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3. 发明申请

US20090297609A1 Method of Biomolecule Immobilization On Polymers Using Click-Type Chemistry 有权
标题翻译：使用点击式化学的聚合物上生物分子固定的方法
公开(公告)号：US20090297609A1
公开(公告)日：2009-12-03
申请号：US11988207
申请日：2006-07-06
申请人： Molly S. Shoichet , Yumin Yuan , Meng Shi , Jordan Wosnick
发明人： Molly S. Shoichet , Yumin Yuan , Meng Shi , Jordan Wosnick
IPC分类号： A61K9/14 , A61K39/395 , A61K35/12 , A61K35/76 , A61K38/43 , A61K38/00 , A61K31/7088 , C08F18/24 , C08F24/00 , C08F116/02 , C08F20/58 , C07C43/00
CPC分类号： C08G63/912 , A61K47/48907 , A61K47/6935 , C08G63/64 , C08G64/0241 , C08G64/42
摘要： The present invention provides a method for the covalent immobilization of biomolecules on polymers for delivery of the biomolecules, which has the advantage of being simple, highly efficient, environmentally friendly and free of side products relative to traditional immobilization techniques. The invention provides a modified micro/nanoparticle system, which uses a functionalized polymer formed into micro or nanoparticles to bind a molecule to the particles using uses facile chemistry, the Diels-Alder cycloaddition between a diene and a dienophile with the polymer being functionalized with one of them and the molecule with the other, or the Huisgen 1,3-dipolar cycloaddition between a terminal alkyne and an azide to bind the molecule to the particle. The molecules and/or other therapeutic agents may be encapsulated within the polymer particles for intravenous therapeutic delivery. The invention also provides a novel synthetic biodegradable polymer, a furan/alkyne-functionalized poly(trimethylene carbonate) (PTMC)-based polymer, whose composition can be designed to meet the defined physical and chemical property requirements. In one example, the particle system self-aggregates from functionalized PTMC-based copolymers containing poly(ethylene glycol) (PEG) segments. The composition of the copolymers can be designed to meet various particle system requirements, including size, thermodynamic stability, surface PEG density, drug encapsulation capacity and biomolecule immobilization capacity.
摘要翻译：本发明提供了生物分子共价固定在聚合物上用于递送生物分子的方法，其具有相对于传统固定技术简单，高效，环保且无副产物的优点。本发明提供了一种修饰的微/纳米颗粒体系，其使用形成微米或纳米颗粒的官能化聚合物使用易于使用的化学方法将分子与颗粒结合，二烯与亲双烯体之间的Diels-Alder环加成与聚合物被一个官能化的分子和另一个分子，或者在末端炔烃和叠氮化物之间的Huisgen 1,3-偶极环加成以将分子结合到颗粒。分子和/或其它治疗剂可以包封在聚合物颗粒内用于静脉内治疗递送。本发明还提供了一种新型的合成可生物降解聚合物，呋喃/炔官能化的聚（碳酸亚丙基酯）（PTMC）（PTMC））聚合物，其组合物可以被设计成满足规定的物理和化学性质要求。在一个实例中，颗粒系统自聚集于含有聚（乙二醇）（PEG）链段的官能化的基于PTMC的共聚物。共聚物的组成可以设计成满足各种颗粒系统的要求，包括尺寸，热力学稳定性，表面PEG密度，药物包封能力和生物分子固定能力。

4. 发明授权

US5834594A Polyethylene-protein conjugates 失效
公开(公告)号：US5834594A
公开(公告)日：1998-11-10
申请号：US457068
申请日：1995-06-01
申请人： John Hakimi , Patricia Kilian , Perry Rosen
发明人： John Hakimi , Patricia Kilian , Perry Rosen
IPC分类号： A61K38/00 , A61K20060101 , A61K31/745 , A61K38/16 , A61K38/19 , A61K38/20 , A61K38/21 , A61K39/00 , A61K39/38 , A61K39/385 , A61K47/42 , A61K47/48 , A61P37/00 , A61P37/02 , A61P43/00 , C07C267/00 , C07C331/18 , C07C331/20 , C07D211/04 , C07D213/63 , C07D213/64 , C07D213/643 , C07D213/70 , C07D213/83 , C07D213/89 , C07K20060101 , C07K1/00 , C07K14/47 , C07K14/52 , C07K14/54 , C07K14/545 , C07K14/55 , C07K14/555 , C07K14/56 , C07K14/765 , C07K17/00 , C07K17/02 , C07K17/06 , C07K17/08 , C07K17/10 , C08F116/02 , C08F216/00 , C08G65/02 , C08G65/08 , C08G65/26 , C08G65/28 , C08G65/32 , C08G65/34 , C08G65/48 , C08H1/00 , C08L23/36 , C08L71/02 , C12N9/96
CPC分类号： A61K47/48215 , Y10S435/964 , Y10S530/816
摘要： The present invention is a physiologically active, substantially non-immunogenic water soluble polyethylene glycol protein conjugate having the same utility as the protein which forms the conjugate, without having the same properties of producing an immunogenic response possessed by the protein which forms this conjugate.

5. 发明授权

US5539063A Polymer for making poly(ethylene glycol)-protein conjugates 失效
标题翻译：制备聚（乙二醇） - 蛋白共轭物的聚合物
公开(公告)号：US5539063A
公开(公告)日：1996-07-23
申请号：US456450
申请日：1995-06-01
申请人： John Hakimi , Patricia Kilian , Perry Rosen
发明人： John Hakimi , Patricia Kilian , Perry Rosen
IPC分类号： A61K38/00 , A61K20060101 , A61K31/745 , A61K38/16 , A61K38/19 , A61K38/20 , A61K38/21 , A61K39/00 , A61K39/38 , A61K39/385 , A61K47/42 , A61K47/48 , A61P37/00 , A61P37/02 , A61P43/00 , C07C267/00 , C07C331/18 , C07C331/20 , C07D211/04 , C07D213/63 , C07D213/64 , C07D213/643 , C07D213/70 , C07D213/83 , C07D213/89 , C07K20060101 , C07K1/00 , C07K14/47 , C07K14/52 , C07K14/54 , C07K14/545 , C07K14/55 , C07K14/555 , C07K14/56 , C07K14/765 , C07K17/00 , C07K17/02 , C07K17/06 , C07K17/08 , C07K17/10 , C08F116/02 , C08F216/00 , C08G65/02 , C08G65/08 , C08G65/26 , C08G65/28 , C08G65/32 , C08G65/34 , C08G65/48 , C08H1/00 , C08L23/36 , C08L71/02 , C12N9/96
CPC分类号： A61K47/48215 , Y10S435/964 , Y10S530/816
摘要： The present invention is a polymer which may be used to produce a physiologically active, substantially non-immunogenic water soluble polyethylene glycol protein conjugate having the same utility as the protein which forms the conjugate, without having the same properties of producing an immunogenic response possessed by the protein which forms this conjugate.
摘要翻译：本发明是一种聚合物，其可用于产生具有与形成缀合物的蛋白质相同效用的生理活性，基本上非免疫原性的水溶性聚乙二醇蛋白质缀合物，而不具有产生具有免疫原性的抗原相同的性质形成该结合物的蛋白质。

6. 发明申请

US20040152843A1 Open-ring copolymer, hydrogenated open-ring copolymer, process for production of both, and compositions 有权
标题翻译：开环共聚物，氢化开环共聚物，二者的生产方法和组合物
公开(公告)号：US20040152843A1
公开(公告)日：2004-08-05
申请号：US10480002
申请日：2004-03-09
发明人： Kazunori Taguchi , Yasuo Tsunogae , Hitomi Takeuchi , Yasuhiro Wakisaka , Kei Sakamoto
IPC分类号： C08F004/06 , C08F010/00 , C08F116/02
CPC分类号： C08G61/06
摘要： A ring-opened metathesis copolymer and its hydrogenated product having a desired monomer unit ratio and a high molecular weight and having hydroxyl groups or hydroxycarbonyl groups can be obtained by conducting a ring-opening metathesis copolymerization of a norbornene-type monomer having hydroxyl groups or hydroxycarbonyl groups with an unsubstituted norbornene-type monomer having at least three rings in the presence of a catalyst predominantly comprised of an organic ruthenium compound having coordinated therewith a neutral electron-donating ligand, and, if desired, hydrogenating the resulting copolymer. The thus-obtained ring-opened metathesis copolymer and its hydrogenation product are characterized by having a low water absorption, good adhesion to metal and other materials, good compatibility with a curing agent and other compounds, and high heat resistance, and exhibiting reduced signal retardation and signal noise.
摘要翻译：通过进行具有羟基或羟基羰基的降冰片烯型单体的开环易位共聚，可以获得具有所需单体单元比和高分子量并具有羟基或羟基羰基的开环复分解共聚物及其氢化产物具有至少三个环的未取代的降冰片烯型单体的基团在主要由与其配位有中性给电子配体的有机钌化合物组成的催化剂的存在下进行，并且如果需要，氢化所得共聚物。由此获得的开环复分解共聚物及其氢化产物的特征在于具有低吸水性，对金属和其他材料的良好粘附性，与固化剂和其它化合物的良好相容性，以及高耐热性，并且表现出降低的信号延迟和信号噪声。

7. 发明授权

US5849860A Polyethylene-protein conjugates 失效
公开(公告)号：US5849860A
公开(公告)日：1998-12-15
申请号：US456449
申请日：1995-06-01
申请人： John Hakimi , Patricia Kilian , Perry Rosen
发明人： John Hakimi , Patricia Kilian , Perry Rosen
IPC分类号： A61K38/00 , A61K20060101 , A61K31/745 , A61K38/16 , A61K38/19 , A61K38/20 , A61K38/21 , A61K39/00 , A61K39/38 , A61K39/385 , A61K47/42 , A61K47/48 , A61P37/00 , A61P37/02 , A61P43/00 , C07C267/00 , C07C331/18 , C07C331/20 , C07D211/04 , C07D213/63 , C07D213/64 , C07D213/643 , C07D213/70 , C07D213/83 , C07D213/89 , C07K20060101 , C07K1/00 , C07K14/47 , C07K14/52 , C07K14/54 , C07K14/545 , C07K14/55 , C07K14/555 , C07K14/56 , C07K14/765 , C07K17/00 , C07K17/02 , C07K17/06 , C07K17/08 , C07K17/10 , C08F116/02 , C08F216/00 , C08G65/02 , C08G65/08 , C08G65/26 , C08G65/28 , C08G65/32 , C08G65/34 , C08G65/48 , C08H1/00 , C08L23/36 , C08L71/02 , C12N9/96
CPC分类号： A61K47/48215 , Y10S435/964 , Y10S530/816
摘要： The present invention is a physiologically active, substantially non-immunogenic water soluble polyethylene glycol protein conjugate having the same utility as the protein which forms the conjugate, without having the same properties of producing an immunogenic response possessed by the protein which forms this conjugate.

8. 发明专利

CA2067846C POLYOL COMPONENTS FOR THE PRODUCTION OF POLYURETHANE MOULDINGS 未知
公开(公告)号：CA2067846C
公开(公告)日：2003-07-15
申请号：CA2067846
申请日：1992-05-01
IPC分类号： C08G18/32 , C08G18/48 , C08G18/65 , C08G18/66 , C08G18/76 , C08J5/00 , C08L71/02 , C08F116/02 , C08L57/10
摘要： The invention relates to polyol compositions, in particular for reaction with polyisocyanates of the diphenylmethane series, which comprise a) a polyol having a hydroxyl equivalent weight of up to 150 and a functionality of 4 to 8, b) a polyether-polyol having a hydroxyl equivalent weight of more than 1900 and a functionality of 2 to 4 and c) a polypropylene glycol having a functionality of 2 to 3, a polytetrahydrofuran, each of which has a hydroxyl equivalent weight of 150 to 500, or a mixture of the two. The polyol compositions are distinguished by a low tendency to demix, even during prolonged storage. Reaction mixtures of the polyol compositions described and polyisocyanates of the diphenylmethane series cure fully without passing through a brittle phase. The mouldings formed have good mechanical properties.

9. 发明专利

EE9400356A 未知
公开(公告)号：EE9400356A
公开(公告)日：1996-04-15
申请号：EE9400356
申请日：1994-11-23
申请人： HOFFMANN LA ROCHE
发明人： HAKIMI JOHN , KILIAN PATRICIA , ROSEN PERRY
IPC分类号： A61K38/00 , A61K20060101 , A61K31/745 , A61K38/16 , A61K38/19 , A61K38/20 , A61K38/21 , A61K39/00 , A61K39/38 , A61K39/385 , A61K47/42 , A61K47/48 , A61P37/00 , A61P37/02 , A61P43/00 , C07C267/00 , C07C331/18 , C07C331/20 , C07D211/04 , C07D213/63 , C07D213/64 , C07D213/643 , C07D213/70 , C07D213/83 , C07D213/89 , C07K20060101 , C07K1/00 , C07K14/47 , C07K14/52 , C07K14/54 , C07K14/545 , C07K14/55 , C07K14/555 , C07K14/56 , C07K14/765 , C07K17/00 , C07K17/02 , C07K17/06 , C07K17/08 , C07K17/10 , C08F116/02 , C08F216/00 , C08G65/02 , C08G65/08 , C08G65/26 , C08G65/28 , C08G65/32 , C08G65/34 , C08G65/48 , C08H1/00 , C08L23/36 , C08L71/02 , C12N9/96
摘要： The present invention relates to physiologically active, substantially non-immunogenic water soluble polyethylene glycol protein conjugates having at least part of the biological activity of the protein which forms the conjugate, without exhibiting the same disadvantageous immunogenic responses thereof.

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