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1. 发明专利

JPS4815950B1 失效
公开(公告)号：JPS4815950B1
公开(公告)日：1973-05-18
申请号：JP9915970
申请日：1970-11-12
IPC分类号： C07D213/61 , C07D213/64 , C07D213/70 , C07D213/73 , C07D213/75 , C07D213/78 , C07D213/82 , C07D213/85 , C07D213/89 , C07D29/40

2. 发明专利

JPS4811102B1 失效
公开(公告)号：JPS4811102B1
公开(公告)日：1973-04-10
申请号：JP11139170
申请日：1970-12-15
IPC分类号： C07D211/90 , C07D29/40

3. 发明专利

JPS4948680A 失效
公开(公告)号：JPS4948680A
公开(公告)日：1974-05-11
申请号：JP6344273
申请日：1973-06-07
IPC分类号： C07D211/80 , A61K31/4422 , C07D211/82 , C07D211/90 , C07D29/40

4. 发明专利

JPS4818236B1 失效
公开(公告)号：JPS4818236B1
公开(公告)日：1973-06-04
申请号：JP11139070
申请日：1970-12-15
IPC分类号： C07D211/90 , C07D29/40

5. 发明申请

US20020006936A1 Bicyclic inhibitors of protein farnesyl transferase 失效
标题翻译：蛋白质法呢基转移酶的双环抑制剂
公开(公告)号：US20020006936A1
公开(公告)日：2002-01-17
申请号：US09910967
申请日：2001-07-23
发明人： Jack Bikker , Ellen Myra Dobrusin , Annette Marian Doherty , Matthew Drowns , James Stanley Kaltenbronn , Juergen Kleinschroth , Dennis Joseph McNamara , John Quin III , Joseph Thomas Repine , Marcin Stasiak
IPC分类号： A61K031/404 , A61K031/4745 , C07D29/40
CPC分类号： C07D233/64 , C07D231/12 , C07D233/56 , C07D249/08 , C07D405/12 , C07D409/12
摘要： The present invention provides compounds of Formula I 1 The present invention also provides a method of treating cancer and treating or preventing restenosis or atherosclerosis. Also provided by the present invention is a pharmaceutically acceptable composition containing a compound of Formula I.
摘要翻译：本发明提供式I化合物本发明还提供了治疗癌症和治疗或预防再狭窄或动脉粥样硬化的方法。本发明还提供了含有式I化合物的药学上可接受的组合物。

6. 发明授权

US3679689A Preparation of substituted pyridines 失效
标题翻译：取代的吡啶的制备
公开(公告)号：US3679689A
公开(公告)日：1972-07-25
申请号：US3679689D
申请日：1970-07-06
申请人： UNION OIL CO
发明人： FENTON DONALD M
IPC分类号： C07D211/02 , C07D211/82 , C07D213/12 , C07D29/40
CPC分类号： C07D213/12 , C07D211/02 , C07D211/82
摘要： Substituted pyridines are prepared by reacting an ethylenically unsaturated hydrocarbon, carbon monoxide, water and ammonia in a liquid medium containing a Group VIII noble metal catalyst in complex association with a biphyllic ligand or an aromatic heterocyclic amine at a temperature of 50* to 400* C and a pressure of 5 to 300 atmospheres. A typical process comprises contacting ethylene, carbon monoxide and water with a liquid reaction medium containing rhodium trichloride and triphenylphosphine to produce dihydrodimethylethylpyridine.
摘要翻译：取代的吡啶通过在含有VIII族贵金属催化剂的液体介质中与烯属不饱和烃，一氧化碳，水和氨反应，在50-400℃的温度下与二元配体或芳族杂环胺复合而制备压力为5〜300个大气压。典型的方法包括使乙烯，一氧化碳和水与含有三氯化铑和三苯基膦的液体反应介质接触以产生二氢二甲基乙基吡啶。

7. 发明授权

US3484447A 4,4'-(bis n,n'-carbamyl methyl) tetrahydrobipyridyls 失效
标题翻译： 4,4' - （BIS N，N'-羰基甲基）四氢吡啶并[
公开(公告)号：US3484447A
公开(公告)日：1969-12-16
申请号：US3484447D
申请日：1966-04-11
申请人： ICI LTD
发明人： COLCHESTER JOHN EDWARD , ENTWISLE JOHN HUBERT
IPC分类号： C07D211/82 , C07D29/40 , C07D57/00
CPC分类号： C07D211/82

8. 发明申请

US20020068756A1 PDE IV inhibiting amides, compositions and methods of treatment 失效
标题翻译： PDE IV抑制酰胺，组合物和治疗方法
公开(公告)号：US20020068756A1
公开(公告)日：2002-06-06
申请号：US09797083
申请日：2001-03-01
发明人： Marc Labelle , Claudio Sturino , Nicolas Lachance , Dwight Macdonald
IPC分类号： C07D29/40 , C07D213/00
CPC分类号： C07D401/12 , C07D209/42 , C07D401/14 , C07D403/12
摘要： Compounds represented by formula I: 1 as well as pharmaceutically acceptable salts and hydrates thereof are disclosed as useful for treating or preventing diseases and conditions mediated by PDE-IV. Pharmaceutical compositions and methods of treatment are also included.
摘要翻译：公开了由式I表示的化合物及其药学上可接受的盐和水合物，其用于治疗或预防由PDE-IV介导的疾病和病症。还包括药物组合物和治疗方法。

9. 发明授权

US3781291A Silylated 1,4-dihydropyridines 失效
标题翻译：苯基1,4-二羟基吡啶
公开(公告)号：US3781291A
公开(公告)日：1973-12-25
申请号：US3781291D
申请日：1971-05-26
申请人： SULZBACH R , IQBAL A
发明人： SULZBACH R , IQBAL A
IPC分类号： C07F7/10 , C07D29/40
CPC分类号： C07F7/10
摘要： SILYLATED NITROGEN CONTAINING HETEROCYCLIC COMPOSITIONS OF THE FORMULA

R1-SI(-R)2-N
WHEREIN X AND Y ARE SELECTED FROM THE GROUP CONSISTING OF C-R3 AND N WITH THE PROVISO THAT NO NITROGEN ATOM IS ADJACENT TO ANOTHER NITROGEN ATOM; R IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF HYDROCARBYL, HETEROCYCLIC, SILYL AND STANNYL WHEREIN THE MEMBER MAY BE ATTACHED VIA AN OXYGEN ATOM; R1 IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF HYDROCARBYL, HETEROCYCLIC, SILYL, STANNYL AND HYDROGEN WHEREIN THE MEMBER MAY OR MAY NOT BE ATTACHED VIA AN OXYGEN ATOM; R2 IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF HYDROCARBYL, HETEROCYCLIC, SILYL, STANNYL, HYDROGEN, TERTIALRY AMINO, PHOSPHINO, OXOPHOSPHINO, ACETAL AND KETAL WHEREIN SAID MEMBER MAY OR MAY NOT BE ATTACHED VIA AN OXYGEN ATOM AND WHEREIN R2 AND X TOGETHER MAY BE AN ORTHO CONDENSED CYCLIC OR POLYCYCLIC SYSTEM; AND R3 IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF HYDROCARBYL, HETEROCYCLIC, SILYL, STANNYL, HYDROGEN, TERTIARY AMINO, PHOSPHINO, OXOPHOSPHINO, ACETAL AND KETAL WHEREIN SAID MEMBER MAY NOT BE ATTACHED VIA AN OXYGEN ATOM . EXEMPLARY OF SUCH COMPOSITIONS ARE 1,4-BIS-(TRIMETHYLSILYL)-1,4-DIHYDROPYRIDINE, 1,4,4-TRIS-(TRIMETHYLSILYL)-1,4DIHYDROPYRIDINE, 1,4-BIS(TRIMETHYL)-1,4-DIHYDROQUINOLINE, AND 1,4 - BIS - (TRIMETHYLSILYL) - 1,4 - DIHYDROPYRAZINE. THE COMPOSITIONS OF THE INVENTION ARE USEFUL AS CATALYSTS FOR THE ADDITION OF CHLOROSILANES TO ESTERS AND KETONES AND AS REDUCING AGENTS FOR PREPARING HYDROGENATION CATALYSTS FROM NOBLE METAL COMPOUNDS SUCH AS RHODIUM AND PLATINUM.

10. 发明授权

US3485847A 4-aryl-1,4-dihydropyridines 失效
标题翻译： 4-亚芳基-1,4-二氢吡啶
公开(公告)号：US3485847A
公开(公告)日：1969-12-23
申请号：US3485847D
申请日：1968-03-13
申请人： BAYER AG
发明人： BOSSERT FRIEDRICH , VATER WULF
IPC分类号： C07D211/90 , C07D29/40 , A61K27/00
CPC分类号： C07D211/90

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