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1. 发明专利

AU2001273388B2 "Pseudo"-native chemical ligation 未知
公开(公告)号：AU2001273388B2
公开(公告)日：2005-01-13
申请号：AU2001273388
申请日：2001-07-12
申请人： GRYPHON THERAPEUTICS INC
发明人： KENT STEPHEN B H , KOCHENDOERFER GERD G , CRESSMAN SONYA , CHEN SHIAH-YUN , HUNTER CHRISTIE L , BRADBURNE JAMES A , LOW DONALD W , BOTTI PAOLO
IPC分类号： A61K38/00 , A61K38/02 , A61K38/22 , A61K47/34 , A61K47/42 , A61K47/48 , A61P7/00 , A61P7/06 , A61P9/10 , A61P11/02 , A61P11/06 , A61P17/00 , A61P19/02 , A61P29/00 , A61P31/12 , A61P37/06 , A61P37/08 , A61P43/00 , C07K1/00 , C07K1/06 , C07K14/47 , C07K14/505 , C07K14/52 , C07K17/08 , C07K19/00 , A61K038/02 , A61K038/21 , A61K038/20 , A61K038/19 , A61K038/18 , C07K014/335 , C07K014/525 , C07K014/52 , C07K014/505 , C07K014/475 , C07K002/00 , C07K001/02 , A61K038/27
摘要： The present invention concerns methods and compositions for extending the technique of native chemical ligation of a wider range of peptides, polypeptides, other polymers and other molecules via an amide bond (see FIG. 1 ). The invention further provides methods and uses for such proteins and derivatized proteins. The invention is particularly suitable for use in the synthesis of optionally polymer-modified, synthetic bioactive proteins, and of pharmaceutical compositions that contain such proteins.

2. 发明申请

US20030095978A1 Novel adherence factors of non pathogenic microorganisms and applications thereof for screening microorganisms for specific probiotic properties; novel pharmaceutical compositions and food additives comprising such microorganisms and adherence factors 审中-公开
标题翻译：非致病微生物的新型依从性因子及其用于筛选微生物以获得特定益生菌特性的应用; 新型药物组合物和包含这些微生物和粘附因子的食品添加剂
公开(公告)号：US20030095978A1
公开(公告)日：2003-05-22
申请号：US10231055
申请日：2002-08-30
申请人： NEDERLANDES ORGANISATIE VOOR TOEGEPAST- NATUURWETENSCHAPPELIJK ONDERZOEK (TNO)
发明人： Robert Jan Leer , Pieter Hendrik Pouwels , Patricia Lynne Conway
IPC分类号： A61K039/02 , C07K014/335
CPC分类号： C07K14/335 , A61K38/00 , Y02A50/47
摘要： A protein obtainable from a non pathogenic microorganism, said protein having mucosa binding promoting activity and a molecular weight of 20-40 kD is disclosed. Application of such a protein or a peptide derived therefrom in a method of screening non pathogenic microorganisms for a microorganism capable of specifically binding mucosa, said method comprising detection in a manner known per se. of the presence of a particular protein on or in a microorganism or in a culture of microorganisms, said particular protein being the already defined protein. Kits suitable for such a screening method are also disclosed. Use of a component selected from the group of components comprising a protein or peptide as defined an expression vector comprising nucleic acid encoding such protein or peptide a recombinant. microorganism or a part of said microorganism expressing such protein or peptide, said part expressing mucosa binding promoting activity a non pathogenic microorganism capable of expressing such protein or peptide or a part of said microorganism, said part expressing mucosa binding promoting activity as pharmaceutically active component in a pharmaceutical composition for prophylaxis and/or treatment of disease or illness associated with a mucosa colonising pathogenic microorganism. Use of such components as food additive and compositions comprising such components are described.
摘要翻译：公开了一种可从非病原微生物获得的蛋白质，所述蛋白质具有粘膜结合促进活性和分子量为20-40kD。将这种蛋白质或其衍生的肽应用于筛选非特异性结合粘膜的微生物的非病原微生物的方法中，所述方法包括以本身已知的方式进行检测。在微生物或微生物培养物中或微生物培养物中存在特定蛋白质，所述特定蛋白质是已定义的蛋白质。还公开了适用于这种筛选方法的试剂盒。使用选自包含蛋白质或肽的组分组的组分定义为包含编码这种蛋白质或肽的核酸的表达载体，重组体。微生物或表达这种蛋白质或肽的所述微生物的一部分，所述部分表达粘膜结合促进活性是能够表达这种蛋白质或肽或一部分所述微生物的非致病微生物，所述部分表达作为药物活性成分的粘膜结合促进活性用于预防和/或治疗与粘膜致病微生物相关的疾病或疾病的药物组合物。描述了使用这些组分作为食品添加剂和包含这些组分的组合物。

3. 发明申请

US20040214173A1 Anti-listeria bacteriocin 有权
标题翻译：抗李斯特菌细菌素
公开(公告)号：US20040214173A1
公开(公告)日：2004-10-28
申请号：US10296723
申请日：2002-11-26
发明人： Jean-Marc Berjeaud , Christophe Fremaux , Yves Cenatiempo , Laurence Simon
IPC分类号： C12Q001/68 , C07H021/04 , C12N001/21 , C07K014/335 , C12N015/74
CPC分类号： C07K14/335 , A23L3/3472 , A23L3/3526 , A23L3/3571
摘要： The invention concerns an isolated polypeptide which is a bacteriocin called Sakacine G derived from Lactobacillus sakei 2512. The invention also concerns a nucleic acid coding for said bacteriocin and the use of said polypeptide as active agent against pathogenic and undesirable flora in the preparation of food products.
摘要翻译：本发明涉及一种分离的多肽，其是称为由赖氨酸乳杆菌2512得到的称为Sakacine G的细菌素。本发明还涉及编码所述细菌素的核酸和所述多肽作为用于制备食品的致病和不良菌群的活性剂的用途。

4. 发明申请

US20040009490A1 Polynucleotides, materials incorporating them, and methods for using them 失效
标题翻译：多核苷酸，包含它们的材料以及使用它们的方法
公开(公告)号：US20040009490A1
公开(公告)日：2004-01-15
申请号：US10264213
申请日：2002-10-03
申请人： GENESIS RESEARCH AND DEVELOPMENT CORP. LTD.
发明人： Matthew Glenn , Ilkka J. Havukkala , Mark Lubbers , James Dekker
IPC分类号： C12Q001/68 , C07H021/04 , C12P021/02 , C12N001/21 , C12N015/74 , C07K014/335
CPC分类号： A23C19/0323 , A23C2220/202 , A61K38/00 , A61K2039/52 , C07K14/335 , C07K2319/00
摘要： Novel polynucleotides isolated from Lactobacillus rhamnosus, as well as oligonucleotide probes and primers, genetic constructs comprising the polynucleotides, biological materials, including plants, microorganisms and multicellular organisms incorporating the polynucleotides, polypeptides expressed by the polynucleotides, and methods for using the polynucleotides and polypeptides are disclosed.
摘要翻译：从鼠李糖杆菌分离的新型多核苷酸以及寡核苷酸探针和引物，包含多核苷酸的遗传构建体，生物材料，包括植物，包含多核苷酸的微生物和多细胞生物，由多核苷酸表达的多肽，以及使用多核苷酸和多肽的方法，披露

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