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1. 发明授权

US06478966B2 System for extracting tetrodotoxin 失效
公开(公告)号：US06478966B2
公开(公告)日：2002-11-12
申请号：US09818775
申请日：2001-03-28
申请人： Maoqing Zhou , Frank Hay Kong Shum
发明人： Maoqing Zhou , Frank Hay Kong Shum
IPC分类号： C07D49100
CPC分类号： B01J20/14 , B01D15/00 , B01J20/20 , B01J39/00
摘要： The invention relates to a system for extracting toxins from biological tissues. The system comprises a lixiviator, an ion-exchange column, a diatomaceous silica-active carbon column, and a vacuum concentrator. Twenty to one hundred kilograms of raw material can be processed at one time when puffer fish ovaries are used as the starting material.

2. 发明授权

US06518421B1 Process for the preparation of epothilone analogs 有权
公开(公告)号：US06518421B1
公开(公告)日：2003-02-11
申请号：US09775361
申请日：2001-02-01
申请人： Wen Sen Li , John E. Thornton , Zhenrong Guo , Shankar Swaminathan
发明人： Wen Sen Li , John E. Thornton , Zhenrong Guo , Shankar Swaminathan
IPC分类号： C07D49100
CPC分类号： C07D303/38 , C07D417/06 , C07D491/04
摘要： The present invention relates to a process for the preparation of epothilone analogs by initially forming novel ring-opened epothilones and carrying out a macrolactamization reaction thereon. The subject process is amenable to being carried out in a single reaction vessel without isolation of the intermediate compound and provides at least about a three-fold increase in yield over prior processes for preparing the desired epothilone analogs.

3. 发明授权

US06500953B1 Preparation of camptothecin and nothapodytine derivatives 失效
标题翻译：喜树碱和非生物素衍生物的制备
公开(公告)号：US06500953B1
公开(公告)日：2002-12-31
申请号：US09744547
申请日：2001-01-26
申请人： Khalid Mekouar , Yves Genisson , Stefanie Leue , Andrew-Elliot Greene
发明人： Khalid Mekouar , Yves Genisson , Stefanie Leue , Andrew-Elliot Greene
IPC分类号： C07D49100
CPC分类号： C07D471/14
摘要： The invention concerns the preparation of nothapodytine or camptothecin derivatives which consists in causing 4-ethyl 2methyl hepta-2,4-dienoic acid act on a 3-aminomethyl 2-bromo quinoline derivative (III) wherein R1 and R2 are H or R1 is a halogen atom or alkyl, R2 is a O—CO—X radical as defined for the camptothecin derivatives; or R1 and R2 are defined for the known camptothecin derivatives or represent protected radicals or radicals easily convertible into the radicals R1 and R2, to obtain the quinoline derivative (IV); adding to the resulting quinoline derivative (2-methoxy carbonyl vinyl) tributyltin in the presence of a complex of palladium and triphenylarsin to obtain the quinoline derivative (V); cyclizing the resulting quinoline derivative to obtain the tetracyclic derivative (VI); then in subjecting said derivative to an ozonolysis followed by treatment with dimethyl sulphide to obtain the tetracyclic derivative (VII); saponification followed by decarboxylation in oxidising conditions of the resulting tetracyclic derivative to obtain the nothopodytine derivative (VIII); then optionally transforming the resulting derivative into a camptothecin derivative or into a mappicine derivative.
摘要翻译：本发明涉及制备异头蛇嘌呤或喜树碱衍生物，其中包括使4-乙基-2-甲基庚-2,4-二烯酸作用于3-氨基甲基2-溴喹啉衍生物（III），其中R 1和R 2为H或R 1为卤素原子或烷基，R2是对于喜树碱衍生物所定义的O-CO-X基团; 或者R 1和R 2定义为已知的喜树碱衍生物，或表示易于转化成基团R 1和R 2的被保护的基团或基团，以获得喹啉衍生物（Ⅳ）。在钯和三苯基胂络合物的存在下，向所得的喹啉衍生物（2-甲氧基羰基乙烯基）三丁基锡中加入，得到喹啉衍生物（Ⅴ）; 使得到的喹啉衍生物环化，得到四环衍生物（VI）; 然后使所述衍生物进行臭氧分解，然后用二甲基硫醚处理以获得四环衍生物（VII）; 皂化，随后在所得四环衍生物的氧化条件下脱羧，得到羟基喹啉衍生物（VIII）; 然后任选将得到的衍生物转化为喜树碱衍生物或映射蛋白衍生物。

4. 发明授权

US06740756B1 Fluorescent lanthanide chelates 失效
标题翻译：荧光镧系螯合物
公开(公告)号：US06740756B1
公开(公告)日：2004-05-25
申请号：US09720965
申请日：2001-06-20
申请人： George Wai-Kin Chan , Robert P. Hertzberg
发明人： George Wai-Kin Chan , Robert P. Hertzberg
IPC分类号： C07D49100
CPC分类号： C07D491/04 , C07D219/06 , C07D311/86
摘要： The present invention provides complexing agents of Formula I which contain novel photosensitizers and produce long-lived fluorescence for use in bioaffinity assays, especially HTRF (homogeneous time-resolved fluorescence) assays.
摘要翻译：本发明提供式I的络合剂，其包含新型光敏剂并产生用于生物亲和测定，特别是HTRF（均相时间分辨荧光）测定的长寿命荧光。

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