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1. 发明授权

US06262251B1 Method for solution phase synthesis of oligonucleotides 失效
标题翻译：寡核苷酸溶液相合成方法
公开(公告)号：US06262251B1
公开(公告)日：2001-07-17
申请号：US09051449
申请日：1998-04-06
申请人： Wolfgang Pieken , Danny McGee , Alecia Settle , Yansheng Zhai , Jianping Huang
发明人： Wolfgang Pieken , Danny McGee , Alecia Settle , Yansheng Zhai , Jianping Huang
IPC分类号： C07H102
CPC分类号： C07H21/00 , B01J19/0046 , B01J2219/00423 , B01J2219/00452 , B01J2219/00497 , B01J2219/00527 , B01J2219/00599 , B01J2219/00686 , B01J2219/00707 , B01J2219/00722 , C07B2200/11 , C07C43/225 , C07C43/23 , C07C57/13 , C07C59/60 , C07F7/12 , C07H19/04 , C07H19/10 , C40B40/06 , C40B50/08 , C40B60/14
摘要： This invention discloses an improved method for the sequential solution phase synthesis of oligonucleotides. The method lends itself to automation and is ideally suited for large scale manufacture of oligonucleotides with high efficiency.
摘要翻译：本发明公开了一种用于寡核苷酸顺序溶液相合成的改进方法。该方法适用于自动化，非常适合大规模生产高效率的寡核苷酸。

2. 发明授权

US06750335B2 Nucleoside derivatives with photolabile protective groups 失效
标题翻译：具有光不稳定保护基团的核苷衍生物
公开(公告)号：US06750335B2
公开(公告)日：2004-06-15
申请号：US10108565
申请日：2002-03-29
申请人： Wolfgang Pfleiderer , Sigrid Bühler , Heiner Giegrich
发明人： Wolfgang Pfleiderer , Sigrid Bühler , Heiner Giegrich
IPC分类号： C07H102
CPC分类号： C07H19/06 , C07B2200/11 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , Y02P20/55
摘要： The invention relates to nucleoside derivatives with photolabile protecting groups of general formula (I) wherein R1 is H, F, Cl, Br, I, or NO2; R2 is H or CN, provided that R1 and R2 are not simultaneously H; R3 is H, 1-4 C alkyl, or phenyl; R4 is H or a conventional functional group for the synthesis of oligonuleotides; R5 is H, OH, halogen or XR6, where X=O or S, and R6 is a conventional nucleotide protecting group; and B is adenine, cytosine, guanine, thymine, uracil, 2,6-diaminopurin-9-yl, hypoxanthin-9-yl, 5-methylcytosin-1-yl, 5-amino-4-imidazolcarboxamid-1-yl or 5-amino-4-imidazolcarboxamid-3-yl, where, if B is adenine, cytosine or guanine the primary amine functionality, optionally, carries a permanent protecting group. Furthermore, these derivatives may be used for the light-controlled synthesis of oligonucleotides on a DNA chip.
摘要翻译：本发明涉及具有通式（I）的光不稳定保护基的核苷衍生物，其中R 1是H，F，Cl，Br，I或NO 2; R 2是H或CN，条件是R 1和R 2不同时为H; R 3是H，1-4C烷基或苯基; R 4是H或用于合成寡核苷酸的常规官能团; R 5是H，OH，卤素或XR 6，其中X = O或S，R 6是常规核苷酸保护基; B是腺嘌呤，胞嘧啶，鸟嘌呤，胸腺嘧啶，尿嘧啶，2,6-二氨基嘌呤-9-基，次黄嘌呤-9-基，5-甲基胞嘧啶-1-基，5-氨基-4-咪唑甲酰胺-1-基或5 其中，如果B是腺嘌呤，胞嘧啶或鸟嘌呤，则伯胺官能团任选地携带永久保护基。此外，这些衍生物可以用于DNA芯片上寡核苷酸的轻度控制合成。

3. 发明授权

US06335439B1 Method of preparing phosphoramidites 失效
标题翻译：制备亚磷酰胺的方法
公开(公告)号：US06335439B1
公开(公告)日：2002-01-01
申请号：US09095811
申请日：1998-06-11
申请人： Alessandra Eleuteri , Daniel C. Capaldi , Vasulinga T. Ravikumar
发明人： Alessandra Eleuteri , Daniel C. Capaldi , Vasulinga T. Ravikumar
IPC分类号： C07H102
CPC分类号： C07H19/10 , C07H19/20
摘要： Improved methods for preparation of phosphoramidite compounds are disclosed. The phosphoramidites are useful, for example, for the preparation of oligonucleotides by solid state oligonucleotide synthetic regimes.
摘要翻译：公开了改进的亚磷酰胺化合物的制备方法。亚磷酰胺可用于例如通过固态寡核苷酸合成方案制备寡核苷酸。

4. 发明授权

US06197949B1 Electronically conductive polymer/nucleotide copolymer. preparation method therefor and use thereof 失效
标题翻译：电子导电聚合物/核苷酸共聚物。其制备方法及其用途
公开(公告)号：US06197949B1
公开(公告)日：2001-03-06
申请号：US09085028
申请日：1998-05-28
申请人： Robert Teoule , André Roget , Thierry Livache , Christelle Barthet , Gérard Bidan
发明人： Robert Teoule , André Roget , Thierry Livache , Christelle Barthet , Gérard Bidan
IPC分类号： C07H102
CPC分类号： C07H21/00 , B01J2219/00713 , C08G61/124 , C12Q1/6825
摘要： A copolymer of general formula (I), wherein unit A is a monomer of an electronically conductive polymer, unit B is a nucleotide, an oligonucleotide or an analogue thereof, x, y, z are integers of 1 or higher or y is 0, and 1 is a covalent bond, or a spacer arm. Methods for preparing polymer (I) and its use, in particular for nucleic acid synthesis, sequencing and hybridization, are also disclosed.
摘要翻译：通式（I）的共聚物，其中单元A是电子导电聚合物的单体，单元B是核苷酸，寡核苷酸或其类似物，x，y，z是1以上的整数或y为0，和1是共价键或间隔臂。还公开了制备聚合物（I）的方法及其用途，特别是用于核酸合成，测序和杂交。

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