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    • 10. 发明申请
    • Nanomotion sensing system and method
    • 纳米传感系统及方法
    • US20040142409A1
    • 2004-07-22
    • US10690809
    • 2003-10-21
    • Michael John AllenLucien Ghislain
    • C12Q001/02C12M001/34
    • G01N33/558C12Q1/02
    • A Nanomotion Sensor comprises a micromechanical device for the detection and characterization of specimen motions when they interact with one or an array of cantilevered sensors set in the path of the moving specimen. In particular, the present invention provides a method for direct sensing and characterization of motion, including position, torsion, magnitude and direction of velocity, acceleration, force, torque, as well as binding, which may include hydrogen bonding, electrostatic attractions, hydrophobic effects, dipole interactions, or through other forces through the deflection of a micromechanical cantilever sensor. The present invention is particularly useful for the detection and characterization of the motion of biological cells such as bacteria and sperm, biological systems including motor proteins, cilia of the hearing organ and the lining of the airways in asthmatics, and microfabricated systems.
    • 纳米运动传感器包括微机械装置,用于当它们与设置在移动样本的路径中的一个或一组悬臂式传感器相互作用时检测和表征样本运动。 特别地,本发明提供了一种用于直接感测和表征运动的方法,包括位置,扭转,幅度和方向的速度,加速度,力,扭矩以及结合,其可以包括氢键,静电吸引力,疏水效应 ,偶极相互作用,或通过其他力通过微机械悬臂传感器的偏转。 本发明特别可用于检测和表征生物细胞如细菌和精子,包括运动蛋白,听觉器官的纤毛和哮喘患者气道衬里以及微细加工系统的生物系统的运动。