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1. 发明公开

EP1145773A2 Sifter frame for powder particle sifter 失效
标题翻译： SiebkastenfürPulverteilchensieb
公开(公告)号：EP1145773A2
公开(公告)日：2001-10-17
申请号：EP01115065.3
申请日：1994-11-11
申请人： NISSHIN FLOUR MILLING CO., LTD.
发明人： Hosokoshi, Yasunobu , Maruo, Toshio c/o Nisshin Flour Milling Co. Ltd. , Sakata, Yasuaki c/o Nisshin Flour Milling Co. Ltd. , Morita, Katsumasa c/o Nisshin Flour Milling Co.Ltd
IPC分类号： B07B1/46 , B07B1/38
CPC分类号： B07B1/4618 , B07B1/38 , B07B1/46
摘要： A sifter frame comprises an outer frame (6) and an inner frame (5). The outer frame (6) is formed from frame members (62 - 64) having the same height and includes a pair of fine powder dropping ports (75), a rough powder dropping port (69) and a rectangular fine powder receiving plate (67) disposed in a region surrounded by these openings and one of the outer block frame members (62). The inner frame (5) is fitted within the space above the receiving plate (67). The two outer frame members (54, 55) of the inner frame (5) in contact with the fine powder dropping ports (65) project towards the rough powder dropping port and beyond the outer block frame member (52) of the inner frame (5) in contact with the rough powder dropping port (69) to form horn portions. The outer frame (6) includes complementary receiving portions (82) for receiving and engaging the horn portions of the inner frame (5).
The engaging surfaces of the horn portions and the receiving portions are formed with mutual sealing surfaces having an arcuate shape, so that a vertical compression force applied to the engaging surfaces via the upper stage sifter provides a sealing effect.
摘要翻译：筛子框架包括外框架（6）和内框架（5）。外框架（6）由具有相同高度的框架构件（62-64）形成，并且包括一对细粉末滴入口（75），粗粉末滴入口（69）和矩形细粉末接收板（67））设置在由这些开口包围的区域中，以及一个外框架构件（62）。内框架（5）装配在接收板（67）上方的空间内。内部框架（5）的与细粉末滴入口（65）接触的两个外框架构件（54,55）朝向粗粉末滴落口突出并且超出内框架的外框架构件（52） 5）与粗粉末滴入口（69）接触以形成喇叭部分。外框架（6）包括用于接收和接合内框架（5）的喇叭部分的互补的接收部分（82）。喇叭部分和接收部分的接合表面形成有具有弓形形状的相互密封表面，使得通过上层筛分器施加到接合表面的垂直压缩力提供了密封效果。

2. 发明公开

EP1145644A2 Glycoprotein having inhibitory activity against helicobacter pylori colonization 有权
标题翻译：糖蛋白mit ender ender ender ge ori ori ori ori ori ori ori ori ori ori ori
公开(公告)号：EP1145644A2
公开(公告)日：2001-10-17
申请号：EP01400969.0
申请日：2001-04-13
申请人： Ghen Corporation , Nisshin Flour Milling Co., Ltd.
发明人： Kodama, Yoshikatsu , Kimura, Nobutake, Nisshin Flour Milling Co, Ltd
IPC分类号： A23J1/20 , A23J1/08 , A23C9/146 , A61K38/38 , A61K38/40
CPC分类号： A23G9/38 , A23G4/126 , A23G4/14 , A23G9/366 , A23L23/10 , A23L33/17 , A23L33/19 , A23L33/40 , A61K38/018 , A61K38/38 , A61K38/40
摘要： An inhibitor of Helicobacter pylori colonization in the stomach comprises as an active ingredient a glycoprotein which specifically binds to H. pylori urease. This glycoprotein is isolated and purified from a glycoprotein-containing substance, especially that derived from bovine milk whey or albumen of chicken eggs by affinity chromatography using a column on which H. pylori urease is immobilized. The glycoprotein is able to effectively inhibit H. pylori colonization, so is useful for the prevention or treatment of diseases caused by infection of H. pylori such as peptic ulcers. A food and medicament comprising the inhibitor are also provided.
摘要翻译：胃中幽门螺旋杆菌定植抑制剂包含特异性结合幽门螺杆菌脲酶的糖蛋白作为活性成分。通过使用固定有幽门螺杆菌脲酶的柱的亲和层析，从含糖蛋白的物质，特别是来自牛奶乳清或鸡蛋白蛋白的物质中分离和纯化该糖蛋白。糖蛋白能够有效地抑制幽门螺旋杆菌定植，因此可用于预防或治疗由幽门螺杆菌感染引起的疾病如消化性溃疡。还提供了包含抑制剂的食品和药物。

3. 发明公开

EP1125914A1 Process for separating and purifying eicosapentaenoic acid or its ester 审中-公开
标题翻译：艾尔斯堡
公开(公告)号：EP1125914A1
公开(公告)日：2001-08-22
申请号：EP01102748.9
申请日：2001-02-08
申请人： Nisshin Flour Milling Co., Ltd.
发明人： Fujita, Shiro, Nisshin Flour Milling Co., Ltd. , Asami, Yuji, Nisshin Flour Milling Co., Ltd. , Ikeda, Toru, Nisshin Flour Milling Co., Ltd.
IPC分类号： C07C67/56 , C07C51/47 , C07C69/587 , C07C57/03
CPC分类号： C07C59/72 , C07C59/64 , C07C67/56 , C07C69/587
摘要： Eicosapentaenoic acid or its ester is separated and purified from a mixture containing a highly unsaturated fatty acid or its ester effectively at low cost by a process, which comprises developing the mixture by a mixed solvent of an ether solvent and a hydrocarbon solvent, using a column filled with a silica gel having a particle diameter of 1-100 micrometers.
摘要翻译：通过一种方法以低成本有效地从包含高度不饱和脂肪酸或其酯的混合物中分离和纯化二十碳五烯酸或其酯，该方法包括通过醚溶剂和烃溶剂的混合溶剂，使用柱填充了粒径为1-100微米的硅胶。

4. 发明授权

EP0720983B1 Diphenyl disulfide compounds 失效
标题翻译：二苯基二硫化物化合物
公开(公告)号：EP0720983B1
公开(公告)日：2001-03-14
申请号：EP95120328.0
申请日：1995-12-21
申请人： NISSHIN FLOUR MILLING CO., LTD.
发明人： Katsuyama, Koichi, c/o Nisshin Flour Milling Co. , Ariga, Masato, c/o Nisshin Flour Milling Co. , Saito, Yukio, c/o Nisshin Flour Milling Co. , Hatanaka, Shigeo, c/o Nisshin Flour Milling Co. , Takahashi, Toshihiro, c/o Nisshin Flour Milling Co
IPC分类号： C07D239/42 , C07D235/18 , A61K31/505
CPC分类号： C07D239/42 , C07D235/18

5. 发明公开

EP0934952A3 Peptides containing an N-substituted glycine residue 审中-公开
标题翻译： N-取代的含有甘氨酸的肽
公开(公告)号：EP0934952A3
公开(公告)日：1999-12-29
申请号：EP98124653.1
申请日：1998-12-24
申请人： Nisshin Flour Milling Co., Ltd.
发明人： Yanai, Makoto , Suzuki, Masashi , Oshida, Norio , Kawamura, Koji , Hiramoto, Shigeru , Yasuda, Orie , Kinoshita, Nobuhiro , Shingai, Akiko , Takasu, Masako
IPC分类号： C07K7/06 , A61K38/08
CPC分类号： C07K7/06 , A61K38/00
摘要： A depsipeptide containing N-substituted glycine residue having the formula (1) or (2):
(wherein R 1 is a straight or branched alkyl group of 5-20 carbon atoms or a straight or branched alkoxymethyl group of 5-15 carbon atoms; R 2 is a group of the formula -A-B-W-(D) m -(E) n , -A-B-W-(D) m -(E) n -F or -A-B-W-(D) m -(E) n -F-Z; R 3 is a hydroxyl group, a lower alkoxy group, a benzyloxy group, or a group of the formula -Z, -Z-G or -Z-G-J; A, B, D, E, F, G and J independently are an N-substituted glycine residue or a residue of an amino acid selected from the group consisting of alanine, valine, leucine, serine, etc.; Wand Z independently are a residue of an amino acid selected from the group consisting of an aspartic acid, a glutamic acid, etc.; at least one of A, B, D, E, F, G and J is an N-substituted glycine residue) or a pharmacologically acceptable salt thereof. The above depsipeptides have a promoting activity on the production of apolipoprotein E, and are useful as a therapeutic agent for neurologic damages, especially dementia, and hyperlipemia.

6. 发明公开

EP0858743A3 Processes for extracting zinc rich mineral components from cereal germs 失效
标题翻译： Verfahren zur Gewinnung von zinkreichen Mineralstoffen aus Kornkeimen
公开(公告)号：EP0858743A3
公开(公告)日：1999-09-29
申请号：EP98101593.6
申请日：1998-01-30
申请人： NISSHIN FLOUR MILLING CO., LTD.
发明人： Motoi, Hirofumi, Nisshin Flour Milling Co., Ltd. , Suzuki, Yoshio, Nisshin Flour Milling Co., Ltd.
IPC分类号： A23L1/304 , A23L1/172
CPC分类号： A23L33/16 , A23L7/152
摘要： A process is disclosed for the preparation of a zinc rich mineral component from a cereal germ which comprises the steps of:
a) extracting the cereal germ with water at a temperature of 70°C or lower under an acid condition of pH 5.0 or lower, b) precipitating the zinc rich mineral component dissolved in the extract solution as insolubles, and c) recovering the precipitated insolubles. The zinc rich mineral components produced by the process are useful as a material for foods.
摘要翻译：公开了从谷物胚芽制备富含锌的矿物成分的方法，该方法包括以下步骤：a）在pH5.0或更低的酸性条件下，在70℃或更低的温度下用水提取谷粒， b）将溶解在提取液中的富锌矿物成分沉淀为不溶物，c）回收沉淀的不溶物。通过该方法生产的富锌矿物成分可用作食品的材料。

7. 发明公开

EP0713918A3 Method for the extraction of glicentin or glicentin analagous substances 失效
标题翻译：一种用于肠高血糖素或Glicentinanalogen的提取处理
公开(公告)号：EP0713918A3
公开(公告)日：1999-03-17
申请号：EP95118398.7
申请日：1995-11-23
申请人： NISSHIN FLOUR MILLING CO., LTD.
发明人： Imai, Shinjirou, c/o Nisshin Flour Milling Co.,Ltd
IPC分类号： C12P21/02 , C07K14/605
CPC分类号： C07K14/605
摘要： In the method for the extraction of glicentin or a glicentin analogous substance from the cells of a transformed microorganism having incorporated therein an expressible gene encoding glicentin or a glicentin analogous substance, the extraction is carried out using an aqueous solution of an inorganic acid and/or an organic acid.

8. 发明公开

EP0882716A1 PYRIDINECARBOXAMIDE DERIVATIVES 失效
标题翻译： PYRIDINCARBOXAMID衍
公开(公告)号：EP0882716A1
公开(公告)日：1998-12-09
申请号：EP97912509.3
申请日：1997-11-19
申请人： Nisshin Flour Milling Co., Ltd.
发明人： OSHIDA, Norio-Nisshin Flour Milling Co., Ltd. , MIMAKI, Yoji-Nisshin Flour Milling Co., Ltd. , SATOH, Hiroaki-Nisshin Flour Milling Co., Ltd. , YOKOYAMA, Shinji-Nisshin Flour Milling Co., Ltd. , MURAKI, Yukiko-Nisshin Flour Milling Co., Ltd. , NISHIMURA, Kazumi-Nisshin Flour Milling Co., Ltd. , HAMADA, Tamiko-Nisshin Flour Milling Co., Ltd. , SAKURAI, Einosuke-Nisshin Flour Milling Co., Ltd. , SAKAI, Hiroshi-Nisshin Flour Milling Co., Ltd. , SUGAI, Toshiji-Nisshin Flour Milling Co., Ltd. , TONOIKE, Tomomi-Nisshin Flour Milling Co., Ltd. , ITOH, Koichi-Nisshin Flour Milling Co., Ltd.
IPC分类号： C07D213/81 , C07D213/80 , C07D213/803 , A61K31/495
CPC分类号： C07D213/80 , C07D213/82
摘要： N-(12-Nitroxydodecyl)-6-(4-ethyl or isopropyl-1-piperazinyl)pyridine-3-carboxamide or physiologically acceptable salts thereof.
The said compounds have excellent inhibiting activity of cerebral edema, especially ischemic cerebral edema, and inhibiting activity of delayed neuronal death (an inhibiting activity of Ca-influx in neuronal cells). Cerebral edema is a pathologic condition accompanying cerebrovascular disorders, especially the acute stage cerebrovascular disorders and then the compounds are useful as an inhibiting agent for cerebral edema or a therapeutic agent for cerebrovascular disorders. Moreover, because the compounds do hardly show a behavior suppressing action, which is considered to be side effect in treating cerebrovascular disorders at the acute stage, they are an excellent therapeutic agent for, in particular, the acute stage cerebrovascular disorders. Moreover, the compounds show a cerebral protective activity (an anti-anoxic activity), an activity of increasing cerebral blood flow, and an activity of inhibiting lipid peroxidation, and these activities may lead to the increased utility as a therapeutic agent for cerebrovascular disorders.
摘要翻译： N-（12-硝基十二烷基）-6-（4-乙基或异丙基-1-哌嗪基）吡啶-3-甲酰胺或其生理上可接受的盐。所述化合物具有优异的脑水肿抑制活性，特别是缺血性脑水肿，抑制延迟性神经元死亡的活性（神经细胞内Ca流入的抑制活性）。脑水肿是伴随脑血管障碍，特别是急性期脑血管障碍的病理状况，然后该化合物可用作脑水肿的抑制剂或脑血管障碍治疗剂。此外，由于化合物几乎不表现出在急性期治疗脑血管障碍中被认为是副作用的行为抑制作用，所以它们是特别是急性期脑血管障碍的优良治疗剂。此外，化合物显示脑保护活性（抗缺氧活性），增加脑血流量的活性和抑制脂质过氧化的活性，并且这些活性可导致作为脑血管障碍治疗剂的效用增加。

9. 发明授权

EP0709455B1 Monoclonal antibody to human glicentin, hybridoma for producing said antibody and assay method for human glicentin using said antibody 失效
标题翻译：使用这种抗体的单克隆抗体对人肠高血糖素，杂交瘤于为人类肠高血糖素这种抗体和试验方法的制备
公开(公告)号：EP0709455B1
公开(公告)日：1998-09-09
申请号：EP95307748.4
申请日：1995-10-31
申请人： NISSHIN FLOUR MILLING CO., LTD.
发明人： Yanaihara, Noboru, c/o Yanaihara Institute Inc. , Sato, Takeya, c/o Nisshin Flour Milling Co., Ltd. , Fukuchi, Kiyoshi, Nisshin Flour Milling Co., Ltd.
IPC分类号： C12N5/20 , C07K16/18
CPC分类号： C07K16/26 , C07K2317/34

10. 发明授权

EP0711510B1 Process for the production of fermenting materials 失效
标题翻译：用于生产可发酵的材料的
公开(公告)号：EP0711510B1
公开(公告)日：1998-05-20
申请号：EP95116721.2
申请日：1995-10-24
申请人： NISSHIN FLOUR MILLING CO., LTD.
发明人： Nagata, Sadao, c/o Nisshin Flour Milling Co., Ltd. , Endo, Shigeru, c/o Nisshin Flour Milling Co., Ltd. , Kishi, Keiichi, c/o Nisshin Flour Milling Co.,Ltd.
IPC分类号： A23L1/23 , A23L1/238
CPC分类号： A23J3/18 , A23L11/09 , A23L27/50 , A23P10/25

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