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91. 发明公开

EP0345711A3 Process for the preparation of pyrrolizine derivatives 失效
标题翻译：制备吡咯烷衍生物的方法
公开(公告)号：EP0345711A3
公开(公告)日：1991-05-22
申请号：EP89110164.4
申请日：1989-06-05
申请人： SANWA KAGAKU KENKYUSHO CO., LTD.
发明人： Kurono, Masayasu Sanwa Kagaku , Kondo, Yasuaki Sanwa Kagaku Kenkyusho Co., Ltd. , Unno, Ryoichi Sanwa Kagaku Kenkyusho Co., Ltd. , Matsumoto, Yukiharu Sanwa Kagaku , Kimura, Hiromoto Sanwa Kagaku Kenkyusho Co., Ltd. , Oka, Mitsuru Sanwa Kagaku Kenkyusho Co., Ltd. , Sawai, Kiichi Sanwa Kagaku Kenkyusho Co., Ltd.
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： A process for the preparation of pyrrolizine derivatives of the formula
wherein R is -CN or -CH₂NH₂,
and salts thereof.

92. 发明公开

EP0342956A3 Use of phytic acid or its salts for the treatment of hyperlipemia, obesity and obesity-related diseases 失效
标题翻译：使用植物酸或其盐处理高脂血症，肥胖和与肥胖有关的疾病
公开(公告)号：EP0342956A3
公开(公告)日：1991-05-02
申请号：EP89304985.8
申请日：1989-05-17
申请人： SANWA KAGAKU KENKYUSHO CO., LTD.
发明人： Sawai, Kiichi , Kurono, Masayasu , Asai, Hiromoto , Mitani, Takahiko , Ninomiya, Naohisa
IPC分类号： A61K31/66
CPC分类号： A61K31/66
摘要： Phytic acid or a salt thereof is known for pharmaceutical use: they are now administered orally as a treatment or preventive of hyperlipemia, obesity and obesity-related diseases. Suitable non-toxic salts are metal salts and salts of an organic base, a base amino acid or an organic ester residue. The phytic acid or salt may be contained in a foodstuff, confectionary or a liquid or pharmaceutical type of composition. A daily dose of 1-100 mg per kg body weight is suitable.

93. 发明公开

EP0418834A1 Hydantoin derivatives for treating complications of diabetes and circulatory diseases 失效
标题翻译：乙酰头孢菌素衍生自Zur Behandlung von Komplikationen bei Diabetes und Kreislauferkrankungen。
公开(公告)号：EP0418834A1
公开(公告)日：1991-03-27
申请号：EP90117960.6
申请日：1990-09-18
申请人： SANWA KAGAKU KENKYUSHO CO., LTD.
发明人： Kurono, Masayasu, c/o Sanwa Kagaku , Unno, Ryoichi, c/o Sanwa Kagaku , Kimura, Hiromoto, c/o Sanwa Kagaku , Tomiya, Noboru, c/o Sanwa Kagaku , Sawai, Kiichi, c/o Sanwa Kagaku , Miura, Kenji, c/o Sanwa Kagaku , Usui, Toshinao, c/o Sanwa Kagaku , Kondo, Yasuaki, c/o Sanwa Kagaku , Tanaka, Yukiya, c/o Sanwa Kagaku , Suzuki, Tsunemasa, c/o Sanwa Kagaku , Hayashi, Motohide, c/o Sanwa Kagaku
IPC分类号： C07D491/10 , C07D495/10 , A61K31/415
CPC分类号： C07D491/10 , C07D495/10
摘要： The invention relates to a hydantoin derivative, salt thereof, process for the preparation thereof, and medicine containing the derivative. The derivative is represented by the formula
wherein M is -CONH-NHR' group, -CONH-OR 2 group,

or -CONH(CH 2 ) n R 7 group, in which R 1 is hydrogen atom, an alkyl group, an alkenyl group, a phenyl radical, a substituted phenyl group, a naphtyl radical, a substituted naphtyl group, a pyridyl radical, a furyl radical or a thienyl radical, R 2 is a hydrogen atom, an alkyl group, a phenyl radical or a substituted phenyl group, R 3 and R 4 are same or different independently, each being a hydrogen atom, an alkyl group, a phenyl radical, a substituted phenyl group or an aralkyl group, or R 3 may form a substituted or non-substituted C 5-6 saturated heterocyclic ring together with R 4 and a possible nitrogen or oxygen atom, R 5 forms a substituted or non-substituted saturated heterocyclic ring together with R 6 and a possible nitrogen or oxygen atom, R 7 is a nitroxy radical or a heteroaryl group, m and n are an integer of 2 to 5, Q is a hydrogen atom or
in which R 8 and R 9 are same or different independently, each being a substituted or non-substituted alkyl group, or R 8 may form a substituted or non-substituted C s - 6 saturated heterocyclic ring together with R 9 and a possible nitrogen or oxygen atom, is an integer of 2 to 5, T and X are same or different independently, each being a hydrogen atom, a halogen atom, an alkyl group, an alkoxy group or an alkylmercapto group, and Z is an oxygen or sulfur atom. The derivatives and salts thereof are useful for the treatment of complications of diabetes and circulatory diseases.
摘要翻译：本发明涉及乙内酰脲衍生物，其盐，其制备方法和含有该衍生物的药物。衍生物由式CHEM（其中M是-CONH-NHR 1基团，-CONH-OR 2基团，CHEM> CHEM或-CONH（CH 2）n R 7）基团的式 R 1是氢原子，烷基，烯基，苯基，取代的苯基，萘基，取代的萘基，吡啶基，呋喃基或噻吩基，R 2 >是氢原子，烷基，苯基或取代的苯基，R 3和R 4各自独立地相同或不同，各自为氢原子，烷基，苯基，取代的苯基或芳烷基，或R 3可以与R 4和可能的氮或氧原子一起形成取代或未取代的C 5-6饱和杂环，R 5形成取代或未取代的C 3-6 - 取代的饱和杂环与R 6和可能的氮或氧原子一起形成，R 7是硝酰基或杂芳基，m和n是2至5的整数，Q是氢原子或在其中R 8和R 9各自独立地相同或不同，各自为取代或未取代的烷基，或R 8可以与R 1，R 2， 9和可能的氮原子或氧原子，r为2〜5的整数，T和X独立地相同或不同，分别为氢原子，卤素原子，烷基，烷氧基或烷基巯基， Z是氧或硫原子。其衍生物和盐可用于治疗糖尿病和循环系统疾病的并发症。

94. 发明公开

EP0299495A3 1-Pyrrolidineacetamide derivatives and use thereof 失效
标题翻译： 1-吡咯烷胺酰胺衍生物及其用途
公开(公告)号：EP0299495A3
公开(公告)日：1991-03-13
申请号：EP88111361.7
申请日：1988-07-14
申请人： SANWA KAGAKU KENKYUSHO CO., LTD.
发明人： Kurono, Masayasu c/o Sanwa Kagaku , Suzuki, Tsunemasa c/o Sanwa Kagaku , Suzuki, Tomoo c/o Sanwa Kagaku , Hirooka, Kiyotaka c/o Sanwa Kagaku , Matsumoto, Yukiharu c/o Sanwa Kagaku , Ozawa, Hiroshi c/o Sanwa Kagaku , Sawai, Kiichi c/o Sanwa Kagaku
IPC分类号： C07F7/08 , A61K31/695
CPC分类号： C07F7/0812
摘要： 1-Pyrrolidineacetamide derivatives of the formula
wherein R₁ is hydrogen atom or a trialkylsilyl group, R₂ and R₃ are hydrogen atom, respectively, when R₁ is hydrogen atom, R₄ is an alkyl group, R₅ is a radical of
in which R₆ and R₇ are an alkyl group, respectively, m and n are an integer of 1 to 3, respectively, or R₄ represents together with R₅ a hetero cyclic ring having nitrogen and silicon atoms or piperazine ring having a substituent of
in which R₆ and n have the meanings as referred to, and R₂ and R₄ as well as R₃ and R₅ form a hetero cyclic ring, respectively, connected with an alkylene chain, when R₁ is the trialkylsilyl group,
salts thereof, a process for the preparation thereof, as well as use thereof as for a medicine.

95. 发明公开

EP0390574A2 Compositions of phytic acid, and pharmaceutical uses thereof 失效
标题翻译： PhytinsäurehaltigeMittel sowie deren pharmazeutische Verwendungen。
公开(公告)号：EP0390574A2
公开(公告)日：1990-10-03
申请号：EP90303397.5
申请日：1990-03-29
申请人： SANWA KAGAKU KENKYUSHO CO., LTD.
发明人： Sawai, Kiichi, c/o Sanwa Kagaku , Kurono, Masayasu, c/o Sanwa Kagaku , Asai, Hiromoto, c/o Sanwa Kagaku , Mitani, Takahiko, c/o Sanwa Kagaku , Ninomiya, Naohisa, c/o Sanwa Kagaku
IPC分类号： A61K31/66 , A61K47/12
CPC分类号： A61K47/183 , A61K31/66 , A61K33/26 , A61K47/12 , A61K2300/00
摘要： An aqueous solution contains (a) phytic acid in amount of 1.00 mmol to 1.00 mol litre and (b) ferric ions to increase the phytic acid solubility,e.g. derived from a monobasic or polybasic acid (e.g. ferric citrate) and (c) carboxylic acid ions to hasten the dissolution and optionally (d) other additives to enhance the bioabsorption of (a) and (b), e.g. as (d) a carboxylic acid or salt, a saccharide, an amino acid or salt or an organic phosphoric acid or salt.
A suitable molar proportion of (a): (b): (c): (d)is 10:1:1:0 to 1:12:36:200.
The solution can be dried to a powder, and the solution or powder incorporated in solid or liquid pharmaceutical compositions.
The solutions or compositions are useful for the removal of uraroma or body smell or as an antidote to the effect of alcohol or drugs on the central nervous system, for the treatment of diabetes, hyperlipemia, hypohepatia, dysmesia or degeneration of erythrocytes, or to inhibit the proliferation of fat cells or reduce lipometabolism.
摘要翻译：水溶液含有（a）植酸，其量为1.00mmol至1.00mol /升，和（b）三价铁离子以增加植酸溶解度，例如，衍生自一元酸或多元酸（例如柠檬酸铁）和（c）羧酸离子以加速溶解和任选地（d）其它添加剂以增强（a）和（b），例如（b）的生物吸收。作为（d）羧酸或盐，糖类，氨基酸或盐或有机磷酸或盐。（a）：（b）：（c）：（d）的合适的摩尔比例为10:1:1:0:1:12:36:200。溶液可以干燥成粉末，并将溶液或粉末掺入固体或液体药物组合物中。溶液或组合物可用于去除尿潴留或身体气味，或作为解决酒精或药物对中枢神经系统的作用的解毒剂，用于治疗糖尿病，高脂血症，低血脂症，红斑或红细胞变性或抑制脂肪细胞的增殖或减少脂肪代谢。

96. 发明公开

EP0384416A1 A pharmaceutical composition containing hydantoin derivative 失效
标题翻译： Pharmanutische Zusammensetzung，死亡乙肝蛋白酶衍生物。
公开(公告)号：EP0384416A1
公开(公告)日：1990-08-29
申请号：EP90103279.7
申请日：1990-02-20
申请人： SANWA KAGAKU KENKYUSHO CO., LTD.
发明人： Kurono, Masayasu , Sato, Makoto , Yoshina, Shigeaki , Kondo, Yoshiya , Inoue, Tsuneaki , Inoue, Akiharu , Sawai, Kiichi
IPC分类号： A61K31/415
CPC分类号： A61K31/415
摘要： A pharmaceutical composition showing an inhibition to aldose reductase enzymes is disclosed. In the composition, a hydantoin derivative known per se is uniformly dispersed in a high molecular carrier for the hydantoin derivative. The composition may further contains a water soluble high molecular substance. The composition is administered to prevent or cure a complication due to diabetes.
摘要翻译：公开了显示抑制醛糖还原酶的药物组合物。在组合物中，本身已知的乙内酰脲衍生物均匀分散在乙内酰脲衍生物的高分子载体中。组合物还可含有水溶性高分子物质。施用组合物以预防或治愈由于糖尿病引起的并发症。

97. 发明公开

EP0345710A3 Composition obtained from rice bran and use thereof 失效
标题翻译：从米糠获得的组合物及其用途
公开(公告)号：EP0345710A3
公开(公告)日：1990-07-18
申请号：EP89110163.6
申请日：1989-06-05
申请人： SANWA KAGAKU KENKYUSHO CO., LTD.
发明人： Sawai, Kiichi c/o Sanwa Kagaku Kenkyusho Co. Ltd. , Kurono, Masayasu Sanwa Kagaku Kenkyusho Co. Ltd. , Asai, Hiromoto Sanwa Kagaku Kenkyusho Co. Ltd. , Mitani, Takahiko Sanwa Kagaku Kenkyusho Co. Ltd. , Ninomiya, Naohisa Sanwa Kagaku Kenkyusho Co. Ltd. , Furukawa, Eiji Sanwa Kagaku Kenkyusho Co. Ltd.
IPC分类号： A61L9/01 , A61K7/32 , A61K7/48
CPC分类号： A61K8/97 , A61K2800/85 , A61L9/01 , A61Q15/00
摘要： Composition obtained from a rice bran, which comprises a filtrate of lactic fermented and aged material of the rice bran, said filtrate being an odorless pale yellow solution, having a salty taste, and solubility with water and alcohols, or a powderized substance of the filtrate, a process for the preparation of the composition, and use of the composition as a deodorant.

98. 发明授权

EP0280239B1 1,4-Dihydropyridine derivatives, production and use thereof 失效
标题翻译： 1,4-二氢吡啶衍生物，生产和使用
公开(公告)号：EP0280239B1
公开(公告)日：1990-07-04
申请号：EP88102577.9
申请日：1988-02-22
申请人： SANWA KAGAKU KENKYUSHO CO., LTD.
发明人： Kurono, Masayasu , Suzuki, Tsunemasa , Kondo, Yasuaki , Suzuki, Tomoo , Sawai, Kiichi
IPC分类号： C07D211/90 , C07D401/12 , A61K31/44
CPC分类号： C07D401/12 , C07D211/90

99. 发明授权

EP0154432B1 Modified urokinase composition 有权
标题翻译：改性尿素组合物
公开(公告)号：EP0154432B1
公开(公告)日：1990-04-11
申请号：EP85301032.0
申请日：1985-02-15
申请人： NIHON CHEMICAL RESEARCH KABUSHIKI KAISHA also known as JAPAN CHEMICAL RESEARCH CO., LTD , KABUSHIKI KAISHA SANWA KAGAKU KENKYUSHO also known as SANWA KAGAKU KENKYUSHO CO., LTD.
发明人： Sawai, Kiichi , Kurono, Masayasu , Awaya, Juichi , Iwata, Tadahiko
IPC分类号： C12N11/08 , A61K37/547
CPC分类号： C12Y304/21073 , A61K38/00 , A61K47/60 , C12N9/6462 , C12N11/08

100. 发明公开

EP0323645A3 Extract of Chlorella and use thereof 失效
标题翻译：柠檬提取物及其用途
公开(公告)号：EP0323645A3
公开(公告)日：1990-03-28
申请号：EP88121857.2
申请日：1988-12-29
申请人： SANWA KAGAKU KENKYUSHO CO., LTD.
发明人： Sawai, Kiichi c/o Sanwa Kagaku Kenkyusho Co. , Kurono, Masayasu c/o Sanwa Kagaku Kenkyusho Co. , Hara, Kazue c/o Sanwa Kagaku Kenkyusho Co. , Jomori, Takahito c/o Sanwa Kagaku Kenkyusho Co. , Mitani, Takahiko c/o Sanwa Kagaku Kenkyusho Co. , Uchida, Keiichi , Tanaka, Hiromi
IPC分类号： A61K35/80
CPC分类号： A61K36/05 , C12N1/12 , C12P1/00 , C12R1/89
摘要： An extract of fresh-water chlorella cultivated in a medium containing iodine ion is disclosed. The extract contains the iodine ion of more than 100ppm, saccharides of 10% by weight or more, proteins of 10% by weight or more, and nucleic acids, which is obtained by cultivating the fresh-water chlorella in the medium to intake the iodine therein, separating the chlorella from the medium, heating the chlorella in water, and filtering-off insoluble materials to obtain the extract as filtrate. The aqueous extract can be freeze-dried for reservation. The extract is employed as an effective ingredient for a pharmaceutical composition to prevent or cure diseases due to deficiency of iodine.

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