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1. 发明授权

US06497157B1 Intrinsic dissolution apparatus with stationary sample holder 有权
标题翻译：具有固定样品架的固有溶解装置
公开(公告)号：US06497157B1
公开(公告)日：2002-12-24
申请号：US09711287
申请日：2000-11-13
申请人： Tacey X. Viegas , Gerald Brinker , Michael Cai
发明人： Tacey X. Viegas , Gerald Brinker , Michael Cai
IPC分类号： G01N3315
CPC分类号： G01N13/00 , G01N33/15 , G01N2013/006
摘要： For intrinsic dissolution testing, a drug pellet (i.e., the dissolution test sample) is retained within a cylindrical recess in a sample holder that is placed at the bottom of a dissolution vessel containing an appropriate dissolution medium with the sample holder oriented with the drug pellet facing up. During the testing cycle, the dissolution medium may be stirred, e.g., using a conventional USP 2 rotating paddle, while the sample holder (and drug pellet) remain stationary at the bottom of the vessel. The orientation of the drug pellet during testing (i.e., facing up) decreases the likelihood of retention of air bubbles formed at the surface of the drug pellet (which bubbles could otherwise decrease the effective dissolution rate), thereby providing more accurate and consistent intrinsic dissolution test results.
摘要翻译：对于固有溶解试验，将药物丸粒（即溶出试验样品）保留在样品保持器的圆柱形凹部内，该样品保持器放置在含有适当溶解介质的溶解容器的底部，样品保持器与药物颗粒朝上。在测试循环期间，可以例如使用常规的USP 2旋转桨来搅拌溶解介质，同时样品保持器（和药物颗粒）在容器的底部保持静止。在测试期间药物颗粒的取向（即面朝上）降低了在药物颗粒表面形成的气泡的保留的可能性（该气泡否则可能降低有效溶解速率），从而提供更准确和一致的内在溶解检测结果。

2. 发明授权

US06257079B1 Tablet testing appliance 失效
标题翻译：平板电脑测试仪器
公开(公告)号：US06257079B1
公开(公告)日：2001-07-10
申请号：US09126085
申请日：1998-07-30
申请人： Werner G. Mueller
发明人： Werner G. Mueller
IPC分类号： G01N3315
CPC分类号： G01G17/00 , G01N33/15 , G01N2033/0077
摘要： An appliance for testing oblong tablets or tablests with a similar form and more especially for weighing, measuring and fracture testing of such tablets in suitable testing stations, the appliance including a feeder for feeding individual oblong tablets to a weighing device having a weighing pan with a floor in the form of a trough inclined in the conveying direction, and being provided with a conveyor underneath the weighing pan on which conveyor the tablets are deposited with their longitudinal axis parallel to the longitudinal direction of the trough and which conveys the tablets with such alignment through the further testing stations, and in which between the point at which the oblong tablets are transferred to the conveyor and the testing stations, a toppling device is arranged, which topples over any oblong tablets standing on their edges so that the tablets fall onto their round sides.
摘要翻译：用于测试具有类似形式的长方形片剂或片状物的装置，更具体地用于在合适的测试站中对这种片剂进行称重，测量和断裂测试，该器具包括用于将各种长圆形片剂供给到具有称重盘的称重装置的进料器地板以沿输送方向倾斜的槽的形式，并且在称重盘下方设置有输送器，输送机上的片剂被平行于槽的纵向方向沉积在其上，并且以这种对准的方式输送片剂通过进一步的测试站，并且其中长方形片剂传送到输送机和测试站之间的位置，布置了倾倒装置，其倾倒在站立在其边缘上的任何长方形片上，使得片剂落在它们的圆边。

3. 发明授权

US06484595B1 Device for determining the disintegration time of compressed pharmaceutical mold bodies, such as tablets and capsules, as well as a method for this purpose 有权
标题翻译：用于确定压缩的药物模具体（例如片剂和胶囊）的崩解时间的装置以及用于该目的的方法
公开(公告)号：US06484595B1
公开(公告)日：2002-11-26
申请号：US09436922
申请日：1999-11-08
申请人： Norbert Krämer
发明人： Norbert Krämer
IPC分类号： G01N3315
CPC分类号： G01N33/15 , G01N13/00 , G01N2013/006
摘要： An apparatus for determining a disintegration time of compressed pharmaceutical mold bodies includes a vessel filled with a liquid, a frame lowerable into the vessel filled with the liquid, a center column attached to the frame, a floor attached to the center column, wherein the floor contains a plurality of holes, a grid covering the holes from below, a test tube disposed upright and positioned in one of the holes, a disk having passing through holes and movably insertable into the test tube as a weight onto an individual pharmaceutical form body, wherein the passing through holes are running parallel to the direction of the center axis of the disk. A permanent magnet is disposed centered within the disk and has a magnetic field directed axially, wherein the center hole of the disk exhibits a bore hole starting from a lower cover face of the disk, wherein the permanent magnet is seated in the bore hole, wherein the permanent magnet exhibits a permanent magnet hole centeredly in the direction of a center axis, which permanent magnet hole is aligned with the center hole within the disk.
摘要翻译：用于确定压缩的药物模具体的崩解时间的装置包括：填充有液体的容器，可放置在容器中的框架，装有液体的容器，附接到框架的中心柱，附接到中心柱的底板，包含多个孔，从下方覆盖孔的格栅，直立设置并定位在其中一个孔中的试管，具有穿过孔并以可重量的方式插入到试管中的盘，该盘作为重物移动到单独的药物形式主体上，其中所述通孔平行于所述盘的中心轴线的方向延伸。永久磁铁设置在圆盘的中心并具有轴向定向的磁场，其中盘的中心孔从盘的下盖面开始出现孔，其中永磁体位于钻孔中，其中永磁体以中心轴方向为中心的永磁体孔，该永磁体孔与盘内的中心孔对准。

4. 发明授权

US06218595B1 Dopamine transporter knockout mice 有权
标题翻译：多巴胺转运蛋白敲除小鼠
公开(公告)号：US06218595B1
公开(公告)日：2001-04-17
申请号：US09134185
申请日：1998-08-14
申请人： Bruno Giros , Mohamed Jaber , Marc G. Caron
发明人： Bruno Giros , Mohamed Jaber , Marc G. Caron
IPC分类号： G01N3315
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0356 , A61K49/0008 , C07K14/47 , C07K14/4702
摘要： A recombinant rodent comprises cells containing a pair genomic dopamine transporter protein alleles, wherein at least one of said alleles is incapable of expressing endogenous dopamine transporter protein. The rodent may be a homozygote, where both of said alleles are incapable of expressing endogenous dopamine transporter protein, or the rodent may be a heterozygote, and one of said alleles expresses endogenous dopamine transporter protein. The rodent is preferably a mouse.
摘要翻译：重组啮齿动物包含含有一对基因组多巴胺转运蛋白等位基因的细胞，其中至少一个所述等位基因不能表达内源性多巴胺转运蛋白。啮齿动物可以是纯合子，其中两个所述等位基因都不能表达内源性多巴胺转运蛋白，或者啮齿动物可以是杂合子，并且所述等位基因之一表达内源性多巴胺转运蛋白。啮齿动物优选是小鼠。

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