A3 Use of triclosan in the treatment of diseases of the gastrointestinal tract 失效
标题翻译：治疗TRICLOSAN治疗胃肠疾病的疾病的应用
公开(公告)号：EP0455475A3
公开(公告)日：1992-02-26
申请号：EP91303929.3
申请日：1991-05-01
申请人： RECKITT AND COLMAN PRODUCTS LIMITED
发明人： Dettmar, Peter William , Lloyd-Jones, John Gareth
IPC分类号： A61K31/085
CPC分类号： A61K9/0065 , A61K9/0007 , A61K9/5026 , A61K9/5047 , A61K31/085
摘要： The use of triclosan for the preparation of medicaments for the treatment of gastrointestinal disorders associated with Helicobacter pylori infections is disclosed. The medicaments may be in the form of powders, granules, spheroids or liquids, or in unit dosage form as capsules or tablets containing 1 to 100mg, preferably 10 to 60mg, of triclosan. The medicaments may also be in gastric sustained release form as raft forming tablets or liquids, optionally to be co-administered with a solid pharmaceutically acceptable carboxylic acid or acid salt, or as muco-adherent-coated granules or spheroids.

95. 发明公开

EP0458590A1 Treatment of ocular hypertention with a synergistic combination 失效
标题翻译： Behandlung von isokularem Druck mit einer synerischen Kombination。
公开(公告)号：EP0458590A1
公开(公告)日：1991-11-27
申请号：EP91304576.1
申请日：1991-05-21
申请人： R-TECH UENO, LTD.
发明人： Ueno, Ryuji
IPC分类号： A61K31/557
CPC分类号： A61K31/557 , Y10S514/913 , A61K31/535 , A61K31/435 , A61K31/335 , A61K31/13 , A61K31/085 , A61K2300/00
摘要： A use of an oculo-hypotensively synergistic combination of

(a) a 13,14-dihydro-15-ketoprostaglandin compound, and
(b) a β-adrenergic blocker
for the manufacture of a medicament useful in treatment of ocular hypertension.
摘要翻译：使用（a）13,14-二氢-15-酮前列腺素化合物和（b）β-肾上腺素能阻滞剂的眼 - 低协同组合来制造用于治疗高眼压症的药物。 Ø

96. 发明公开

EP0304842A3 Isoprenoid derivatives and anti-ulcer agents containing the same 失效
标题翻译：异噻唑类衍生物和含有它的抗真菌剂
公开(公告)号：EP0304842A3
公开(公告)日：1991-01-16
申请号：EP88113617.0
申请日：1988-08-22
申请人： NISSHIN FLOUR MILLING CO., LTD. , GRELAN PHARMACEUTICAL CO., LTD.
发明人： Yamada, Kazuhiko , Tahara, Yoshiyuki , Toyoda, Masashi , Irino, Osamu , Misaki, Noriyuki
IPC分类号： C07C39/19 , C07C50/06 , C07D311/72
CPC分类号： C07C43/215 , A61K31/05 , A61K31/085 , A61K31/09 , A61K31/12 , A61K31/22 , A61K31/355 , C07C39/19 , C07C50/06 , C07D311/58 , C07D311/72
摘要： Anti-ulcer agents containing isoprenoid derivatives are provided. The isoprenoid derivatives are represented by the formula:
Wherein: R represents a group of formula In the above formula, Ri, R 2 and R 3 may be the same or different each other and each represents a hydrogen atom, a hydroxy group, a lower alkanoyloxy group, a lower alkyl group or a lower alkoxy group, provided that two or more of them do not represent hydrogen atoms at the same time; R 4 and Rs may be the same or different each other and each represents a hydrogen atom, a hydroxy group or a lower alkanoyloxy group; represents the single or the double bond between the carbon atoms; m represents 0 or 1; n represents 0 or an integer of from 1 to 9, provided that the sum of m and n is an integer of from 1 to 9.

97. 发明公开

EP0163270A3 A lipoxygenase inhibitor 失效
标题翻译：脂氧合酶抑制剂
公开(公告)号：EP0163270A3
公开(公告)日：1989-05-17
申请号：EP85106390.9
申请日：1985-05-23
申请人： GREEN CROSS CORPORATION
发明人： Yokoyama, Kazumasa , Fukaya, Chikara , Sugiura, Masanori , Naito, Youichiro , Nishida, Masayuki , Suyama, Tadakazu
IPC分类号： A61K31/215 , C07C69/732 , C07C103/60 , C07C49/255 , C07C49/248 , C07C39/19
CPC分类号： C07D309/12 , A61K31/05 , A61K31/085 , A61K31/09 , A61K31/12 , A61K31/165 , A61K31/216 , C07C39/19 , C07C43/23 , C07C45/673 , C07C45/72 , C07C49/248 , C07C49/255 , C07C69/732 , C07C235/34
摘要： A lipoxygenase inhibitor comprising as active ingredient a substituted styrene derivative having a radical of the general formula
wherein X denotes a hydroxyl group or a lower alkoxy group and q is an integer of 2 or 3, and containing carbon atoms in total of at least 8.
摘要翻译：一种脂肪氧合酶抑制剂，它含有作为活性成分的具有下列通式基团的取代苯乙烯衍生物其中X表示羟基或低级烷氧基，q是2或3的整数，并且总共含有至少8个碳原子。

98. 发明公开

EP0201784A3 Pharmaceutical composition decreasing side effects of anticancer chemotherapy and increasing the immune function and method of producing the same 失效
标题翻译：药物组合物减少抗癌药物的副作用和增加免疫功能及其生产方法
公开(公告)号：EP0201784A3
公开(公告)日：1987-12-02
申请号：EP86105751
申请日：1986-04-25
IPC分类号： A61K35/78
CPC分类号： A61K36/23 , A61K31/085 , A61K31/192 , A61K31/704 , A61K36/235 , A61K36/258 , A61K36/54 , A61K2300/00
摘要： A new pharmaceutical composition for treatment and prevention of side effects of anticancer chemotherapy and increasing the immune function contains Ferulic acid, Ginsenoside, Anethole and sodium Cinnamate. Processes for producing the composition respectively its components and related pharmacological effect are provided.

99. 发明公开

EP0201784A2 Pharmaceutical composition decreasing side effects of anticancer chemotherapy and increasing the immune function 失效
标题翻译：药物组合物用于降低抗癌化学疗法的副作用，提高免疫力。
公开(公告)号：EP0201784A2
公开(公告)日：1986-11-20
申请号：EP86105751.1
申请日：1986-04-25
申请人： Liu, Yaguang
发明人： Liu, Yaguang
IPC分类号： A61K35/78
CPC分类号： A61K36/23 , A61K31/085 , A61K31/192 , A61K31/704 , A61K36/235 , A61K36/258 , A61K36/54 , A61K2300/00
摘要： A new pharmaceutical composition for treatment and prevention of side effects of anticancer chemotherapy and increasing the immune function contains Ferulic acid, Ginsenoside, Anethole and sodium Cinnamate. Processes for producing the composition respectively its components and related pharmacological effect are provided.

100. 发明公开

EP0163270A2 A lipoxygenase inhibitor 失效
标题翻译：脂氧合酶抑制剂。
公开(公告)号：EP0163270A2
公开(公告)日：1985-12-04
申请号：EP85106390.9
申请日：1985-05-23
申请人： GREEN CROSS CORPORATION
发明人： Yokoyama, Kazumasa , Fukaya, Chikara , Sugiura, Masanori , Naito, Youichiro , Nishida, Masayuki , Suyama, Tadakazu
IPC分类号： A61K31/215 , C07C69/732 , C07C103/60 , C07C49/255 , C07C49/248 , C07C39/19
CPC分类号： C07D309/12 , A61K31/05 , A61K31/085 , A61K31/09 , A61K31/12 , A61K31/165 , A61K31/216 , C07C39/19 , C07C43/23 , C07C45/673 , C07C45/72 , C07C49/248 , C07C49/255 , C07C69/732 , C07C235/34
摘要： A lipoxygenase inhibitor comprising as active ingredient a substituted styrene derivative having a radical of the general formula
wherein X denotes a hydroxyl group or a lower alkoxy group and q is an integer of 2 or 3, and containing carbon atoms in total of at least 8.

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