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1. 发明授权

US06294541B1 Purine derivatives having phosphodiesterase IV inhibition activity 失效
标题翻译：具有磷酸二酯酶IV抑制活性的嘌呤衍生物
公开(公告)号：US06294541B1
公开(公告)日：2001-09-25
申请号：US09418330
申请日：1999-10-14
申请人： David J. Cavalla , Mark Chasin , Peter Hofer , Andre Gehrig , Peter Wintergerst
发明人： David J. Cavalla , Mark Chasin , Peter Hofer , Andre Gehrig , Peter Wintergerst
IPC分类号： C07D27320
CPC分类号： C07D473/24 , C07D473/18 , C07D473/20 , C07D473/30 , C07D473/34
摘要： A compound of the formula: wherein R3 represent a C1-8 alkyl which is unbranched or branched and unsubstituted or substituted with OH, alkoxy, CO2H, ═NOH, ═NOCONH2, or ═O; C3-8 cycloalkyl which is unsubstituted or substituted with OH, alkoxy, CO2H, ═NOH, ═NOCONH2, or ═O; C4-8 cycloalkylalkyl wherein the cycloalkyl portion is unsubstituted or substituted with OH, alkoxy, CO2H, ═NOH, ═NOCONH2, or ═O; aryl which is unsubstituted or substituted with Cl, NH2, alkylamino, dialkylamino, amido, C1-C8 alkylamido, C1-C3 dialkylamido, OH, alkoxy, HC═NOH, HC═NOCONH2, C1-C3 alkyl, phenyl or benzyl; aralkyl (C1-4); heterocyclyl; heterocyclylalkyl (C1-C4); and heteroaryl; R8 represents H or a C1-8 alkyl which is unbranched or branched and unsubstituted or substituted with OH, alkoxy, CO2H, ═NOH, ═NOCONH2, or ═O; C3-8 cycloalkyl which is unsubstituted or substituted with OH, alkoxy, CO2H, ═NOH, ═NOCONH2, or ═O; C4-8 cycloalkylalkyl wherein the cycloalkyl portion is unsubstituted or substituted with OH, alkoxy, CO2H, ═NOH, ═NOCONH2, or ═O; aryl which is unsubstituted or substituted with Cl, NH2, alkylamino, dialkylamino, amido, C1-C8 alkylamido, C1-C3 dialkylamido, OH, alkoxy, HC═NOH, HC═NOCONH2, C1-C3 alkyl, phenyl or benzyl; aralkyl (C1-4); heterocyclyl; heterocyclylalkyl (C1-C4); and heteroaryl.
摘要翻译：下式的化合物：其中R 3表示未支链或未支化或被OH，烷氧基，CO 2 H，= NOH，= NOCONH 2或= O取代的C 1-8烷基; 未取代或被OH，烷氧基，CO 2 H，= NOH，= NOCONH 2或= O取代的C 3-8环烷基; C4-8环烷基烷基，其中环烷基部分未被取代或被OH，烷氧基，CO 2 H，= NOH，= NOCONH 2或= O取代; 未取代或被Cl，NH 2，烷基氨基，二烷基氨基，酰氨基，C 1 -C 8烷基酰氨基，C 1 -C 3二烷基氨基，OH，烷氧基，HC = NOH，HC = NOCONH 2，C 1 -C 3烷基，苯基或苄基取代的芳基; 芳烷基（C1-4）; 杂环基杂环基烷基（C1-C4）; R 8表示H或未分支或未被取代或被OH，烷氧基，CO 2 H，= NOH，= NOCONH 2或= O取代的C 1-8烷基; 未取代或被OH，烷氧基，CO 2 H，= NOH，= NOCONH 2或= O取代的C 3-8环烷基; C4-8环烷基烷基，其中环烷基部分未被取代或被OH，烷氧基，CO 2 H，= NOH，= NOCONH 2或= O取代; 未取代或被Cl，NH 2，烷基氨基，二烷基氨基，酰氨基，C 1 -C 8烷基酰氨基，C 1 -C 3二烷基氨基，OH，烷氧基，HC = NOH，HC = NOCONH 2，C 1 -C 3烷基，苯基或苄基取代的芳基; 芳烷基（C1-4）; 杂环基杂环基烷基（C1-C4）; 和杂芳基。

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