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1. 发明授权

US06410279B1 Process for producing optically active azetidine-2-carboxylic acid derivative 有权
标题翻译：光学活性氮杂环丁烷-2-羧酸衍生物的制备方法
公开(公告)号：US06410279B1
公开(公告)日：2002-06-25
申请号：US09619386
申请日：2000-07-19
申请人： Junko Kudo , Motoo Hazama , Norihiko Hirata
发明人： Junko Kudo , Motoo Hazama , Norihiko Hirata
IPC分类号： C12P1710
CPC分类号： C12P17/10 , C12P41/005
摘要： There is provided a process for producing N-substituted azetidine-2-carboxylic acid of the formula I: wherein R1 denotes an aralkyl group or an arylated lower alkoxycarbonyl group and * designates an asymmetric carbon atom, which is characterized by: reacting an N-substituted azetidine-2-carboxylic acid ester of the formula II: wherein R1 has the same meaning as defined above and R2 denotes an alkyl group, an aralkyl group or an allyl group, with an enzyme capable of selectively hydrolyzing a stereoisomer based on the carbon atom of the 2-position of the azetidine ring.
摘要翻译：提供了制备式I的N-取代的氮杂环丁烷-2-羧酸的方法：其中R1表示芳烷基或芳基化低级烷氧基羰基，*表示不对称碳原子，其特征在于：使N- 取代的氮杂环丁烷-2-羧酸酯，其中R 1具有与上述相同的含义，R 2表示烷基，芳烷基或烯丙基，具有能够基于碳选择性水解立体异构体的酶氮杂环丁烷2位的原子。

2. 发明授权

US06613550B2 Microbial process for preparation of optically active 3-hydroxypyrrolidine derivatives 失效
标题翻译：用于制备光学活性3-羟基吡咯烷衍生物的微生物方法
公开(公告)号：US06613550B2
公开(公告)日：2003-09-02
申请号：US09796278
申请日：2001-02-28
申请人： John W. Wong
发明人： John W. Wong
IPC分类号： C12P1710
CPC分类号： C12P41/002 , C12P17/10 , C12P41/00
摘要： The present invention is directed to a process for the production of compounds of the formula: from a compound of the formula comprising hydroxylating a compound of the formula I in the presence of an enzyme produced by a microorganism of the genera Cunninghamella species or Aspergillus. Preferred microorganisms are Cunninghamella echinulata var. elegans and Aspergillus flavipes. Mixtures of compounds of formulae II and III may also be highly enriched in their composition of compound II by using the enzyme from Cunninghamella echinulata ATC 8688b.
摘要翻译：本发明涉及一种制备下式化合物的方法：由在本发明的化合物中制备式I化合物的化合物在由坎宁坎属或曲霉属的微生物产生的酶的存在下进行羟化。优选的微生物是Cunninghamella echinulata var。线虫和曲霉菌。通过使用Cunninghamella echinulata ATC 8688b的酶，式II和III化合物的混合物也可以高度富集其化合物II的组成。

3. 发明授权

US06391597B1 Method for producing optically active 1-(4-t-butylphenyl)-5-oxo-3-pyrrolidine carboxylic acid and/or an enantiomeric ester thereof 失效
标题翻译：光学活性1-（4-叔丁基苯基）-5-氧代-3-吡咯烷羧酸和/或其对映异构体酯的制备方法
公开(公告)号：US06391597B1
公开(公告)日：2002-05-21
申请号：US09557131
申请日：2000-04-25
申请人： Koutaro Ohtsuka , Shunji Kamiyama , Masafumi Moriwaki
发明人： Koutaro Ohtsuka , Shunji Kamiyama , Masafumi Moriwaki
IPC分类号： C12P1710
CPC分类号： C12P17/10 , C12N9/16 , C12P41/005 , Y10S435/833
摘要： A method for producing an optically active 1-(4-t-butylphenyl)-5-oxo-3-pyrrolidine carboxylic acid and/or an enantiomeric ester thereof which includes treating an ester of (±)-1-(4-t-butylphenyl)-5-oxo-3-pyrrolidine carboxylic acid with an esterase derived from Bacillus brevis 042-24 (FERM BP-5872).
摘要翻译：一种光学活性1-（4-叔丁基苯基）-5-氧代-3-吡咯烷羧酸和/或其对映异构体酯的制备方法，包括（±）-1-（4-叔丁基苯基）丁基苯基）-5-氧代-3-吡咯烷羧酸与衍生自短芽孢杆菌042-24（FERM BP-5872）的酯酶。

4. 发明授权

US06379935B1 Method of producing &agr;-halo-&agr;,&bgr;-saturated carbonyl compounds from the corresponding &agr;,&bgr;-unsaturated compounds 失效
标题翻译：从相应的α，β-不饱和化合物生产α-卤代-α，β-饱和羰基化合物的方法
公开(公告)号：US06379935B1
公开(公告)日：2002-04-30
申请号：US09369144
申请日：1999-08-05
申请人： Harumi Kamachi , Tadashi Yoneda , Motoaki Kamachi , Nobuyoshi Esaki
发明人： Harumi Kamachi , Tadashi Yoneda , Motoaki Kamachi , Nobuyoshi Esaki
IPC分类号： C12P1710
CPC分类号： C12P7/24 , C12P7/40 , C12P7/52
摘要： A method of producing an &agr;-halo-&agr;,&bgr;-saturated carbonyl compound from an &agr;-halocarbonyl compound having an &agr;, &bgr;-carbon-carbon double bond by reducing said &agr;,&bgr;-carbon-carbon double bond using a microorganism belonging to any one of the genera Acetobacter, Actinomyces, Acinetobacter, Agrobacterium, Aeromonas, Alcaligenes, Arthrobacter, Azotobacter, Bacillus, Brevibacterium, Burkholderia, Cellulomonas, Corynebacterium, Enterobacter, Enterococcus, Escherichia, Flavobacterium, Gluconobacter, Halobacteium, Halococccus, Klebsiella, Lactobacillus, Microbacterium, Micrococcus, Micropolyspora, Mycobacterium, Nocardia, Pseudomonas, Pseudonocardia, Rhodococcus, Rhodobacter, Serratia, Staphylococcus, Streptococcus and Streptomyces, Xanthomonas, or a microbial product thereof. Pseudomonas sp. SD810, SD811 and SD812, Burkholderia sp. SD 816, and mutants thereof having an activity of reducing the &agr;,&bgr;-carbon-carbon double bond of an a-halocarbonyl compound having an &agr;, &bgr;-carbon-carbon double bond.
摘要翻译：一种由具有α，β-碳 - 碳双键的α-卤代羰基化合物生产α-卤代-α，β-饱和羰基化合物的方法，通过使用属于醋杆菌属，放线菌属，不动杆菌属，农杆菌属，气单胞菌属，产碱杆菌属，节杆菌属，固氮菌属，芽孢杆菌属，短杆菌属，伯克霍尔德杆菌属，丝杆菌属，棒状杆菌属，肠杆菌属，肠球菌属，棒状杆菌属，黄杆菌属，葡萄球菌属，卤杆菌属，卤杆菌属，克雷伯菌属，乳杆菌属，微杆菌属，微球菌，微孢子虫，分枝杆菌，诺卡氏菌，假单胞菌属，假诺卡氏菌属，红球菌属，红细菌属，沙雷氏菌属，葡萄球菌属，链球菌属和链霉菌属，黄单胞菌属或其微生物产物。假单胞菌属伯克霍尔德氏菌属SD810，SD811和SD812 SD 816及其具有降低具有α，β-碳 - 碳双键的α-卤代羰基化合物的α，β-碳 - 碳双键活性的突变体。

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