专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06673793B2 Oxazinoquinolones useful for the treatment of viral infections 失效
标题翻译：用于治疗病毒感染的氧嗪喹诺酮类
公开(公告)号：US06673793B2
公开(公告)日：2004-01-06
申请号：US09894354
申请日：2001-06-28
申请人： Steven Ronald Turner , Suvit Thaisrivongs , Atli Thorarensen
发明人： Steven Ronald Turner , Suvit Thaisrivongs , Atli Thorarensen
IPC分类号： C07D49804
CPC分类号： C07D498/06 , C07D498/10 , C07D498/20
摘要： The present invention provides a compound of formula I which is useful as antiviral agents, in particular, as agents against viruses of the herpes family.
摘要翻译：本发明提供式I化合物，其可用作抗病毒剂，特别是作为抗疱疹家族病毒的药剂。

2. 发明授权

US06225310B1 Fused 1,2,4-thiadiazine derivatives, their preparation and use 失效
标题翻译：稠合1,2,4-噻二嗪衍生物，其制备和用途
公开(公告)号：US06225310B1
公开(公告)日：2001-05-01
申请号：US09539242
申请日：2000-03-30
申请人： Flemming Elmelund Nielsen , John Bondo Hansen , Holger Claus Hansen , Tina Møller Tagmose , John Patrick Mogensen
发明人： Flemming Elmelund Nielsen , John Bondo Hansen , Holger Claus Hansen , Tina Møller Tagmose , John Patrick Mogensen
IPC分类号： C07D49804
CPC分类号： C07D513/04
摘要： 1,2,4-Thiadiazine and 1,4-thiazine derivates represented by formula (I): wherein A, B, D, R1, R2, R3 and R4 are defined in the description, compositions thereof and methods for preparing the compounds are described. The compounds are useful in the treatment of diseases of the central nervous system, the cardiovascular system, the pulmonary system, the gastrointestinal system and the endocrinological system.
摘要翻译：由式（I）表示的1,2,4-噻二嗪和1,4-噻嗪衍生物：其中A，B，D，R 1，R 2，R 3和R 4在说明书中定义，其组成及其制备方法为所述化合物可用于治疗中枢神经系统，心血管系统，肺系统，胃肠系统和内分泌系统的疾病。

3. 发明授权

US06740656B2 Gonadotropin-releasing hormone receptor antagonists and methods relating thereto 有权
标题翻译：促性腺激素释放激素受体拮抗剂及其相关方法
公开(公告)号：US06740656B2
公开(公告)日：2004-05-25
申请号：US10211993
申请日：2002-08-02
申请人： Joseph Pontillo , Chen Chen
发明人： Joseph Pontillo , Chen Chen
IPC分类号： C07D49804
CPC分类号： C07D513/04
摘要： GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein A, R1, R2, R3a, R3b, R4, R5, R6, and n are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
摘要翻译：公开了GnRH受体拮抗剂，其可用于治疗男性和女性中各种性激素相关病症。本发明的化合物具有以下结构：其中A，R1，R2，R3a，R3b，R4，R5，R6和n如本文所定义，包括其立体异构体，前药和药学上可接受的盐。还公开了含有本发明化合物与药学上可接受的载体组合的组合物，以及涉及其在有需要的受试者中拮抗促性腺激素释放激素的方法。

4. 发明授权

US06608048B2 Tricyclic protein kinase inhibitors 失效
标题翻译：三环蛋白激酶抑制剂
公开(公告)号：US06608048B2
公开(公告)日：2003-08-19
申请号：US09820132
申请日：2001-03-28
申请人： Hwei-Ru Tsou , Elsebe Geraldine Overbeek-Klumpers , Allan Wissner
发明人： Hwei-Ru Tsou , Elsebe Geraldine Overbeek-Klumpers , Allan Wissner
IPC分类号： C07D49804
CPC分类号： C07D513/04
摘要： This invention provides compounds of Formula (I), where A″, Z, X and n are defined herein, or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of polycystic kidney disease.
摘要翻译：本发明提供式（I）化合物，其中A“，Z，X和n如本文所定义，或其药学上可接受的盐，其可用作抗肿瘤剂并用于治疗多囊肾病。

5. 发明授权

US06472416B1 Sulfonylphenylpyrazole compounds useful as COX-2 inhibitors 失效
标题翻译：可用作COX-2抑制剂的磺酰基苯基吡唑化合物
公开(公告)号：US06472416B1
公开(公告)日：2002-10-29
申请号：US09648202
申请日：2000-08-25
申请人： Teodozyj Kolasa , Meena V. Patel
发明人： Teodozyj Kolasa , Meena V. Patel
IPC分类号： C07D49804
CPC分类号： C07D487/04
摘要： The present invention encompasses novel sulfonylphenylpyrazole compounds useful in the treatment of cyclooxygenase-2 mediated diseases.
摘要翻译：本发明包括可用于治疗环氧合酶-2介导的疾病的新型磺酰基苯基吡唑化合物。

6. 发明授权

US06350745B1 Thrombin inhibitors 失效
标题翻译：凝血酶抑制剂
公开(公告)号：US06350745B1
公开(公告)日：2002-02-26
申请号：US09585740
申请日：2000-06-02
申请人： Craig A. Coburn , Christopher S. Burgey
发明人： Craig A. Coburn , Christopher S. Burgey
IPC分类号： C07D49804
CPC分类号： C07D498/04
摘要： Compounds of the invention, useful as thrombin inhibitors and having therapeutic value in for example, preventing coronary artery disease, have the following structure: or a pharmaceutically acceptable salt thereof, wherein A is wherein Y1 and Y2 are independently hydrogen, C1-4 alkyl, C1-4 alkoxy, FuHvC(CH2)0-1 O—, wherein u and v are either 1 or 2, provided that when u is 1, v is 2, and when u is 2, v is 1, C3-7 cycloalkyl, thio C1-4 alkyl, C1-4 sulfinylalkyl, C1-4 sulfonylalkyl, halogen cyano, or trifluoromethyl, and wherein b is 0 or 1.
摘要翻译：可用作凝血酶抑制剂并具有例如预防冠状动脉疾病的治疗价值的本发明化合物具有以下结构：或其药学上可接受的盐，其中A在其中Y 1和Y 2独立地为氢，C 1-4烷基，C 1-4烷氧基（CH 2）0-1 O-，其中u和v为1或2，条件是当u为1时，v为2，当u为2时，v为1，C 3-7环烷基，硫代C1- C4烷基，C1-4亚磺酰基烷基，C1-4磺酰基烷基，卤代，三氟甲基，其中b为0或1。

7. 发明授权

US06800648B2 Antipsychotic aminomethyl derivatives of 7,8-dihydro-3H-1,6,9-trioxa-3-AZA-cyclopenta[a]naphthalen-2-one 失效
标题翻译： 7,8-二氢-3H-1,6,9-三氧杂-3-AZA-环戊二烯并[a]萘-2-酮的抗精神病药物氨基甲基衍生物
公开(公告)号：US06800648B2
公开(公告)日：2004-10-05
申请号：US10133994
申请日：2002-04-25
申请人： Megan Tran , Gary P. Stack
发明人： Megan Tran , Gary P. Stack
IPC分类号： C07D49804
CPC分类号： C07D498/04
摘要： Compounds of the formula useful for treatment of disorders of the dopaminergic system, such as schizophrenia, schizoaffective disorder, bipolar disorder, Parkinson's disease, L-DOPA induced pychoses and dyskinesias, Tourette's syndrome and hyperprolactinemia and in the treatment of drug addiction such as the addiction to ethanol, nicotine or cocaine and related illnesses.
摘要翻译：用于治疗多巴胺能系统疾病如精神分裂症，分裂情感障碍，双相情感障碍，帕金森病，L-DOPA诱导的真菌和运动障碍，Tourette综合征和高催乳素血症以及治疗药物成瘾的成瘾的化合物，例如成瘾乙醇，尼古丁或可卡因及相关疾病。

8. 发明授权

US06800642B2 Antipsychotic aminomethyl derivatives of 7,8-dihydro-2,6,9-trioxa-3-aza-cyclopenta[a]naphthalene 失效
标题翻译： 7,8-二氢-2,6,9-三氧杂-3-氮杂 - 环戊二烯并[a]萘的抗精神病药物氨基甲基衍生物
公开(公告)号：US06800642B2
公开(公告)日：2004-10-05
申请号：US10131343
申请日：2002-04-24
申请人： Megan Tran , Gary P. Stack
发明人： Megan Tran , Gary P. Stack
IPC分类号： C07D49804
CPC分类号： C07D498/04
摘要： Compounds of the formula: useful for treatment of disorders such as schizophrenia, schizoaffective disorder, bipolar disorder, Parkinson's disease, L-DOPA induced pychoses and dyskinesias, Tourette's syndrome and hyperprolactinemia and in the treatment of drug addiction such as the addiction to ethanol, nicotine or cocaine and related illnesses.
摘要翻译：用于治疗精神分裂症，分裂情感障碍，双相性精神障碍，帕金森病，L-DOPA诱导的嗜酸性细菌和运动障碍，Tourette综合征和高催乳素血症和治疗药物成瘾如酒精，尼古丁成瘾的化合物或可卡因及相关疾病。

9. 发明授权

US06423843B1 Enantiomerically pure substituted oxaaza compounds, salts of the same, and processes for the preparation of both 失效
标题翻译：对映体纯的取代的氧杂杂环化合物，其盐，以及二者的制备方法
公开(公告)号：US06423843B1
公开(公告)日：2002-07-23
申请号：US09719687
申请日：2000-12-15
申请人： Naoki Ohta , Toru Makino , Sadahiro Shimizu
发明人： Naoki Ohta , Toru Makino , Sadahiro Shimizu
IPC分类号： C07D49804
CPC分类号： C07D207/14
摘要： This invention provides a method for conveniently obtaining a compound of formula (Ia) which is a production intermediate of antimicrobial compounds, in which a salt of optically active acid of formula (IIIa) is obtained by allowing a compound of formula (I), a ketone compound and an optically active acid to react with one another, converted into its free form and then hydrolyzed. In the formula, R1: hydrogen atom or alkyl, aryl or aralkyl group; R2: hydrogen atom or alkyl, aryl, aralkyl, acyl, alkyloxycarbonyl, aralkyloxycarbonyl or substituted sulfonyl; these may further have substituents.)
摘要翻译：本发明提供了一种方便地获得作为抗微生物化合物的生产中间体的式（Ia）化合物的方法，其中式（Ia）的光学活性酸盐通过使式（I）化合物，酮化合物和光学活性酸反应，转化为游离形式，然后水解。式中R1：氢原子或烷基，芳基或芳烷基; R2：氢原子或烷基，芳基，芳烷基，酰基，烷氧基羰基，芳烷氧基羰基或取代的磺酰基; 这些可以进一步具有取代基。）

10. 发明授权

US06306851B1 Cyclocarbamate and cyclic amide derivatives 失效
标题翻译：环氨基甲酸酯和环酰胺衍生物
公开(公告)号：US06306851B1
公开(公告)日：2001-10-23
申请号：US09552036
申请日：2000-04-19
申请人： Arthur A. Santilli , Andrew Q. Viet , Puwen Zhang , Andrew Fensome , Jay E. Wrobel , James P. Edwards , Todd K. Jones , Christopher M. Tegley , Lin Zhi
发明人： Arthur A. Santilli , Andrew Q. Viet , Puwen Zhang , Andrew Fensome , Jay E. Wrobel , James P. Edwards , Todd K. Jones , Christopher M. Tegley , Lin Zhi
IPC分类号： C07D49804
CPC分类号： C07D498/04 , A61K31/5365
摘要： This invention provides compounds of the formula: wherein A and B are independent substituents selected from S, CH or N; provided that when A is S, B is CH or N; and when B is S, A is CH or N; and A and B cannot both be CH; and when A and B both equal N, one N may be optionally substituted with an C1 to C6 alkyl group; R1 and R2 are independent substituents selected from the group of H, C1 to C6 alkyl, substituted C1 to C6 alkyl, C2 to C6 alkenyl, substituted C2 to C6 alkenyl, C2 to C6 alkynyl, substituted C2 to C6 alkynyl, C3 to C8 cycloalkyl, substituted C3 to C8 cycloalkyl, aryl, substituted aryl, heterocyclic, substituted heterocyclic, CORA, or NRBCORA; or R1 and R2 are fused to form optionally substituted 3 to 8 membered spirocyclic alkyl, alkenyl or heterocyclic ring, the heterocyclic ring containing one to three heteroatoms selected from the group of O, S and N; or pharmaceutically useful salts thereof. The compounds of this invention are useful as agonists and antagonists of the progesterone receptor and in methods of inducing contraception and in the treatment or prevention of benign or malignant neoplastic diseases.
摘要翻译：本发明提供下式的化合物：其中A和B是选自S，CH或N的独立取代基; 条件是当A为S时，B为CH或N; 当B为S时，A为CH或N; A和B不能同时为CH; 并且当A和B均等于N时，一个N可以任选地被C 1至C 6烷基取代; R1和R2是选自H，C1至C6烷基，取代C1至C6烷基，C2至C6烯基，取代C2至C6烯基，C2至C6炔基，取代C2至C6炔基，C3至C8环烷基的独立取代基取代的C 3至C 8环烷基，芳基，取代的芳基，杂环，取代的杂环，CORA或NRBCORA; 或R 1和R 2稠合形成任选取代的3至8元螺环烷基，烯基或杂环，所述杂环含有一至三个选自O，S和N的杂原子; 或其药学上有用的盐。本发明的化合物可用作孕激素受体的激动剂和拮抗剂以及诱导避孕和治疗或预防良性或恶性肿瘤疾病的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式