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91. 发明公开

EP2155873A2 METHODS AND COMPOSITIONS FOR INCREASED TRANSGENE EXPRESSION 有权转让
标题翻译：方法和组合物增强转基因表达
公开(公告)号：EP2155873A2
公开(公告)日：2010-02-24
申请号：EP08754665.1
申请日：2008-05-22
申请人： Sangamo BioSciences, Inc.
发明人： HOLMES, Michael C. , LEE, Gary Ka Leong
IPC分类号： C12N15/00
CPC分类号： C12N15/86 , C12N5/0636 , C12N15/63 , C12N2501/2315 , C12N2501/51 , C12N2501/515 , C12N2510/02 , C12N2710/10343
摘要： Described herein are methods of expressing nucleic acids in T cells pre-exposed to a co-stimulatory signal and then transduced with adenoviral vectors. In some embodiments, the co-stimulation is provided by anti-CD3 and anti-CD28 antibodies and the adenoviral vector is pseudotyped for T-cell entry. The invention also relates to compositions for carrying out these methods, provided as kits or pharmaceutical compositions that can be used to treat diseases including immunological conditions and hematological malignancies.

92. 发明公开

EP1993586A4 METHOD FOR TREATING PERIPHERAL ARTERIAL DISEASE WITH ZINC FINGER PROTEINS 审中-公开
标题翻译：法外周动脉疾病与锌指蛋白的治疗
公开(公告)号：EP1993586A4
公开(公告)日：2009-10-21
申请号：EP07763713
申请日：2007-02-09
申请人： SANGAMO BIOSCIENCES INC
发明人： TREMBLE PATRICE , ROKOVICH JOE , ANNEX BRIAN
IPC分类号： A61K38/16 , A61K31/7105
CPC分类号： A61K38/16
摘要： Disclosed is a method for the administration of zinc finger proteins (ZFPs) or nucleic acids that encode such ZFPs for treating peripheral arterial disease, particularly by the repeated administration at regular intervals if such ZFPs or nucleic acids that encode such ZFPs.

93. 发明公开

EP2027262A2 VARIANT FOKI CLEAVAGE HALF-DOMAINS 有权
标题翻译： VARIANT的FokⅠ-分裂半部DOMAINS
公开(公告)号：EP2027262A2
公开(公告)日：2009-02-25
申请号：EP07795299.2
申请日：2007-05-23
申请人： Sangamo BioSciences, Inc.
发明人： MILLER, Jeffrey C.
IPC分类号： C12N9/22 , C12N15/55 , C12N15/62
CPC分类号： C12N9/22
摘要： Disclosed herein are engineered cleavage half-domains; fusion polypeptides comprising these engineered cleavage half-domains; polynucleotides encoding the engineered cleavage half-domains and fusion proteins; and cells comprising said polynucleotides and/or fusion proteins. Also described are methods of using these polypeptides and polynucleotides, for example for targeted cleavage of a genomic sequence.

94. 发明公开

EP2018424A2 METHODS AND COMPOSITIONS FOR INACTIVATION OF DIHYDROFOLATE REDUCTASE 审中-公开
标题翻译：方法和组合物用于禁用二氢叶酸还原酶
公开(公告)号：EP2018424A2
公开(公告)日：2009-01-28
申请号：EP07777118.6
申请日：2007-05-17
申请人： Sangamo BioSciences, Inc.
发明人： COLLINGWOOD, Trevor
IPC分类号： C12N9/22 , C12N15/62 , C07K14/00 , C12N15/87
CPC分类号： C12N15/62 , A61K48/00 , C12N9/22
摘要： Disclosed herein are methods and compositions for inactivating dihydrofolate reductase genes, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.

95. 发明公开

EP1546400A4 HIGH-THROUGHPUT SCREEN FOR MODULATORS OF CHROMATIN MODIFYING ACTIVITY 审中-公开
标题翻译：高通量筛选调节剂染色质修饰活动
公开(公告)号：EP1546400A4
公开(公告)日：2007-09-19
申请号：EP03793288
申请日：2003-08-22
申请人： SANGAMO BIOSCIENCES INC
发明人： SNOWDEN ANDREW
IPC分类号： C12N9/10 , C12Q1/68 , C07H21/04 , C12N15/00 , C12N15/09
CPC分类号： C12Q1/6897 , C07K2319/00 , C12N9/1007
摘要： Disclosed herein are compositions and method useful in screening a compound for its ability to modulate the activity of a chromatin modifying enzyme. These include fusions between a targeted DNA-binding domain and a chromatin modifying enzyme (or functional fragment thereof), polynucleotides encoding such fusions, and methods for their use.

96. 发明公开

EP1720995A2 METHODS AND COMPOSTIONS FOR TARGETED CLEAVAGE AND RECOMBINATION 有权
标题翻译：方法和组合物靶向剪切和重组
公开(公告)号：EP1720995A2
公开(公告)日：2006-11-15
申请号：EP05756438.7
申请日：2005-02-03
申请人： Sangamo BioSciences, Inc.
发明人： MILLER, Jeffrey C. , ZHANG, Lei
IPC分类号： C12P19/34 , C12N9/22
CPC分类号： A61K35/12 , C07K14/43595 , C07K14/4717 , C07K14/715 , C07K2319/00 , C07K2319/09 , C07K2319/81 , C12N9/14 , C12N9/22 , C12N15/62 , C12N15/85 , C12N2800/80
摘要： Disclosed herein are methods and compositions for targeted cleavage of a genomic sequence, targeted alteration of a genomic sequence, and targeted recombination between a genomic region and an exogenous polynucleotide homologous to the genomic region. The compositions include fusion proteins comprising a cleavage domain (or cleavage half-domain) and an engineered zinc finger domain, as well as polynucleotides encoding same. Fusion proteins comprising cleavage half-domains are used in pairs, to reconstitute a functional cleavage domain. In these fusion proteins, the zinc finger domain can be N-terminal to the cleavage half-domain, or the cleavage half-domain can be N-terminal to the zinc finger domain. The availability of fusion endonucleases having these different polarities allows targeting (and thereby binding) of zinc finger endonucleases either to opposite strands of the DNA target or to the same strand of the DNA target, thereby increasing the number of possible sequences which can be targeted and cleaved by the fusion proteins.

97. 发明公开

EP1678315A4 ENGINEERED ZINC FINGER PROTEINS FOR REGULATION OF GENE EXPRESSION 有权
标题翻译： Sa基因生产的锌指蛋白用于基因表达调控
公开(公告)号：EP1678315A4
公开(公告)日：2006-11-08
申请号：EP04784464
申请日：2004-09-17
申请人： SANGAMO BIOSCIENCES INC
发明人： MOORE MICHAEL , CHOO YEN , KLUG AARON
IPC分类号： C12P21/06 , C07H17/00 , C07K14/00 , C07K14/47 , C12N20060101
CPC分类号： C07K14/4702
摘要： Disclosed herein are methods and compositions for modulation of gene expression, with single-gene specificity, in a human sized genome.

98. 发明公开

EP1579005A1 METHODS AND COMPOSITIONS FOR ANALYSIS OF REGULATORY SEQUENCES 审中-公开
标题翻译：方法和组合物分析的调控序列
公开(公告)号：EP1579005A1
公开(公告)日：2005-09-28
申请号：EP03786893.2
申请日：2003-11-17
申请人： Sangamo BioSciences, Inc.
发明人： URNOV, Fyodor , RHODES, Eric
IPC分类号： C12Q1/68 , C12P19/36 , C12M1/36
CPC分类号： C12Q1/6837 , C12N15/1034
摘要： Methods for constructing arrays of regulatory sequences, and the arrays so obtained, are provided. Regulatory sequences for use on the arrays are isolated based on their accessibility in cellular chromatin. A number of methods for using the arrays are disclosed, including regulatory DNA profiling, epigenome profiling, toxicological profiling and identification of in vivo binding sites of DNA binding proteins in complex genomes.

99. 发明公开

EP1546400A2 HIGH-THROUGHPUT SCREEN FOR MODULATORS OF CHROMATIN MODIFYING ACTIVITY 审中-公开
标题翻译：高通量筛选调节剂染色质修饰活动
公开(公告)号：EP1546400A2
公开(公告)日：2005-06-29
申请号：EP03793288.6
申请日：2003-08-22
申请人： Sangamo Biosciences Inc.
发明人： SNOWDEN, Andrew
IPC分类号： C12Q1/68 , C12N15/00 , C12N15/09 , C07H21/04
CPC分类号： C12Q1/6897 , C07K2319/00 , C12N9/1007
摘要： Disclosed herein are compositions and method useful in screening a compound for its ability to modulate the activity of a chromatin modifying enzyme. These include fusions between a targeted DNA-binding domain and a chromatin modifying enzyme (or functional fragment thereof), polynucleotides encoding such fusions, and methods for their use.

100. 发明公开

EP1352975A2 Selection of sites for targeting by zinc finger proteins and methods of designing zinc fingers proteins to binds to preselected sites 有权
标题翻译：结合区域的选择锌指蛋白和设计方法能够结合到这样的预选择的区域的锌指蛋白
公开(公告)号：EP1352975A2
公开(公告)日：2003-10-15
申请号：EP03015798.6
申请日：2000-01-06
申请人： Sangamo Biosciences Inc.
发明人： Eisenberg, Stephen P. , Case, Casey C. , Cox, George III N. , Jamieson, Andrew , Rebar, Edward J.
IPC分类号： C12Q1/68 , G06F19/00
CPC分类号： C12N15/1089 , C07K14/47 , C07K14/4702 , C12Q1/6811 , G01N33/5308 , G01N33/6875 , G06F19/18
摘要： The invention provides criteria and methods for selecting optimum subsequence(s) from a target for targeting by a zinc finger protein. Some of the methods of targetgene site selection seek to identify one or more target segments having a DNA motif containing one or more so-called D-able subsites having the sequence 5'NNGK3'. Other methods of the invention are directed to selection of target segments within target genes using a correspondence regime between different triplets of three bases and the three possible positions of a triplet within a nine-base site. In another aspect, the invention provides methods of designing zinc finger proteins that bind to a preselected target site. These methods can be used following the preselection of target sites according to the procedures and criteria described above. The methods of design use a database containing information about previously characterized zinc finger proteins.
摘要翻译：本发明提供了用于选择从目标最佳子序列（一个或多个），用于通过一个锌指蛋白定位条件和方法。一些的靶基因选址的方法设法识别具有DNA基序包含一个或具有序列5'NNGK3”多个所谓的D-能够亚位点的一个或多个目标的段。本发明的其它方法涉及的靶区段的选择使用的三个碱基不同三元组和三重的九碱基位点内的三个可能的位置之间的对应关系政权靶基因内。在另一个方面，本发明提供了设计的锌指蛋白并结合到预选目标部位的方法。这些可以按照目标部位的预选可以使用的方法gemäß于上述的程序和标准。设计的方法使用约以前的特点锌指蛋白数据库中包含的信息。

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