会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 1. 发明授权
    • Method for preparing high molecular weight random polyhydroxypolyamides
    • 制备高分子量无规多羟基聚酰胺的方法
    • US06894135B2
    • 2005-05-17
    • US10734418
    • 2003-12-10
    • Donald E. KielyKylie KramerJinsong Zhang
    • Donald E. KielyKylie KramerJinsong Zhang
    • C08G63/685C08G69/26C08G69/28C08G283/04
    • C08G69/28C08G69/26Y10S525/926
    • High molecular weight random polyhydroxypolyamides (PHPAs) are produced by creating prepolymers which are further polymerized. Random prepolymers are formed from a stoichiometrically molar balance (1:1) starting material. The starting material is a 1:1 stoichiometrically balanced esterified aldaric acid:alkylene or alkylene derived diammonium salt. Alternatively, the starting material is an esterified stoichiometrically balanced diacid:diamine salt and a N′-ammoniumalkyl (or alkyl derived)-D-aldaramic acid terminal carboxylate zwitterionic salt mixture. The starting materials are polymerized in a basic alcohol using a second amine. The polymerized material, or the random prepolymers, are isolated and then further polymerized in a solvent, typically a mixed solvent of an alcohol and non-alcohol, to obtain the high molecular weight PHPAs.
    • 通过产生进一步聚合的预聚物制备高分子量无规多羟基聚酰胺(PHPAs)。 随机预聚物由化学计量摩尔平衡(1:1)原料形成。 原料是1:1化学计量平衡的酯化醛酸:亚烷基或亚烷基衍生的二铵盐。 或者,原料是酯化的化学计量平衡的二酸:二胺盐和N'-烷基(或烷基衍生的)-D-阿拉斯加酸末端羧酸酯两性离子盐混合物。 使用第二种胺将原料在碱性醇中聚合。 分离聚合的材料或无规预聚物,然后在溶剂(通常为醇和非醇的混合溶剂)中进一步聚合,得到高分子量的PTA。
    • 3. 发明申请
    • DEGRADABLE POLYMERS
    • 可降解聚合物
    • WO01017515A1
    • 2001-03-15
    • PCT/US2000/024232
    • 2000-09-01
    • A61K47/48A61K31/337A61K31/704A61P35/00C08G63/00C08G65/329C08G65/332C08G65/333C08G69/34C08G69/40C08G69/48A61K31/00C08G63/44C08G69/10C08G73/10C08L77/04C08L79/08C08G283/04
    • C08G63/00C08G69/34
    • A polymer comprising: a polymeric backbone comprising at least one unit having the structure (I), wherein R-R comprise groups selected from the group consisting of H, C1-C12 alkyl, C6-C18 aryl, C7-C18 aralkyl, C6-C18 cycloalkyl or any of the group consisting of C1-C12 alkyl, C6-C18 aryl, C7-C18 aralkyl, C6-C18 cycloalkyl substituted, within the carbon chain or appended thereto, with one or more heteroatoms; R and R or R and R or R and R or R and R may be joined so that with the carbon atom(s) to which they are attached they together form a saturated, partially unsaturated or unsaturated ring system respectively, may have a pendent group which may incorporate a linker unit, (for example a peptide linkage) or a unit having the structure (I); A comprises a proton donating moiety selected from the group consisting of formula (1). B comprises a hydrolytically labile group and is selected from the group consisting of formula (2), wherein each R is individually selected from the group consisting of H, C1-C12 alkyl, C6-C18 aryl, C7-C18 aralkyl, C6-C18 cycloalkyl; wherein groups A and B are in a cis-configuration about bond Ca-Cb; m is an integer of 0 to 100, n, p and q are each an integer of 0 or 1; Q comprises 1 or more structures selected from the group consisting of formula (3) wherein R -R are individually selected from the same group as defined for group R above and r is an integer between 1 and 5000, preferably 1 to 10, most preferably 1 to 6; methods for the production, and uses thereof.
    • 一种聚合物,其包括:包含至少一个具有结构(I)的单元的聚合物主链,其中RR 4包含选自H,C 1 -C 12烷基,C 6 -C 18芳基,C 7 -C 18芳烷基,C 6 -C 18环烷基或由碳原子链或其附着的一个或多个杂原子取代的C 1 -C 12烷基,C 6 -C 18芳基,C 7 -C 18芳烷基,C 6 -C 18环烷基中的任何一种; R和R 2或R和R 4或R和R 1或R 2和R 3可以连接成与它们所连接的碳原子一起形成 饱和的,部分不饱和的或不饱和的环系统可以具有可以结合接头单元(例如肽键)或具有结构(I)的单元的侧基; A包含选自式(1)的质子供体部分。 B包含水解不稳定基团,并且选自式(2),其中每个R 5分别选自H,C 1 -C 12烷基,C 6 -C 18芳基,C 7 -C 18芳烷基, C6-C18环烷基; 其中基团A和B是关于键Ca-Cb的顺式构型; m为0〜100的整数,n,p和q各自为0或1的整数; Q包括选自式(3)的一种或多种结构,其中R 6 -R 11分别选自与上述R基团所定义相同的基团,r是1至5000之间的整数,优选 1〜10,最优选1〜6; 生产方法及其用途。