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    • 4. 发明授权
    • Peptides and compositions for inhibiting fungal growth
    • 用于抑制真菌生长的肽和组合物
    • US08026207B2
    • 2011-09-27
    • US11992552
    • 2006-09-06
    • Hiroki NikawaMasahiro NishimuraKoichiro TsuijiRyoko KawabataNobue Hiromoto
    • Hiroki NikawaMasahiro NishimuraKoichiro TsuijiRyoko KawabataNobue Hiromoto
    • A61K38/04C07K9/00C07K9/14C07K9/20
    • C07K7/06A61K38/00
    • It is intended to provide a novel peptide which can exert higher antifungal effect also on a patient whose organ function is impaired with no side effect problems. The peptide comprises the following amino acid sequence: (1) SEQ ID NO:1: Lys -Arg-Leu-Phe-Arg-Arg-Trp-Gln-Trp-Arg-Tyr, (2) SEQ ID NO:2: Arg-Arg-Trp-Gln -Trp-Arg-Met-Lys-Lys-Tyr, (3) SEQ ID NO:3: Lys-Arg-Trp-Gln-TTp-Arg-Leu-Tyr, or (4) SEQ ID NO:4: Lys-Arg-Leu-Phe-Lys-Tyr, an antifungal agent comprising the peptide, a composition having a fungicidal and/or growth inhibitory action against fungus containing an effective amount of the peptide as an active ingredient, a medical apparatus/device which contains the peptide, whereby a fungicidal action is conferred, and a fungicidal and/or growth inhibiting method against fungus comprising administering the peptide and the like.
    • 旨在提供一种能够对器官功能受损但没有副作用问题的患者施用更高抗真菌作用的新型肽。 肽包含以下氨基酸序列:(1)SEQ ID NO:1:Lys-Arg-Leu-Phe-Arg-Arg-Trp-Gln-Trp-Arg-Tyr,(2)SEQ ID NO:2:Arg -Arg-Trp-Gln-Trp-Arg-Met-Lys-Lys-Tyr,(3)SEQ ID NO:3:Lys-Arg-Trp-Gln-TTp-Arg-Leu-Tyr,或(4)SEQ ID NO:4:Lys-Arg-Leu-Phe-Lys-Tyr,包含该肽的抗真菌剂,对含有有效量的肽作为活性成分的对真菌具有杀真菌和/或生长抑制作用的组合物, 含有肽的装置/装置,其中赋予杀真菌作用,以及针对真菌的杀真菌和/或生长抑制方法,包括施用肽等。