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1. 发明授权

US06926815B2 Copolymers for capillary gel electrophoresis 有权
标题翻译：用于毛细管凝胶电泳的共聚物
公开(公告)号：US06926815B2
公开(公告)日：2005-08-09
申请号：US09843918
申请日：2001-04-30
申请人： Changsheng Liu , Qingbo Li
发明人： Changsheng Liu , Qingbo Li
IPC分类号： C08F220/56 , G01N27/447 , G01N27/441 , G01N27/453
CPC分类号： G01N27/44747
摘要： This invention relates to an electrophoresis separation medium having a gel matrix of at least one random, linear copolymer comprising a primary comonomer and at least one secondary comonomer, wherein the comonomers are randomly distributed along the copolymer chain. The primary comonomer is an acrylamide or an acrylamide derivative that provides the primary physical, chemical, and sieving properties of the gel matrix. The at least one secondary comonomer imparts an inherent physical, chemical, or sieving property to the copolymer chain. The primary and secondary comonomers are present in a ratio sufficient to induce desired properties that optimize electrophoresis performance. The invention also relates to a method of separating a mixture of biological molecules using this gel matrix, a method of preparing the novel electrophoresis separation medium, and a capillary tube filled with the electrophoresis separation medium.
摘要翻译：本发明涉及一种具有至少一种含有主要共聚单体和至少一种次级共聚单体的无规线性共聚物的凝胶基质的电泳分离介质，其中共聚单体沿共聚物链无规分布。主要共聚单体是提供凝胶基质的主要物理，化学和筛分性质的丙烯酰胺或丙烯酰胺衍生物。至少一种次级共聚单体赋予共聚物链固有的物理，化学或筛分特性。初级和次级共聚单体以足以引发优化电泳性能的所需性质的比例存在。本发明还涉及使用该凝胶基质分离生物分子的混合物的方法，制备新型电泳分离介质的方法和填充有电泳分离介质的毛细管。

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