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93. 发明公开

EP3119896A1 STABLE GENE TRANSFER TO PROLIFERATING CELLS 有权
标题翻译： STABILER GENTRANSFER AN PROLIFERIERENDE ZELLEN
公开(公告)号：EP3119896A1
公开(公告)日：2017-01-25
申请号：EP15764909.6
申请日：2015-03-23
申请人： The Sydney Children's Hospitals Network (Randwick and Westmead) , Children's Medical Research Institute , Mt. Sinai Hospital
发明人： ALEXANDER, Ian , CUNNINGHAM, Sharon , NAGY, Andras
IPC分类号： C12N15/86 , C12N15/90 , A61K48/00
CPC分类号： A61K48/0066 , A61K48/0041 , A61K48/005 , C12N9/1018 , C12N9/1241 , C12N9/14 , C12N9/93 , C12N15/86 , C12N2750/14143 , C12N2800/90 , C12N2840/007 , C12Y201/03003 , C12Y207/07 , C12Y306/03044 , C12Y603/04005
摘要： Provided herein are methods for facilitating or inducing stable transgene integration and expression in a proliferating cell, comprising administering to the cell (i) a recombinant AAV (rAAV) vector comprising the transgene flanked by transposon-derived inverted terminal repeat sequences, which sequences are in turn flanked by AAV-derived inverted terminal repeat regions, and (ii) a source of a transposase that recognises said transposon-derived inverted terminal repeat sequences and directs the genomic integration of the transgene into the genome of the proliferating cell. Also provided are methods and transgene delivery systems for the treatment or prevention of diseases affecting, associated with or characterised by proliferating cells, including paediatric liver diseases, bone marrow diseases and cancer.
摘要翻译：本文提供了促进或诱导在增殖细胞中稳定的转基因整合和表达的方法，包括向细胞施用（i）包含转座子的重组AAV（rAAV）载体，其侧翼为转座子衍生的反向末端重复序列，该序列位于转化为侧翼为AAV衍生的反向末端重复区，以及（ii）识别所述转座子衍生的反向末端重复序列并指导转基因的基因组整合进入增殖细胞基因组的转座酶的来源。还提供了用于治疗或预防影响与细胞增殖相关或特征在于包括儿科肝脏疾病，骨髓疾病和癌症的细胞的疾病的方法和转基因递送系统。

94. 发明授权

EP1461424B1 GENERATION OF VIRUS-LIKE PARTICLES AND DEMONSTRATION OF LIPID RAFTS AS SITES OF FILOVIRUS ENTRY AND BUDDING 有权
标题翻译：病毒样颗粒作为切入点纤丝和发芽生产和检测脂质筏
公开(公告)号：EP1461424B1
公开(公告)日：2013-01-16
申请号：EP02789508.5
申请日：2002-11-07
申请人： U.S. Army Medical Research Institute of Infectious Diseases; Department of the Army
发明人： BAVARI, Sina , AMAN, M., Javad , SCHMALJOHN, Alan, L.
IPC分类号： C12N7/01 , C12N7/02 , C12N7/04 , C12N15/80 , C12N15/87 , A61K39/12
CPC分类号： C12N7/00 , A61K31/365 , A61K31/7048 , A61K31/724 , A61K2039/525 , A61K2039/5258 , C07K14/005 , C12N2760/14122 , C12N2760/14123 , C12N2760/14145 , C12N2760/14222 , C12N2760/14223 , C12N2760/14245 , C12N2810/60

95. 发明公开

EP2516396A1 THERAPEUTIC COMPOUNDS 审中-公开
标题翻译：治疗性化合物
公开(公告)号：EP2516396A1
公开(公告)日：2012-10-31
申请号：EP10798937.8
申请日：2010-12-23
申请人： Wayne State University , Sanford-Burnham Medical Research Institute , Fontana, Joseph A. , Dawson, Marcia , Xia, Zebin
发明人： FONTANA, Joseph, A. , DAWSON, Marcia , XIA, Zebin
IPC分类号： C07D213/06 , C07D213/60 , C07D239/26 , C07D239/42 , A61K31/435 , A61K31/495 , A61P35/02
CPC分类号： C07D241/12 , A61K31/4965 , A61K31/497 , A61K31/505 , C07D213/06 , C07D213/55 , C07D213/60 , C07D237/08 , C07D239/26 , C07D239/42
摘要： The invention provides compounds of formula I or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for inducing apoptosis or treating cancer using compounds of formula I.
摘要翻译：本发明提供如本文所述的式I的化合物或其盐。本发明还提供了包含式I化合物的药物组合物，制备式I化合物的方法，可用于制备式I化合物的中间体和使用式I化合物诱导细胞凋亡或治疗癌症的治疗方法。

96. 发明公开

EP2485721A2 APOGOSSYPOLONE DERIVATIVES AS ANTICANCER AGENTS 审中-公开
标题翻译： APOGOSSYPOLONDERIVATE作为抗恶性肿瘤药
公开(公告)号：EP2485721A2
公开(公告)日：2012-08-15
申请号：EP10822706.7
申请日：2010-10-07
申请人： Sanford-Burnham Medical Research Institute
发明人： PELLECCHIA, Maurizio , WEI, Jun
IPC分类号： A61K31/12
CPC分类号： C07C50/10 , C07C50/32 , C07C235/84 , G01N2510/00 , G01N2800/52 , Y10T436/143333
摘要： The disclosure provides compounds and methods of using Apogossypolone derivatives for treating diseases and disorders. In particular, the disclosure provides compounds of Formula (I): or a pharmaceutically acceptable salt, hydrate, or solvate thereof, and provides methods for the preparation of compounds of Formula (I); and methods for treating cancer, autoimmune diseases, and inflammation by administering a compound of Formula (I).

97. 发明公开

EP2432465A1 USE OF DYNAMIN RING STABILIZERS 失效转让
标题翻译：使用动态RING稳定剂
公开(公告)号：EP2432465A1
公开(公告)日：2012-03-28
申请号：EP10777248.5
申请日：2010-05-21
申请人： Children's Medical Research Institute , The General Hospital Corporation
发明人： ROBINSON, Phillip J. , SEVER, Sanja
IPC分类号： A61K31/275 , A61K31/404 , A61K31/352 , A61P13/12
CPC分类号： A61K31/275 , A61K31/352 , A61K31/404
摘要： There is provided a method for promoting dynamin ring formation and/or maintenance of dynamin rings in a cell, comprising treating the cell with an effective amount of a dynamin ring stabilizer, or a prodrug or pharmaceutically acceptable salt of the dynamin ring stabilizer. The maintenance or accumulation of dynamin ring formation has particular application in the prophylaxis or treatment of a kidney disease or condition characterized by proteinuria. A dynamin ring stabilizer can be any agent that interacts with dynamin to promote dynamin ring assembly and/or inhibit dynamin ring disassembly. There are also provided methods for prophylaxis or treatment of podocyte dysfunction and/or maintaining or inducing actin cytoskeleton formation in a cell utilizing dynamin ring stabilizers, and for screening a test agent for use as a dynamin ring stabilizer.

98. 发明公开

EP2381779A1 SELECTIVE INHIBITORS OF AKT AND METHODS OF USING SAME 审中-公开
标题翻译：选择性的Akt抑制剂和方法供其使用
公开(公告)号：EP2381779A1
公开(公告)日：2011-11-02
申请号：EP09835795.7
申请日：2009-12-22
申请人： Sanford-Burnham Medical Research Institute
发明人： PELLECCHIA, Maurizio , RONAI, Ze'ev , CHIANG, Gary
IPC分类号： A01N43/42 , A61K31/47 , A61K31/415
CPC分类号： A61K31/415 , A61K31/47 , C07D215/227 , C07D307/46 , C07D401/06 , C07D405/06 , C07D471/04
摘要： The present invention describes an improved method for screening compounds for activity in inhibiting the enzymatic activity of Aktl protein kinase, also known as Protein Kinase B, an enzyme that is believed to playa key role in the inhibition of apoptosis and thus in the etiology of cancer and other conditions, including neurodegenerative diseases.

99. 发明公开

EP2241322A1 DENTAL STERILIZING WATER, METHOD FOR PRODUCING THE WATER, AND DEVICE FOR PRODUCING THE WATER 有权
标题翻译：口腔医疗消毒水，用于生产这样的水和装置这种水生产
公开(公告)号：EP2241322A1
公开(公告)日：2010-10-20
申请号：EP09707454.6
申请日：2009-02-04
申请人： Noguchi Dental Medical Research Institute
发明人： NOGUCHI, Munenori
IPC分类号： A61K33/40 , A61K33/10 , A61P1/02 , A61P31/04
CPC分类号： A61K8/20 , A61K8/19 , A61K33/00 , A61K33/10 , A61K33/20 , A61K33/40 , A61Q11/00 , A61K2300/00
摘要： This aims to produce dental sterilizing water having not only a sterilizing action but also an action to break a biofilm. Provided is a sterilizing water producing device (51) comprising a stock solution tank (3) for storing a stock solution (52), a stroke pump (4) connected in communication to the stock solution tank, an electrolytic bath (5) connected in communication to the stroke pump, a discharge pipe (6) connected in communication to the electrolytic bath, and a dilution water tank (8) reserving dilution water (57). The dilution water tank (8) is so positioned relative to the tip position of the discharge pipe (6) that the tip of the discharge pipe (6) may be lower than the water level of the dilution water (57) reserved in the dilution watertank (8). The stock solution (52) is prepared by selecting any of the methods shown at (a-1) to (d).
摘要翻译：这个目标是生产不仅具有杀菌作用，但这样的行动，打破了生物膜牙科用杀菌水。（5），其连接提供的是包含一个储液罐（3），用于存储的储备溶液（52），通信连接中在电解槽原液罐一个冲程泵（4）一个杀菌水生成部件（51）在通信到行程泵，通信连接中的电解浴的排出管（6），和一个稀释水槽（8）保留稀释水（57）。稀释水槽（8），以便相对于定位在排出管的前端位置（6）那样（6）可以比稀释水的水位降低（57）保留在稀释排出管的前端水箱（8）。储备溶液（52）通过选择任何的在（A-1）至（d）中所示的方法制备。

100. 发明授权

EP1119626B1 BOTULINUM NEUROTOXIN VACCINE 有权
标题翻译：肉毒杆菌的疫苗反对神经毒素
公开(公告)号：EP1119626B1
公开(公告)日：2008-01-02
申请号：EP99940801.6
申请日：1999-07-09
申请人： U.S. Army Medical Research Institute of Infectious Diseases
发明人： LEE, John, S. , PUSHKO, Peter , SMITH, Jonathan, F. , PARKER, Michael , DERTZBAUGH, Mark, T. , SMITH, Leonard
IPC分类号： C12N15/31 , C12N15/86 , C12N15/70 , C12N5/10 , C12N1/21 , C07K14/33 , A61K39/08 , A61K48/00
CPC分类号： C07K14/32 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , C07K14/31 , C07K14/33 , C12N2799/021

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