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1. 发明专利

IE842503L MOULDING GELS INTO FILMS FOR ELECTROPHORESIS 未知
公开(公告)号：IE842503L
公开(公告)日：1985-04-04
申请号：IE250384
申请日：1984-10-02
申请人： INTRACEL CORP
IPC分类号： G01N27/26 , B01D57/02 , B29C37/00 , B29C39/08 , G01N27/447 , G01N30/90 , G01N27/477
摘要： A mould for the moulding by casting of thin, cross-linked, polymerized resin films is used which is subjected, when being filled with the liquid to be polymerized, to a centrifugal force field exceeding that of the earth gravitation field, the whole being for equalizing the intimate structure of the polymer and to expel therefrom the bubbles of gas possibly present therein.

2. 发明授权

US6027627A Automated parallel capillary electrophoretic system 失效
标题翻译：自动并行毛细管电泳系统
公开(公告)号：US6027627A
公开(公告)日：2000-02-22
申请号：US105988
申请日：1998-06-29
申请人： Qingbo Li , Thomas E. Kane , Changsheng Liu , Bernard Sonnenschein , Michael V. Sharer , John R. Kernan
发明人： Qingbo Li , Thomas E. Kane , Changsheng Liu , Bernard Sonnenschein , Michael V. Sharer , John R. Kernan
IPC分类号： G01N27/447 , G01N27/26 , G01N27/477
CPC分类号： G01N27/44782
摘要： An automated electrophoretic system is disclosed. The system employs a capillary cartridge having a plurality of capillary tubes. The cartridge has a first array of capillary ends projecting from one side of a plate. The first array of capillary ends are spaced apart in substantially the same manner as the wells of a microtitre tray of standard size. This allows one to simultaneously perform capillary electrophoresis on samples present in each of the wells of the tray. The system includes a stacked, dual carousel arrangement to eliminate cross-contamination resulting from reuse of the same buffer tray on consecutive executions from electrophoresis. The system also has a gel delivery module containing a gel syringe/a stepper motor or a high pressure chamber with a pump to quickly and uniformly deliver gel through the capillary tubes. The system further includes a multi-wavelength beam generator to generate a laser beam which produces a beam with a wide range of wavelengths. An off-line capillary reconditioner thoroughly cleans a capillary cartridge to enable simultaneous execution of electrophoresis with another capillary cartridge. The streamlined nature of the off-line capillary reconditioner offers the advantage of increased system throughput with a minimal increase in system cost.
摘要翻译：公开了一种自动电泳系统。该系统采用具有多个毛细管的毛细管盒。盒具有从板的一侧突出的第一阵列的毛细管端。毛细管端部的第一阵列以与标准尺寸的微量托盘的孔基本相同的方式间隔开。这允许人们同时对存在于托盘的每个孔中的样品进行毛细管电泳。该系统包括堆叠的双转盘装置，以消除由连续的电泳执行中重复使用相同的缓冲盘引起的交叉污染。该系统还具有含有凝胶注射器/步进电机或具有泵的高压室的凝胶递送模块，以通过毛细管快速均匀地输送凝胶。该系统还包括多波长光束发生器，以产生产生具有宽波长范围的光束的激光束。离线毛细管修复器彻底清洁毛细管柱，以便同时执行另一个毛细管柱的电泳。离线毛细管再生器的流线型性质提供了增加系统吞吐量的优点，同时最小化了系统成本。

3. 发明申请

WO0153819A9 SEPARATION MEDIA, MULTIPLE ELECTROSPRAY NOZZLE SYSTEM AND METHOD 审中-公开
标题翻译：分离介质，多电极喷雾系统和方法
公开(公告)号：WO0153819A9
公开(公告)日：2002-10-17
申请号：PCT/US0101785
申请日：2001-01-18
申请人： ADVION BIOSCIENCES INC
发明人： CORSO THOMAS N , SCHULTZ GARY A , PROSSER SIMON J , HUANG XIAN
IPC分类号： G01N27/62 , B01D15/08 , B01D57/02 , B01D59/44 , B01J20/281 , B01J20/283 , B01J20/285 , B03C5/00 , B05B5/043 , G01N1/10 , G01N21/33 , G01N21/53 , G01N21/64 , G01N27/447 , G01N30/28 , G01N30/46 , G01N30/52 , G01N30/60 , G01N30/72 , G01N30/74 , G01N30/88 , G01N37/00 , H01J49/00 , H01J49/04 , H01J49/10 , G01N27/26 , B32B31/00 , H01J49/14 , G01N27/477
CPC分类号： G01N30/466 , B01J20/261 , B01J20/267 , B01J20/281 , B01J20/285 , B01J2220/54 , B01J2220/82 , G01N27/44717 , G01N30/463 , G01N30/467 , G01N30/48 , G01N30/6095 , G01N30/7266 , G01N2030/285 , G01N2030/528 , H01J49/0018 , H01J49/167
摘要： A microfabricated silicon chip with a separation material, such as in situ prepared porous polymer monoliths (254) in its microchannels is disclosed. The polymer monoliths are liquid-permeable and serve as microcolumns for liquid chromatography, which are prepared by in situ radical polymerization of a mixture containing vinyl monomers and solvents (porogen) in the microchannels. A method and system are disclosed to generate one or more electrospray plumes from one or more nozzles that provide an ion intensity as measured by a mass spectrometer that is approximately proportional to the number of electrospray plumes formed for analyses contained within the fluid. A plurality of electrospray devices (250) can be used in the form of an array of miniaturized separate electrospray devices for the purpose of generating multiple electrospray plumes from multiple nozzles (242) for the same fluid for analysis.
摘要翻译：公开了一种具有分离材料的微制造硅芯片，例如其微通道中原位制备的多孔聚合物整料（254）。聚合物整料是液体可渗透的，用作液相色谱的微柱，其通过在微通道中含有乙烯基单体和溶剂（致孔剂）的混合物的原位自由基聚合制备。公开了一种方法和系统，以从一个或多个喷嘴产生一个或多个电喷雾羽流，其提供与质量分析仪测量的离子强度，其大小与为流体中包含的分析形成的电喷雾羽流的数量成比例。多个电喷射装置（250）可以以小型化的独立电喷雾装置阵列的形式使用，用于从用于分析的相同流体的多个喷嘴（242）产生多个电喷雾羽流。

4. 发明申请

WO01053819A1 SEPARATION MEDIA, MULTIPLE ELECTROSPRAY NOZZLE SYSTEM AND METHOD 审中-公开
标题翻译：分离介质，多电极喷雾系统和方法
公开(公告)号：WO01053819A1
公开(公告)日：2001-07-26
申请号：PCT/US2001/001785
申请日：2001-01-18
IPC分类号： G01N27/62 , B01D15/08 , B01D57/02 , B01D59/44 , B01J20/281 , B01J20/283 , B01J20/285 , B03C5/00 , B05B5/043 , G01N1/10 , G01N21/33 , G01N21/53 , G01N21/64 , G01N27/447 , G01N30/28 , G01N30/46 , G01N30/52 , G01N30/60 , G01N30/72 , G01N30/74 , G01N30/88 , G01N37/00 , H01J49/00 , H01J49/04 , H01J49/10 , G01N27/26 , B32B31/00 , H01J49/14 , G01N27/477
CPC分类号： G01N30/466 , B01J20/261 , B01J20/267 , B01J20/281 , B01J20/285 , B01J2220/54 , B01J2220/82 , G01N27/44717 , G01N30/463 , G01N30/467 , G01N30/48 , G01N30/6095 , G01N30/7266 , G01N2030/285 , G01N2030/528 , H01J49/0018 , H01J49/167
摘要： A microfabricated silicon chip with a separation material, such as in situ prepared porous polymer monoliths (254) in its microchannels is disclosed. The polymer monoliths are liquid-permeable and serve as microcolumns for liquid chromatography, which are prepared by in situ radical polymerization of a mixture containing vinyl monomers and solvents (porogen) in the microchannels. A method and system are disclosed to generate one or more electrospray plumes from one or more nozzles that provide an ion intensity as measured by a mass spectrometer that is approximately proportional to the number of electrospray plumes formed for analyses contained within the fluid. A plurality of electrospray devices (250) can be used in the form of an array of miniaturized separate electrospray devices for the purpose of generating multiple electrospray plumes from multiple nozzles (242) for the same fluid for analysis.
摘要翻译：公开了一种具有分离材料的微制造硅芯片，例如其微通道中原位制备的多孔聚合物整料（254）。聚合物整料是液体可渗透的，用作液相色谱的微柱，其通过在微通道中含有乙烯基单体和溶剂（致孔剂）的混合物的原位自由基聚合制备。公开了一种方法和系统，以从一个或多个喷嘴产生一个或多个电喷雾羽流，其提供与质量分析仪测量的离子强度，其大小与为流体中包含的分析形成的电喷雾羽流的数量成比例。多个电喷射装置（250）可以以小型化的独立电喷雾装置阵列的形式使用，用于从用于分析的相同流体的多个喷嘴（242）产生多个电喷雾羽流。

5. 发明申请

WO1996023221A1 POLYVINYLALCOHOL COATED CAPILLARY ELECTROPHORESIS COLUMNS 审中-公开
标题翻译：聚乙烯醇包衣毛细管电泳柱
公开(公告)号：WO1996023221A1
公开(公告)日：1996-08-01
申请号：PCT/US1996001347
申请日：1996-01-23
申请人： BECKMAN INSTRUMENTS, INC. , NORTHEASTERN UNIVERSITY , NORTHEASTERN UNIVERSITY , KARGER, Barry, L. , GOETZINGER, Wolfgang , MUTH, Jochen , SHIEH, Chia-Hui
发明人： BECKMAN INSTRUMENTS, INC. , NORTHEASTERN UNIVERSITY , NORTHEASTERN UNIVERSITY
IPC分类号： G01N27/477
CPC分类号： G01N27/44704 , G01N27/44752
摘要： Coated capillary electrophoresis columns and methods for their use in electrophoretic separations are disclosed. The coated capillary columns include a length of tubing having an interior surface having an interconnected polymeric coating. The interconnected polymeric coating includes a hydrophobic hydrocarbon polymeric functionality covalently bound to the interior surface and polyvinylalcohol interconnected with the hydrophobic polymeric functionality. Exemplary columns are prepared by causing a Si-OH reactive compound, having a hydrophobic polymeric functionality, to react with Si-OH functionalities on the interior surface of capillary columns. Then causing vinyl acetate to polymerize in contact with the hydrophobic polymeric functionality and hydrolyzing the resulting polyvinylacetate forms a coating of interconnecting hydrophilic and hydrophobic polymers. Alternative exemplary coatings include a modified polyvinylalcohol such as a polyvinylether.
摘要翻译：公开了涂布毛细管电泳柱及其用于电泳分离的方法。涂覆的毛细管柱包括具有内表面的一段长度的管，其具有互连的聚合物涂层。相互连接的聚合物涂层包括与内表面共价结合的疏水性烃聚合物官能团和与疏水性聚合物官能团互连的聚乙烯醇。通过使具有疏水聚合官能度的Si-OH反应性化合物与毛细管柱内表面上的Si-OH官能团反应来制备示例性柱。然后使乙酸乙烯酯与疏水聚合官能团接触聚合并水解所得聚乙酸乙烯酯形成互连的亲水和疏水聚合物的涂层。替代的示例性涂层包括改性的聚乙烯醇，例如聚乙烯醚。

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