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1. 发明申请

US20040268439A1 Genes encoding carotenoid compounds 失效
标题翻译：编码类胡萝卜素的基因
公开(公告)号：US20040268439A1
公开(公告)日：2004-12-30
申请号：US10808979
申请日：2004-03-25
发明人： Qiong Cheng , Luan Tao
IPC分类号： A01H001/00 , C12N015/82 , C12P023/00 , C07H021/04 , C12N009/10 , C12N005/04
CPC分类号： C12N9/001 , C12N9/00 , C12N9/0004 , C12N9/0071 , C12N9/0083 , C12N9/1051 , C12N9/1085 , C12N9/90 , C12N15/52 , C12P23/00
摘要： Genes have been isolated from strain DC260, a member of the Enterobacteriaceae family, encoding geranylgeranyl pyrophosphate (GGPP) synthetase (CrtE), phytoene synthase (CrtB), phytoene desaturase (CrtI), lycopene cyclase (CrtY), null-carotene hydroxylase (CrtZ), and zeaxanthin glucosyl transferase (CrtX) activity. The genes and their products are useful for the conversion of farnesyl pyrophosphate to carotenoids. Vectors containing those DNA segments, host cells containing the vectors and methods for producing those enzymes by recombinant DNA technology in transformed host organisms are disclosed.
摘要翻译：基因已经从肠杆菌科家族的成员DC260中分离出来，编码香叶基香叶基焦磷酸（GGPP）合成酶（CrtE），八氢番茄红素合酶（CrtB），八氢番茄红素去饱和酶（CrtI），番茄红素环化酶（CrtY），β-胡萝卜素羟化酶）和玉米黄质葡萄糖基转移酶（CrtX）活性。这些基因及其产物可用于将焦磷酸法呢基转化成类胡萝卜素。公开了含有这些DNA片段的载体，含有载体的宿主细胞和通过重组DNA技术在转化的宿主生物体中产生这些酶的方法。

2. 发明申请

US20040253664A1 Process for production of carotenoids, xanthophylls and apo-carotenoids utilizing eukaryotic microorganisms 审中-公开
标题翻译：利用真核微生物生产类胡萝卜素，叶黄素和apo类胡萝卜素的方法
公开(公告)号：US20040253664A1
公开(公告)日：2004-12-16
申请号：US10893636
申请日：2004-07-16
发明人： Thomas Veach Long II
IPC分类号： C12P023/00 , C12N001/12
CPC分类号： C12P23/00 , A23K10/16 , A23K20/10 , A23K20/174 , A23K20/179 , A23K50/75 , A23K50/80 , A23L5/44 , A23L5/46 , A23L29/065 , A23L33/105
摘要： Disclosed is a method for producing an effective amount of one or more carotenoid, xanthophyll, or apo-carotenoid pigments from a microorganism from the Order Thraustochytriales. Suitable microorganisms put forth are of the genus Thraustochytrium and Schizochytrium. Preferred culture conditions and mediums are discussed. Examples are given of production of specific pigments, such as null-carotene, lutein, adonirubin, canthaxanthin, and astaxanthin, as are examples of methods of isolation of the pigment from the microorganism. Also disclosed is a food product that contains a microorganism from the Order Thraustochytriales, the microorganism having produced internally an effective amount of one or more carotenoid, xanthophyll, or apo-carotenoid pigments. The food product is used in a method for delivering one or more of the pigments to an animal or human for either pharmaceutical, nutritional or coloration purposes, by feeding the food product to the animal or human.
摘要翻译：本发明公开了一种从命令性破囊壶菌中产生有效量的一种或多种类胡萝卜素，叶黄素或脱辅胡萝卜素色素的方法。合适的微生物属于Thraustochytrium属和Schizochytrium属。讨论优选的培养条件和培养基。给出了与微生物分离颜料的方法的实例，例如β-胡萝卜素，叶黄素，adonirubin，角黄素和虾青素等特定颜料的生产。还公开了一种食品，其含有来自止咳药类的微生物，微生物在内部产生有效量的一种或多种类胡萝卜素，叶黄素或脱辅胡萝卜素色素。该食品用于将药物，营养或着色目的中的一种或多种颜料递送给动物或人，方法是通过将食品喂给动物或人来输送。

3. 发明申请

US20040253663A1 Genes encoding carotenoid compounds 失效
标题翻译：编码类胡萝卜素的基因
公开(公告)号：US20040253663A1
公开(公告)日：2004-12-16
申请号：US10808807
申请日：2004-03-24
发明人： Qiong Cheng , Natalia Sedkova , Luan Tao
IPC分类号： C07H021/04 , C12P007/26 , C12P023/00 , C12N009/10 , C12N001/21
CPC分类号： C12N9/00 , C12N9/0004 , C12N9/001 , C12N9/0083 , C12N9/1051 , C12N9/1085 , C12N9/90 , C12N15/52 , C12N15/825 , C12P23/00 , C12Y205/01029 , Y02E50/343
摘要： A unique carotenogenic biosynthetic gene cluster has been isolated from Panteoa agglomerans strain DC404, wherein the genetic organization of the cluster is crtE-idi-crtY-crtI-crtB-crtZ. The genes contained within this cluster encode geranylgeranyl pyrophosphate (GGPP) synthetase (CrtE), isopentenyl pyrophosphate isomerase (Idi), lycopene cyclase (CrtY), phytoene desaturase (CrtI), phytoene synthase (CrtB), and null-carotene hydroxylase (CrtZ). The gene cluster, genes and their products are useful for the conversion of farnesyl pyrophosphate to carotenoids. Vectors containing those DNA segments, host cells containing the vectors and methods for producing those enzymes by recombinant DNA technology in transformed host organisms are disclosed.
摘要翻译：已经从成团Panthena菌株DC404中分离出独特的致病基因生物合成基因簇，其中簇的遗传组织为crtE-idi-crtY-crtI-crtB-crtZ。包含在该簇内的基因编码er牛儿基焦磷酸（GGPP）合成酶（CrtE），异戊烯焦磷酸异构酶（Idi），番茄红素环化酶（CrtY），八氢番茄红素去饱和酶（CrtI），八氢番茄红素合酶（CrtB）和β-胡萝卜素羟化酶（CrtZ）。基因簇，基因及其产物可用于将焦磷酸法呢基转化为类胡萝卜素。公开了含有这些DNA片段的载体，含有载体的宿主细胞和通过重组DNA技术在转化的宿主生物体中产生这些酶的方法。

4. 发明申请

US20040175785A1 Increasing bioavailability of carotenoids 审中-公开
公开(公告)号：US20040175785A1
公开(公告)日：2004-09-09
申请号：US10477520
申请日：2004-04-12
发明人： Joseph Kanner , Rina Granit , Arieh Levy
IPC分类号： C12P023/00
CPC分类号： C12Q1/44 , A23K20/179 , A23L5/44 , A23L33/105 , A23L33/12 , A23V2002/00 , C12P23/00 , A23V2250/211 , A23V2250/186
摘要： A method of increasing a fraction of free carotenoids in a source of carotenoids in which at least some of the carotenoids are fatty acid esterified carotenoids is disclosed. The method is effected by contacting the source of carotenoids with an effective amount of an esterase under conditions effective in deesterifying the fatty acid esterified carotenoids, thereby increasing the fraction of free carotenoids in the source of carotenoids.

5. 发明申请

US20030143660A1 Method for production of asymmetric carotenoids 失效
标题翻译：不对称类胡萝卜素生产方法
公开(公告)号：US20030143660A1
公开(公告)日：2003-07-31
申请号：US10292577
申请日：2002-11-12
发明人： Qiong Cheng , Luan Tao
IPC分类号： C12P023/00 , C07H021/04 , C12N009/10 , C12N001/21 , C12N015/74
CPC分类号： C12N9/0004 , C12P23/00
摘要： Genes have been isolated from Rhodococcus and Deinococcus which encode a specific lycopene null-cyclase capable of converting acyclic carotenoids with at least one null-end group to the corresponding asymmetric carotenoid containing a single null-ionone ring end group. The genes are new. Transformed host cells expressing the present genes and methods for the bio-conversion of acylic carotenoid substrates to corresponding asymmetric carotenoid are also provided.
摘要翻译：基因已经从红球菌和灭球菌分离出来，其编码能够将具有至少一个psi端基的无环类胡萝卜素转化成含有单个β-紫罗烯酮环端基的相应不对称类胡萝卜素的特异性番茄红素β-环化酶。这些基因是新的。还提供了表达本发明基因的转化的宿主细胞和将酰基类胡萝卜素底物生物转化成相应的不对称类胡萝卜素的方法。

6. 发明申请

US20030100045A1 Carotenoid ketolase gene 失效
标题翻译：类胡萝卜酮酮醇酶基因
公开(公告)号：US20030100045A1
公开(公告)日：2003-05-29
申请号：US10209372
申请日：2002-07-30
发明人： Qiong Cheng , Luan Tao
IPC分类号： C12P023/00 , C12P021/02 , C12N001/21 , C07H021/04 , C12N009/02
CPC分类号： C12N9/0069 , C12P23/00 , C12Y114/15802
摘要： A ketolase gene has been isolated from Rhodococcus erythropolis AN12 strain encoding a carotenoid modification enzyme of the carotenoid biosynthetic pathway. The gene and gene product are the first isolated from a Rhodococcus strain. Six conserved amino acid motifs have been identified as the characteristic of this type of ketolase enzymes. The gene and gene product of the present invention may be used in a variety of ways for the production of keto-carotenoid compounds in a variety of organisms.
摘要翻译：已经从编码类胡萝卜素生物合成途径的类胡萝卜素修饰酶的红球菌AN12菌株中分离出一种酮糖酶基因。该基因和基因产物是首先从红球菌菌株中分离出来的。已经鉴定了六种保守的氨基酸基序作为这种类型的酮糖酶的特征。本发明的基因和基因产物可以以各种方式用于在各种生物体中生产酮类胡萝卜素化合物。

7. 发明申请

US20030077691A1 Astaxanthin synthase 失效
公开(公告)号：US20030077691A1
公开(公告)日：2003-04-24
申请号：US10066007
申请日：2002-02-01
申请人： ROCHE VITAMINS INC.
发明人： Tatsuo Hoshino , Kazuyuki Ojima , Yutaka Setoguchi
IPC分类号： C12P023/00 , C07H021/04 , C12N009/02 , C12N001/21 , C12P021/02
CPC分类号： C12P23/00 , C12N9/00
摘要： The present invention is directed to genetic materials useful for the preparation of astaxanthin from beta-carotene, such as polypeptides having astaxanthin synthase activity, DNA fragments coding for astaxanthin synthase, recombinant organisms and the like. Those novel genetic materials may be derived from Phaffia rhodozyma. The present invention also provides a process for the production of astaxanthin.

8. 发明申请

US20030059868A1 Retinal cell lines with extended life-span and their applications 失效
标题翻译：具有延长使用寿命的视网膜细胞系及其应用
公开(公告)号：US20030059868A1
公开(公告)日：2003-03-27
申请号：US09559707
申请日：2000-04-27
发明人： John Greenwood , Peter Adamson , Raymond Lund
IPC分类号： C12P023/00 , C12P021/02 , C12N005/06 , C07H021/04 , C12N001/18
CPC分类号： C12N5/0621 , A61K35/12 , C12N2503/00 , C12N2510/02 , C12N2510/04
摘要： The invention features retina-derived (retinal endothelial or retinal epithelial pigment) cell lines with extended life-span and capable of being implanted in the retina and of carrying a therapeutic substance to the eye and to the central nervous system. Such lines can also be used as a model for studying blood central nervous system interfaces. These lines are derived from primary retinal cultures selected from the group consisting of primary retinal endothelial cells and primary retinal epithelial cells, comprise a polynucleotide containing an oncogene, which polynucleotide is optionally associated with at least one selection gene, and have the morphological characteristics and at least the expression characteristics of the surface antigens of corresponding primary cultures.
摘要翻译：本发明特征在于视网膜衍生（视网膜内皮或视网膜上皮细胞色素）细胞系具有延长的寿命并且能够植入视网膜并且将治疗物质携带到眼睛和中枢神经系统。这样的线也可以用作研究血液中枢神经系统界面的模型。这些系衍生自选自原发性视网膜内皮细胞和原代视网膜上皮细胞的原代视网膜培养物，包含含有癌基因的多核苷酸，所述多核苷酸任选地与至少一个选择基因相关，并具有形态特征最小表达相关原代培养物的表面抗原特征。

9. 发明申请

US20040152154A1 Method of producing $g(b)-carotene by means of mixed culture fermentation using (+) and (null) strains of blakeslea trispora 有权
标题翻译：通过使用（+）和（ - ）菌株的混合培养发酵生产$ g（b） - 胡萝卜素的方法
公开(公告)号：US20040152154A1
公开(公告)日：2004-08-05
申请号：US10469190
申请日：2004-01-21
发明人： Javier Costa Perez , Ana Teresa Marcos Rodriguez , Juan Luis De La Fuente Moreno , Marta Rodriguez Saiz , Bruno Diez Garcia , Enrique Peiro Cezon , Walter Cabri , Jose Luis Barredo Fuente
IPC分类号： C12P023/00
CPC分类号： C12P23/00
摘要： Method of production of null-carotene by fermentation in mixed culture using (null) and (null) strains of Blakeslea trispora The invention consists of fermenting selected strains of Blakeslea trispora in conditions such that null-carotene is produced in the form of stabilized preparations with residual contents of other carotenoids (null-carotene and null-zeacarotene). The fermentation conditions chosen include the programmed addition of oxygen and/or null-ionone during fermentation, and control of the age of the vegetative growth phases of the strains employed. The null-carotene obtained can be used in the pharmaceutical and food sectors.
摘要翻译：使用（+）和（ - ）三倍体布鲁氏菌菌株在混合培养中发酵生产β-胡萝卜素的方法本发明包括在使β-胡萝卜素以稳定的制剂形式产生的条件下发酵选定的三倍体布鲁氏菌其他类胡萝卜素（γ-胡萝卜素和β-玉米胡萝卜素）的残留物含量。选择的发酵条件包括在发酵过程中编程加入氧和/或β-紫罗兰酮，并控制所用菌株的营养生长期的年龄。获得的β-胡萝卜素可用于制药和食品行业。

10. 发明申请

US20040115758A1 Method of purifying crude xanthophylls 审中-公开
标题翻译：粗叶黄素的纯化方法
公开(公告)号：US20040115758A1
公开(公告)日：2004-06-17
申请号：US10466994
申请日：2004-01-15
发明人： Yuji Shimada , Toshihiro Nagao , Akio Sugihara , Yoshio Tominaga , Heiji Ikushima , Tadashi Hukami , Hisato Ikai
IPC分类号： C12P023/00
CPC分类号： C09B61/00 , C12P23/00
摘要： There is disclosed herein a process for purifying a crude xanthophyll which is characterized by acting a lipase on the crude xanthophyll, which is obtained by extracting algae with a solvent, in the present of water under an acidic condition without adjusting the pH whereupon the contaminating neutral lipids (mono-, di- and triglycerides) are selectively hydrolyzed, subjecting the lipase-treated liquor to oil/water separation and removing free fatty acids from the oil layer fractioned thereby elevating the content of xanthophyll.
摘要翻译：本文公开了一种纯化叶绿叶黄素的方法，其特征在于在酸性条件下，在水中，在水中提取藻类所得到的粗叶黄素上的脂肪酶，而不调节pH，因此污染中性脂质（单 - ，二 - 和甘油三酸酯）被选择性水解，经脂肪酶处理的液体进行油/水分离，并从分馏的油层中除去游离脂肪酸，从而提高叶黄素的含量。

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