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1. 发明申请

US20040191400A1 High-intensity sweetener composition and delivery of same 失效
标题翻译：高强度甜味剂组合物和交付相同
公开(公告)号：US20040191400A1
公开(公告)日：2004-09-30
申请号：US10403918
申请日：2003-03-31
发明人： Steven Catani , Anne-Lise Lucas
IPC分类号： A23G003/00 , C07H013/02
CPC分类号： A23L27/37 , A23P10/28 , A61K9/2018
摘要： A composition for sweetening ingestable solids or liquids. The composition is compressed and comprises less than about 7.5 weight-% sucralose and one or more diluents. The composition is compressed at a pressure of greater than 2 pounds per square inch. A method of forming the composition and a system for delivering the composition are also provided.
摘要翻译：用于甜化可摄取固体或液体的组合物。组合物被压缩并且包含小于约7.5重量％的三氯蔗糖和一种或多种稀释剂。组合物在大于2磅/平方英寸的压力下被压缩。还提供了形成组合物的方法和用于输送组合物的系统。

2. 发明申请

US20040175808A1 Process to ribofuranose sugar derivatives as intermediates to branched-chain nucleosides 失效
标题翻译：将呋喃核糖衍生物作为支链核苷的中间体的方法
公开(公告)号：US20040175808A1
公开(公告)日：2004-09-09
申请号：US10729105
申请日：2003-12-05
发明人： Kimberly A. Savary , Zhiguo J. Song , J. Michael Williams , Feng Xu
IPC分类号： C12P019/02 , C07H013/02
CPC分类号： C07H13/02
摘要： A novel process is provided for the preparation of ribofuranose sugar derivatives which are useful in the synthesis of branched-chain ribonucleoside inhibitors of HCV polymerase for the treatment of HCV infection. Also provided are useful intermediates obtained from the instant process.
摘要翻译：提供了一种制备呋喃核糖衍生物的新方法，其可用于合成用于治疗HCV感染的HCV聚合酶的支链核糖核苷抑制剂。还提供了从本方法获得的有用的中间体。

3. 发明申请

US20030013862A1 Solid- and solution-phase synthesis of heparin and other glycosaminoglycans 有权
标题翻译：固相和溶液相合成肝素和其他糖胺聚糖
公开(公告)号：US20030013862A1
公开(公告)日：2003-01-16
申请号：US10054724
申请日：2002-01-22
发明人： Peter H. Seeberger , Hernan Orgueira , Peter Schell
IPC分类号： C07H013/02 , C07H005/04
CPC分类号： C07H3/06 , C07H3/04 , C08B37/0075
摘要： Described is a modular, general synthetic strategy for the preparation in solution and on a solid support of heparin, heparin-like glycosaminoglycans, glycosaminoglycans and non-natural analogs of each of them. Additionally, the modular strategy provides the basis for the preparation of combinatorial libraries and parallel libraries of defined glycosaminoglycan oligosaccharides. The defined glycosaminoglycan structures may be used in high-throughput screening experiments to identify carbohydrate sequences that regulate a host of recognition and signal-transduction processes. The determination of specific sequences involved in receptor binding holds great promise for the development of molecular tools which will allow modulation of processes underlying viral entry, angiogenesis, kidney diseases and diseases of the central nervous system. Notably, the present invention enables the automated synthesis of glycosaminoglycans in much the same fashion that peptides and oligonucleotides are currently assembled.
摘要翻译：描述了一种模块化的，一般的合成策略，用于制备溶液和固体支持肝素，肝素样糖胺聚糖，糖胺聚糖和它们各自的非天然类似物。此外，模块化策略为制备组合文库和定义的糖胺聚糖寡糖的平行文库提供了基础。所定义的糖胺聚糖结构可用于高通量筛选实验以鉴定调节宿主识别和信号转导过程的碳水化合物序列。涉及受体结合的具体序列的确定对于分子工具的开发具有很大的希望，这将允许调节病毒进入，血管生成，肾脏疾病和中枢神经系统疾病的过程。值得注意的是，本发明能够以与肽和寡核苷酸当前组装的大致相同的方式自动合成糖胺聚糖。

4. 发明申请

US20020103369A1 Methods of preparing disaccharide and trisaccharide C6-C12 fatty acid esters with high alpha content and materials therefrom 失效
标题翻译：制备具有高α含量的二糖和三糖C6-C12脂肪酸酯的方法及其材料
公开(公告)号：US20020103369A1
公开(公告)日：2002-08-01
申请号：US09933409
申请日：2001-08-20
发明人： John Steele Debenham , Charles Michael Buchanan , Matthew Davie Wood , Michael Orlando Malcolm , Mary Kathleen Moore
IPC分类号： C07H013/02
CPC分类号： C07H13/06
摘要： The present invention provides chemical processes for the preparation of disaccharide and trisaccharide C6 to C12 fatty acid esters having a high alpha content. Yet still further, the invention provides materials prepared by the processes disclosed herein.
摘要翻译：本发明提供了制备具有高α含量的二糖和三糖C6至C12脂肪酸酯的化学方法。另外，本发明提供了通过本文公开的方法制备的材料。

5. 发明申请

US20030050252A1 Process for preparing tannate liquid and semi-solid dosage forms 失效
标题翻译：制备鞣酸液体和半固体剂型的方法
公开(公告)号：US20030050252A1
公开(公告)日：2003-03-13
申请号：US10119285
申请日：2002-04-09
发明人： Jeffrey S. Kiel , H. Greg Thomas , Narasimhan Mani
IPC分类号： A61K031/7024 , C07H013/02
CPC分类号： A61K31/205 , A61K9/007 , A61K9/2004 , A61K9/4858 , A61K9/4866 , A61K31/7024 , Y10S514/849 , Y10S514/85 , Y10S514/853 , Y10S514/855 , Y10S514/937
摘要： An active ingredient from the group of an antihistamine, a decongestant, an antitussive or anticholinergic is dissolved in a suitable solvent and added to a dispersion of tannic acid in water to form the tannate salt complex of the active ingredient. The active ingredient tannate salt complex without isolation or purification is then added to a liquid or semi-solid medium composed of thickening, suspending, coloring, sweetening and flavoring agents, with stirring. Thereafter, preservatives, pH-adjusting and anti-caking agents in a suitable solvent are mixed with the liquid or semi-solid medium to generate a therapeutic dosage form.
摘要翻译：将抗组胺剂，减充血剂，镇咳药或抗胆碱能药物的活性成分溶解在合适的溶剂中，并加入到鞣酸在水中的分散体中以形成活性成分的鞣酸盐复合物。然后将不分离或纯化的活性成分单宁盐复合物在搅拌下加入到由增稠剂，悬浮剂，着色剂，甜味剂和调味剂组成的液体或半固体培养基中。然后，将合适溶剂中的防腐剂，pH调节剂和抗结块剂与液体或半固体培养基混合以产生治疗剂型。

6. 发明申请

US20020120133A1 Trans-acidolysis process for the preparation of carbohydrate fatty-acid esters 失效
标题翻译：用于制备碳水化合物脂肪酸酯的反式酸解过程
公开(公告)号：US20020120133A1
公开(公告)日：2002-08-29
申请号：US10050402
申请日：2002-01-15
发明人： Olobo Jonathan Obaje
IPC分类号： C07H013/02
CPC分类号： C07H13/04 , Y02P20/582
摘要： The present invention relates to a low temperature, solvent-free trans-acidolysis process for preparing surface-active carbohydrate fatty-acid esters comprising the steps of: (e) reacting acylated carbohydrate with free fatty acid in the presence of acid catalyst, under reduced pressure, and without adding any solvent; (f) decolorizing and separating the reaction mixture obtained in step (a) into unreacted fatty acid layer and a carbohydrate fatty-ester layer; (g) precipitating out the unreacted acylated carbohydrate; (h) librating the hydroxyl groups by partial hydrolysis in the presence of an acid catalyst; (i) removing the unreacted free fatty acids and unreacted carbohydrate esters of low molecular-weight carboxylic acids during purification, and recycling the removed unreacted free fatty acids and carbohydrate esters to the starting reactant mixture.
摘要翻译：本发明涉及一种用于制备表面活性碳水化合物脂肪酸酯的低温无溶剂的反式酸解方法，包括以下步骤：（e）在酸催化剂存在下，将酰化碳水化合物与游离脂肪酸反应，压力，不加任何溶剂; （f）将步骤（a）中获得的反应混合物脱色并分离成未反应的脂肪酸层和碳水化合物脂肪酸酯层; （g）沉淀未反应的酰化碳水化合物; （h）在酸催化剂存在下，通过部分水解来回收羟基; （i）在纯化期间除去低分子量羧酸的未反应游离脂肪酸和未反应的碳水化合物酯，并将除去的未反应的游离脂肪酸和碳水化合物酯循环到起始反应物混合物中。

7. 发明申请

US20020106747A1 Esterified polysaccharide products and beta-lactone ring opened ketene dimer products containing the compositions, and process of making the same 有权
标题翻译：酯化多糖产物和β-内酯环打开含有组合物的烯酮二聚体产物，以及制备相同的方法
公开(公告)号：US20020106747A1
公开(公告)日：2002-08-08
申请号：US10068501
申请日：2002-02-06
发明人： H. N. Cheng , Qu Ming Gu
IPC分类号： C12P019/04 , C07H013/02 , C12N009/18
CPC分类号： C08B3/02 , C08B3/00 , C08B11/20 , C08B37/0096
摘要： Esterified polysaccharides and the process of making such products are disclosed. The process can be enzymatic where an enzyme is used as a catalyst for the reaction. The process can also be chemical where no enzyme is used. Novel Products are obtained through lipase-catalyzed null-lactone ring opening alcoholysis of ketene dimers and the process of making such compositions containing products.
摘要翻译：公开了酯化多糖及其制备方法。该方法可以是酶，其中酶用作反应的催化剂。该方法也可以是不使用酶的化学物质。新产品通过脂肪酶催化的β-内酯开环烯酮二聚体的醇解和制备含有产物的组合物的方法获得。

8. 发明申请

US20020103370A1 Genetic control of acetylation and pyruvylation of xanthan based polysaccharide polymers 审中-公开
标题翻译：黄原胶多糖聚合物的乙酰化和丙酮酸化的遗传控制
公开(公告)号：US20020103370A1
公开(公告)日：2002-08-01
申请号：US09986803
申请日：2001-11-13
发明人： Daniel H. Doherty , Donna M. Ferber , John D. Marrelli , Rebecca W. Vanderslice , Randal A. Hassler
IPC分类号： C07H013/02
CPC分类号： C12R1/64 , C08B37/0033 , C09K8/08 , C12N15/00 , C12N15/01 , C12P19/06 , Y10S435/822
摘要： Variant xanthan gums are provided which include a water-soluble polysaccharide polymer comprising repeating pentamer units having a D-glucose:D-mannose:D-glucuronic acid ratio of about 2:2:1, and a water-soluble polysaccharide polymer comprising repeating tetramer units having a D-glucose:D-mannose:D-glucuronic acid ratio of about 2:1:1. The D-glucose moieties are linked in a beta-null1,4null configuration. The inner D-mannose moieties are linked in an alpha-null1,3null configuration, generally to alternate glucose moieties. The D-glucuronic acid moieties are linked in a beta-null1,2null configuration to the inner mannose moieties. The outer mannose moieties are linked to the glucuronic acid moieties in a beta-null1,4null configuration. Processes for preparing the polysaccharide polymers are also provided.
摘要翻译：提供变体黄原胶，其包括水溶性多糖聚合物，其包含具有约2:2:1的D-葡萄糖：D-甘露糖：D-葡萄糖醛酸比率的重复五聚体单元和包含重复四聚体的水溶性多糖聚合物具有D-葡萄糖：D-甘露糖：D-葡萄糖醛酸比例为约2:1:1的单元。 D-葡萄糖部分以β-（1,4）构型连接。内部D-甘露糖部分以α-[1,3]构型连接，通常为交替的葡萄糖部分。 D-葡萄糖醛酸部分以β-（1,2）构型连接到内部甘露糖部分。外部甘露糖部分以β-（1,4）构型与葡萄糖醛酸部分连接。还提供了制备多糖聚合物的方法。

9. 发明申请

US20020031562A1 Recovery of gaultherin from plants 审中-公开
标题翻译：从植物中回收高乐宁
公开(公告)号：US20020031562A1
公开(公告)日：2002-03-14
申请号：US09887766
申请日：2001-06-21
发明人： David M. Ribnicky , Alexander A. Poulev , Ilya Raskin
IPC分类号： A61K035/78 , C07H013/02
CPC分类号： A61K36/45
摘要： The present invention provides methods for obtaining gaultherin, a natural salicylate derivative, from plant tissue. The methods involve preventing the hydrolysis of the gaultherin in the plant tissue by disrupting the plant tissue under solvent conditions lacking a drying agent. The invention further provides various forms of plant-derived gaultherin, including alcohol extracts, aqueous solutions and dried preparations, all suitable for use as a natural aspirin substitute.
摘要翻译：本发明提供从植物组织获得天然水杨酸衍生物的高乐酚的方法。所述方法包括通过在不含干燥剂的溶剂条件下破坏植物组织来防止植物组织中的高丝氨酸的水解。本发明还提供各种形式的植物来源的高丝氨酸，包括醇提取物，水溶液和干燥制剂，所有这些都适合用作天然阿司匹林替代物。

10. 发明申请

US20040063928A1 Preparation of aliphatic acid ester of carbohydrate 审中-公开
标题翻译：碳水化合物脂肪酸酯的制备
公开(公告)号：US20040063928A1
公开(公告)日：2004-04-01
申请号：US10466444
申请日：2003-07-16
发明人： In-Ho Jo
IPC分类号： C07H013/02
CPC分类号： C07H13/06
摘要： The present invention is a process for producing an aliphatic acid ester of carbohydrate comprising the steps of preparing an emulsion containing a salt of aliphatic acid and aqueous solution of carbohydrate or its derivative, obtaining a solid by removing water from said emulsion, and reacting said solid and an aliphatic acid ester.
摘要翻译：本发明是一种生产碳水化合物脂肪酸酯的方法，包括以下步骤：制备含有脂肪酸盐和碳水化合物或其衍生物的水溶液的乳液，通过从所述乳液中除去水得到固体，并使所述固体和脂族酸酯。

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